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| 1 | EGFR and HER2 expression in advanced biliary tract cancer显示文摘AIM:To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2)in patients with advanced biliary tract cancer(BTC). METHODS:EGFR and HER2 expression was studied in biopsy samples from 124 patients(51%women; median age 64.8 years),with advanced BTC diagnosed between 1997 and 2004.Five micrometers sections of paraffin embedded tissue were examined by standard, FDA approved immunohistochemistry.Tumors with scores of 2+or 3+for HER2 expression on immunochemistry were additionally tested for HER2 gene amplification by fluorescence in situ hybridisation(FISH).RESULTS:34/124 patients(27.4%)had gallbladder cancer,47(37.9%)had intrahepatic BTC and 43(34.7%)had extrahepatic or perihilar BTC.EGFR expression was examined in a subset of 56 samples. EGFR expression was absent in 22/56 tumors(39.3%). Of the remaining samples expression was scored as 1+in 12(21.5%),2+in 13(23.2%)and 3+in 9(16%), respectively.HER2 expression was as follows:score 0 73/124(58.8%),score 1+27/124(21.8%),score 2+ 21/124(17%)and score 3+4/124(3.2%).HER2 gene amplification was present in 6/124,resulting in an overall amplification rate of 5%. CONCLUSION:Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC,while targeting EGFR may be promising. | Jan Harder Oliver Waiz Florian Otto Michael Geissler Manfred Olschewski Brigitte Weinhold Hubert E Blum Annette Schmitt-Graeff Oliver G Opitz | 2009 | World Journal of Gastroenterology2009，15，36： | 18 |
| 2 | Outcome in a hepatitis C (genotype 1b) single source outbreak in Germany—a 25-year multicenter study显示文摘 | Manfred Wiese Kurt Grüngreiff Wolfgang Güthoff Michael Lafrenz Ute Oesen Heiner Porst | 2005 | Journal of Hepatology2005，，4： | 2 |
| 3 | Laparoscopic Partial Nephrectomy in Cold Ischemia:: Renal Artery Perfusion显示文摘 | GüNTER JANETSCHEK ALAA ABDELMAKSOUD FARIBORZ BAGHERI HASSAN AL-ZAHRANI KARL LEEB MANFRED GSCHWENDTNER | 2004 | The Journal of Urology2004，，： | 2 |
| 4 | Salicylic Acid Alleviates the Cadmium Toxicity in Barley Saedlings显示文摘 | Ashraf M Iris F Manfred G | 2003 | Plant Physiology2003，132，： | 1 |
| 5 | Effect of CO2 and steam gasification reactions on the oxy- combustion of pulverized coal char显示文摘 | Ethan S H Christopher R S Manfred G | 2012 | Combustion and Flame2012，159，11： | 1 |
| 6 | Salicylic Acid Alleviates the Cadmium Toxicity in Barley Seedlings显示文摘 | Ashraf M Iris F Manfred G | 2003 | Plant Physiol2003，132，： | 1 |
| 7 | Phytoene desaturase is localized exclusively in the chlorplast and up-regulated at the mRNA level during accumulation of secondary carotenoids in Haematococcus pluvialis (Volvocales,Chlorophyceae)显示文摘 | Manfred E Joseph H | 2000 | Plant Physiol2000，122，4： | 1 |
| 8 | Association of Laryngopharyngeal Symptoms with Gastroesophageal Reflux Disease显示文摘 | Tauber S Manfred G Issing W J | 2002 | Laryngoscope2002，112，5： | 1 |
| 9 | Event study concerning international bond price effects of credit rating actions 显示文摘 | MANFRED Steiner VOLKER G H | 2001 | International Journal of Finance & Economics2001，，6： | 1 |
| 10 | Comparison of differ ent vibrant soundbridge audioprocessors with conventional hearing aids显示文摘 | Ingo T Rainer OS Manfred G | 2002 | Otology & Neurotology2002，23，： | 1 |
| 11 | A consistent input-output formulation of shared consumer and producer responsibility 显示文摘 | Blanca G Manfred L | 2005 | Economic Systems Research2005，17，4： | 1 |
| 12 | A Homologous Series of O-and N-Functionalized2,2-Difluoro-1,3-benzodioxoles:An Exercise in Organometallic Meth-odology显示文摘 | MANFRED S JOANNA G EVA C | 2003 | European Journal of Organic Chemistry2003，，3： | 1 |
| 13 | Mitochondrial sulfide oxidation in Arenicola marina, Evidence for alternative electron pathways显示文摘 | SUSANNE V MANFRED K G | 2004 | European Journal of Biochemistry2004，235，12： | 1 |
| 14 | Heart rate variability and cardiac troponin I are incremental and independent predictors of one-year all-cause mortality after major noncardiac surgery in patients at risk of coronary artery disease显示文摘 | Miodrag Filipovic Raban Jeger Cecilia Probst Thierry Girard Matthias Pfisterer Lorenz Gürke Karl Skarvan Manfred D. Seeberger | 2003 | Journal of the American College of Cardiology2003，，10： | 1 |
| 15 | Homologous Series of O- and N-Functionalized 2,2-Difluoro- 1,3-benzodioxoles: an Exercise in Organometallic Methodology显示文摘 | MANFRED S JOANNA G EVA C A | 2003 | European Journal of Organic Chemistry2003，3，： | 1 |
| 16 | Zika virus in Gabon(Central Africa)-2007:a new threat from Aedes albopictus?显示文摘 | Grard G Mélanie C Illich Manfred M DieudonnéN Statiana MO Davy J Didier F Christophe P Eric Maurice L | 2014 | PLoS Negl Trop Dis2014，8，2： | 1 |
| 17 | Theory, development and implementation of national customer satisfaction indices: The Swiss index of customer satisfaction (SWICS)显示文摘 | Manfred B Michael A G | 2000 | Total Quality Management2000，7，： | 1 |
| 18 | Performance characteristics of pulsating heat pipes as integral thermal spreaders 显示文摘 | YANG H H KHANDEKAR S MANFRED G | 2009 | International Journal of Thermal Science2009，48，4： | 1 |
| 19 | Is the efficacy of hormonal therapy affected by lymph node status? data from the bicalutamide (Casodex) Early Prostate Cancer program显示文摘 | Peter Iversen Manfred P Wirth William A See David G McLeod Ira Klimberg Donald Gleason Gerald Chodak James Montie Chris Tyrrell D.M.A Wallace Karl P.J Delaere Per Lundmo Teuvo L.J Tammela Jan-Erik Johansson Tom Morris Kevin Carroll | 2004 | Urology2004，，5： | 1 |
| 20 | Importance of cardiac troponins I and T in risk stratification of patients with acute pulmonary embolism显示文摘 | STAVROS K ANNETTE G MANFRED O | 2002 | Circulation2002，106，3： | 1 |
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