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| 1 | Liver fat content determined by magnetic resonance imaging and spectroscopy显示文摘Hepatic steatosis as the most prevalent liver disorder can either be related to alcoholic liver disease (ALD) or non-alcoholic fatty liver disease (NAFLD). In both conditions, hepatocytes excessively accumulate fatcontaining vacuoles within their cytoplasm, which is the key histological feature. In contrast to ALD, NAFLD is commonly associated with metabolic syndrome, obesity and insulin resistance. To determine increased liver fat content, liver biopsy is currently considered the gold standard. Besides the invasive technique, various other non-invasive techniques have been developed, such as ultrasound, computed tomography (CT), magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) based methods. Among these techniques, ultrasound and CT provide only qualitative information about hepatic steatosis, whereas MRS-or MRI-based methods are able to determine even small amounts of fat accurately. These non-invasive magnetic resonance techniques have already proven their great potential, especially in longitudinal and cross-sectional studies regarding various metabolic conditions and medical treatment regimens. In this review, the most common, non-invasive MRS/MRI techniques for assessment of intrahepatic lipid content are described with their inherent advantages and limitations. | Fabian Springer Jürgen Machann Claus D Claussen Fritz Schick Nina F Schwenzer | 2010 | World Journal of Gastroenterology2010，16，13： | 19 |
| 2 | Machine-learning-assisted discovery of polymers with high thermal conductivity using a molecular design algorithm显示文摘The use of machine learning in computational molecular design has great potential to accelerate the discovery of innovative materials.However,its practical benefits still remain unproven in real-world applications,particularly in polymer science.We demonstrate the successful discovery of new polymers with high thermal conductivity,inspired by machine-learning-assisted polymer chemistry.This discovery was made by the interplay between machine intelligence trained on a substantially limited amount of polymeric properties data,expertise from laboratory synthesis and advanced technologies for thermophysical property measurements.Using a molecular design algorithm trained to recognize quantitative structure—property relationships with respect to thermal conductivity and other targeted polymeric properties,we identified thousands of promising hypothetical polymers.From these candidates,three were selected for monomer synthesis and polymerization because of their synthetic accessibility and their potential for ease of processing in further applications.The synthesized polymers reached thermal conductivities of 0.18–0.41 W/mK,which are comparable to those of state-of-the-art polymers in non-composite thermo-plastics. | Stephen Wu Yukiko Kondo Masa-aki Kakimoto Bin Yang Hironao Yamada Isao Kuwajima Guillaume Lambard Kenta Hongo Yibin Xu Junichiro Shiomi Christoph Schick Junko Morikawa Ryo Yoshida | 2019 | npj Computational Materials2019，，1： | 14 |
| 3 | Let’s talk about Secs: Sec61, Sec62 and Sec63 in signaltransduction, oncology and personalized medicine显示文摘The heterotrimeric Sec61 complex and the dimeric Sec62/Sec63 complex are located in the membrane of the human endoplasmic reticulum(ER)and play a central role in translocation of nascent and newly synthesized precursor polypeptides into the ER.This process involves targeting of the precursors to the membrane and opening of the polypeptide conducting Sec61 channel for translocation.Apart from this central role in the intracellular transport of polypeptides,several studies of the last decade uncovered additional functions of Sec proteins in intracellular signaling:Sec62 can induce ER-phagy in the process of recovery of cells from ER stress and the Sec61 channel can also act as a passive ER calcium leak channel.Furthermore,mutations,amplifications and an overexpression of the SEC genes were linked to various diseases including kidney and liver diseases,diabetes and human cancer.Studies of the last decade could not only elucidate the functional role of Sec proteins in the pathogenesis of these diseases,but also demonstrate a relevance of Sec62 as a prognostic and predictive biomarker in head and neck cancer,prostate and lung cancer including a basis for new therapeutic strategies.In this article,we review the current understanding of protein transport across the ER membrane as central function of Sec proteins and further focus on recent studies that gave first insights into the functional role and therapeutic relevance of Sec61,Sec62 and Sec63 in human diseases. | Maximilian Linxweiler Bernhard Schick Richard Zimmermann | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 8 |
