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| 1 | 阿尔茨海默病患者脑组织中突触蛋白表达改变显示文摘阿尔茨海默病(Alzheimer’s disease,AD)是一种常见于老年人的中枢神经系统退行性变疾病,以进行性认知功能障碍为主要临床表现,其典型神经病理学特征是老年斑、神经原纤维缠结及神经元丢失等。近来研究显示,AD脑中突触功能并非最佳状态,许多与突触功能密切相关的蛋白表达异常。 | 曹颖 Rivka Ravid 官志忠 | 2009 | 中华病理学杂志2009，38，12： | 6 |
| 2 | 核转录因子及炎性趋化因子在阿尔茨海默病患者脑组织中的改变显示文摘目的 探讨核转录因子(NF) -κBp65、炎性趋化因子单核细胞趋化蛋白1(MCP-1/CCL-2)、巨噬细胞炎性蛋白-1α(MIP-1 α/CCL-3)和胶质纤维酸性蛋白(GFAP)等在阿尔茨海默病(AD)发病中的改变。方法 选择尸体解剖后的10例AD患者及8例对照脑组织,用免疫组织化学EnVision方法检测海马、大脑额叶及颞叶皮质中NF-κBp65、MCP-1、MIP-1α、GFAP和Aβ1-42的表达。结果 与对照组相比,AD患者脑组织海马、额叶和颞叶皮质等部位均显示神经细胞中NF-κBp65[每高倍视野(×400)阳性细胞数分别为3.6±1.5、2.2±1.2和2.2±1.2]表达较对照组(每高倍视野阳性细胞数分别为0.31±0.20、0.25±0.20和0.25±0.20)明显增高(P<0.05);MCP-1及MIP-1α在海马、额叶和颞叶皮质等部位神经细胞中(每高倍视野阳性细胞数分别为8.0±1.3、8.8±1.0、9.3±1.4;及8.1±1.5、12.5±1.1、6.4±1.1)表达均较对照组(每高倍视野阳性细胞数分别为4.5±0.9、4.5±0.6、4.0±1.8;及5.0±1.9、6.3±2.2、3.8±1.5)明显增多(P<0.05);GFAP显示的星形胶质细胞数增多(P<0.05),并大量聚集在老年斑周围。相关系数分析表明,在AD脑组织中MCP-1、MIP-1α蛋白水平与NF-κBp65的改变有关。结论 AD脑组织中核转录因子及炎性趋化因子表达升高,NF-κBp65可能调节MCP-1和MIP-1α的表达,其机制可能与Aβ引起的炎性作用有关。 | 廖媛 官志忠 Rivka Ravid | 2011 | 中华病理学杂志2011，40，9： | 5 |
| 3 | Monounsaturated fat decreases hepatic lipid content in non-alcoholic fatty liver disease in rats显示文摘AIM: To evaluate the effects of different types of dietary fats on the hepatic lipid content and oxidative stress parameters in rat liver with experimental non-alcoholic fatty liver disease (NAFLD). METHODS: A total of 32 Sprague-Dawley rats were randomly divided into fi ve groups. The rats in the control group (n = 8) were on chow diet (Group 1), rats (n = 6) on methionine choline-defi cient diet (MCDD) (Group 2), rats (n = 6) on MCDD enriched with olive oil (Group 3), rats (n = 6) on MCDD with fish oil (Group 4) and rats (n = 6) on MCDD with butter fat (Group 5). After 2 mo, blood and liver sections were examined for lipids composition and oxidative stress parameters.RESULTS: The liver weight/rat weight ratio increased in all treatment groups as compared with the control group. Severe fatty liver was seen in MCDD + fish oil and in MCDD + butter fat groups, but not in MCDD and MCDD + olive oil groups. The increase in hepatic triglycerides (TG) levels was blunted by 30% in MCDD + olive oil group (0.59 ± 0.09) compared with MCDD group (0.85 ± 0.04, P < 0.004), by 37% compared with MCDD + fi sh oil group (0.95 ± 0.07, P < 0.001), and by 33% compared with MCDD + butter group (0.09 ± 0.1, P < 0.01). The increase in serum TG was lowered by 10% in MCDD + olive oil group (0.9 ± 0.07) compared with MCDD group (1.05 ± 0.06). Hepatic cholesterol increased by 15-fold in MCDD group [(0.08 ± 0.02, this increment was blunted by 21% in MCDD + f ish oil group (0.09 ± 0.02)]. In comparison with the control group, ratio of long-chain polyunsaturated fatty acids omega-6/ | Osamah Hussein Masha Grosovski Etti Lasri Sergio Svalb Uzi Ravid Nimer Assy | 2007 | World Journal of Gastroenterology2007，13，3： | 3 |
