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| 1 | Emerging role of microRNAs in lipid metabolism显示文摘micro RNAs(mi RNAs or mi Rs) are small non-coding RNAs that are involved in posttranscriptional regulation of their target genes in a sequence-specific manner. Emerging evidence demonstrates that mi RNAs are critical regulators of lipid synthesis, fatty acid oxidation and lipoprotein formation and secretion. Dysregulation of mi RNAs disrupts gene regulatory network, leading to metabolic syndrome and its related diseases. In this review, we introduced epigenetic and transcriptional regulation of mi RNAs expression. We emphasized on several representative mi RNAs that are functionally involved into lipid metabolism, including mi R-33/33 n, mi R122, mi R27a/b, mi R378/378 n, mi R-34 a and mi R-21.Understanding the function of mi RNAs in lipid homeostasis may provide potential therapeutic strategies for fatty liver disease. | Zhihong Yang Tyler Cappello Li Wang | 2015 | Acta Pharmaceutica Sinica B2015，5，2： | 18 |
| 2 | Inflammation in irritable bowel syndrome:Myth or newtreatment target?显示文摘Low-grade intestinal inflammation plays a key role in the pathophysiology of irritable bowel syndrome(IBS), and this role is likely to be multifactorial. The aim of this review was to summarize the evidence on the spectrum of mucosal inflammation in IBS, highlighting the relationship of this inflammation to the pathophysiology of IBS and its connection to clinical practice. We carried out a bibliographic search in Medline and the Cochrane Library for the period of January 1966 to December 2014, focusing on publications describing an interaction between inflammation and IBS. Several evidences demonstrate microscopic and molecular abnormalities in IBS patients. Understanding the mechanisms underlying low-grade inflammation in IBS may help to design clinical trials to test the efficacy and safety of drugs that target this pathophysiologic mechanism. | Emanuele Sinagra Giancarlo Pompei Giovanni Tomasello Francesco Cappello Gaetano Cristian Morreale Georgios Amvrosiadis Francesca Rossi Attilio Ignazio Lo Monte Aroldo Gabriele Rizzo Dario Raimondo | 2016 | World Journal of Gastroenterology2016，22，7： | 16 |
| 3 | New therapeutic perspectives in irritable bowel syndrome: Targeting low-grade inflammation, immuno-neuroendocrine axis, motility, secretion and beyond显示文摘Irritable bowel syndrome(IBS)is a chronic,recurring,and remitting functional disorder of the gastrointestinal tract characterized by abdominal pain,distention,and changes in bowel habits.Although there are several drugs for IBS,effective and approved treatments for one or more of the symptoms for various IBS subtypes are needed.Improved understanding of pathophysiological mechanisms such as the role of impaired bile acid metabolism,neurohormonal regulation,immune dysfunction,the epithelial barrier and the secretory properties of the gut has led to advancements in the treatment of IBS.With regards to therapies for restoring intestinal permeability,multiple studies with prebiotics and probiotics are ongoing,even if to date their efficacy has been limited.In parallel,much progress has been made in targeting low-grade inflammation,especially through the introduction of drugs such as mesalazine and rifaximin,even if a better knowledge of the mechanisms underlying the low-grade inflammation in IBS may allow the design of clinical trials that test the efficacy and safety of such drugs.This literature review aims to summarize the findings related to new and investigational therapeutic agents for IBS,most recently developed in preclinical as well as Phase 1 and Phase 2clinical studies. | Emanuele Sinagra Gaetano Cristian Morreale Ghazaleh Mohammadian Giorgio Fusco Valentina Guarnotta Giovanni Tomasello Francesco Cappello Francesca Rossi Georgios Amvrosiadis Dario Raimondo | 2017 | World Journal of Gastroenterology2017，23，36： | 14 |
