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| 1 | Origin and accumulation of high-maturity oil and gas in deep parts of the Baxian Depression, Bohai Bay Basin, China显示文摘Great quantities of light oil and gas are produced from deep buried hill reservoirs at depths of 5,641 m to 6,027 m and 190 °C to 201 °C in the Niudong-1 Well, representing the deepest and hottest commercial hydrocarbons discovered in the Bohai Bay Basin in eastern China. This discovery suggests favorable exploration prospects for the deep parts of the basin. However, the discovery raises questions regarding the genesis and accumulation of hydrocarbons in deep reservoirs. Based on the geochemical features of the hydrocarbons and characteristics of the source rocks as well as thermal simulation experiments of hydrocarbon generation, we conclude that the oil and gas were generated from the highly mature Sha-4 Member (Es4 ) source rocks instead of thermal cracking of crude oils in earlier accumulations. The source kitchen with abnormal pressures and karsted carbonate reservoirs control the formation of high-maturity hydrocarbon accumulations in the buried hills (i.e., Niudong-1) in conjunction with several structural-lithologic traps in the Es4 reservoirs since the deposition of the upper Minghuazhen Formation. This means the oil and gas exploration potential in the deep parts of the Baxian Depression is probably high. | Zhao Xianzheng Jin Qiang Jin Fengming Ma Peng Wang Quan Wang Jing Ren Chunling Xi Qiuling | 2013 | Petroleum Science2013，10，3： | 10 |
| 2 | Characterization of Basic Nitrogen Aromatic Species Obtained during Fluid Catalytic Cracking by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry显示文摘The basic-nitrogen aromatic compounds in feedstocks and liquid products from the micro-reactor and soluble components of coke obtained during fluid catalytic cracking (FCC) process were analyzed by the micro-electrospray ionization (ESI) 9.4T Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) with an average mass resolving power of 300 000 at a mass range of 100-1 200. The analytical results revealed that the coker gas oil (CGO) contained a higher abundance of basic-nitrogen aromatic compounds with the type of -5N to -9N compared with those in deasphalted oil (DAO) and mixed FCC feedstock. After catalytic cracking, the abundance of lowly condensed basic-nitrogen aromatic compounds was much less than those of highly condensed aromatics in the liquid products, with the carbon number mainly ranging from 6 to 25 and the average carbon number of the side-chains equating to 1-5. On the contrary, with respect to the soluble components of coke, the abundance of lowly condensed basic-nitrogen aromatic compounds was more than those of highly condensed aromatics, and the carbon number ranged from 12 to 30, which was much smaller than that of the mixed FCC feedstock but slightly larger than that of the cracked liquid products. These results have provided some fundamental information on FCC process. | Liu Yingrong Wang Wei Hu Qiuling Zhu Yuxia Deng Jinghui Tian Songbai | 2012 | China Petroleum Processing & Petrochemical Technology2012，14，2： | 8 |
