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| 1 | Critical role of bioinformatics in translating huge amounts of next-generation sequencing data into personalized medicine显示文摘Realizing personalized medicine requires integrating diverse data types with bioinformatics.The most vital data are genomic information for individuals that are from advanced next-generation sequencing(NGS) technologies at present.The technologies continue to advance in terms of both decreasing cost and sequencing speed with concomitant increase in the amount and complexity of the data.The prodigious data together with the requisite computational pipelines for data analysis and interpretation are stressors to IT infrastructure and the scientists conducting the work alike.Bioinformatics is increasingly becoming the rate-limiting step with numerous challenges to be overcome for translating NGS data for personalized medicine.We review some key bioinformatics tasks,issues,and challenges in contexts of IT requirements,data quality,analysis tools and pipelines,and validation of biomarkers. | HONG HuiXiao ZHANG WenQian SHEN Jie SU ZhenQiang NING BaiTang HAN Tao PERKINS Roger SHI LeMing TONG WeiDa | 2013 | Science China(Life Sciences)2013，56，2： | 7 |
| 2 | The Toxicology of Perfluorooctanoate显示文摘 | Gerald L. Kennedy John L. Butenhoff Geary W. Olsen John C. O’Connor Andrew M. Seacat Roger G. Perkins Lisa B. Biegel Sandra R. Murphy David G. Farrar | 2004 | Critical Reviews in Toxicology2004，，4： | 1 |
| 3 | Cloning, sequencing, and characterization of the Bacillus subtilis biotin biosynthetic operon 显示文摘 | Stanley B Perkins J B Rogers R | 1996 | J Bacterial1996，178，14： | 1 |
| 4 | The Toxicology of Perfluorooctanoate显示文摘 | Gerald L. Kennedy John L. Butenhoff Geary W. Olsen John C. O’Connor Andrew M. Seacat Roger G. Perkins Lisa B. Biegel Sandra R. Murphy David G. Farrar | 2004 | Critical Reviews in Toxicology2004，，4： | 1 |
| 5 | 不相交主成分分析(PCA)和遗传算法(GA)用于差异表达基因的识别显示文摘建立了一种基于不相交主成分分析(Disjoint PCA)和遗传算法(GA)的特征变量选择方法,并用于从基因表达谱(Gene expression profiles)数据中识别差异表达的基因.在该方法中,用不相交主成分分析评估基因组在区分两类不同样品时的区分能力;用GA寻找区分能力最强的基因组;所识别基因的偶然相关性用统计方法评估.由于该方法考虑了基因间的协同作用更接近于基因的生物过程,从而使所识别的基因具有更好的差异表达能力.将该方法应用于肝细胞癌(HCC)样品的基因芯片数据分析,结果表明,所识别的基因具有较强的区分能力,优于常用的基因芯片显著性分析(Significance analysis of microarrays,SAM)方法. | 苏振强 HONG Hui—Xiao TONG Wei-Da PERKINS Roger 邵学广 蔡文生 | 2007 | 高等学校化学学报2007，28，9： | 1 |
| 6 | The Oxidation Behavior and Protection of Niobium显示文摘 | Gerald H M | 1990 | JOM1990，，8： | 1 |
| 7 | Cloning,sequencing,and characterization of the Bacillus subtilis biotin biosynthetic operon显示文摘 | Stanley B Perkins J B Rogers R | 1996 | J Bacteriol1996，178，14： | 1 |
| 8 | Legionella pneumophila infection up-regulates dendritic cell Toll-like receptor (TLR2)/TLR4 expression and key maturation markers 显示文摘 | Rogers J Hakki A Perkins I | 2007 | Infect Immun2007，75，6： | 1 |
| 9 | Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane显示文摘 | Tomomi Kuwana Mason R. Mackey Guy Perkins Mark H. Ellisman Martin Latterich Roger Schneiter Douglas R. Green Donald D. Newmeyer | 2002 | Cell2002，，3： | 1 |
| 10 | Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane显示文摘 | Tomomi Kuwana Mason R. Mackey Guy Perkins Mark H. Ellisman Martin Latterich Roger Schneiter Douglas R. Green Donald D. Newmeyer | 2002 | Cell2002，，3： | 1 |
| 11 | Synthesis of Substituted 4-Keto-1:2:3:4- tetrahydroquinolines and an Attempt to Synthesise 4-keto-1:2:3:4-tetra hydroisoquinoline 显示文摘 | George Roger Clemo William Henry Perkin Jun | 1925 | J Chem Soc1925，125，： | 1 |