| 4 | Malignant gastric outlet obstruction:Which is the best therapeutic option?显示文摘Malignant gastric outlet obstruction(MGOO)is a clinical condition characterized by the mechanical obstruction of the pylorus or the duodenum due to tumor compression/infiltration,with consequent reduction or impossibility of an adequate oral intake.MGOO is mainly secondary to advanced pancreatic or gastric cancers,and significantly impacts on patients’survival and quality of life.Patients suffering from this condition often present with intractable vomiting and severe malnutrition,which further compromise therapeutic chances.Currently,palliative strategies are based primarily on surgical gastrojejunostomy and endoscopic enteral stenting with self-expanding metal stents.Several studies have shown that surgical approach has the advantage of a more durable relief of symptoms and the need of fewer re-interventions,at the cost of higher procedure-related risks and longer hospital stay.On the other hand,enteral stenting provides rapid clinical improvement,but have the limit of higher stent dysfunction rate due to tumor ingrowth and a subsequent need of frequent reinterventions.Recently,a third way has come from interventional endoscopic ultrasound,through the development of endoscopic ultrasound-guided gastroenterostomy technique with lumen-apposing metal stent.This new technique may ideally encompass the minimal invasiveness of an endoscopic procedure and the long-lasting effect of the surgical gastrojejunostomy,and brought encouraging results so far,even if prospective comparative trial are still lacking.In this Review,we described technical aspects and clinical outcomes of the above-cited therapeutic approaches,and discussed the open questions about the current management of MGOO. | Edoardo Troncone Alessandro Fugazza Annalisa Cappello Giovanna Del Vecchio Blanco Giovanni Monteleone Alessandro Repici Anthony Yuen Bun Teoh Andrea Anderloni | 2020 | World Journal of Gastroenterology2020，26，16： | 7 |
| 5 | Functions of Uni- and Multi-citations: Implications for Weighted Citation Analysis显示文摘Purpose:(1) To test basic assumptions underlying frequency-weighted citation analysis:(a) Uni-citations correspond to citations that are nonessential to the citing papers;(b) The influence of a cited paper on the citing paper increases with the frequency with which it is cited in the citing paper.(2) To explore the degree to which citation location may be used to help identify nonessential citations.Design/methodology/approach:Each of the in-text citations in all research articles published in Issue 1 of the Journal of the Association for Information Science and Technology(JASIST) 2016 was manually classified into one of these five categories:Applied,Contrastive,Supportive,Reviewed,and Perfunctory.The distributions of citations at different in-text frequencies and in different locations in the text by these functions were analyzed.Findings:Filtering out nonessential citations before assigning weight is important for frequency-weighted citation analysis.For this purpose,removing citations by location is more effective than re-citation analysis that simply removes uni-citations.Removing all citation occurrences in the Background and Literature Review sections and uni-citations in the Introduction section appears to provide a good balance between filtration and error rates.Research limitations:This case study suffers from the limitation of scalability and generalizability.We took careful measures to reduce the impact of other limitations of the data collection approach used.Relying on the researcher's judgment to attribute citation functions,this approach is unobtrusive but speculative,and can suffer from a low degree of confidence,thus creating reliability concerns.Practical implications:Weighted citation analysis promises to improve citation analysis for research evaluation,knowledge network analysis,knowledge representation,and information retrieval.The present study showed the importance of filtering out nonessential citations before assigning weight in a weighted citation analysis,which may be a significant step forward to realizing these promises.Originality/value:Weighted citation analysis has long been proposed as a theoretical solution to the problem of citation analysis that treats all citations equally,and has attracted increasing research interest in recent years.The present study showed,for the first time,the importance of filtering out nonessential citations in weighted citation analysis,pointing research in this area in a new direction. | Dangzhi Zhao Alicia Cappello Lucinda Johnston | 2017 | Journal of Data and Information Science2017，2，1： | 5 |
