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| 1 | Histopathological differences utilizing the nonalcoholic fatty liver disease activity score criteria in diabetic(type 2 diabetes mellitus) and non-diabetic patients with nonalcoholic fatty liver disease显示文摘AIM: To study clinical and histopathological features of nonalcoholic fatty liver disease(NAFLD) in patients with and without type 2 diabetes mellitus(T2DM) using updated nonalcoholic steatohepatitis clinical research network(NASH-CRN) grading system.METHODS: We retrospectively analyzed data of 235 patients with biopsy proven NAFLD with and without T2 DM.This database was utilized in the previously published study comparing ethnicity outcomes in NAFLD by the same corresponding author.The pathology database from University of Chicago was utilized for enrolling consecutive patients who met the criteria for NAFLD and their detailed clinical and histopathology findings were obtained for comparison.The relevant clinical profile of patients was collected from the Electronic Medical Records around the time of liver biopsy and the histology was read by a single well-trained histopathologist.The updated criteria for type 2 diabetes have been utilized for analysis.Background data of patients with NASH and NAFLD has been included.The mean differences were compared using χ2 and t-test along with regression analysis to evaluate the predictors of NASH and advanced fibrosis.RESULTS: Patients with NAFLD and T2 DM were significantly older(49.9 vs 43.0,P < 0.01),predominantly female(71.4 vs 56.3,P < 0.02),had higher rate of metabolic syndrome(88.7 vs 36.4,P < 0.01),had significantly higher aspartate transaminase(AST)/alanine transaminase(ALT) ratio(0.94 vs 0.78,P < 0.01) and Fib-4 index(1.65 vs 1.06,P < 0.01) as markers of NASH,showed higher mean NAFLD activity score(3.5 vs 3.0,P = 0.03) and higher mean fibrosis score(1.2 vs 0.52,P < 0.01) compared to patients with NAFLD without T2 DM.Furthermore,advanced fibrosis(32.5 vs 12.0,P < 0.01) and ballooning(27.3 vs 13.3,P < 0.01) was significantly higher among patients with NAFLD and T2 DM compared to patients with NAFLD without T2 DM.On multivariate analysis,T2 DM was independently associated with NASH(OR = 3.27,95%CI: 1.43-7.50,P < 0.01) and advanced fibrosis(OR = 3.45,95%CI: 1.53-7.77,P < 0.01) in all patients with NAFLD.There was a higher rate of T2DM(38.1 vs 19.4,P < 0.01) and cirrhosis(8.3 vs 0.0,P = 0.01) along with significantly higher mean Bilirubin(0.71 vs 0.56,P = 0.01) and AST(54.2 vs 38.3,P < 0.01) and ALT(78.7 vs 57.0,P = 0.01) level among patients with NASH when compared to patients with steatosis alone.The mean platelet count(247 vs 283,P < 0.01) and high-density lipoprotein cholesterol level(42.7 vs 48.1,P = 0.01) was lower among patients with NASH compared to patients with steatosis.CONCLUSION: Patients with NAFLD and T2 DM tend to have more advanced stages of NAFLD,particularly advanced fibrosis and higher rate of ballooning than patients with NAFLD without T2 DM. | Bharat K Puchakayala Siddharth Verma Pushpjeet Kanwar John Hart Raghavendra R Sanivarapu Smruti R Mohanty | 2015 | World Journal of Hepatology2015，7，25： | 10 |
| 2 | Outcome of complex tibial plateau fractures with Ilizarov external fixation with or without minimal internal fixation显示文摘Purpose: To evaluate the clinico-radiological outcome of complex tibial plateau fractures treated with Ilizarov external fixation with or without minimal internal fixation. Methods: This retrospective review was conducted on all the cases of Schatzker types V and VI tibial plateau fractures treated by Ilizarov external fixation between July 2006 and December 2015 with the minimum follow-up duration of one year. There were 30 patients: 24 males and 6 females, mean age 43.33 years, and mean follow-up 3.6 years. Three of them were open fractures;15 cases were Schatzkertype V fractures and the other 