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| 1 | High-energy Metal Fuels for Rocket Propulsion: Characterization and Performance显示文摘A joint international effort to improve solid propellant performance within the framework of a FP7European Project was described.Several metallized solid rocket propellants,of the broad family AP/HTPB/Metal in the ratio 68/14/18,were experimentally analyzed seeking to optimize the delivered specific impulse by identifying the most suitable high-energy fuel.Keeping the same nominal composition,different metallic fuels(including micrometric and nanometric Al,AlH3,and a variety of dual metal compositions)were characterized,tested,and contrasted to a conventional micrometric aluminum(30μm average grain size)certified for space flights.In order to overcome the intrinsic performance limitations of the matrix AP/HTPB,a new matrix consisting of ADN/GAP satisfying also the need for environmentally benign propellant formulation was considered as well.A comparative analysis between the two solid propellant systems in terms of ideal thermochemistry and experimental combustion properties reveals advantages and disadvantages of both.Overall,it is judged worthwhile to develop ADN/GAP propellants,with or without metallic fuels,to enhance the current status of solid rocket propulsion.Controlling morphology and mechanical properties of ADN/GAP compositions and understanding their flame structure and aggregation/agglomeration properties are the main issues still challenging industrial users. | Luigi T. DELUCA Filippo MAGGI Stefano DOSSI Volker WEISER Andrea FRANZIN Volker GETTWERT Thomas HEINTZ | 2013 | 火炸药学报2013，36，6： | 11 |
| 2 | Role of MGMT as biomarker in colorectal cancer显示文摘O6-methylguanine DNA methyltransferase(MGMT) gene promoter methylation plays an important role in colorectal carcinogenesis, occurring in about 30%-40% of metastatic colorectal cancer. Its prognostic role has not been defined yet, but loss of expression of MGMT, which is secondary to gene promoter methylation, results in an interesting high response to alkylating agents such as dacarbazine and temozolomide. In a phase 2 study on heavily pre-treated patients with MGMT methylated metastatic colorectal cancer, temozolomide achieved about 30% of disease control rate. Activating mutations of RAS or BRAF genes as well as mismatch repair deficiency may represent mechanisms of resistance to alkylating agents, but a dose-dense schedule of temozolomide may potentially restore sensitivity in RAS-mutant patients. Further development of temozolomide in MGMT methylated colorectal cancer includes investigation of synergic combinations with other agents such as fluoropyrimidines and research for additional biomarkers, in order to better define the role of temozolomide in the treatment of individual patients. | Alessandro Inno Giuseppe Fanetti Maria Di Bartolomeo Stefania Gori Claudia Maggi Massimo Cirillo Roberto Iacovelli Federico Nichetti Antonia Martinetti Filippo de Braud Ilaria Bossi Filippo Pietrantonio | 2014 | World Journal of Clinical Cases2014，2，12： | 10 |
