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| 1 | Signet-ring cell carcinoma of the stomach: Impact on prognosis and specific therapeutic challenge显示文摘While the incidence of gastric cancer has decreased worldwide in recent decades,the incidence of signetring cell carcinoma(SRCC) is rising. SRCC has a specific epidemiology and oncogenesis and has two forms: early gastric cancer,which can be resected endoscopically in some cases and which has a better outcome than non-SRCC,and advanced gastric cancer,which is generally thought to have a worse prognosis and lower chemosensitivity than non-SRCC. However,the prognosis of SRCC and its chemosensitivity with specific regimens are still controversial as SRCC is not specifically identified in most studies and its poor prognosis may be due to its more advanced stage. It therefore remains unclear if a specific therapeutic strategy is justified,as the benefit of perioperative chemotherapy and the value of taxanebased chemotherapy are unclear. In this review we analyze recent data on the epidemiology,oncogenesis,prognosis and specific therapeutic strategies in both early and advanced SRCC of the stomach and in hereditary diffuse gastric cancer. | Simon Pernot Thibault Voron Geraldine Perkins Christine Lagorce-Pages Anne Berger Julien Taieb | 2015 | World Journal of Gastroenterology2015，21，40： | 30 |
| 2 | 孕前血压及其到妊娠早期的变化:先兆子痫和妊娠期高血压的早期危险因素显示文摘先兆子痫和妊娠期高血压是常见的妊娠并发症,与母婴发病率显著相关。尽管对怀孕期间的危险因素进行了广泛的研究,但大多数患妊娠期高血压疾病的妇女并不被认为是高风险的,预防措施仍不清楚。研究者评估了妊娠前的血压及其到妊娠早期的变化,将其作为妊娠高血压疾病发展新的危险标志。 | 刘青(译) 刘莉(摘/审校) Nobles CJ Mendola P Mumford SL Silver RM Kim K Andriessen VC Connell M Sjaarda L Perkins NJ Schisterman EF | 2020 | 中华高血压杂志2020，28，12： | 12 |
| 3 | 文化变迁、制度演进与改革和发展——制度与文化变迁视角的社会发展机制和改革发展比较分析显示文摘文化与制度的相互制约与促进的机制是社会发展的根本动力之一,文化可以影响对制度的选择,而制度反过来又改变或强化人们的文化理念,并最终影响社会发展中的某些关键要素,进一步影响社会和经济发展的模式选择。文化变迁和制度演进的两个显著特点是内敛性和趋同性,初始文化和制度背景对文化变迁和制度演进有显著的内敛作用,而最终所有文化和制度又都朝同一个方向发展,这是为什么富国的制度和文化模式几乎都一样,而穷国则各有各的文化和制度模式的原因;在走向发达的进程中,传统文化假借某些理念对进步的促进作用而整体上复兴。中国当前从以增长为中心的发展到以人为本的科学发展的转变反映了这种文化和制度变迁的进程。 | 张勇 古明明 Dwright Perkins | 2008 | 北方论丛2008，，5： | 7 |
| 4 | Critical role of bioinformatics in translating huge amounts of next-generation sequencing data into personalized medicine显示文摘Realizing personalized medicine requires integrating diverse data types with bioinformatics.The most vital data are genomic information for individuals that are from advanced next-generation sequencing(NGS) technologies at present.The technologies continue to advance in terms of both decreasing cost and sequencing speed with concomitant increase in the amount and complexity of the data.The prodigious data together with the requisite computational pipelines for data analysis and interpretation are stressors to IT infrastructure and the scientists conducting the work alike.Bioinformatics is increasingly becoming the rate-limiting step with numerous challenges to be overcome for translating NGS data for personalized medicine.We review some key bioinformatics tasks,issues,and challenges in contexts of IT requirements,data quality,analysis tools and pipelines,and validation of biomarkers. | HONG HuiXiao ZHANG WenQian SHEN Jie SU ZhenQiang NING BaiTang HAN Tao PERKINS Roger SHI LeMing TONG WeiDa | 2013 | Science China(Life Sciences)2013，56，2： | 7 |