| 3 | Ages, Trace Elements and Hf-Isotopic Compositions of Zircons from Claystones around the Permian-Triassic Boundary in the Zunyi Section, South China: Implications for Nature and Tectonic Setting of the Volcanism显示文摘证据的成长身体证明二叠三叠纪的边界(PTB ) 附近的那个火山作用可能在触发 PermianTriassic (PTr ) 是关键的集体扑灭。因此,在华南的 PTB 附近的灰床可以在这个事件上带信息。三暴烈的灰层,改变了到泥土,在在 Zunyi 节的 PTB 床上的 outcropped,贵州省,西南中国。从这三张灰床的锆石谷物的 U-Pb 年龄,踪迹元素,和 Hf 同位素作文用 LA-ICPMS 和 LA-MC-ICPMS 被分析。锆石主要除了二 inherited/xenocrystic 锆石(939 和 2 325 妈) 是在起源(241-279 妈) 的 magmatic。这些 magmatic 锆石的年龄显示发生在中间附近的 magmatism 的三个事件 -- 晚二叠的边界(~ 261.5 妈, MLPB ) , Wuchiapingian-Changhsingian 边界(~ 254.5 妈, WCB ) ,并且 PTB (~ 250.5 妈) 分别地。MLPB 和 WCB 附近的 magmatism 的开始的二个事件可以被归因于 magmatic 继承或重新免职。所有 magmatic 锆石分享类似的踪迹元素和 Hf 同位素作文。他们有 Y, Hf, Th 和 U 内容和 Nb/Ta 比率典型地代表从硅的计算碱的岩浆的锆石。这些锆石也与 -11.4 的 Hf (t) 价值展出充实的 Hf 同位素作文到 +0.2,它建议三个 magmatic 事件涉及大陆人外壳融化。更多的充实的 Hf 同位素作文(床 ZY13 的 Hf (t)=-11.4--4.8)(~ 250.5 妈) 在岩浆暗示古老的外壳的材料的更多的输入。magmatic 锆石的 Hf 同位素和踪迹元素作文的集成建议 magmatism 的这三个事件可以由于 Palaeo-Tethys 海洋的闭合沿着会聚的大陆边缘发生在或在西南的华南附近。 | Qiuling Gao Zhong-Qiang Chen Ning Zhang William L.Griffin Wenchen Xia Guoqing Wang Tengfei Jiang Xuefei Xia Suzanne Y.O'Reilly | 2015 | Journal of Earth Science2015，26，6： | 8 |
| 4 | Correlation between the cumulative analgesic effect of electroacupuncture intervention and synaptic plasticity of hypothalamic paraventricular nucleus neurons in rats with sciatica显示文摘In the present study, a rat model of chronic neuropathic pain was established by ligation of the sciatic nerve and a model of learning and memory impairment was established by ovariectomy to investigate the analgesic effect of repeated electroacupuncture stimulation at bilateral Zusanli (ST36) and Yanglingquan (GB34). In addition, associated synaptic changes in neurons in the paraventricular nucleus of the hypothalamus were examined. Results indicate that the thermal pain threshold (paw withdrawal latency) was significantly increased in rats subjected to 2-week electroacupuncture intervention compared with 2-day electroacupuncture, but the analgesic effect was weakened remarkably in ovariectomized rats with chronic constrictive injury. 2-week electroacupuncture intervention substantially reversed the chronic constrictive injury-induced increase in the synaptic cleft width and thinning of the postsynaptic density. These findings indicate that repeated electroacupuncture at bilateral Zusanli and Yanglingquan has a cumulative analgesic effect and can effectively relieve chronic neuropathic pain by remodeling the synaptic structure of the hypothalamic paraventricular nucleus. | Qiuling Xu Tao Liu Shuping Chen Yonghui Gao Junying Wang Lina Qiao Junling Liu | 2013 | Neural Regeneration Research2013，8，3： | 6 |
| 5 | Formation mechanism of yolk-shell LaMnO3 microspheres prepared by P123-template and oxidation of NO显示文摘The yolk-shell LaMnO3 perovskite microspheres were fabricated by a novel,simple and mild soft template approach.A series of template-P123 concentrations(0-6.12 mmol·L^-1)were employed to optimize the most complete spheres.When the concentration of P123 is 3.0 mmol·L^-1,the obtained yolk-shell microspheres with a diameter of 200-700 nm were constructed by nanoparticles.The possible formation mechanism of the yolk-shell microspheres was revealed step by step via XRD,SEM,TEM,EDS and HRTEM.Molecules of P123 were suitably mixed with solvents for double shelled vesicles through self-assembly,which interacted with metal complexes to form P123-metal vesicles.After the removal of P123 and citric acid by calcination at 700 ℃,the yolk-shell LaMnO3 microspheres with through-channels were obtained.Through-channels on the surface were due to citric acid and the solid core was attributed to the shrink of inner vesicles.Prepared yolk-shell microsphere samples possessed a larger surface area and a higher maximum NO conversion value of 78% at 314 ℃ for NO oxidation,compared with samples without the yolk-shell structure. | Lihui WU Qiuling JIANG Li WANG Ying WANG Mengxue WANG | 2019 | Frontiers of Materials Science2019，13，1： | 3 |