| 3 | A truncated hepatitis E virus ORF2 protein expressed in tobacco plastids is immunogenic in mice显示文摘瞄准:表示 23-ku pE2 到花费有效地,肝炎 E 病毒(HEV ) 的 3'-portion 包括的 E2 碎片编码的最有希望的子单元疫苗打开读物框架 2 (ORF2 ) 在烟草的质体(Nicotiana 烟 cv。SR1 ) ,在质体调查 transgene 表示和 pE2 累积,并且评估反在老鼠的导出质体的 pE2 的遗传因子的效果。方法:包含米饭 psbA 倡导者驾驶的 E2 碎片的指向质体的向量 pRB94-E2 被构造。在进烟草质体的交货之上,这构造能在质体染色体在 psaB-trnfM 和 trnG-psbC 碎片开始相应再结合,并且导致在二碎片之间插入的 transgene。pRB94-E2 与一个 biolistic 粒子轰炸方法被交付,并且转变质体的工厂被获得在补充 spectinomycin 的媒介上跟随炮轰的叶纸巾的新生。改革工厂的 Transplastomic 地位被 PCR 和南部的污点分析证实, transgene 表示被北污点分析调查,并且 pE2 的累积被 ELISA 测量。而且,蛋白浸出物被用来使老鼠免疫,并且在使免疫的老鼠的浆液样品的 pE2 反应的抗体的存在被 ELISA 学习。结果:PCR 和南部的污点分析证实的 Transplastomic 线能活跃地抄录 E2 mRNA。pE2 多肽象 13.27 microg/g 一样高被积累到水平新鲜叶子。pE2 能刺激使免疫的老鼠产生 pE2 特定的抗体。结论:HEV-E2 碎片能被插入到质体染色体,导出的 recombinant pE2 抗原是在老鼠遗传因子的反。因此,质体可以是为 HEV 疫苗的划算的生产的新奇来源。 | Yuan-Xiang Zhou Maggie Yuk-Ting Lee James Ming-Him Ng Mee-Len Chye Wing-Kin Yip Sze-Yong Zee Eric Lam | 2006 | World Journal of Gastroenterology2006，12，2： | 10 |
| 4 | 阴茎勃起障碍的研究现状显示文摘 | 张新华 Mario Maggi 胡礼泉 | 2004 | 中国男科学杂志2004，18，3： | 9 |
| 5 | Erectile dysfunction and central obesity: an Italian perspective显示文摘可勃起的机能障碍(编辑) 是肥胖的经常的复杂并发症。这评论的目的是极其分析肥胖和编辑的框架,把在二个病理学的实体之间的连接。当前的临床的证据显示出那肥胖,和特别地中央的肥胖,与两个 arteriogenic 版本被联系并且减少了睾丸激素(T) 层次。联系肥胖的性腺机能减退和增加的心血管的风险可能部分在超重、肥胖的个人认为编辑的更高的流行正当,是想得到的。相反地,与肥胖有关的心理骚乱不似乎然而在肥胖相关的编辑的致病起一个主要作用,在编辑之间的协会和内脏的胖累积从已知的联系肥胖的 comorbidities 是独立的临床、现出症状之前的潜的数据表演。因此,内脏的脂肪怎么能损害阴茎 microcirculation,仍然保持未知。自从在编辑题目的中央肥胖在高心血管的风险分类个人,这个点是特别地相关的,特别在最年轻的。在肥胖的题目的编辑的存在可能在说服他们开始一个善良的周期帮助保健专业人员,在性机能障碍的修正将是为改进生活方式行为的报酬的地方。Unsatisfying 性活动为请教接着,应该利用机会鼓励肥胖的病人对待的保健专业版代表有意义的、直接动机,除编辑以外,内在的相反的条件,这样不仅恢复可勃起的功能,而且全面健康。 | Giovanni Corona Giulia Rastrelli Sandra Filippi Linda Vignozzi Edoardo Mannucci Mario Maggi | 2014 | Asian Journal of Andrology2014，16，4： | 9 |
| 6 | Treatment of peri-anal fistula in Crohn's disease显示文摘Anal fistulas are a common manifestation of Crohn's disease(CD). The first manifestation of the disease is often in the peri-anal region, which can occur years before a diagnosis, particularly in CD affecting the colon and rectum. The treatment of peri-anal fistulas is difficult and always multidisciplinary. The European guidelines recommend combined surgical and medical treatment with biologic drugs to achieve best results. Several different surgical techniques are currently em-ployed. However, at the moment, none of these tech-niques appear superior to the others in terms of healing rate. Surgery is always indicated to treat symptomatic, simple, low intersphincteric fistulas refractory to medi-cal therapy and those causing disabling symptoms. Ut-most attention should be paid to correcting the balance between eradication of the fistula and the preservationof fecal continence. | Giuseppe S Sica Sara Di Carlo Giorgia Tema Fabrizio Montagnese Giovanna Del Vecchio Blanco Valeria Fiaschetti Giulia Maggi Livia Biancone | 2014 | World Journal of Gastroenterology2014，20，37： | 8 |
| 7 | 世界各国神奇有趣的绿色建筑显示文摘在西方发达国家,节能与绿色建筑已经有几十年的成功发展史。有的国家甚至已经取得经济发展和能耗持续下降的突出成就。及时、系统、广泛地引进它们的成功经验和技术,对引导我国刚起步的节能与绿色建筑的发展尤为重要。这对于我们少走弯路、加快节能与绿色建筑的新技术、新产品和管理经验的推广是不可替代的。 | Maggie | 2007 | 数字社区&智能家居2007，，7： | 7 |
| 8 | 【原创论文】不育夫妇中男方的代谢综合征与前列腺异常的情况显示文摘目前尚无年轻男性不育症患者代谢综合征与前列腺相关的症状和体征之间关系的系统研究。我们研究了171对不育夫妇中的男性(36.5±8.3岁),代谢综合征是根据国家胆固醇教育计划成人治疗专题小组第三次报告确定。所有人接受了激素(包括总睾酮和胰岛素)、精液f包括白细胞介素8,精浆中白细胞介素8(SIL-8))、阴囊及经直肠超声评估。因为我们此前已有大样本队列研究了不育男性代谢综合征和阴囊检测指标之间的相关性,这里我们重点研究代谢综合征与经直肠前列腺B超资料的相关性。前列腺相关症状采用美国国立卫生研究院评估慢性前列腺炎症状指数(NIH-CPSI)和国际前列腺症状评分(iPSS)。22位受试者符合代谢综合征的诊断标准。经年龄调整后的有序多项Logistic回归模型分析显示:胰岛素水平增加是代谢综合征的一个组分(Wald=29.5,P〈0.0001)并与TT负相关(调整后的r=0.359,P〈O.0001)。未观察到代谢综合征和NIH.CPSI或IPSS评分之间有相关性。经年龄、睾酮、胰岛素校正后有序多项Logistic回归模型显示:代谢综合征组分数目的增加与正常精子形态负相关(Wald=5.59,P〈0.02)、与前列腺炎症的分子标志物血清sIL-8水平正相关(Wald=4.32,P〈0.05),与前列腺总体积和移行带体积(Wald=17.6和12.5,P〈0.0001)、动脉收缩期峰值流速(Wald=9.57,P=0.002)、质地不均匀性(HR=8711.05—3.33],P〈0.05)、钙化灶大小(Wald=3.11,P〈0.05)正相关,但不与精囊体积或功能指标正相关。总之,不育夫妇中的男性代谢综合征与前列腺增大、生化指标(sIL8)和前列腺炎症的超声指标呈正相关,而与前列腺相关症状无正相关,表明代谢综合征可能是良性前列腺增生症的早期亚临床表现的触发点。 | Francesco Lotti Giovanni Corona Linda Vignozzi Matteo Rossi Elisa Maseroli Sarah Cipriani Mauro Gacci Gianni Forti Mario Maggi | 2014 | Asian Journal of Andrology2014，16，2： | 6 |
