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| 1 | Gastric cancer and the epoch of immunotherapy approaches显示文摘The incidence of gastric cancer(GC) fell dramatically over the last 50 years, but according to IARC-Globocan 2008, it is the third most frequent cause of cancerrelated deaths with a case fatality GC ratio higher than other common malignancies. Surgical resection is the primary curative treatment for GC though the overall 5-year survival rate remains poor(approximately 20%-25%). To improve the outcome of resectable gastric cancer, different treatment strategies have been evaluated such as adjuvant or perioperative chemotherapy. In resected gastric cancer, the addition of radiotherapy to chemotherapy does not appear to provide any additional benefit. Moreover, in metastatic patients, chemotherapy is the mainstay of palliative therapy with a median overall survival of 8-10 mo and objective response rates of merely 20%-40%. Therefore, the potential for making key beneficial progress is to investigate the GC molecular biology to realize innovative therapeutic strategies, such as specific immunotherapy. In this review, we provide a panoramic view of the different immune-based strategies used for gastric cancer treatment and the results obtained in the most significant clinical trials. In detail, firstly we describe the therapeutic approaches that utilize the monoclonal antibodies while in the second part we analyze the cell-based immunotherapies. | Elena Niccolai Antonio Taddei Domenico Prisco Amedeo Amedei | 2015 | World Journal of Gastroenterology2015，21，19： | 24 |
| 2 | Ten years of hip fractures in Italy: For the first time a decreasing trend in elderly women显示文摘AIM:To evaluate the hospitalization rate of femoralneck fractures in the elderly Italian population over ten years.METHODS:We analyzed national hospitalizations records collected at central level by the Ministry of Health from 2000 to 2009.Age-and sex-specific rates of fractures occurred at femoral neck in people≥65 years old.We performed a sub-analysis over a three-year period(2007-2009),presenting data per five-year age groups,in order to evaluate the incidence of the hip fracture in the oldest population.RESULTS:We estimated a total of 839008 hospitalizations due to femoral neck fractures between 2000 and2009 in people≥65,with an overall increase of 29.8%over 10 years.The incidence per 10000 inhabitants remarkably increased in people≥75,passing from158.5 to 166.8(+5.2%)and from 72.6 to 77.5(+6.8%)over the ten-year period in women and men,respectively.The oldest age group(people>85 years old)accounted for more than 42%of total hospital admissions in 2009(n=39000),despite representing only 2.5%of the Italian population.Particularly,women aged>85accounted for 30.8%of total fractures,although they represented just 1.8%of the general population.The results of this analysis indicate that the incidence of hip fractures progressively increased from 2000 to 2009,but a reduction can be observed for the first time in women≤75(-7.9%between 2004 and 2009).CONCLUSION:Incidence of hip fractures in Italy are continuously increasing,although women aged 65-74years old started showing a decreasing trend. | Prisco Piscitelli Maurizio Feola Cecilia Rao Monica Celi Elena Gasbarra Cosimo Neglia Giuseppe Quarta Federico Maria Liuni Simone Parri Giovanni Iolascon Maria Luisa Brandi Alessandro Distante Umberto Tarantino | 2014 | World Journal of Orthopedics2014，5，3： | 2 |