| 5 | Recent trends in liver transplantation for alcoholic liver disease in the United States显示文摘AIM To examine temporal changes in the indications for liver transplantation(LT) and characteristics of patients transplanted for alcoholic liver disease(ALD).METHODS We performed a retrospective cohort analysis of trends in the indication for LT using the United Network for Organ Sharing(UNOS) database between 2002 and 2015. Patients were grouped by etiology of the liver disease and characteristics were compared using χ~2 and t-tests. Time series analysis was used identifying any year with a significant change in the number of transplants per year for ALD, and before and after eras were modeled using a general linear model. Subgroup analysis of recipients with ALD was performed by age group, gender, UNOS region and etiology(alcoholic cirrhosis, alcoholic hepatitis and hepatitis C-alcoholic cirrhosis dual listing).RESULTS Of 74216 liver transplant recipients, ALD(n = 9400, 12.7%) was the third leading indication for transplant after hepatitis C and hepatocellular carcinoma. Transplants for ALD, increased from 12.8%(553) in 2002 to 16.5%(1020) in 2015. Time series analysis indicated a significant increase in the number of transplants per year for ALD in 2013(P = 0.03). There were a stable number of transplants per year between 2002 and 2012(linear coefficient 3, 95%CI:-4.6, 11.2) an increase of 177 per year between 2013 and 2015(95%CI: 119, 234). This increase was significant for all age groups except those 71-83 years old, was observed for both genders, and was incompletely explained by a decrease in transplants for hepatitis C and ALD dual listing. All UNOS regions except region 9 saw an increase in the mean number of transplants per year when comparing eras, and this increase was significant in regions 2, 3, 4, 5, 6, 8, 10 and 11.CONCLUSION There has been a dramatic increase in the number of transplants for ALD starting in 2013. | Catherine E Kling James D Perkins Robert L Carithers Dennis M Donovan Lena Sibulesky | 2017 | World Journal of Hepatology2017，9，36： | 6 |
| 6 | 圈养环境中不同来源成年雄性马麝的行为差异显示文摘于2004年8月—2005年1月,采用焦点取样和连续记录方法,对甘肃兴隆山自然保护区马麝(Moschus sifanicus)繁育中心的雄性马麝进行了行为取样。按照动物来源,将样本动物区分为野捕雄麝(17头)和圈养繁殖雄麝(6头),记录了静卧及站立凝视等12种行为的发生频次,并分别对其在交配季节和非交配季节的行为发生频率进行比较。结果表明,由于圈养环境和管理模式相同,甘肃兴隆山繁育中心的野捕和圈养繁殖马麝的总体行为格局类似,但由于幼年期人工哺乳等因素对其行为发育的影响,野捕雄麝在非交配季节和交配季节的冲突行为的表达频次显著多于圈养繁殖雄麝(P<0.05),而圈养繁殖雄麝在交配季节的亲和行为极显著地多于野捕雄麝(P<0.01)。此外,雄麝在非交配季节的静卧行为发生频次极显著地多于交配季节(P<0.01),而在交配季节的站立凝视、运动和环境探究及冲突的发生频次均极显著地比非交配季节多(P<0.01)。 | 孟秀祥 Genevieve Perkins 杨奇森 冯祚建 徐宏发 | 2008 | 生态学杂志2008，27，8： | 5 |
| 7 | 柳州市看护者教育水平与饮食方式对学前儿童缺铁的影响显示文摘缺铁是世界上营养失调的最常见原因,且是唯一在发展中国家和工业化国家都十分流行的营养缺乏现象[1]。当一个人的铁储量被耗尽且血红素形成减缓,就会出现缺铁。缺铁性贫血是铁耗尽的严重阶段,如果没有尽早治疗,缺铁性贫血会导致儿童出现许多临床并发症,包括不可逆的认知功能障碍[2]和教育成效不佳[3]。 | Magvanjav O Perkins DD Lilienthal GM Kopsombut UG 周丽芳 白娟 张永 | 2016 | 中国学校卫生2016，37，2： | 4 |
| 8 | Phosphonium and arsonium ylides(?)——ⅩⅦ.A facile synthesis of methyl 2,6-bisperfluoroalkylbenzoates via acyclic precursors显示文摘The title compounds 6a—6f were prepared with high yield via intramolecular Wittigreaction of methyl 3-perfluoroalkyl-6-perfluoroacyl-2-triphenylphosphoranylidenehex-3,5-dienoates(5a—5i)which were obtained from the reaciton of 3-perfluoroacylprop-2-enylidenetriphenylphos-phoranes(3a—3c)with methyl perfluoroalkynoates(4a—4c). | DING,Wei-Yu CAO,Wei-Guo XU,Zhen-Rong SHI,Zhi-Jian YAO,Yuan Department of Chemistry,Shanghai University of Science and Technology,Shanghai 201800 For part XVI of the series,see J.Chem.Soc.,Perkin Trans.1,1369(1991). | 1993 | Chinese Journal of Chemistry1993，11，1： | 3 |
| 9 | Eigentaste: A Constant Time Collaborative Filtering Algorithm显示文摘 | Ken Goldberg Theresa Roeder Dhruv Gupta Chris Perkins | 2001 | Information Retrieval2001，，2： | 3 |
| 10 | 场依存型学习风格对语言教学的启示(英文)显示文摘学习风格是学习者在学习过程中表现出来的一种整体性的、持久的、具有个性化的认知方式。学习风格有多种类型,不同的学习者有不同的学习风格。在语言学习的表现方面,一般认为“场依存型”学习者受学习环境影响较大,喜欢与人交往,属于感性学习者。这类学习者在正规课堂学习中具有一定的优势。本文主要探讨以认知方式为基础的场依存型学习风格以及这种学习风格对今后教学工作的启示。 | 张涛 Va Neda Perkins(英文校对) | 2006 | 语文学刊(高等教育版)2006，，2： | 3 |