| 6 | Single-cell transcriptomic landscape of human blood cells显示文摘High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis.However,an elaborate and comprehensive transcriptome reference of the whole blood system is lacking.Here,we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types,including hematopoietic stem cells,progenitors and mature blood cells derived from 21 healthy donors.With high sequencing depth and coverage,we constructed a single-cell transcriptional atlas of blood cells(ABC) on the basis of both protein-coding genes and long noncoding RNAs(lncRNAs),and showed a high consistence between them.Notably,putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified.While common transcription factor regulatory networks were activated in neutrophils and monocytes,lymphoid cells dramatically changed their regulatory networks during differentiation.Furthermore,we showed a subset of nucleated erythrocytes actively expressing immune signals,suggesting the existence of erythroid precursors with immune functions.Finally,a web portal offering transcriptome browsing and blood cell type prediction has been established.Thus,our work provides a transcriptional map of human blood cells at single-cell resolution,thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis. | Xiaowei Xie Mengyao Liu Yawen Zhang Bingrui Wang Caiying Zhu Chenchen Wang Qing Li Yingying Huo Jiaojiao Guo Changlu Xu Linping Hu Aiming Pang Shihui Ma Una Wang Wenbin Cao Shulian Chen Qiuling Li Sudong Zhang Xueying Zhao Wen Zhou Hongbo Luo Guoguang Zheng Erlie Jiang Sizhou Feng Lixiang Chen Lihong Shi Hui Cheng Sha Hao Ping Zhu Tao Cheng | 2021 | National Science Review2021，8，3： | 3 |
| 7 | A Multicenter Application and Evaluation of the Oxford Classification of IgA Nephropathy in Adult Chinese Patients显示文摘 | Cai-Hong Zeng Weibo Le Zhaohui Ni Minfang Zhang Lining Miao Ping Luo Rong Wang Zhimei Lv Jianghua Chen Jiong Tian Nan Chen Xiaoxia Pan Ping Fu Zhangxue Hu Lining Wang Qiuling Fan Hongguang Zheng Dewei Zhang Yaping Wang Yanhong Huo Hongli Lin Shuni Chen Sh | 2012 | American Journal of Kidney Diseases2012，，5： | 2 |
| 8 | Significance and strategies in developing delivery systems for bio-macromolecular drugs显示文摘 | Huining HE Qiuling LIANG Meong Cheoi SHIN Kyuri LEE Junbo GONG Junxiao YE Quan LIU Jingkang WANG Victor YANG | 2013 | Frontiers of Chemical Science and Engineering2013，7，4： | 2 |
| 9 | Regulation of mTORC1 by amino acids in mammalian cells: A general picture of recent advances显示文摘The mechanistic target of rapamycin complex 1(mTORC1)integrates various types of signal inputs,such as energy,growth factors,and amino acids to regulate cell growth and proliferation mainly through the 2 direct downstream targets,eukaryotic translation initiation factor 4 E-binding protein 1(4 EBP1)and ribosomal protein S6 kinase 1(S6 K1).Most of the signal arms upstream of mTORCl including energy status,stress signals,and growth factors converge on the tuberous sclerosis complex(TSC)-Ras homologue enriched in brain(Rheb)axis.Amino acids,however,are distinct from other signals and modulate mTORCl using a unique pathway.In recent years,the transmission mechanism of amino acid signals upstream of mTORCl has been gradually elucidated,and some sensors or signal transmission pathways for individual amino acids have also been discovered.With the help of these findings,we propose a general picture of recent advances,which demonstrates that various amino acids from lysosomes,cytoplasm,and Golgi are sensed by their respective sensors.These signals converge on mTORCl and form a huge and complicated signal network with multiple synergies,antagonisms,and feedback mechanisms. | Shizhe Zhang Xueyan Lin Qiuling Hou Zhiyong Hu Yun Wang Zhonghua Wang | 2021 | Animal Nutrition2021，，4： | 2 |