| 6 | Epidemiology and clinical features of cystic hydatidosis in Western Sicily:A ten-year review显示文摘AIM:To assess retrospectively the epidemiological and clinical aspects of cystic echinococcosis(CE)and to evaluate follow-up and response to treatment in patients affected by CE.METHODS:From January 2000 to December 2010,all patients affected by CE at the Infectious Diseases Units of the University of Catania and of Basilotta Hospital in Nicosia-Enna,were enrolled as participants in the study.Epidemiological,clinical and laboratory data were collected for each patient.Diagnosis of CE was performed using clinical imaging and laboratory parameters.Response to treatment was categorized as follows:'cure'as the disappearance or complete calcification of cyst/s;'improvement'as a reduction in the diameter and/or number of existing cysts;and'impairment'as an increase in the diameter and/or number of existing cyst/s and the onset of relapses(i.e.,the onset of new cyst/s and an increase in the diameter of previously existing cyst/s and/or complications.Immunoglobulin E(IgE)titers and eosinophil percentages were evaluated at diagnosis,at six months after the initiation of treatment and again in the case of relapse.Hyper-eosinophilia was defined as an eosinophil percentage of≥6%.RESULTS:Thirty-two patients were diagnosed with CE in our Unit during the research period,with a malefemale ratio of 2:1.At the time of diagnosis,40%of patients presented a single CE cyst.Sixty percent showed multi-organ involvement.The liver-lung localization ratio was 2:1.Patients below the age of 50 at diagnosis were more likely to have multiple cysts(73.7%vs 35.5%,P<0.05).Regarding treatment,30 patients were treated medically and 16 surgically.Fourteen patients were treated both medically and surgically.Relapses were seen to be less frequent in patients treated with albendazole before and after surgery.Complete cure or an improvement was achieved in 23 patients.Impairment was observed in one patient.Two patients showed no improvement.Relapses were more frequent in those patients treated before 2005.At diagnosis,71%of patients were positive for specific CE IgE,and 56.3%showed an eosinophil percentage of≥6%.Patients who were diagnosed with hyper-eosinophilia developed complications more frequently than the other patients,but did not suffer relapses.CONCLUSION:On the basis of our results,we propose cystic echinococcosis screening for family members of patients,appropriate pre-and post-surgery treatment and the assessment of anti-echinococcus IgE titer or eosinophil percentage as a therapy response marker in settings with limited resources. | Elisa Cappello Bruno Cacopardo Eleonora Caltabiano Sigismindo Li Volsi Rosa Chiara Mauro Sapienza Luciano Nigro | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 7 | Lumen-apposing metal stents for malignant biliary obstruction: Is this the ultimate horizon of our experience?显示文摘In the last years, endoscopic ultrasonography (EUS) has evolved from a purely diagnostic technique to a more and more complex interventional procedure, with the possibility to perform several type of therapeutic interventions. Among these, EUS-guided biliary drainage (BD) is gaining popularity as a therapeutic approach after failed endoscopic retrograde cholangiopancreatography in distal malignant biliary obstruction (MBO), due to the avoidance of external drainage, a lower rate of adverse events and re-interventions, and lower costs compared to percutaneous trans-hepatic BD. Initially, devices created for luminal procedures (e.g., luminal biliary stents) have been adapted to the new trans-luminal EUSguided interventions, with predictable shortcomings in technical success, outcome and adverse events. More recently, new metal stents specifically designed for transluminal drainage, namely lumen-apposing metal stents (LAMS), have been made available for EUS-guided procedures. An electrocautery enhanced delivery system (EC-LAMS), which allows direct access of the delivery system to the target lumen, has subsequently simplified the classic multi-step procedure of EUS-guided drainages. EUS-BD using LAMS and ECLAMS has been demonstrated effective and safe, and currently seems one of the most performing techniques for EUS-BD. In this Review, we summarize the evolution of the EUS-BD in distal MBO, focusing on the novelty of LAMS and analyzing the unresolved questions about the possible role of EUS as the first therapeutic option to achieve BD in this setting of patients. | Andrea Anderloni Edoardo Troncone Alessandro Fugazza Annalisa Cappello Giovanna Del Vecchio Blanco Giovanni Monteleone Alessandro Repici | 2019 | World Journal of Gastroenterology2019，25，29： | 3 |
