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| 1 | 英国胃肠病学会关于胃癌风险患者的诊断和管理指南显示文摘胃癌预后较差,部分原因在于诊断较晚。胃癌的危险因素包括幽门螺杆菌(H.pylori,HP)感染和胃癌家族史,尤其是遗传性弥漫性胃癌和恶性贫血。胃癌发展的阶段包括慢性胃炎、胃黏膜萎缩(GA)、胃黏膜肠化生(GIM)和异型增生。胃癌早期发现和提高生存率的关键是在内镜检查前以非侵入性方式识别高危人群。然而,尽管生物标志物可能有助于检测慢性萎缩性胃炎,但尚无足够的证据支持其用于人群筛查。高质量内镜检查是胃癌早期发现的重要组成部分,图像增强内镜结合组织病理学活检是GA和GIM最佳的诊断方法,并能准确进行风险分层。按照悉尼标准从胃窦、角切迹、小弯和大弯进行活检,既能明确诊断,也能对胃癌进行风险分层。理想状态应当是在高质量内镜检查中对GA或GIM区域活检。英国属于低危地区,可根据需要接受常规诊断性胃镜检查,但没有足够证据支持筛查,对于广泛GA或GIM的患者,每3年检查内镜。对于胃异型增生和早期癌,只要满足标准,内镜下黏膜切除术或内镜黏膜下剥离术的治疗有效,成功率高,复发率低。 | Matthew Banks David Graham Marnix Jansen TakujiGotoda Sergio Coda Massimiliano di Pietro NoriyaUedo Pradeep Bhandari D Mark Pritchard Ernst J Kuipers Manuel Rodriguez-Justo Marco R Novelli KrishRagunath Neil Shepherd Mario Dinis-Ribeiro 乌雅罕(译) 张冬雪(译) 牛占岳(校) 刘鑫(校) 丁士刚(译/校) | 2020 | 中华胃肠内镜电子杂志2020，7，2： | 10 |
| 2 | 精细油水煤浆制备及其在柴油机上应用的生命周期评价显示文摘论述了精细油水煤浆的制备及其在柴油机上燃用的试验结果,采用生命周期评价方法对精细油水煤浆和柴油的生产及其燃用进行了评价.结果表明,随着精细油水煤浆中柴油含量的减少,除光化臭氧形成潜能降低以外,其它污染指标值都增加,说明精细油水煤浆系统比柴油系统对全球环境冲击更为严重,但在局部地区与燃油相比,燃用精细油水煤浆可以减少NOx的排放量,与燃煤相比,可以减少SO2的排放量. | 付晓恒 王祖讷 Giovanni Novelli Bruno De Benedetti | 2005 | 煤炭学报2005，30，4： | 8 |
| 3 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 4 | Barrett’s metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor显示文摘 | Anna M Nicholson Trevor A Graham Ashley Simpson Adam Humphries Nicola Burch Manuel Rodriguez-Justo Marco Novelli Rebecca Harrison Nicholas A Wright Stuart A C McDonald Janusz A Jankowski | 2012 | Gut2012，，10： | 3 |
| 5 | Nonsense variant of ATP8B1 gene in heterozygosis and benign recurrent intrahepatic cholestasis: A case report and review of literature显示文摘BACKGROUND Benign recurrent intrahepatic cholestasis is a genetic disorder with recurrent cholestatic jaundice due to ATP8B1 and ABCB11 gene mutations encoding for hepato-canalicular transporters.Herein,we firstly provide the evidence that a nonsense variant of ATP8B1 gene(c.1558A>T)in heterozygous form is involved in BRIC pathogenesis.CASE SUMMARY A 29-year-old male showed severe jaundice and laboratory tests consistent with intrahepatic cholestasis despite normal gamma-glutamyltranspeptidase.Acute and chronic liver diseases with viral,metabolic and autoimmune etiology were excluded.Normal intra/extra-hepatic bile ducts were demonstrated by magnetic resonance.Liver biopsy showed:Cholestasis in the centrilobular and intermediate zones with bile plugs and intra-hepatocyte pigment,Kupffer’s cell activation/hyperplasia and preserved biliary ducts.Being satisfied benign recurrent intrahepatic cholestasis diagnostic criteria,ATP8B1 and ABCB11 gene analysis was performed.Surprisingly,we found a novel nonsense variant of ATP8B1 gene(c.1558A>T)in heterozygosis.The variant was confirmed by Sanger sequencing following a standard protocol and tested for familial segregation,showing a maternal inheritance.Immunohistochemistry confirmed a significant reduction of mutated gene related protein(familial intrahepatic cholestasis 1).The patient was treated with ursodeoxycholic acid 15 mg/kg per day and colestyramine 8 g daily with total bilirubin decrease and normalization at the 6th and 12th mo.CONCLUSION A genetic abnormality,different from those already known,could be involved in familial intrahepatic cholestatic disorders and/or pro-cholestatic genetic predisposition,thus encouraging further mutation detection in this field. | Mariano Piazzolla Nicola Castellaneta Antonio Novelli Emanuele Agolini Dario Cocciadiferro Leonardo Resta Loren Duda Michele Barone Enzo Ierardi Alfredo Di Leo | 2020 | World Journal of Hepatology2020，12，2： | 3 |
| 6 | Clonality, Founder Mutations, and Field Cancerization in Human Ulcerative Colitis–Associated Neoplasia显示文摘 | Simon J. Leedham Trevor A. Graham Dahmane Oukrif Stuart A.C. McDonald Manuel Rodriguez–Justo Rebecca F. Harrison Neil A. Shepherd Marco R. Novelli Janusz A.Z. Jankowski Nicholas A. Wright | 2009 | Gastroenterology2009，，2： | 2 |