| 4 | Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy显示文摘 | Jens G. Lohr Petar Stojanov Scott L. Carter Peter Cruz-Gordillo Michael S. Lawrence Daniel Auclair Carrie Sougnez Birgit Knoechel Joshua Gould Gordon Saksena Kristian Cibulskis Aaron McKenna Michael A. Chapman Ravid Straussman Joan Levy Louise M. Perkins | 2013 | Cancer Cell2013，，： | 2 |
| 5 | Spontaneous spinal epidural hematnma: an uncommon presentation of a rare disease 显示文摘 | Ravid S Schneider S Maytal J | 2002 | Childs Nerv Syst2002，18，67： | 1 |
| 6 | Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells显示文摘 | Lucero H A Ravid K Grimsby J L | 2008 | J Biol Chem2008，283，24： | 1 |
| 7 | Caveolin-1 inhibits anoikis and promotes sur- vival signaling in cancer cells 显示文摘 | Ravid D Maor S Wemer H | 2006 | Enzyme Regul2006，7，： | 1 |
| 8 | Caveolin-1 inhibits anchorage-independent growth,anoikis and invasiveness in MCF-7 human breast cancer cells显示文摘 | Fiucci G Ravid D Reich R | 2002 | Oncogene2002，21，15： | 1 |
| 9 | Analysis of muscular fatigue and foot stability during high-heeled gait 显示文摘 | Gefen A Megido - Ravid M Itzchak Y | 2002 | Gait Posture2002，15，1： | 1 |
| 10 | Broad expression of Toll-like receptors in the human central nervous system 显示文摘 | Bsibsi M Ravid R Gveric D | 2002 | J Neuropath Exp Neurol2002，61，： | 1 |
| 11 | Sleep disorder and daytime sleepiness in children with attention-deficit/hyperactive disorder 显示文摘 | Golan N Shahar E Ravid S | 2004 | Sleep2004，27，2： | 1 |
| 12 | Tetraploidy/anerploidy and stem cells in Cancer promotion: The role of chromosome passenger proteins 显示文摘 | Nguyen HG Ravid K | 2006 | Cell Physiol2006，208，1： | 1 |
| 13 | Extenal hydrocephalus a probable cause for subdural hematoma in infancy显示文摘 | Ravid S Maytal J | 2003 | Pediatr Neurol2003，28，2： | 1 |
| 14 | Studies on the effects of essential oils isolated from 14 species of Labiatae on the carmine spider miteTetran ych us cinnabarinus显示文摘 | Mansour F Ravid U Putievsky E | 1986 | Phytoparasitica1986，14，： | 1 |
| 15 | Rapid recovery from transverse yelopa- thy in children treated with methylprednisolone 显示文摘 | Lahat E Pillar G Ravid S | 1998 | Pediatr Neu- rol1998，19，4： | 1 |
| 16 | On the relevance of debt maturity structure显示文摘 | Brick I E Ravid S A | 1985 | Journal of Finance1985，40，： | 1 |
| 17 | Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease显示文摘 | Cuan ZZ Zhang X Ravid R | 2000 | J Neurochemistry2000，74，1： | 1 |
| 18 | Structure of glandular trichomes and identification of the main components of their secreted material in some species of Labiatae 显示文摘 | WERKER E RAVID U PUTIEVSKY E | 1985 | Israel J Bot1985，34，： | 1 |
| 19 | Long-tern stabilizing effect of Angiotensin converting enzyme inhibition on plasms creatinine and on protrinuria in normotensive type 2 diabetic patients显示文摘 | Ravid M Savi H Jutrin I | 1993 | Ann Intern Med1993，118，8： | 1 |
| 20 | Sleep disorder and daytime sleepiness in children with attention-defic/hyperactive disorder显示文摘 | Golan N Shahar E Ravid S | 2004 | Sleep2004，27，2： | 1 |
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