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| 1 | The microsatellite polymorphism of heme oxygenase-1 is associated with baseline plasma IL-6 level but not with restenosis after coronary in-stenting显示文摘Background Vascular smooth muscle cells (VSMCs) can express heme-oxygenase (HO), a rate-limiting enzyme in the degradation of heme to bilirubin, ferritin and carbon monoxide (CO). VSMC-derived CO can suppress VSMC proliferation and may serve as an antiproliferation factor. The promoter region of HO-1 shows a polymorphism with different (GT)_n repeats that has been reported to differently induce gene expression. The objective of this study was to examine the effect of this variation on the occurrence of restenosis after in-stent treatment in patients with coronary artery disease. Methods Candidates who underwent coronary stent implantation were genotyped for the HO-1 promoter polymorphism using polymerase chain reaction (PCR) and automated DNA capillary sequencer. Serum levels of IL-6 and C-reactive protein (CRP) were obtained at baseline, 24 hours and 48 hours after stenting. The primary end point for the study was angiographic evidence of in-stent restenosis at 6 months. All parameters for evaluation of restenosis were analysed by quantitatve computer-assisted angiographic analysis (QCA). Results One hundred and eighty-seven patients who underwent coronary stent implantation were studied of whom 27.8% showed ≥50% restenosis after 6 months. The distribution of (GT)_n repeats of all patients in the promoter region of HO-1 genotype ranged from 22 to 42, with (GT)_ 25 and (GT)_ 32 being the two most common alleles. The allelic repeats were divided into the short class (S) with 29 (GT)_n, the middle class (M) with 30-37 (GT)_n and the long class (L) with 38 (GT)_n. There was no significant difference in the restenosis between the genotype groups or between post operation levels of inflammation markers, but carriers of the S allele (n=120) had 33.3% lower baseline IL-6 compared with non-S carriers (n=67, P=0.0008). Conclusions Although no association was observed between the HO-1 promoter polymorphism aod coronary in-stent restenosis following the stent procedure, the association with plasma IL-6 levels suggests that HO-1 S allele might protect from the atherosclerotic inflammatory process. | LI Ping Mohamed A. Elrayess Abuzeid H. Gomma Jutta Palmen Emma Hawe Kim M. Fox Steve E. Humphries | 2005 | Chinese Medical Journal2005，，18： | 6 |
| 2 | Census of Kuiper Comets-the TAOS Project显示文摘Cometary nuclei, the remnant icy bodies of planet formation, located at the outer edge of the solar system, are relatively poorly studied because of their small sizes and thus faintness. Thus far more than a hundred large members (size about 100 km) of this cometary population in the Kuiper belt have been identified. Smaller bodies (10 km) are much too faint to image directly and their number so far can only be extrapolated on theoretical grounds. The Taiwan-America Occultation Survey (TAOS) will conduct a census of the number of Kuiper belt objects down to a few km size by monitoring chance stellar occultations by these cometary nuclei. We will set up an array of small (50cm), wide-field (f/1 9) telescopes, each equipped with a 2K squared CCD camera, along a 7 km baseline in central Taiwan at an elevation above ~ 3000 m. The robot telescopes will operate in a coincidence mode, so the sequence and timing of any candidate occultation event can be recorded and distinguished against a false detection. The Lawrence Livermore National Laboratory, the National Central University, and the Academia Sinica, will each contribute one telescope system. Researchers from an international variety of institutes are also participating in the project. Our experiment provides the only means to study the cometary population in the small-sized end of the distrbution. A great number of scientific byproducts, notably variable stars, will also derive from the huge TAOS database, some 10, 000 giga-bytes worth of photometrical measuremements per year. | Wen Ping ChenOther TAOS team members: C. Alcock, K. Cook, S. Marshall, M. Hammergren(LLNL) T. Lee, C. Yuan, C. Y. Wen, S. K. King(ASIAA) W. S. Tsay, W. Ip, C. Lemme, J. H. Wang(NCU) T. Axelrod(ANU) I. de Pater(UCB) J.Lissauer(Ames) Y. I. Byun(Yonsei | 1999 | 天文研究与技术1999，，S1： | 3 |
| 3 | Uric Acid Stimulates Monocyte Chemoattractant Protein-1 Production in Vascular Smooth Muscle Cells Via Mitogen-Activated Protein Kinase and Cyclooxygenase-2显示文摘 | John Kanellis Susumu Watanabe Jin H. Li Duk Hee Kang Ping Li Takahiko Nakagawa Ann Wamsley David Sheikh-Hamad Hui Y. Lan Lili Feng Richard J. Johnson | 2003 | Hypertension: Journal of the American Heart Association2003，，6： | 2 |