| 12 | Legionella pneumophila infection up-regulates dendritic cell toll-like receptor 2 (TLR2)/ TLR4 expression and key maturation markers 显示文摘 | Rogers J Hakki A Perkins I | 2007 | Infect Immun2007，75，6： | 1 |
| 13 | The Toxicology of Perfluorooctanoate显示文摘 | Gerald L. Kennedy John L. Butenhoff Geary W. Olsen John C. O’Connor Andrew M. Seacat Roger G. Perkins Lisa B. Biegel Sandra R. Murphy David G. Farrar | 2004 | Critical Reviews in Toxicology2004，，4： | 1 |
| 14 | Legionella pneumophila infection up-regulates dendritic cell Toll-like receptor 2 (TLR2)/TLR4 expression and key maturation markers显示文摘 | Rogers J Hakki A Perkins I | | 0，，06： | 1 |
| 15 | Design,application and verification of a novel system utilizing bacteria and microalgae to treat swine farm wastewater and produce value-added biomass显示文摘Swine farm wastewater is extremely harmful to the environment if not treated before it is discharged.In this study,a system was developed and optimized for testing the high levels of organic matter in swine farm wastewater utilizing a microalgae/bacteria co-culture combined with a novel closed-loop extraction and dilution process.Importantly,the system produces biomass that also could be harvested and used in value-added applications.The efficacy of biomass as a biofertilizer was demonstrated by using a model plant of Arabidopsis.In addition,the analysis of biomass indicates that it also has potential as a source for biofuel.After a 20-d cultivation period,a yield of biomass was achieved to 2.063 g/L of wastewater.The highest removal rates recorded in steady state conditions were:13.8 mg/L·d of Total Nitrogen(TN);11.5 mg/L·d of Ammonia Nitrogen(NH_(4)^(+)-N);24.8 mg/L·d of Chemical Oxygen Demand(COD);and 16.9 mg/L·d of Total Phosphorus(TP).After cultivation,the composition of the biomass was analyzed on a dry basis;the major components were protein(44.9%),lipids(24.6%),carbohydrates(19.9%),Chlorophyll-A(2.75%),Chlorophyll-B(1.66%),and carotenoids(0.57%).This biomass was diluted with water(5%by weight)and used as a biofertilizer to grow Arabidopsis.The results showed that the average root and stem lengths of Arabidopsis were 43.0%and 55.0%longer compared to those of the control group.Additionally,the number of leaves and the maximum leaf length increased by 30.2%and 39.7%;and the fresh and dry leaf weights increased by 44.0%and 33.7%,respectively.These results demonstrate the efficacy of this system for treating swine farm wastewater whilst simultaneously producing a value-added microalgae/bacteria biomass.This paper also demonstrated the use of biomass as a fertilizer for cultivating a value-added crop and,based on the compositional analyses,propose that the biomass could be used as a raw material for biofuel production due to its high lipid content of 24.6%.By constructing a microalgae/bacteria symbiosis system,Swine farm wastewater can be treated as resources utilizing producing value-added biomass with demonstrated efficacy as a biofertilizer. | Xin Zhen Yali Li Jingwen Qiang Manyu Tang Wei Hua Wanqing Wang Shuang Wu Phil Perkins Roger Ruan Yanling Cheng | 2023 | International Journal of Agricultural and Biological Engineering2023，16，4： | 0 |
| 16 | Erratum to:Critical role of bioinformatics in translating huge amounts of next-generation sequencing data into personalized medicine显示文摘 | HONG HuiXiao ZHANG WenQian SHEN Jie SU ZhenQiang NING BaiTang HAN Tao PERKINS Roger SHI LeMing TONG WeiDa | 2013 | Science China(Life Sciences)2013，56，3： | 0 |
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