|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Biomarkers for pancreatic cancer:Recent achievements in proteomics and genomics through classical and multivariate statistical methods显示文摘Pancreatic cancer(PC) is one of the most aggressive and lethal neoplastic diseases. A valid alternative to the usual invasive diagnostic tools would certainly be the determination of biomarkers in peripheral fluids to provide less invasive tools for early diagnosis. Nowadays, biomarkers are generally investigated mainly in peripheral blood and tissues through high-throughput omics techniques comparing control vs pathological samples. The results can be evaluated by two main strategies:(1) classical methods in which the identification of significant biomarkers is accomplished by monovariate statistical tests where each biomarker is considered as independent from the others; and(2) multivariate methods, taking into consideration the correlations existing among the biomarkers themselves. This last approach is very powerful since it allows the identification of pools of biomarkers with diagnostic and prognostic performances which are superior to single markers in terms of sensitivity, specificity and robustness. Multivariate techniques are usually applied with variable selection procedures to provide a restricted set of biomarkers with the best predictive ability; however, standard selection methods are usually aimed at the identification of the smallest set of variables with the best predictive ability and exhaustivity is usually neglected. The exhaustive search for biomarkers is instead an important alternative to standard variable selection since it can provide information about the etiology of the pathology by producing a comprehensive set of markers. In this review, the most recent applications of the omics techniques(proteomics, genomics and metabolomics) to the identification of exploratory biomarkers for PC will be presented with particular regard to the statistical methods adopted for their identification. The basic theory related to classical and multivariate methods for identification of biomarkers is presented and then, the most recent applications in this field are discussed. | Emilio Marengo Elisa Robotti | 2014 | World Journal of Gastroenterology2014，20，37： | 5 |
| 2 | Proteomic changes involved in tenderization of bovine Longissimus dorsi muscle during prolonged ageing显示文摘 | Rita Polati Michele Menini Elisa Robotti Renato Millioni Emilio Marengo Enrico Novelli Stefania Balzan Daniela Cecconi | 2012 | Food Chemistry2012，，3： | 2 |
| 3 | Ductility of a Ti6A14V alloy produced by selective laser melting of prealloyed powders显示文摘 | Facchini L Magalini E Robotti P | 2010 | Rapid Prototyping Journal2010，16，6： | 1 |
| 4 | Regulation of axonal development by plasma membrane gangliosides显示文摘 | Abad-Rodriguez J Robotti A | 2007 | JNeurochem2007，103，1： | 1 |
| 5 | Diffusion of antibiotics across tissue expanders:an in vitro study显示文摘 | ROBOTTI E B BOCCHIOTTI G | 1994 | Ann Plast Surg1994，32，4： | 1 |
| 6 | Early single-stage repair of complex craniofacial trauma显示文摘 | Benzil DL Robotti E Dagi TF | 1992 | Neurosurgery1992，30，2： | 1 |
| 7 | Measurement of liver volume by ultrasound and computed tomography 显示文摘 | Fritschy P Robotti G Schneekloth G | 1983 | J Clin Ultrasound1983，11，6： | 1 |
| 8 | Symptomonset -to -balloon time and mortality in the first seven yearsafter STEMI treated with primary percutaneous coronaryintervention显示文摘 | ROLLANDO D PUGGIONI E ROBOTTI S | 2012 | Heart2012，98，23： | 1 |
| 9 | Proteomic changes involved in tenderization of bovine Longissimus dots muscle during prolonged ageing显示文摘 | Polati R Menini M Robotti E | 2012 | Food Chemistry2012，135，3： | 1 |
| 10 | Diffusion of antibiotics across tissue expanders:an in vitro study显示文摘 | Robotti EB Bocchiotti G | 1994 | Ann Plast Surg1994，32，： | 1 |
| 11 | Early single-stage repair of complex craniofacial trauma显示文摘 | Benzil DL Robotti E Dagi TF | 1992 | Neurosurgery1992，30，2： | 1 |
| 12 | Study of pro-teomic changes associated w ith healthy and tumoral mu-rine samples in neuroblastoma by principal component a-nalysis and classification methods显示文摘 | Marengo E Robotti E Righetti P G | 2004 | Clin Chim Acta2004，345，12： | 1 |
| 13 | Investigation of anthropic effects connected with metal ions concentration, organic matter and grain size in Bormida river sediments显示文摘 | Marengo E Gennaro M C Robotti E | 2006 | Analytica Chimica Acta2006，560，1： | 1 |
| 14 | Investigation of anthropic effects connected with metal ions concentration organic matter and grain size in Bormida River sediments显示文摘 | MARENGO E GENNAROM C ROBOTTIE E | 2006 | Analytica Chimica Acta2006，560，： | 1 |
| 15 | Investigation of anthropic effects connected with metal ions concentration, organic matter and grain size in Bormida River sediments 显示文摘 | Marengo E Gennaro M C Robottie E | 2006 | Analytica Chlmica Acta2006，560，： | 1 |
| 16 | US evaluation of patients affected by IBD: How to do it, methods and findings 显示文摘 | Cammarotaa T Sarnoa A Robotti D | 2009 | Eu J Radi- ol2009，69，3： | 1 |
| 17 | Model comparison using the Hansen-Jagannathan distance 显示文摘 | Kan R Robotti C | 2009 | Review of Financial Studies2009，22，9： | 1 |
| 18 | Pricing model performance and the two-pass cross-sectional regression methodology 显示文摘 | Kan R Robotti C Shanken J | 2013 | The Journal of Finance2013，68，6： | 1 |
| 19 | A new integrated statistical approach to the diagnostic use of two-dimensional maps显示文摘 | Marengo E Robotti E Gianotti V | 2003 | Electrophoresis2003，，24： | 1 |
| 20 | Numerical approaches for quantitative analysis of two-dimensional maps: A review of com- mercial software and home-made systems 显示文摘 | Marengo E Robotti E Antonueei F | 2005 | Proteomies2005，5，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员