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| 1 | Effects of Saccharomycesboulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition显示文摘AIM: To assess the effects of Sb on fecal flora and shortchain fatty acids (SCFA) in patients on long-term TEN.METHODS: Ten patients (3 females, 7 males, 59±5.5 years),on TEN for a median of 13 mo (1-125), and 15 healthy volunteers (4 females, 11 males, 32±2.0 years) received Sb (0.5 g bid PO) for 6 d. Two stool samples were taken before, on the last 2 d and 9-10 d after treatment, for SCFA measurement and for culture and bacterial identification.Values (mean±SE) were compared using sign tests and ANOVA.RESULTS: Fecal butyrate levels were lower in patients(10.1±2.9 mmol/kg) than in controls (19.2±3.9, P= 0.02).Treatment with Sb increased total fecal SCFA levels in patients (150.2±27.2 vs 107.5±18.2 mmol/kg, P = 0.02)but not in controls (129.0±28.6 vs 113.0±15.2 mmol/kg,NS). At the end of treatment with Sb, patients had higher fecal butyrate (16.0±4.4 vs 10.1 [2.9] mmol/kg, P = 0.004).Total SCFAs remained high 9 d after treatment was discontinued. Before the treatment, the anaerobe to aerobe ratio was lower in patients compared to controls (2.4±2.3 vs69.8±1.8, P = 0.003). There were no significant changes in the fecal flora of TEN patients.CONCLUSION: Sb-induced increase of fecal SCFA concentrations (especially butyrate) may explain the preventive effects of this yeast on TEN-induced diarrhea. | Stéphane M Schneider Fernand Girard-Pipau Jér(o|^)me Filippi Xavier Hébuterne Dominique Moyse Gustavo Calle Hinojosa Anne Pompei Patrick Rampal | 2005 | World Journal of Gastroenterology2005,11,39: | 26 |
| 2 | Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome显示文摘AIM To evaluate the safety and efficacy of inhaled milrinone in acute respiratory distress syndrome(ARDS).METHODS Open-label prospective cross-over pilot study where fifteen adult patients with hypoxemic failure meeting standard ARDS criteria and monitored with a pulmonary artery catheter were recruited in an academic 24-bed medico-surgical intensive care unit. Random sequential administration of i NO(20 ppm) or nebulized epoprostenol(10 μg/mL) was done in all patients. Thereafter, inhaled milrinone(1 mg/mL) alone followed by inhaled milrinone in association with inhaled nitric oxide(iN O) was administered. A jet nebulization device synchronized with the mechanical ventilation was use to administrate the epoprostenol and the milrinone. Hemodynamic measurements and partial pressure of arterial oxygen(PaO_2) were recorded before and after each inhaled therapyadministration.RESULTS The majority of ARDS were of pulmonary cause(n = 13) and pneumonia(n = 7) was the leading underlying initial disease. Other pulmonary causes of ARDS were: Post cardiopulmonary bypass(n = 2), smoke inhalation injury(n = 1), thoracic trauma and pulmonary contusions(n = 2) and aspiration(n = 1). Two patients had an extra pulmonary cause of ARDS: A polytrauma patient and an intra-abdominal abscess Inhaled nitric oxide, epoprostenol, inhaled milrinone and the combination of inhaled milrinone and i NO had no impact on systemic hemodynamics. No significant adverse events related to study medications were observed. The median increase of PaO 2 from baseline was 8.8 mmH g [interquartile range(IQR) = 16.3], 6.0 mm Hg(IQR = 18.4), 6 mm Hg(IQR = 15.8) and 9.2 mm Hg(IQR = 20.2) respectively with i NO, epoprostenol, inhaled milrinone, and i NO added to milrinone. Only i NO and the combination of inhaled milrinone and i NO had a statistically significant effect on PaO 2. CONCLUSION When comparing the effects of inhaled NO, milrinone and epoprostenol, only NO significantly improved oxygenation. Inhaled milrinone appeared safe but failed to improve oxygenation in ARDS. | Martin Albert Daniel Corsilli David R Williamson Marc Brosseau Patrick Bellemare Stéphane Delisle Anne QN Nguyen France Varin | 2017 | World Journal of Critical Care Medicine2017,6,1: | 4 |
