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| 1 | STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation显示文摘 | Wanqiang Sheng Fan Yang Yi Zhou Henry Yang Pey Yng Low David Michael Kemeny Patrick Tan Akira Moh Mark H Kaplan Yongliang Zhang Xin-Yuan Fu | 2014 | Cell Research2014，24，12： | 7 |
| 2 | Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease显示文摘AIM: To establish a mouse model of alcohol-driven hepatocellular carcinoma(HCC) that develops in livers with alcoholic liver disease(ALD).METHODS: Adult C57BL/6 male mice received multiple doses of chemical carcinogen diethyl nitrosamine(DEN) followed by 7 wk of 4% Lieber-De Carli diet. Serum alanine aminotransferase(ALT), alpha fetoprotein(AFP) and liver Cyp2e1 were assessed. Expression of F4/80, CD68 for macrophages and Ly6 G, MPO, E-selectin for neutrophils was measured. Macrophage polarization was determined by IL-1β/i NOS(M1) and Arg-1/IL-10/CD163/CD206(M2) expression. Liver steatosis and fibrosis were measured by oil-red-O and Sirius red staining respectively. HCC development was monitored by magnetic resonance imaging, confirmed by histology. Cellular proliferation was assessed by proliferating cell nuclear antigen(PCNA).RESULTS: Alcohol-DEN mice showed higher ALTs than pair fed- DEN mice throughout the alcohol feeding without weight gain. Alcohol feeding resulted in increased ALT, liver steatosis and inflammation compared to pair-fed controls. Alcohol-DEN mice had reduced steatosis and increased fibrosis indicatingadvanced liver disease. Molecular characterization showed high estlevels of both neutrophil and macrophage markers in alcohol-DEN livers. Importantly, M 2 macrophages were edominantly higher in alcohol-DEN livers. Magnetic resonance imaging revealed increased numbers of intrahepatic cysts and liver histology confirmed the presence of early HCC in alcohol-DEN mice compared to al l other groups. This correlated with increased serum alphafetoprotein, a marker of HCC, in alcohol-DEN mice. PCNA immunostaining revealed significantly increased hepatocyte proliferation in livers from alcohol-DEN compared to pair fed-DEN or alcohol-fed mice.CONCLUSION: We describe a new 12-wk HCC model in adult mice that develops in livers with alcoholic hepatitis and defines ALD as co-factor in HCC. | Aditya Ambade Abhishek Satishchandran Benedek Gyongyosi Patrick Lowe Gyongyi Szabo | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 3 | Discordant atrial natriuretic peptide and brain natriuretic peptide levels in lone atrial fibrillation显示文摘 | Patrick T. Ellinor Adrian F. Low Kristen K. Patton Marisa A. Shea Calum A. MacRae | 2005 | Journal of the American College of Cardiology2005，，1： | 2 |
| 4 | Dependence of Achievable Plan Quality on Treatment Technique and the Planning Goal Refinement: A Head-and-Neck IMRT Application显示文摘 | X. Sharon Qi Dan Ruan Steve P. Lee Andrew Pham Patrick Kupelian Daniel A. Low Michael Steinberg John Demarco | 2014 | International Journal of Radiation Oncology, Biology, Physics2014，，： | 1 |
| 5 | What is the slowest-yet-normal cervical dilation rate among nulliparous women with spontaneous labor onset?显示文摘 | Neal JL Lowe NK Patrick TE | 2010 | J Obstet Gynecol Neonatal Nurs2010，39，4： | 1 |
| 6 | Phase II clinical trial of bevacizumab with albumin-bound paclitaxel in patients with recurrent, platinum-resistant primary epithelial ovarian or primary peritoneal carcinoma显示文摘 | Todd D. Tillmanns M. Patrick Lowe Mark S. Walker Edward J. Stepanski Lee S. Schwartzberg | 2012 | Gynecologic Oncology2012，，： | 1 |
| 7 | Does globalization cause a higher concentration of international trade and investment flow? 显示文摘 | Low Marcelo Olarreage and Javier Suarez | 1998 | WTO Staff Working Paper1998，1998，： | 1 |
| 8 | Prevalence and echocardiographic features of iatrogenic atrial septal defect after catheter‐based mitral valve repair with the mitraclip system显示文摘 | Thomas Smith Patrick McGinty William Bommer Reginald I. Low Scott Lim Peter Fail Jason H. Rogers | 2012 | Cathet Cardiovasc Intervent2012，，4： | 1 |
| 9 | Percutaneous Mitral Repair With the MitraClip System显示文摘 | Ted Feldman Saibal Kar Michael Rinaldi Peter Fail James Hermiller Richard Smalling Patrick L. Whitlow William Gray Reginald Low Howard C. Herrmann Scott Lim Elyse Foster Donald Glower | 2009 | Journal of the American College of Cardiology2009，，8： | 1 |
| 10 | 'Nontariff Measures and Developing Countries: Has the Uruguay Round Leveled the Playing Field' 显示文摘 | Patrick Low Alexander Yeats | 1995 | World Economy1995，，1： | 1 |
| 11 | Diagnostic Performance of Magnetic Resonance Elastography in Staging Liver Fibrosis: A Systematic Review and Meta-analysis of Individual Participant Data显示文摘 | Siddharth Singh Sudhakar K. Venkatesh Zhen Wang Frank H. Miller Utaroh Motosugi Russell N. Low Tarek Hassanein Patrick Asbach Edmund M. Godfrey Meng Yin Jun Chen Andrew P. Keaveny Mellena Bridges Anneloes Bohte Mohammad Hassan Murad David J. Lomas Jayant | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 1 |
| 12 | Utility of Amino-Terminal Pro-Brain Natriuretic Peptide, Galectin-3, and Apelin for the Evaluation of Patients With Acute Heart Failure显示文摘 | Roland R. van Kimmenade James L. Januzzi Patrick T. Ellinor Umesh C. Sharma Jaap A. Bakker Adrian F. Low Abelardo Martinez Harry J. Crijns Calum A. MacRae Paul P. Menheere Yigal M. Pinto | 2006 | Journal of the American College of Cardiology2006，，6： | 1 |
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