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| 1 | Enhanced stability of Pt nanoparticle electrocatalysts for fuel cells显示文摘尽管聚合物电解质膜燃料房间(PEMFC ) 由于他们的几乎零排出物,高力量密度,和高效率收到了宽广注意,目前, electrocatalysts 的有限稳定性在 PEMFC 使用了是到他们的大规模商品化的批评限制。作为流行地使用的 electrocatalyst 材料的一种类型,尽管高度碳,磅溶解,成熟的 Ostwald,和在严厉化学、电气化学的氧化下面的磅 nanoparticles (NP ) 的聚集的 efficientundergoes 腐蚀调节,碳黑色支持了铂(Pt/C ) ,它导致 electrocatalysts 的表演降级。以便克服这些劣势,许多组试着改进磅在上被装载的碳支持材料。它在强烈氧化下面与高表面区域,足够的抛锚地点,高电的传导性,和高氧化抵抗被发现了那一些小说碳 nanomaterials 和 noncarbon 材料在 PEMFC 的状况是理想的其他的支持。这评论加亮下列方面:(i) 在使用新奇的碳 nanomaterials 和 noncarbon 的最近的进展支持材料提高 electrocatalysts 的长期的耐久性;(ii ) 改进电的传导性,表面区域,和在金属和支持之间的强壮的相互作用的答案;并且(iii ) 在帮助的混合支持的 synergistic 效果改进 electrocatalysts 的稳定性。 | Li Li Linping Hu Jin Li Zidong Wei | 2015 | Nano Research2015，8，2： | 13 |
| 2 | Single-cell transcriptomic landscape of human blood cells显示文摘High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis.However,an elaborate and comprehensive transcriptome reference of the whole blood system is lacking.Here,we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types,including hematopoietic stem cells,progenitors and mature blood cells derived from 21 healthy donors.With high sequencing depth and coverage,we constructed a single-cell transcriptional atlas of blood cells(ABC) on the basis of both protein-coding genes and long noncoding RNAs(lncRNAs),and showed a high consistence between them.Notably,putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified.While common transcription factor regulatory networks were activated in neutrophils and monocytes,lymphoid cells dramatically changed their regulatory networks during differentiation.Furthermore,we showed a subset of nucleated erythrocytes actively expressing immune signals,suggesting the existence of erythroid precursors with immune functions.Finally,a web portal offering transcriptome browsing and blood cell type prediction has been established.Thus,our work provides a transcriptional map of human blood cells at single-cell resolution,thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis. | Xiaowei Xie Mengyao Liu Yawen Zhang Bingrui Wang Caiying Zhu Chenchen Wang Qing Li Yingying Huo Jiaojiao Guo Changlu Xu Linping Hu Aiming Pang Shihui Ma Una Wang Wenbin Cao Shulian Chen Qiuling Li Sudong Zhang Xueying Zhao Wen Zhou Hongbo Luo Guoguang Zheng Erlie Jiang Sizhou Feng Lixiang Chen Lihong Shi Hui Cheng Sha Hao Ping Zhu Tao Cheng | 2021 | National Science Review2021，8，3： | 3 |
| 3 | A novel PD-L1 targeting peptide self-assembled nanofibers for sensitive tumor imaging and photothermal immunotherapy in vivo显示文摘Programmed death 1(PD-1)and its ligand PD-L1 are two typical immune checkpoints.Antibody-based immune checkpoint blockade(ICB)strategy targeting PD-1/PD-L1 achieved a significant therapeutic effect on cancer.However,due to the impenetrability of antibody drugs and the occurrence of immune-related adverse events,only a minority of patients benefit from this treatment.Peptides multimerization has been widely proved to be an effective method to improve receptor binding affinity through a multivalent synergistic effect.In this study,we report a novel peptide-aggregation-induced emission(AIE)hybrid supramolecular TAP,which can self-assemble into nanofibers through non-covalent interactions such as hydrogen bonds,with a specific nanomolar affinity to PD-L1 in vivo and in vitro.Combined with near-infrared agents,it can be used for tumor imaging and photothermal therapy,which enables photothermal ablation of cancer cells for generating tumor-associated antigen(TAA)and triggering a series of immunological events.Collectively,our work suggests that synthetic self-assembled peptide nanofibers can be developed as attractive platforms for active photothermal immunotherapies against cancer. | Linping Fu Jianhu Zhang Chenchen Wu Weizhi Wang Dong Wang Zhiyuan Hu Zihua Wang | 2022 | Nano Research2022，15，8： | 0 |
| 4 | Spatiotemporal variations of ambient air pollutants and meteorological influences over typical urban agglomerations in China during the COVID-19 lockdown显示文摘To investigate the air quality change during the COVID-19 pandemic,we analyzed spatiotemporal variations of six criteria pollutants in nine typical urban agglomerations in China using ground-based data and examined meteorological influences through correlation analysis and backward trajectory analysis under different responses.Concentrations of PM2.5,PM10,NO2,SO2 and CO in urban agglomerations respectively decreased by 18%–45%(30%–62%),17%–53%(22%–39%),47%-64%(14%–41%),9%–34%(0%–53%)and 16%-52%(23%–56%)during Lockdown(Post-lockdown)period relative to Pre-lockdown period.PM2.5 pollution events occurred during Lockdown in Beijing-Tianjin-Hebe(BTH)and Middle and South Liaoning(MSL),and daily O3 concentration rose to gradeⅡstandard in Post-lockdown period.Distinct from the nationwide slump of NO2 during Lockdown period,a rebound(~40%)in Post-lockdown period was observed in Cheng-Yu(CY),Yangtze River Middle-Reach(YRMR),Yangtze River Delta(YRD)and Pearl River Delta(PRD).With slightly higher wind speed compared with 2019,the reduction of PM2.5(51%–62%)in Post-lockdown period is more than2019(15%–46%)in HC(Harbin-Changchun),MSL,BTH,CP(Central Plain)and SP(ShandongPeninsula),suggesting lockdown measures are effective to PM2.5 alleviation.Although O3 concentrations generally increased during the lockdown,its increment rate declined compared with 2019 under similar sunlight duration and temperature.Additionally,unlike HC,MSL and BTH,which suffered from additional(>30%)air masses from surrounding areas after the lockdown,the polluted air masses reaching YRD and PRD mostly originated from the long-distance transport,highlighting the importance of joint regional governance. | Linping Fan Shuang Fu Xin Wang Qingyan Fu Haohao Jia Hao Xu Guimei Qin Xue Hu Jinping Cheng | 2021 | Journal of Environmental Sciences2021，33，8： | 0 |
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