| 3 | Localized amyloidosis of the stomach:A case report显示文摘We report an unusual case of primary amyloidosis of the stomach in a patient complaining of dyspeptic symptoms. The diagnosis was confirmed histologically and other gastrointestinal site or systemic involvement was ruled out. Uncharacteristic dyspeptic symptoms may hide this rare metabolic disease. | Gianluca Rotondano Raffaele Salerno Fabio Cipolletta Maria Antonia Bianco Antonino De Gregorio Raffaele Miele Antonio Prisco Maria Lucia Garofano Livio Cipolletta | 2007 | World Journal of Gastroenterology2007，13，12： | 2 |
| 4 | Ex vivo analysis of pancreatic cancer-infiltrating T lymphocytes reveals that ENO-specific Tregs accumulate in tumor tissue and inhibit Th1/Th17 effector cell functions显示文摘 | Amedeo Amedei Elena Niccolai Marisa Benagiano Chiara Della Bella Fabio Cianchi Paolo Bechi Antonio Taddei Lapo Bencini Marco Farsi Paola Cappello Domenico Prisco Francesco Novelli Mario Milco D’Elios | 2013 | Cancer Immunology, Immunotherapy2013，，7： | 2 |
| 5 | High prevalence of mild hyper- homocysteinemia in patients with abdominal aortic aneurysm 显示文摘 | BruneUi T Prisco D Fedl S | 2000 | J Vase Surg2000，32，3： | 1 |
| 6 | Homocysteine in vascular Behcet disease:a meta-analysis显示文摘 | la Regina M Orlandini F Prisco D | 2010 | Arterioscler Thromb Vasc Biol2010，30，10： | 1 |
| 7 | The role of D-dimer testing in patients with suspected venous tbromboembolism显示文摘 | Prisco D Grifoni E | 2009 | Semin Thromb Hemost2009，35，： | 1 |
| 8 | The role of D-Dimer testing inpatients with suspected venous thromboembolism显示文摘 | Prisco D Grifoni E | 2009 | SeminThrombHemost2009，35，1： | 1 |
| 9 | Obstetrical emergency:an unusual case of an ectopic pregnancy 显示文摘 | Levine HR O'Connor J Prisco G | 2012 | Proc (Bay 1 Univ Med Cent)2012，25，1： | 1 |
| 10 | Cold-adapted esterases and lipases : from fundamentals Peptide Letters, 2009,16(10) : to application 显示文摘 | Tutino M L di Prisco G Marino G | 2009 | Protein and2009，，： | 1 |
| 11 | Effect of salt stress on antioxidative enzymes and lipid peroxidation in leaves and roots of salt-tolerant and salt-sensitive maize genotypes 显示文摘 | DE AZEVEDO NETO A D PRISCO J T ENEAS-FILHO J | 2006 | Environmental and Experimental Botany2006，56，1： | 1 |
| 12 | Hydrogen peroxide pre - treatment induces salt - stress acclimation in maize plants 显示文摘 | Neto A D de A Prisco J T Eneas - Filho J Medeiros J V R Gomes -Filho E | 2005 | Journal of Plant Physiology2005，162，10： | 1 |
| 13 | MicroRNA 145 targets the insulin receptor substrate-1 and inhibits the growth o{ colon cancer cells显示文摘 | Shi B SeplyLorenzino L Prisco M | 2007 | J Biol Chem2007，282，32： | 1 |
| 14 | Videolaparoscopic chule- cystectomy induces a hemostasis activation of lower grade than does open surgery显示文摘 | Prisco D De Gaudio AR Carla R | 2000 | Surg Endosc2000，14，2： | 1 |
| 15 | Mechanical modeling of drained creep triaxial tests on loose sand显示文摘 | Di Prisco C | 2000 | Géotechnique2000，，01： | 1 |
| 16 | Identification of can- didates for prevention of venous thromboembolism 显示文摘 | Gensini GF Prisco D Falciani M | 1997 | Semin Thromh Hemost1997，23，1： | 1 |
| 17 | Association Between Giardiasis and Allergy显示文摘 | Maria Cristina Di Prisco Isabel Hagel Neil R Lynch Juan Carlos Jimenez Rafael Rojas Magdalena Gil Emperatriz Mata | 1998 | Annals of Allergy Asthma & Immunology1998，，3： | 1 |
| 18 | Signaling differences from the A and B isoforms of the insulin receptor(IR)in 32D cells in the presence or absence of IR substrate-1显示文摘 | Prisco M Wu A | 2003 | Endocrinology2003，144，3： | 1 |
| 19 | The role of D-dimer testing in patients with suspected venous thromboembolism显示文摘 | Prisco D Grifoni E | | 0，，01： | 1 |
| 20 | Hydro-gen peroxide pre-treatment induces salt stress acclimation in maizeplants显示文摘 | AZEVEDO N A D PRISCO J T ENEAS-FILHO J | 2005 | J Plant Physiol2005，162，10： | 1 |
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