15 type VI. According to AO/OTA classification, there were 11 type C1, 12 C2 and 7 type C3 fractures. Outcome assessment was made with American Knee Society Score (AKSS) and Rasmussen's Radiological Score (RRS) at final follow-up. Results: Out of the 30 cases, mini-open reduction was performed in 7, bone graft in 4, minimal internal fixation in 10 and knee temporary immobilisation in 11 patients. Mean duration of external fixation was 11.8 weeks. All fractures united. Pin tract infections in 7 and common peroneal neuropathy in 2 patients were self-limiting. Two patients had axial misalignment of less than 10°. At final follow-up, the mean knee range of motion was 114.7, mean AKSS 81.5 and mean RRS 16.7. On statistical analysis, Schatzker type of fractures, use of minimal internal fixation and knee-spanning did not influence the final outcome. Conclusion: Ilizarov external fixator with or without minimal internal fixation provides acceptable outcome for complex tibial plateau fractures. Care must be taken to look for minor loss of alignment, especially in Type VI Schatzker fractures after removal of the fixator. However small sample size precludes firm conclusions. | Koushik Narayan Subramanyam Madhusudhan Tammanaiah Abhishek Vasant Mundargi Ritesh Nilakanthrao Bhoskar Patllola Siddharth Reddy | 2019 | Chinese Journal of Traumatology2019，22，3： | 10 |
| 3 | Investigation of cubic Pt alloys for ammonia oxidation reaction显示文摘As a promising fuel candidate,ammonia has been successtully used as anode feed in alkaline fuel cells.However,current technology in catalysts for ammonia electro-oxidation reaction(AOR)with respect to both cost and performance is inadequate to ensure large scale commercial application of direct ammonia fuel cells.Recent studies found that alloying Pt with different transition metals and controlling the morphology of catalysts can improve the AOR activity,and thus potentially can solve the cost issue.Herein,(100)-terminated Pt-M nanocubes(M=3d-transition metals Fe,Co,Ni,Zn)are synthesized via wet-chemistry method and their catalytic activities toward AOR are evaluated.The addition of Fe,Co,Ni and Zn elements can enhance the AOR activity due to decrease in oxophilicity of platinum and bifunctional mechanism.Pt-Zn exhibits the maximum mass activity and specific ativity with values of 0.41 A/mgpt and 169 mA/cm2 that are 1.6 and 1.8 times higher than Pt nanocubes,respectively.Pt-Fe,Pt-Co and PI-Ni nanocubes also ilustrate higher mass and specific activities compared to Pt nanocubes. | Yat Tung Chan Kumar Siddharth Minhua Shao | 2020 | Nano Research2020，13，7： | 10 |
| 4 | Immune monitoring post liver transplant显示文摘Many of the causes of short and late morbidity following liver transplantation are associated with immunosuppression or immunosuppressive medications. Current care often involves close monitoring of liver biochemistry as well as therapeutic drug levels. However, the postoperative course following liver transplantation can often be associated with significant complications including infection and rejection, suggesting an inadequacy in current immune function monitoring. Many assays have been tested in the research setting to identify possible biomarkers that may be used to predict clinical events such as acute cellular rejection, and therefore allow modification of a patient's immunosuppressive regimen prior to a clinical event. However, these generally require significant laboratory processing and have had difficulty becoming established in common clinical use outside the research setting. One assay, Cylex ImmuK now has been food and drug administration approved but has had variable results. In this review we discuss the assays that have been used to assess monitoring of immune function after liver transplantation and consider possible future directions. | Siddharth Sood Adam G Testro | 2014 | World Journal of Transplantation2014，4，1： | 8 |