| 10 | Clinical Benefit of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors Plus Radiotherapy for Epidermal Growth Factor Receptor-Mutated Metastatic Non-Small Cell Lung Cancer: A Retrospective Analysis on Real World Data显示文摘Objective: To investigate the benefit of epidermal growth factor receptor( EGFR) tyrosine kinase inhibitors( TKIs)with radiotherapy in patients with EGFR mutation-positive metastatic non-small cell lung cancer( NSCLC),compared with TKIs alone.Methods: A total of 103 patients with stage Ⅳ EGFR-mutated NSCLC treated from February 2015 to May 2017 at Sichuan Cancer Hospital were analyzed retrospectively. Fifty patients were treated with EGFR-TKIs( gefitinib or erlotinib) plus radiotherapy( the TKI +RT group) and 53 patients received EGFR-TKIs alone( the TKI group). Tumor response,survival and toxicities were compared between the two groups. Results: Median follow-up time was 11. 7 months( 2. 8-36. 3 months). The overall response rate( ORR) and disease control rate( DCR) in the TKI + RT group vs the TKI group were 62% vs 37. 7%( P = 0. 014) and 88% vs 75. 5%( P =0. 101),respectively. The median progression-free survival( PFS) and median overall survival( OS) in the TKI + RT group were superior to those of the TKI group( 18. 87 months vs 12. 80 months,P = 0. 035 and 23. 10 months vs 18. 30 months,P = 0. 011). OS rates in the TKI + RT group and the TKI group were 56. 0% vs 35. 8% at year 1( P = 0. 04) and 16. 0% vs 3. 8% at year 2( P =0. 036). Multivariate Cox model found that TKI + RT related to significantly better OS( hazard ratio = 0. 209;95% CI,0. 066 to0. 661;P = 0. 008) than TKI alone. Adverse events did not differ significantly between the two groups( P > 0. 050). Conclusion:Compared with EGFR-TKIs alone,EGFR-TKIs combined with radiotherapy was well tolerated and showed benefit in tumor response and survival for EGFR mutation-positive metastatic NSCLC patients. | Wang Ranlin Li Tao Lv Jiahua Sun Chang Shi Qiuling | 2019 | 肿瘤预防与治疗2019，32，5： | 2 |
| 11 | Preparation and doping mode of doped LiMn2O4 for Li-Ion batteries显示文摘 | LIU Qiuling WANG Shengping TAN Haibo | 2013 | Energies2013，6，3： | 1 |
| 12 | High rate ca-pabilities Fe-doped EMD electrodes for Li/MnO2 primary battery 显示文摘 | Liu Qiuling Wang Shengping Cheng Hong | 2013 | International Journal of Electrochemical Sci- ence2013，8，10： | 1 |
| 13 | Controllable synthesis of carbon nanotubes with ultrafine inner diameters in ethanol flame 显示文摘 | Wang Lanjuan Li Chunzhong Zhou Qiuling | 2007 | Phisica B2007，398，： | 1 |
| 14 | Controllable synthesis of carbon nanotubes with ultrafine inner diameters in ethanol flame显示文摘 | Wang Lanjuan Li Chunzhong Zhou Qiuling etal | 2007 | Physica B2007，398，1： | 1 |
| 15 | Multiple promoters and targeted micro RNA s direct the expressions of HMGB 3 gene transcripts in dairy cattle显示文摘 | Liming Li Jinming Huang Zhihua Ju Qiuling Li Changfa Wang Chao Qi Yan Zhang Qinlei Hou Suqin Hang Jifeng Zhong | 2012 | Anim Genet2012，，3： | 1 |
| 16 | Refractive-diffractive visual system for micro-display of LCOS显示文摘One head-mounted display visual system for computer entertainment and three-dimensional display of virtual-reality was achieved, which consists of a hybrid re-fractive-diffractive eyepiece and a relay reflector. It can be used in micro-display of liquid crystal on silicon (LCOS) diagonal of 18 mm. The whole system has better performance, with 60° field of view, 10 mm exit pupil, 23 mm eye relief, and reduces weight and size. | ZHAO Qiuling WANG Zhaoqi MU Guoguang LU Zhenwu | 2002 | Chinese Science Bulletin2002，47，16： | 1 |