| 9 | 美国十大钻头公司的十大钻头新技术显示文摘以美国十大天然气和石油钻头制造厂商为主线 ,对这些厂商当前所开发的钻头制造新技术及其推出的各类新产品进行了详细的描述 ,产品及技术范围涉及牙轮钻头、金刚石钻头、随钻扩眼钻具、双中心钻头以及相关钻头零部件等 ,这些新技术和新产品可满足当前各种钻井方式的不同需求 ,并都已在世界范围内各种钻井环境下得到了验证 ,使钻井效率得到大幅度提高。 | Maggie Lee 申守庆 | 2002 | 国外油田工程2002，18，7： | 5 |
| 10 | 当当与卓越 角逐B2C电子商务竞技场显示文摘当当网与卓越网都是国内B2C模式电子商务网站排名比较靠前的经营网站,两者的业务模式、所卖商品都极其类似,他们也取得不同程度上的成功,两者之间的直接竞争也是不可避免的事,角逐B2C领域竞技场,最终谁将是王者? | Maggie Yu | 2008 | 中国科技财富2008，，1： | 5 |
| 11 | Temporal clinical, proteomic, histological and cellular immune responses of dextran sulfate sodium-induced acute colitis显示文摘AIM To investigate the temporal clinical, proteomic, histological and cellular immune profiles of dextran sulfate sodium(DSS)-induced acute colitis.METHODS Acute colitis was induced in C57 BL/6 female mice by administration of 1%, 2% or 3% DSS in drinking water for 7 d. Animals were monitored daily for weight loss, stool consistency and blood in the stool, while spleens and colons were harvested on day 8. A time course analysis was performed in mice ingesting 3% DSS, which included colon proteomics through multiplex assay, colon histological scoring by a blinded investigator, and immune response through flow cytometry or immunohistochemistry of the spleen, mesenteric lymph node and colon.RESULTS Progressive worsening of clinical colitis was observed with increasing DSS from 1% to 3%. In mice ingesting 3% DSS, colon shortening and increase in proinflammatory factors starting at day 3 was observed, with increased spleen weights at day 6 and day 8. This coincided with cellular infiltration in the colon from day 2 to day 8, with progressive accumulation of macrophages F4/80^+, T helper CD4^+(Th), T cytotoxic CD8^+(Tcyt) and T regulatory CD25^+(Treg) cells, and progressive changes in colonic pathology including destruction of crypts, loss of goblet cells and depletion of the epithelial barrier. Starting on day 4, mesenteric lymph node and/or spleen presented with lower levels of Treg, Th and Tcyt cells, suggesting an immune cell tropism to the gut. CONCLUSION These results demonstrate that the severity of experimental colitis is dependent on DSS concentration, correlated with clinical, proteomic, histological and cellular immune response on 3% DSS. | Natalia Schneider Nunes Saejeong Kim Maggie Sundby Parwathy Chandran Scott Robert Burks Ana Helena Paz Joseph Alan Frank | 2018 | World Journal of Gastroenterology2018，24，38： | 5 |
| 12 | A systematic review and meta-analysis of clinical trials implementing aromatase inhibitors to treat male infertility显示文摘Aromatase activity has commonly been associated with male infertility characterized by testicular dysfunction with low serum testosterone and/or testosterone to estradiol ratio.In this subset of patients,and particularly in those with hypogonadism,elevated levels of circulating estradiol may establish a negative feedback on the hypothalamic–pituitary–testicular axis by suppressing follicle-stimulating hormone(FSH)and luteinizing hormone(LH)production and impaired spermatogenesis.Hormonal manipulation via different agents such as