| 5 | A solution to the unit commitment problem a review显示文摘 | B. SARAVANAN Siddharth DAS Surbhi SIKRI D. P. KOTHARI | 2013 | Frontiers in Energy2013，7，2： | 7 |
| 6 | High-resolution multimodal flexible coherent Raman endoscope显示文摘Coherent Raman scattering microscopy is a fast,label-free,and chemically specific imaging technique that shows high potential for future in vivo optical histology.However,the imaging depth in tissues is limited to the sub-millimeter range because of absorption and scattering.Realization of coherent Raman imaging using a fiber endoscope system is a crucial step towards imaging deep inside living tissues and providing information that is inaccessible with current microscopy tools.Until now,the development of coherent Raman endoscopy has been hampered by several issues,mainly related to the fiber delivery of the excitation pulses and signal collection.Here,we present a flexible,compact,coherent Raman,and multimodal nonlinear endoscope(4.2mm outer diameter,71mm rigid length)based on a resonantly scanned hollow-core Kagomé-lattice double-clad fiber.The fiber design enables distortion-less,background-free delivery of femtosecond excitation pulses and back-collection of nonlinear signals through the same fiber.Sub-micrometer spatial resolution over a large field of view is obtained by combination of a miniature objective lens with a silica microsphere lens inserted into the fiber core.We demonstrate high-resolution,high-contrast coherent anti-Stokes Raman scattering,and second harmonic generation endoscopic imaging of biological tissues over a field of view of 320μm at a rate of 0.8 frames per second.These results pave the way for intraoperative label-free imaging applied to real-time histopathology diagnosis and surgery guidance. | Alberto Lombardini Vasyl Mytskaniuk Siddharth Sivankutty Esben Ravn Andresen Xueqin Chen Jérôme Wenger Marc Fabert Nicolas Joly Frédéric Louradour Alexandre Kudlinski Hervé Rigneault | 2018 | Light(Science & Applications)2018，7，1： | 6 |
| 7 | Predictive value of ALT levels for non‐alcoholic steatohepatitis ( NASH ) and advanced fibrosis in non‐alcoholic fatty liver disease ( NAFLD )显示文摘 | Siddharth Verma Donald Jensen John Hart Smruti R. Mohanty | 2013 | Liver Int2013，，9： | 5 |
| 8 | Thermodynamic limits for simultaneous energy harvesting from the hot sun and cold outer space显示文摘The sun and outer space are two of the most important fundamental thermodynamic resources for renewable energy harvesting.A significant amount of work has focused on understanding the fundamental limit of energy harvesting from the sun.More recently,there have been several theoretical analyses of the fundamental limit of energy harvesting from outer space.However,far less is understood about the fundamental limits of simultaneous energy harvesting from both the sun and outer space.Here,we consider and introduce various schemes that are capable of simultaneous energy harvesting and elucidate the fundamental thermodynamic limits of these schemes.We show that the theoretical limits can far exceed the previously established limit associated with utilizing only one thermodynamic resource.Our results highlight the significant potential of simultaneous energy harvesting and indicate new fundamental opportunities for improving the efficiency of energy harvesting systems. | Wei Li Siddharth Buddhiraju Shanhui Fan | 2020 | Light(Science & Applications)2020，9，1： | 4 |
| 9 | Statins Are Associated With a Reduced Risk of Hepatocellular Cancer: A Systematic Review and Meta-analysis显示文摘 | Siddharth Singh Preet Paul Singh Abha Goyal Singh Mohammad Hassan Murad William Sanchez | 2013 | Gastroenterology2013，，： | 3 |
| 10 | Risk of Cerebrovascular Accidents and Ischemic Heart Disease in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis显示文摘 | Siddharth Singh Harkirat Singh Edward V. Loftus Darrell S. Pardi | 2014 | Clinical Gastroenterology and Hepatology2014，，3： | 3 |