| 17 | A high-resolution cell atlas of the domestic pig lung and an online platform for exploring lung single-cell data显示文摘The genetically engineered pig is regarded as an optimal source of organ transplantation for humans and an excellent model for human disease research,given its comparable physiology to human beings.A myriad of single-cell RNA sequencing(sc RNA-seq)data on humans has been reported,but such data on pigs are scarce.Here,we apply sc RNA-seq technology to study the cellular heterogeneity of 3-month-old pig lungs,generating the single-cell atlas of 13,580 cells covering 16 major cell types.Based on these data,we systematically characterize the similarities and differences in the cellular cross-talk and expression patterns of respiratory virus receptors in each cell type of pig lungs compared with human lungs.Furthermore,we analyze pig lung xenotransplantation barriers and reported the cell-type expression patterns of 10 genes associated with pig-to-human immunobiological incompatibility and coagulation dysregulation.We also investigate the conserved transcription factors(TFs)and their candidate target genes and constructed five conserved TF regulatory networks in the main cell types shared by pig and human lungs.Finally,we present a comprehensive and openly accessible online platform,Scdb Lung.Our sc RNA-seq atlas of the domestic pig lung and Scdb Lung database can guide pig lung research and clinical applicability. | Lijing Zhang Jiacheng Zhu Haoyu Wang Jun Xia Ping Liu Fang Chen Hui Jiang Qiuling Miao Weiying Wu Lingli Zhang Lihua Luo Xiaosen Jiang Yong Bai Chengcheng Sun Dongsheng Chen Xingliang Zhang | 2021 | Journal of Genetics and Genomics2021，48，5： | 1 |
| 18 | Estrogen improved metabolic syndrome through down-regulation of VEGF and HIF-1α to inhibit hypoxia of periaortic and intra-abdominal fat in ovariectomized female rats显示文摘 | JinWen Xu QiuLing Xiang GuiPing Lin XiaoDong Fu KeWen Zhou Ping Jiang ShuHui Zheng TingHuai Wang | 2012 | Molecular Biology Reports2012，，8： | 1 |
| 19 | Anisotropic Expansion and High Rate Discharge Performance of V-doped MnO2for Li/MnO2 Primary Battery显示文摘 | Wang Shengping Liu Qiuling | 2012 | Int J Electrochem Sci2012，7，2： | 1 |
| 20 | PRMT5 determines the pattern of polyploidization and prevents liver from cirrhosis and carcinogenesis显示文摘Human hepatocellular carcinoma(HCC)occurs almost exclusively in cirrhotic livers.Here,we report that hepatic loss of protein arginine methyltransferase 5(PRMT5)in mice is sufficient to cause cirrhosis and HCC in a clinically relevant way.Furthermore,pathological polyploidization induced by hepatic loss of PRMT5 promotes liver cirrhosis and hepatic tumorigenesis in aged liver.The loss of PRMT5 leads to hyperaccumulation of P21 and endoreplication-dependent formation of pathological mono-nuclear polyploid hepatocytes.PRMT5 and symmetric dimethylation at histone H4 arginine 3(H4R3me2s)directly associate with chromatin of P21 to suppress its transcription.More importantly,loss of P21 rescues the pathological mono-nuclear polyploidy and prevents PRMT5-deficiency-induced liver cirrhosis and HCC.Thus,our results indicate that PRMT5-mediated symmetric dimethylation at histone H4 arginine 3(H4R3me2s)is crucial for preventing pathological polyploidization,liver cirrhosis and tumorigenesis in mouse liver. | Jincheng Wang Xiang Huang Daoshan Zheng Qiuling Li Mei Mei Shilai Bao | 2023 | Journal of Genetics and Genomics2023，50，2： | 1 |
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