| 3 | Laparoscopic resection of hepatocellular carcinoma: a F rench survey in 351 patients显示文摘 | Olivier Soubrane Claire Goumard Alexis Laurent Hadrien Tranchart Stéphanie Truant Brice Gayet Chadi Salloum Guillaume Luc Safi Dokmak Tullio Piardi Daniel Cherqui Ibrahim Dagher Emmanuel Boleslawski Eric Vibert Antonio Sa Cunha Jacques Belghiti Patrick Pe | 2014 | HPB2014,,4: | 2 |
| 4 | HDAC6 Regulates Hsp90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor显示文摘 | Jeffrey J. Kovacs Patrick J.M. Murphy Stéphanie Gaillard Xuan Zhao June-Tai Wu Christopher V. Nicchitta Minoru Yoshida David O. Toft William B. Pratt Tso-Pang Yao | 2005 | Molecular Cell2005,,: | 2 |
| 5 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013,,9867: | 2 |
| 6 | Heavy metal accumulation by recombinant mammalian metallothionein within Escherichia coli protects against elevated metal exposure显示文摘 | Sandrine Sauge-Merle Catherine Lecomte-Pradines Patrick Carrier Stéphan Cuiné Michael DuBow | 2012 | Chemosphere2012,,8: | 1 |
| 7 | Splenic Trapping of Nanoparticles: Complementary Approaches for In Situ Studies显示文摘 | Marina Demoy Stéphane Gibaud Jean Paul Andreux Colette Weingarten Bruno Gouritin Patrick Couvreur | 1997 | Pharmaceutical Research1997,,: | 1 |
| 8 | Adjunctive Thrombectomy for Acute Myocardial Infarction: A Bayesian Meta-Analysis显示文摘 | Fran?ois-Pierre Mongeon Patrick Bélisle Lawrence Joseph Mark J. Eisenberg Stéphane Rinfret | 2010 | Circulation: Cardiovascular Interventions2010,,1: | 1 |
| 9 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet2013,,9867: | 1 |
| 10 | Structural and Genetic Bases of Arterial Stiffness显示文摘 | st' ephane Laurent Pierre Boutouyrie Patrick Lacolley | 2005 | Hypertension2005,45,: | 1 |
| 11 | Irrigation Versus Suction Alone During Laparoscopic Appendectomy for Perforated Appendicitis: A Prospective Randomized Trial显示文摘 | Shawn D. St Peter Obinna O. Adibe Corey W. Iqbal Frankie B. Fike Susan W. Sharp David Juang David Lanning J. Patrick Murphy Walter S. Andrews Ronald J. Sharp Charles L. Snyder George W. Holcomb Daniel J. Ostlie | 2012 | Annals of Surgery2012,,4: | 1 |
| 12 | Incidental durotomy during spine surgery: Incidence, management and complications. A retrospective review显示文摘 | Patrick Guerin Abdelkrim Benchikh El Fegoun Ibrahim Obeid Olivier Gille Luc Lelong Stéphane Luc Anouar Bourghli Jean Christophe Cursolle Vincent Pointillart Jean-Marc Vital | 2010 | Injury2010,,4: | 1 |
| 13 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet2013,,9867: | 1 |
| 14 | High Prevalence of Sleep Apnea Syndrome in Patients With Long-Term Pacing: The European Multicenter Polysomnographic Study显示文摘 | Stéphane Garrigue Jean-Louis Pépin Pascal Defaye Francis Murgatroyd Yann Poezevara Jacques Clémenty Patrick Lévy | 2007 | Circulation2007,,13: | 1 |
| 15 | Comparison of the gaseous and particulatematter emissions from the combustion of agricultural andforest biomasses 显示文摘 | Brassard Patrick Palacios Joahnn H Godbout Stéphane | 2014 | Bioresource Technology2014,155,: | 1 |
| 16 | Transient apical ballooning syndrome — clinical characteristics, ballooning pattern, and long-term follow-up in a Swiss population显示文摘 | Parham Eshtehardi Simon C. Koestner Patrick Adorjan Stephan Windecker Bernhard Meier Otto M. Hess Andreas Wahl Stéphane Cook | 2008 | International Journal of Cardiology2008,,: | 1 |
| 17 | Surviving the heat: heterogeneity of response in S accharomyces cerevisiae provides insight into thermal damage to the membrane显示文摘 | Stéphane Guyot Patrick Gervais Michael Young Pascale Winckler Jennifer Dumont Hazel Marie Davey | 2015 | Environ Microbiol2015,,8: | 1 |
| 18 | Eye movement correlates of younger and older adults' strategies for complex addition显示文摘 | Heather J.Green Patrick Lemaire Stéphane Dufau | | 0,,03: | 1 |
| 19 | Methane oxidation by NO and O 2 from reverse spillover on alumina supported palladium catalysts显示文摘 | Rui Marques Sandra Capela Stéphanie Da Costa Franck Delacroix Gérald Djéga-Mariadassou Patrick Da Costa | 2008 | Catalysis Communications2008,,8: | 1 |
| 20 | Corrosion effects between molten salts and thermal storage material for concentrated solar power plants显示文摘 | Stéphanie Guillot Abdessamad Faik Aydar Rakhmatullin Julien Lambert Emmanuel Veron Patrick Echegut Catherine Bessada Nicolas Calvet Xavier Py | 2011 | Applied Energy2011,,: | 1 |