| 11 | Chemical and behavioral analysis of the cuticular hydrocarbons from Asian citrus psyllid, Diaphorina citri显示文摘Huanglongbing (HLB ) 是世界范围的柠檬的最破坏的疾病。亚洲柠檬 psyllid, Diaphorina citri Kuwayama (半翅类:Psyllidae ) ,住在韧皮部的细菌的向量, Candidatus Liberibacter asiaticus,它被假定在佛罗里达引起 HLB 柠檬。实验室和领域研究被进行检验男、女的 D 的行为的回答。citri 到他们的表皮的摘录。在 olfactometer 试金,更多的男 D。citri 比空白的控制被吸引到一,五,或 10 个女表皮的摘录等价物单位。结果在清楚或黄的陷井在引诱了, 10 个女表皮的摘录等价物单位吸引了的领域研究被证实成比例地更多的男性与男表皮的摘录或 unbaited 陷井比清楚的陷井引诱了。男、女的 D 的表皮的成分的分析。citri 在他们的表皮的摘录的化学作文揭示了性之间的差别。有从表皮的摘录识别的合成化学药品的实验室生物鉴定显示 dodecanoic 酸比干净空气吸引了更多的男性。与 dodecanoic 酸引诱的陷井没增加 D 的全部的钩子。作为与空白相比,在剂量的陷井测试了的 citri;然而, psyllid 钩子的性比率是在与装载测试的剂量(10.0 mg ) 的最高的诱惑引诱的陷井上偏导的男性。 | Rajinder S. Mann Russell L. Rouseff Jack Smoot Nandikeswara Rao Wendy L. Meyer Stephen L. Lapointe Paul S. Robbins Dong Cha Charles E. Linn Francis X. Webster Siddharth Tiwari Lukasz L. Stelinski | 2013 | Insect Science2013，20，3： | 3 |
| 12 | Graph theory approach to determine configurations of multidentate and high coverage adsorbates for heterogeneous catalysis显示文摘Heterogeneous catalysts constitute a crucial component of many industrial processes,and to gain an understanding of the atomicscale features of such catalysts,ab initio density functional theory is widely employed.Recently,growing computational power has permitted the extension of such studies to complex reaction networks involving either high adsorbate coverages or multidentate adsorbates,which bind to the surface through multiple atoms.Describing all possible adsorbate configurations for such systems,however,is often not possible based on chemical intuition alone.To systematically treat such complexities,we present a generalized Python-based graph theory approach to convert atomic scale models into undirected graph representations.These representations,when combined with workflows such as evolutionary algorithms,can systematically generate high coverage adsorbate models and classify unique minimum energy multidentate adsorbate configurations for surfaces of low symmetry,including multi-elemental alloy surfaces,steps,and kinks. | Siddharth Deshpande Tristan Maxson Jeffrey Greeley | 2020 | npj Computational Materials2020，，1： | 3 |
| 13 | Antioxidant activity and total phenolic content of ethanolic extract of Caesalpinia bonducella seeds显示文摘 | Shruti Shukla Archana Mehta Jinu John Siddharth Singh Pradeep Mehta Suresh Prasad Vyas | 2009 | Food and Chemical Toxicology2009，，8： | 3 |
| 14 | Fibrosis Progression in Nonalcoholic Fatty Liver vs Nonalcoholic Steatohepatitis: A Systematic Review and Meta-analysis of Paired-Biopsy Studies显示文摘 | Siddharth Singh Alina M. Allen Zhen Wang Larry J. Prokop Mohammad H. Murad Rohit Loomba | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 2 |
| 15 | Systematic review: Safety of balloon assisted enteroscopy in Crohn's disease显示文摘AIM To determine the overall and comparative risk of procedure related perforation of balloon assisted enteroscopy(BAE) in Crohn's disease(CD). METHODS Systematic review(PROSPERO #CRD42015016381) of studies reporting on CD patients undergoing BAE. Seventy-three studies reporting on 1812 patients undergoing 2340 BAEs were included. Primary outcome of interest was the overall and comparative risk of procedure related perforation of diagnostic BAE in CD. Secondary outcomes of interest were risk of procedure related perforation of diagnostic double balloon enteroscopy(DBE), risk of procedure related perforation of therapeutic BAE, efficacy of stricture dilation, and clinical utility of endoscopically assessing small bowel disease activity.RESULTS Per procedure perforation rate of diagnostic BAE in CD was 0.15%(95%CI: 0.05-0.45), which was similar to diagnostic BAE for all indications(0.11%; IRR = 1.41, 95%CI: 0.28-4.50). Per procedure perforation rate of diagnostic DBE in CD was 0.12%(95%CI: 