| 7 | Proteomic changes involved in tenderization of bovine Longissimus dorsi muscle during prolonged ageing显示文摘 | Rita Polati Michele Menini Elisa Robotti Renato Millioni Emilio Marengo Enrico Novelli Stefania Balzan Daniela Cecconi | 2012 | Food Chemistry2012，，3： | 2 |
| 8 | Baseline airway inflammation may be a determinant of the response to ozone exposure in asthmatic patients显示文摘 | Maria Laura Bartoli Barbara Vagaggini Laura Malagrinò Elena Bacci Silvana Cianchetti Federico L. Dente Federica Novelli Francesco Costa Pierluigi Paggiaro | 2013 | Inhalation Toxicology2013，，3： | 2 |
| 9 | Altered expression and allelic association of the hypervariable membrane mucin MUC1 in Helicobacter pylori gastritis显示文摘 | Lynne E. Vinall Marie King Marco Novelli Carole A. Green Geoff Daniels John Hilkens Martin Sarner Dallas M. Swallow | 2002 | Gastroenterology2002，，1： | 2 |
| 10 | Ex vivo analysis of pancreatic cancer-infiltrating T lymphocytes reveals that ENO-specific Tregs accumulate in tumor tissue and inhibit Th1/Th17 effector cell functions显示文摘 | Amedeo Amedei Elena Niccolai Marisa Benagiano Chiara Della Bella Fabio Cianchi Paolo Bechi Antonio Taddei Lapo Bencini Marco Farsi Paola Cappello Domenico Prisco Francesco Novelli Mario Milco D’Elios | 2013 | Cancer Immunology, Immunotherapy2013，，7： | 2 |
| 11 | Intra-brain microinjection of human mesenchymal stem cells decreases allodynia in neuropathic mice显示文摘 | Dario Siniscalco Catia Giordano Umberto Galderisi Livio Luongo Nicola Alessio Giovanni Bernardo Vito Novellis Francesco Rossi Sabatino Maione | 2010 | Cellular and Molecular Life Sciences2010，，4： | 2 |
| 12 | CO in the atmosphere:measurement techniques and related issues显示文摘 | | 1999 | Chemosphere:Global Change Science1999，1，： | 1 |
| 13 | T-cell costimulatory molecules in acute-graft-versus host disease: Therapeutic implications 显示文摘 | Briones J Novelli S Sierra J | 2011 | Bone Marrow Res2011，2011，97： | 1 |
| 14 | Nuclear and cytoplasmic cellular distribution of survivin as survival predictor in resected non - small - cell lung cancer 显示文摘 | Bria E Visca P Novelli F | 2008 | Eur J Surg Oncol2008，34，5： | 1 |
| 15 | Usefulness of Whole-Body Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography in Patients with Neurofibromatosis Type 1: A Systematic Review显示文摘 | Giorgio Treglia Silvia Taralli Francesco Bertagna Marco Salsano Barbara Muoio Pierluigi Novellis Maria Letizia Vita Fabio Maggi Alessandro Giordano Jenny T. Bencardino | 2012 | <journal-title>Radiology Research and Practice2012，，： | 1 |
| 16 | Simultaneous Pancreas-Kidney Transplantation: A Single-Center Experience and Prospective Analysis显示文摘 | M. Rossi Q. Lai G. Spoletini L. Poli F. Nudo S. Ferretti F. Della Pietra F. Pugliese G. Ferretti G. Novelli R. Pretagostini P.B. Berloco | 2008 | Transplantation Proceedings2008，，6： | 1 |
| 17 | Transferability and level of heterozygosity of microsatellite mark- ers in citrus species显示文摘 | CRISTOFANI-YALY M NOVELLI V M BASTIANEL M | 2011 | Plant Molecular Biology Reporter2011，29，2： | 1 |
| 18 | In vitro postantibiotic effect and postantibiotic leukocyte enhancement of tobramyein 显示文摘 | Novelli A Mazzei T Fallani S | 1995 | J Chemother1995，7，： | 1 |
| 19 | Determination of glycated hemoglobins in the rat:comparison between two different chromatographic methods and application in experimental diabetology显示文摘 | De Tata V Novelli M Bombara M | 1996 | Res Exp Med (Berl)1996，196，1： | 1 |
| 20 | Field cancerization, clonality, and epithelial stem cells: the spread of mutated clones in epithelial sheets显示文摘 | GARCIA S B PARK H S NOVELLI M | 1999 | J Pathol1999，187，： | 1 |
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