selective estrogen modulators or aromatase inhibitors to increase endogenous testosterone production and improve spermatogenesis in the setting of infertility is an off-label option for treatment.We carried out a systematic review and meta-analysis of the literature of the past 30 years in order to evaluate the benefits of the use of aromatase inhibitors in the medical management of infertile/hypoandrogenic males.Overall,eight original articles were included and critically evaluated.Either steroidal(Testolactone)or nonsteroidal(Anastrozole and Letrozole)aromatase inhibitors were found to statistically improve all the evaluated hormonal and seminal outcomes with a safe tolerability profile.While the evidence is promising,future prospective randomized placebo-controlled multicenter trials are necessary to better define the efficacy of these medications. | Francesco Del Giudice Gian Maria Busetto Ettore De Berardinis Isabella Sperduti Matteo Ferro Martina Maggi Martin S Gross Alessandro Sciarra Michael L Eisenberg | 2020 | Asian Journal of Andrology2020，22，4： | 5 |
| 13 | 世界生态博物馆共同面临的问题及怎样面对它们显示文摘 | 毛里齐奥·马吉(Maurizio Maggi) 张晋平(译) | 2005 | 中国博物馆2005，，3： | 5 |
| 14 | Functional magnetic resonance imaging and the brain: A brief review显示文摘Functional magnetic resonance imaging(fMRI) is em-ployed in many behavior analysis studies, with blood oxygen level dependent-(BOLD-) contrast imaging being the main method used to generate images. The use of BOLD-contrast imaging in f MRI has been refined over the years, for example, the inclusion of a spin echo pulse and increased magnetic strength were shown to produce better recorded images. Taking careful precautions to control variables during measurement, comparisons between different specimen groups can be illustrated by f MRI imaging using both quantitative and qualitative methods. Differences have been observed in comparisons of active and resting, developing and aging, and defective and damaged brains in various studies. However, cognitive studies using f MRI still face a number of challenges in interpretation that can only be overcome by imaging large numbers of samples. Furthermore, f MRI studies of brain cancer, lesions and other brain pathologies of both humans and animals are still to be explored. | Maggie SM Chow Sharon L Wu Sarah E Webb Katie Gluskin DT Yew | 2017 | World Journal of Radiology2017，9，1： | 4 |
| 15 | Estimation of exponential growth rate and basic reproduction number of the coronavirus disease 2019 (COVID-19)in Africa显示文摘Background:Since the first case of coronavirus disease 2019(COVID-19)in Africa was detected on February 14,2020,the cumulative confirmations reached 15207 including 831 deaths by April 13,2020.Africa has been described as one of the most vulnerable region with the COVID-19 infection during the initial phase of the outbreak,due to the fact that Africa is a great commercial partner of China and some other EU and American countries.Which result in large volume of travels by traders to the region more frequently and causing African countries face even bigger health threat during the COVID-19 pandemic.Furthermore,the fact that the control and management of COVID-19 pandemic rely heavily on a country's health care system,and on average Africa has poor health care system which make it more vulnerable indicating a need for timely intervention to curtail the spread.In this paper,we estimate the exponential growth rate