| 4 | Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance显示文摘 | Nina F. Schwenzer Fabian Springer Christina Schraml Norbert Stefan Jürgen Machann Fritz Schick | 2009 | Journal of Hepatology2009，，3： | 4 |
| 5 | The Effect of Self-nucleation on Isothermal Crystallization Kinetics of Poly(butylene succinate)(PBS) Investigated by Differential Fast Scanning Calorimetry显示文摘Differential fast scanning calorimetry(DFSC) was employed on the study of self-nucleation behavior of poly(butylene succinate)(PBS).The ultra-fast cooling ability of DFSC allows investigating the effect of self-nucleation on the isothermal crystallization kinetics over a wide temperature range.Crystallization half-time,instead of crystallization peak temperature,was used to describe the self-nucleation behavior,and the self-nucleation domain for the samples crystallized at different temperatures was determined.Due to the competition between homogenous nucleation and self-nuclei,the effect of self-nucleation was less pronounced at high supercooling than that for the sample isothermally crystallized at higher temperature.An efficiency scale to judge the efficiency of nucleating agents from the crystallization half-time was also introduced in this work. | Jing Jiang Evgeny Zhuravlev Wen-bing Hu Christoph Schick 周东山 | 2017 | Chinese Journal of Polymer Science2017，35，8： | 4 |
| 6 | PTFE纤维:通过专利生产技术获取的特性显示文摘描述了PTFE纤维LenzingProfilen的特性和应用。PTFE纤维提供独特的性质,从而具有多种用途,例如热气体过滤、压缩包装、汽车和其他产业用途、特种纺织品和建筑,以及医疗卫生领域。生产这类高性能PTFE纤维的生产技术是相当昂贵的。 | M. Marsche W. Schick 桑榆(译) 申熠(校) | 2006 | 国际纺织导报2006，34，12： | 4 |
| 7 | Role of contrast enhanced ultrasound in detection of abdominal aortic abnormalities in comparison with multislice computed tomography显示文摘 | Dirk-André Clevert Kerstin Schick CHEN Min-hua ZHU Qing-li Maximilian Reiser | 2009 | Chinese Medical Journal2009，，7： | 3 |
| 8 | 高合金化Al-Zn-Mg-Cu系7049A合金的连续冷却析出图(英文)显示文摘研究了所有有技术价值的冷却速率范围内7049A铝合金的析出行为。冷却速率从接近平衡冷却时的慢速条件变化到形成完全超饱和固溶体的高速率,跨越了7个数量级(0.0005到5000K/s)。7049A铝合金连续冷却析出行为采用差热分析(DSC)、扫描电镜(SEM)和维氏硬度测量相结合的方法记录。冷却速率在0.0005到4K/s时,对高合金化、高强度和高淬火敏感性的变形铝合金7049A从固溶温度下的淬火析出行为采用传统的DSC方法研究。在此冷却速率范围内,至少观察到了两个放热反应:一个是在很窄的温度区间430~450℃内的高温反应;另外一个是最低到200℃且范围很宽的低温反应。这两个反应的强度随着冷却速率的增高而降低。采用快速差热分析(DFSC)和差分再加热方法(DRM)对合金淬火冷却速率从慢速到数千K/s时的析出行为进行了研究。该合金不析出沉淀相时的临界淬火速率为100~300K/s。 | Davit ZOHRABYAN Benjamin MILKEREIT Christoph SCHICK Olaf KESSLER | 2014 | Transactions of Nonferrous Metals Society of China2014，24，7： | 3 |
| 9 | High Hepatic SCD1 Activity Is Associated with Low Liver Fat Content in Healthy Subjects under a Lipogenic Diet显示文摘 | Günther Silbernagel Marketa Kovarova Alexander Cegan Jürgen Machann Fritz Schick Rainer Lehmann Hans-Ulrich H?ring Norbert Stefan Erwin Schleicher Andreas Fritsche Andreas Peter | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，，12： | 3 |
| 10 | 鞍结节脑膜瘤手术疗效以及对视神经管和视力的影响 | Schick U. Hassler W. 邓剑平 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，10： | 2 |
| 11 | African Homo erectus: old radiometric ages and young Oldowan assemblages in the middle Awash Valley, Ethiopia 显示文摘 | Clark JD de Heinzelin J Schick | 1994 | Science1994，264，： | 2 |
| 12 | 快速可控降温及纳米薄膜体系用芯片量热仪:综述显示文摘本论文主要介绍在过去的5年中,Rostock大学物理研究所发展起来的可控降温,以及升温速度可以达到106K.s-1的薄膜芯片量热仪。许多材料,特别是高分子材料的物理性质通常都强烈地依赖于其热历史,这一量热仪已经成功地用于它们的快速热处理以及同步的热力学量(如热容、焓等)的测量。从而为我们进行亚稳态结构的形成与演化、超快热处理中新的人工材料的制备等问题提供了新的研究手段。此外,由于其非常小的附加热容,该量热仪具有非常高的灵敏性,可用于只有几十纳克的样品的研究。利用交流差分(AC)设计,量热仪的灵敏度提高到几十pico pJ.K-1的量级。从而可以研究受限于厚度仅为几个纳米的高分子薄膜的玻璃化转变过程中热容的变化。本文先讨论要实现快速降温的策略,然后描述该量热仪的传感器的静态和动态热温性质,最后介绍在高分子研究中的几个例子,证实该量热仪在不同测量模式下的应用能力。 | 陈葳 周东山 薛奇 Christoph Schick | 2008 | 物理学进展2008，28，2： | 2 |
| 13 | The Road to PPB:The States of Budget Reform显示文摘 | ALLEN SCHICK | 1966 | Public Administration Review1966，，： | 1 |
| 14 | Technique of micrcoendoscopy inmedial lumbar hemiation显示文摘 | Schick U Dohnert J | 2002 | Minim Invasive Neurosurg2002，45，2： | 1 |
| 15 | p53 and Her2/neu in juvenile angiofibromas显示文摘 | Schick B Veldung B Wemmert S | 2005 | Oncol Rep2005，13，3： | 1 |
| 16 | Diagnostics and treatment of spontaneous intracranial hypotension显示文摘 | Schick U Musahl C Papke K | 2010 | Minim Invasive Neurosurg2010，53，： | 1 |
| 17 | New aspects of pathogenesis of juvenile angiofibroma显示文摘 | Schick B Urbschat S | 2004 | Hosp Med2004，65，5： | 1 |
| 18 | Subtle bone marrow edema assessed by frequency selective chemical shift MRI 显示文摘 | Schick F Bongers H Aicher K | 1992 | J Comput Assist Tomogr1992，16，3： | 1 |
| 19 | Effect of β-casomorphins and analogs on insulin release in dogs显示文摘 | SCHUSDZIARRA V SCHICK A D de la FUENTE A | 1983 | Endocrinology1983，112，3： | 1 |
| 20 | Whole-body MRI at high field: technical limits and clinical potential显示文摘 | Fritz Schick | 2005 | European Radiology2005，，5： | 1 |
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