| 11 | Genome-level analysis of genetic regulation of liver gene expression networks显示文摘 | Gatti, D Maki, A Chesler, EJ Kirova, R Kosyk, O Lu, L Williams, RW Perkins, A Langston, MA Threadgill, DW Rusyn, I | 2007 | 中国生物学文摘2007，21，11： | 3 |
| 12 | Helicobacter pylori eradication in Western Australia using novel quadruple therapy combinations显示文摘 | C. Y. Tay H. M. Windsor F. Thirriot W. Lu C. Conway T. T. Perkins B. J. Marshall | 2012 | Aliment Pharmacol Ther (pt)2012，，11： | 3 |
| 13 | A O-dimensional cavity growth submodel for use in reactor models of underground coal gasification显示文摘Modelling of the underground coal gasification process is dependent upon a range of sub-models. One of the most important is the calculation of the cavity growth rate as a function of various operating conditions and coal properties. While detailed 1-dimensional models of coal block gasification are available, it is not easy to couple them directly with reactor models, which aim to simulate the complete process. In this paper, a O-dimensional cavity growth sub-model is presented. The model is based on the concept of a surface reaction and incorporates physics to account for moisture evaporation, water influx, coal pyrolysis, coal thermo-mechanical fragmentation and the build up of an ash layer on the char. The model is validated using measurements from laboratory experiments on coal cores and coal blocks. A comparison of calculated results from several UCG field trials shows that the model can provide good estimates of cavity growth rate for reasonable input parameters. Finally, simulation results of cavity growth in the combustion and gasification zones as a function of the bulk gas temperature, gas pressure, water influx rate, ash layer thickness and coal fragmentation behaviour are presented. | Greg Perkins | 2019 | International Journal of Coal Science & Technology2019，6，3： | 2 |
| 14 | Low-dose continuous intravenous insulin infusion in childhood diabetic ketoacidosis 显示文摘 | Perkin RM Marks JF | 1979 | Clin Pediatr (Phila)1979，18，54： | 2 |
| 15 | Impact of double helical CT and three-dimensional CT arteriography on surgical planning for hepatic transplantation显示文摘 | H. V. Nghiem C. T. Dimas J. P. McVicar J. D. Perkins J. A. Luna T. C. Winter III A. Harris P. C. Freeny | 1999 | Abdominal Imaging1999，，3： | 2 |
| 16 | Longitudinal variability in hydraulic geometry and substrate characteristics of a Great Plains sand-bed river显示文摘 | Katie H. Costigan Melinda D. Daniels Joshuah S. Perkin Keith B. Gido | 2013 | Geomorphology2013，，： | 2 |
| 17 | Sediment phosphorus cycling in a large shallow lake: spatio-temporal variation in phosphorus pools and release显示文摘 | Bryan M. Spears Laurence Carvalho Rupert Perkins Alex Kirika David M. Paterson | 2007 | Hydrobiologia2007，，1： | 2 |
| 18 | The functions of formulaic language: an integrated model显示文摘 | Alison Wray Michael R. Perkins | 1999 | Language and Communication1999，，1： | 2 |
| 19 | Brownian motion on the Sierpinski gasket显示文摘 | Martin T. Barlow Edwin A. Perkins | 1988 | Probability Theory and Related Fields1988，，4： | 2 |
| 20 | Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy显示文摘 | Jens G. Lohr Petar Stojanov Scott L. Carter Peter Cruz-Gordillo Michael S. Lawrence Daniel Auclair Carrie Sougnez Birgit Knoechel Joshua Gould Gordon Saksena Kristian Cibulskis Aaron McKenna Michael A. Chapman Ravid Straussman Joan Levy Louise M. Perkins | 2013 | Cancer Cell2013，，： | 2 |
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