and basic reproduction number(R0)of COVID-19 in Africa to show the potential of the virus to spread,and reveal the importance of sustaining stringent health measures to control the disease in Africa.Methods:We analyzed the initial phase of the epidemic of COVID-19 in Africa between 1 March and 13 April 2020,by using the simple exponential growth model.We examined the publicly available materials published by the WHO situation report to show the potential of COVID-19 to spread without sustaining strict health measures.The Poisson likelihood framework is adopted for data fitting and parameter estimation.We modelled the distribution of COVID-19 generation interval(GI)as Gamma distributions with a mean of 4.7 days and standard deviation of 2.9 days estimated from previous work,and compute the basic reproduction number.Results:We estimated the exponential growth rate as 0.22 per day(95%CI:0.20-0.24),and the basic reproduction number,R0,as 2.37(95%CI:2.22-2.51)based on the assumption that the exponential growth starting from 1 March 2020.With an R0 at 2.37,we quantified the instantaneous transmissibility of the outbreak by the time-varying effective reproductive number to show the potential of COVID-19 to spread across African region.Conclusions:The initial growth of COVID-19 cases in Africa was rapid and showed large variations across countries.Our estimates should be useful in preparedness planning against further spread of the COVID-19 epidemic in Africa. | Salihu S.Musa Shi Zhao Maggie H.Wang Abdurrazaq G.Habib Umar T.Mustapha Daihai He | 2020 | Infectious Diseases of Poverty2020，9，4： | 3 |
| 16 | How to recognize late-onset hypogonadism in men wit sexual dysfunction显示文摘迟了发作的性腺机能减退(LOH ) 在 100 个人与约 1 的流行被认为男性腺机能减退的最普通的形式。LOH 的诊断应该与不含糊地低的浆液睾丸激素(T) 层次在征兆的人被做。然而,因为它被与生理的变老做微分诊断的 nonspecific 症状描绘,它的临床的演讲经常暗中为害、困难认出有问题。性机能障碍是为医药会诊和与低 T 联系的最特定的症状的最重要的决定因素。我们因此分析了出席了我们的单位的 1734 个题目的一个连续系列因为调查在低 T (不同阀值) 之间的协会的性机能障碍,性参数,病历数据(推迟的发身,垂体疾病或 cryptorchidism ) 和他们的物理考试结果。新陈代谢的参数,特别地腰圆周,在检测低 T 显示最大的精确性。我们发现仅仅几症状和符号的协会能显著地提起低 T 的临床的怀疑。结构化的库存,一起聚类性腺机能减退的症状和症状,能帮助临床医生怀疑雄激素缺乏。特别地,组织了会见,例如 ANDROTEST,被表明了有更大的精确性什么时候在检测低 T 与自我相比报导了问询表,铺平。 | Giovanni Corona Giulia Rastrelli Linda Vignozzi Edoardo Mannucci Mario Maggi | 2012 | Asian Journal of Andrology2012，14，2： | 3 |
| 17 | 斯诺克 古老而睿智的绅士运动显示文摘打出单杆147分是每一个斯诺克选手所梦寐以求的,十五个红色球依次打进后,每次都打进黑球,红色球一分、黑色球七分,15X8=120分,六个彩色球分值相加为27分,总分为147分,这也是斯诺克球坛上所能出现的单杆最高分。斯诺克已有几百年的历史,选手良好的意识和精湛的杆法决定着比赛的胜负。斯诺克的魅力席卷全球,如今更多的人都痴迷于其中,追随着这项古老而睿智的绅士运动。 | Maggie Yu | 2008 | 中国科技财富2008，，7： | 3 |
| 18 | Optimal Management of Peptic Ulcer Disease in the Elderly显示文摘 | Alberto Pilotto Marilisa Franceschi Stefania Maggi Filomena Addante Daniele Sancarlo | 2010 | Drugs & Aging2010，，7： | 3 |
| 19 | Membrane-type Ⅰ matrix metalloproteinase(MT1-MMP),lipid metabolism,and therapeutic implications显示文摘Lipids exert many essential physiological functions,such as serving as a structural component of biological membranes,storing energy,and regulating cell signal transduction.Dysregulation of lipid metabolism can lead to dyslipidemia related to various human diseases,such as obesity,diabetes,and cardiovascular disease.Therefore,lipid metabolism is strictly regulated through multiple mechanisms at different levels,including the extracellular matrix.Membrane-type I matrix metalloproteinase(MT1-MMP),a zinc-dependent endopeptidase,proteolytically cleaves extracellular matrix components,and non-matrix proteins,thereby