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| 1 | Regulation of mTORC1 by amino acids in mammalian cells: A general picture of recent advances显示文摘The mechanistic target of rapamycin complex 1(mTORC1)integrates various types of signal inputs,such as energy,growth factors,and amino acids to regulate cell growth and proliferation mainly through the 2 direct downstream targets,eukaryotic translation initiation factor 4 E-binding protein 1(4 EBP1)and ribosomal protein S6 kinase 1(S6 K1).Most of the signal arms upstream of mTORCl including energy status,stress signals,and growth factors converge on the tuberous sclerosis complex(TSC)-Ras homologue enriched in brain(Rheb)axis.Amino acids,however,are distinct from other signals and modulate mTORCl using a unique pathway.In recent years,the transmission mechanism of amino acid signals upstream of mTORCl has been gradually elucidated,and some sensors or signal transmission pathways for individual amino acids have also been discovered.With the help of these findings,we propose a general picture of recent advances,which demonstrates that various amino acids from lysosomes,cytoplasm,and Golgi are sensed by their respective sensors.These signals converge on mTORCl and form a huge and complicated signal network with multiple synergies,antagonisms,and feedback mechanisms. | Shizhe Zhang Xueyan Lin Qiuling Hou Zhiyong Hu Yun Wang Zhonghua Wang | 2021 | Animal Nutrition2021，，4： | 2 |
| 2 | Multiple promoters and targeted micro RNA s direct the expressions of HMGB 3 gene transcripts in dairy cattle显示文摘 | Liming Li Jinming Huang Zhihua Ju Qiuling Li Changfa Wang Chao Qi Yan Zhang Qinlei Hou Suqin Hang Jifeng Zhong | 2012 | Anim Genet2012，，3： | 1 |
| 3 | Deep reinforcement learning for optimal denial-of-service attacks scheduling显示文摘We consider an optimal denial-of-service(DoS)attack scheduling problem of N independent linear time-invariant processes,where sensors have limited computational capability.Sensors transmit measurements to the remote estimator via a communication channel that is exposed to DoS attackers.However,due to limited energy,an attacker can only attack a subset of sensors at each time step.To maximally degrade the estimation performance,a DoS attacker needs to determine which sensors to attack at each time step.In this context,a deep reinforcement learning(DRL)algorithm,which combines Q-learning with a deep neural network,is introduced to solve the Markov decision process(MDP).The DoS attack scheduling optimization problem is formulated as an MDP that is solved by the DRL algorithm.A numerical example is provided to illustrate the efficiency of the optimal DoS attack scheduling scheme using the DRL algorithm. | Fangyuan HOU Jian SUN Qiuling YANG Zhonghua PANG | 2022 | Science China(Information Sciences)2022，65，6： | 1 |
| 4 | Responses in splanchnic and mammary amino acid metabolism to short-term graded removal of methionine in lactating goats显示文摘Four multi-catheterized lactating goats were used in a 4×4 Latin square experiment to investigate the responses of amino acid metabolism in portal-drained viscera(PDV),liver,and mammary glands to short-term varying supplies of methionine(Met).During the last 45 h in each experimental period,goats were fasted for 12 h and then abomasally infused with an amino acid(AA)mixture plus glucose for 33 h.Treatments consisted of graded removal of Met from an infused AA mixture to achieve Met content in the infusate of 100%(complete),60%,30%,or 0%that in casein.Graded Met removal decreased the pro-duction of milk,milk protein,lactose,and fat linearly whilst also decreasing arterial Met concentration linearly(P<0.05).Meanwhile,net PDV uptake and liver removal of Met decreased linearly(P<0.05)due to decreased Met affinity of PDV and liver(P<0.05).Net mammary uptake of Met(P>0.1)was maintained as Met supply declined.This was achieved through increased mammary affinity(P<0.05)and increased mammary blood flow(P<0.05)totally offsetting the negative effect of decreased circu-lating Met concentration.Graded removal of Met from the infusate linearly decreased mammary uptake-to-milk output ratios of Met(P<0.05)and tended to decrease essential amino acid(EAA)linearly(0.05 | Yantao Li Mark D.Hanigan Xueyan Lin Zhiyong Hu Zhengui Yan Qiuling Hou Yun Wang Zhonghua Wang | 2023 | Animal Nutrition2023，，2： | 0 |
| 5 | Atom Recombination of Difluorocarbene Enables 3-Fluorinated Oxindoles from 2-Aminoarylketones显示文摘Contrary to the traditional implementation as a difluoromethyl group and recently disclosed role of C1 synthons in synthetic organic chemistry,difluorocarbene(:CF_(2))is reported herein to proceed in unprecedented atom recombination as both a C1 synthon and F1 reagent simultaneously to render valuable 3-fluorinated oxindoles from 2-aminoarylketones.The reaction does not require catalyst and features a broad range of substrates with good functional group compatibility and ease of execution.This transformation could be employed to the quick-constructions of certain bioactive molecule derivatives.The mechanistic experiments and density functional theory(DFT)calculations indicate that this atom recombination reaction of:CF_(2) for the synthesis of 3-fluorinated oxindoles may involve a rearrangement process of epoxide intermediates. | Guan Zhang Qianqian Shi Mengyuan Hou Kai Yang Shihui Wang Shuai Wang Wangyang Li Chaokun Li Jian Qiu Hetao Xu Lu Zhou Cece Wang Shi-Jun Li Yu Lan Qiuling Song | 2022 | CCS Chemistry2022，4，5： | 0 |
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