| 4 | Overexpression of Interleukin-1β in the Murine Pancreas Results in Chronic Pancreatitis显示文摘 | Frederic Marrache Shui Ping Tu Govind Bhagat Swaroop Pendyala Christoph H. ?sterreicher Shanisha Gordon Vigneshwaran Ramanathan Melitta Penz-?sterreicher Kelly S. Betz Zhigang Song Timothy C. Wang | 2008 | Gastroenterology2008，，4： | 1 |
| 5 | Theoretical study of intermolecular proton transfer reaction in isolated 5-hydroxyisoxazole–water complexes显示文摘 | Ping G. Yi Yong H. Liang Zhen Q. Tang | 2005 | Chemical Physics2005，，3： | 1 |
| 6 | Chronic stress induces mast cell–dependent bacterial adherence and initiates mucosal inflammation in rat intestine显示文摘 | Johan D. S?derholm Ping–Chang Yang Peter Ceponis Angeli Vohra Robert Riddell Philip M. Sherman Mary H. Perdue | 2002 | Gastroenterology2002，，4： | 1 |
| 7 | Sulforaphane protects brains against hypoxic–ischemic injury through induction of Nrf2-dependent phase 2 enzyme显示文摘 | Zhang Ping Wenwu Liu Zhimin Kang Jianmei Cai Qiusha Wang Ni Cheng Sujian Wang Shizhong Wang John H. Zhang Xuejun Sun | 2010 | Brain Research2010，，： | 1 |
| 8 | Comparative study of thin sectional anatomical images from Chinese Visible Human data set and computed tomography images of superior mediastinum显示文摘 | Yi Wu Na Luo Li‐Wen Tan Bing‐Ji Fang Ying Li Bing Xie Hao‐Tong Xu Nan Hu Wei‐Ping Yang Wei Wu Wouter H. Lamers Shao‐Xiang Zhang | 2012 | Clin Anat2012，，8： | 1 |
| 9 | Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs显示文摘 | Anju Singh Guoyu Ling Avvaru N. Suhasini Ping Zhang Masayuki Yamamoto Ana Navas-Acien Gregory Cosgrove Rubin M. Tuder Thomas W. Kensler Walter H. Watson Shyam Biswal | 2008 | Free Radical Biology and Medicine2008，，： | 1 |
| 10 | The Interactions of Midazolam and Flumazenil on Human Memory and Cognition显示文摘 | M. M. Ghoneim Robert I. Block S. T. Sum Ping H. M. El-Zahaby James V. Hinrichs | 1993 | Anesthesiology1993，，6： | 1 |
| 11 | Super-ferric Dipole Prototype for Super-FRS of FAIR显示文摘 | Yuan Ping Ma Lizhen H. Leibrock Zhang Xiaoqi Zhang Bin Yao Qinggao Wu Weiyue Wang Qiuliang Wu Wei Wu xi Yang Tongjun Cuo Beilei Han Shaofei He Yuan Zhang Siling | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 1 |
| 12 | Polychlorinated dibenzo- p -dioxins and dibenzofurans pollution in China: Sources, environmental levels and potential human health impacts显示文摘 | Gene J. Zheng Anna O.W. Leung Li Ping Jiao Ming H. Wong | 2008 | Environment International2008，，7： | 1 |
| 13 | pH-Dependent Swelling and Solute Diffusion Characteristics of Poly(Hydroxyethyl Methacrylate–CO–Methacrylie Acid) Hydrogels显示文摘 | Jim H. Kou Gordon L. Amidon Ping I. Lee | 1988 | Pharmaceutical Research1988，，9： | 1 |
| 14 | Fluorocurcumins as Cyclooxygenase-2 Inhibitor: Molecular Docking, Pharmacokinetics and Tissue Distribution in Mice显示文摘 | Subhash Padhye Sanjeev Banerjee Deepak Chavan Shubhangini Pandye K.Venkateswara Swamy Shadan Ali Jing Li Q. Ping Dou Fazlul H. Sarkar | 2009 | Pharmaceutical Research2009，，11： | 1 |
| 15 | The Tarim picrite–basalt–rhyolite suite, a Permian flood basalt from northwest China with contrasting rhyolites produced by fractional crystallization and anatexis显示文摘 | Wei Tian Ian H. Campbell Charlotte M. Allen Ping Guan Wenqing Pan Mimi Chen Hongjiao Yu Wenping Zhu | 2010 | Contributions to Mineralogy and Petrology2010，，3： | 1 |
| 16 | Gene expression profiling in INS-1 cells overexpressing thioredoxin-interacting protein显示文摘 | Alexandra H. Minn Cynthia A. Pise-Masison Michael Radonovich John N. Brady Ping Wang Christina Kendziorski Anath Shalev | 2005 | Biochemical and Biophysical Research Communications2005，，3： | 1 |
| 17 | Quality of Life and Symptom Burden among Long-Term Lung Cancer Survivors显示文摘 | Ping Yang Andrea L. Cheville Jason A. Wampfler Yolanda I. Garces Aminah Jatoi Matthew M. Clark Stephen D. Cassivi David E. Midthun Randolph S. Marks Marie-Christine Aubry Scott H. Okuno Brent A. Williams Francis C. Nichols Victor F. Trastek Hiroshi Sugimu | 2012 | Journal of Thoracic Oncology2012，，1： | 1 |
| 18 | Characterization of Ga/ZSM-5 for the catalytic aromatization of dilute ethylene streams显示文摘 | Ping Qiu Jack H. Lunsford Michael P. Rosynek | 1998 | Catalysis Letters (-)1998，，1： | 1 |
| 19 | Oxygenated Carotenoid Lutein and Progression of Early Atherosclerosis: The Los Angeles Atherosclerosis Study显示文摘 | James H. Dwyer Mohamad Navab Kathleen M. Dwyer Kholood Hassan Ping Sun Anne Shircore Susan Hama-Levy Greg Hough Xuping Wang Thomas Drake C. Noel Bairey Merz Alan M. Fogelman | 2001 | Circulation: Journal of the American Heart Association2001，，24： | 1 |
| 20 | Overexpression of Interleukin-1β in the Murine Pancreas Results in Chronic Pancreatitis显示文摘 | Frederic Marrache Shui Ping Tu Govind Bhagat Swaroop Pendyala Christoph H. ?sterreicher Shanisha Gordon Vigneshwaran Ramanathan Melitta Penz-?sterreicher Kelly S. Betz Zhigang Song Timothy C. Wang | 2008 | Gastroenterology2008，，4： | 1 |
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