regulating many physiological and pathophysiological processes.Emerging evidence supports the vital role of MT1-MMP in lipid metabolism.For example,MT1-MMP mediates ectodomain shedding of low-density lipoprotein receptor and increases plasma low-density lipoprotein cholesterol levels and the development of atherosclerosis.It also increases the vulnerability of atherosclerotic plaque by promoting collagen cleavage.Furthermore,it can cleave the extracellular matrix of adipocytes,affecting adipogenesis and the development of obesity.Therefore,the activity of MT1-MMP is strictly regulated by multiple mechanisms,such as autocatalytic cleavage,endocytosis and exocytosis,and post-translational modifications.Here,we summarize the latest advances in MT1-MMP,mainly focusing on its role in lipid metabolism,the molecular mechanisms regulating the function and expression of MT1-MMP,and their pharmacotherapeutic implications. | Xiao-Dan Xia Adekunle Alabi Maggie Wang Hong-Mei Gu Rui Zhe Yang Gui-Qing Wang Da-Wei Zhang | 2021 | Journal of Molecular Cell Biology2021，13，7： | 3 |
| 20 | Association of upper gastrointestinal symptoms with functional and clinical characteristics in the elderly显示文摘AIM:To evaluate the prevalence of upper gastrointestinal symptoms and their association with clinical and functional characteristics in elderly outpatients.METHODS:The study involved 3238 outpatients ≥ 60 years consecutively enrolled by 107 general practitioners.Information on social,behavioral and demographic characteristics,function in the activities of daily living (ADL),co-morbidities and drug use were collected by a structured interview.Upper gastrointestinal symptom data were collected by the 15-items upper gastro-intestinal symptom questionnaire for the elderly,a validated diagnostic tool which includes the following five symptom clusters:(1) abdominal pain syndrome;(2) reflux syndrome;(3) indigestion syndrome;(4) bleeding;and (5) non-specific symptoms.Presence and severity of gastrointestinal symptoms were analyzed through a logistic regression model.RESULTS:3100 subjects were included in the final analysis.The overall prevalence of upper gastrointestinal symptoms was 43.0%,i.e.cluster (1) 13.9%,(2) 21.9%,(3) 30.2%,(4) 1.2%,and (5) 4.5%.Upper gastrointestinal symptoms were more frequently reported by females (P < 0.0001),with high number of co-morbidities (P < 0.0001),who were taking higher number of drugs (P < 0.0001) and needed assistance in the ADL.Logistic regression analysis demonstrated that female sex (OR=1.39,95% CI:1.17-1.64),disability in the ADL (OR=1.47,95% CI:1.12-1.93),smoking habit (OR=1.29,95% CI:1.00-1.65),and body mass index (OR=1.06,95% CI:1.04-1.08),as well as the presence of upper (OR=3.01,95% CI:2.52-3.60) and lower gastroenterological diseases (OR=2.25,95%CI:1.70-2.97),psychiatric (OR=1.60,95% CI:1.28-2.01) and respiratory diseases (OR=1.25,95% CI:1.01-1.54) were significantly associated with the presence of upper gastrointestinal symptoms.CONCLUSION:Functional and clinical characteristics are associated with upper gastrointestinal symptoms.A multidimensional comprehensive evaluation may be useful when approaching upper gastrointestinal symptoms in older subjects. | Alberto Pilotto Stefania Maggi Marianna Noale Marilisa Franceschi Giancarlo Parisi Gaetano Crepaldi | 2011 | World Journal of Gastroenterology2011，17，25： | 3 |
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