0.03-0.44), which was similar to diagnostic DBE for all indications(0.22%; IRR = 0.54, 95%CI: 0.06-0.24). Per procedure perforation rate of therapeutic BAE in CD was 1.74%(95%CI: 0.85-3.55). Eighty-six percentof therapeutic perforations were secondary to stricture dilation. Dilation was attempted in 207 patients and 30% required surgery during median follow-up of 18 months. When diagnostic BAE assessed small bowel disease activity, changes in medical therapy resulted in endoscopic improvement in 77% of patients. CONCLUSION Diagnostic BAE in CD has a similar rate of perforation as diagnostic BAE for all indications and can be safely performed in assessment of mucosal healing. | Ahilan Arulanandan Parambir S Dulai Siddharth Singh William J Sandborn Denise Kalmaz | 2016 | World Journal of Gastroenterology2016，22，40： | 2 |
| 16 | Effects of the COVID-19 pandemic on semen quality in male partners of infertile couples: a hospitalbased observational study显示文摘The effects of the coronavirus disease 2019(COVID-19)pandemic on male fertility have received considerable attention because human testes contain high levels of angiotensin-converting enzyme-2 receptors,through which severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)can enter.Early studies showed decreases in semen quality during and after recovery from COVID-19.However,no semen quality studies have examined the effects of widespread subclinical and mild disease,as well as changes in lifestyle,psychosocial behavior,intake of dietary supplements,and stress.This cross-sectional study compared semen quality parameters in male partners of infertile couples between men who underwent semen analysis before the COVID-19 pandemic(prepandemic group)and men who underwent semen analysis during the pandemic period(pandemic group);the analysis sought to clarify the overall effects of the pandemic.No participants in the pandemic group had experienced clinically overt disease.Among the 239 participants,mean body weight(P=0.001),mean body mass index(P<0.001),median sperm concentration(P=0.014),total sperm count(P=0.006),and total percentages of motile(P=0.013)and abnormal cells(P<0.001)were significantly greater in the pandemic group(n=137)than those in the prepandemic group(n=102).Among abnormal cells,the percentages of cells with excess residual cytoplasm(P<0.001),head defects(P<0.001),and tail defects(P=0.015)were significantly greater in the pandemic group than those in the prepandemic group.With the exception of morphology,the overall semenogram results were better in the pandemic group than those in the prepandemic group. | Tribhuwan Kumar Kamlesh Jha Md Zabihullah Kumari Neelu Yogesh Kumar Kumar Siddharth | 2023 | Asian Journal of Andrology2023，25，2： | 2 |
| 17 | Incidence of esophageal adenocarcinoma in Barrett’s esophagus with low-grade dysplasia: a systematic review and meta-analysis显示文摘 | Siddharth Singh Palaniappan Manickam Anita V. Amin Niharika Samala Leo J. Schouten Prasad G. Iyer Tusar K. Desai | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 18 | 基于Photogrammetry的地表变形监测技术研究显示文摘主要讨论了采用Photogrammetry技术监测地下施工过程中地表变形的主要方法和应用情况。地表变形过大往往会导致地表既有建筑物的破碎,所以量化监测其变形程度在地下施工中尤为重要。Photogrammetry技术是一种非接触式的变形监测技术,主要通过影像手段获取目标点的三维变形大小。该方法需要从空间多角度对目标点进行摄影测量,获取连续的三维影像信息,通过Photogrammetry软件进行现场目标点重现,进而获取三维可视目标点坐标值。本文通过现场的监测,获取了地表变形的数据,提出了监测的方法。 | 孙平贺 何中导 赵仁明 乌效鸣 Siddharth Banerjee | 2010 | 地下空间与工程学报2010，6，6： | 2 |
| 19 | Probiotics Prevent Hepatic Encephalopathy in Patients With Cirrhosis: A Randomized Controlled Trial显示文摘 | Manish Kumar Lunia Barjesh Chander Sharma Praveen Sharma Sanjeev Sachdeva Siddharth Srivastava | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 2 |
| 20 | Primary Sclerosing Cholangitis: Diagnosis, Prognosis, and Management显示文摘 | Siddharth Singh Jayant A. Talwalkar | 2013 | Clinical Gastroenterology and Hepatology2013，，8： | 2 |
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