| 8 | clinical course and prognostic factors of hepatorenal syndrome:a retrospective single-center cohort study显示文摘AIM: To investigate clinical and biochemical features of hepatorenal syndrome(HRS), to assess short and long- term survival evaluating potential predictors of early mortality. METHODS: Sixty-two patients with liver cirrhosis and renal failure, defined as a serum creatinine value > 1.5 mg/dL on at least two measurements within 48 h, admitted to our tertiary referral Unit from 2001 to 201, were retrospectively reviewed. Among them, 33 patients(53.2%) fulfilled the revised criteria of the International Ascites Club for the diagnosis of HRS. Twenty-eight patients were treated with combinations of terlipressin and albumin, two with dopamine and al- bumin, and three with albumin alone. No patients were suitable for liver transplantation. Complete response was defined as normalization of creatinine levels to less than 1.5 mg/dL, partial response as a decrease of at least 50% but not to less than 1.5 mg/dL, no response as no reduction in creatinine or a decrease of less 50% compared to pre-treatment values. All of the patients were followed up for at least 1 year until January 2013. RESULTS: HRS type 1 was diagnosed in 15 patients(45.5%). Hepatitis C virus infection was the primary etiology(69.6%), followed by alcohol(15.2%), and cryptogenesis(15.2%). Complete response to therapy was obtained in only 3 cases(9.1%) and partial re- sponse in 7 patients(21.2%). Median survival was 30 d(range: 10-274) without significant differences be- tween type 1 and type 2 HRS. By univariate analysis, Child-Pugh class C(P = 0.009), presence of hepatocel- lular carcinoma(P = 0.04), low serum sodium(P = 0.02), high bilirubin values(P = 0.009) and high Model for End-stage Liver Disease(MELD) score(P = 0.03) were predictive factors of 30-d mortality. By multivari- ate analysis, only serum sodium < 132 mEq/L(OR = 31.39; P = 0.02) and MELD score > 27(OR = 18.72; P = 0.01) were independently associated with a survival of less than one month. CONCLUSION: HRS still has a poor prognosis, even when vasoactive drug therapies are extensively used. | Anna Licata Marcello Maida Ambra Bonaccorso Fabio Salvatore Macaluso Maria Cappello Antonio Craxì Piero Luigi Almasio | 2013 | World Journal of Hepatology2013，5，12： | 2 |
| 9 | Ex vivo analysis of pancreatic cancer-infiltrating T lymphocytes reveals that ENO-specific Tregs accumulate in tumor tissue and inhibit Th1/Th17 effector cell functions显示文摘 | Amedeo Amedei Elena Niccolai Marisa Benagiano Chiara Della Bella Fabio Cianchi Paolo Bechi Antonio Taddei Lapo Bencini Marco Farsi Paola Cappello Domenico Prisco Francesco Novelli Mario Milco D’Elios | 2013 | Cancer Immunology, Immunotherapy2013，，7： | 2 |
| 10 | Cypermethrin toxicity to aquatic life:bioassays for the freshwater prawn Palaemonetes argentinus显示文摘 | COLLINS P CAPPELLO S | 2006 | Archives of Environment Contamination and Toxicologyl2006，51，： | 1 |
| 11 | Numerical analysis of composite plates with multiple delaminations subjected to uniaxial buckling load显示文摘 | Cappello F Tumino D | | 0，，： | 1 |
| 12 | Human recombinant Chromogranin A-derived Vasostatin-1 Mimics Preconditioning via an Adenosine/Nitric Oxide Signalling Mechanism显示文摘 | Angelone T Tota B | 2007 | Am J Physiol Heart Circ Physiol2007，293，1： | 1 |
| 13 | Defective apoptosis and tumorigenesis: role of p53 mutation and Fas/FasL system dysregulation 显示文摘 | Cappello F Bellafiore M Palma A | 2002 | Eur J Histochem2002，46，3： | 1 |
| 14 | Adaptivealgorithm for minimizing cloud task length with prediction errors 显示文摘 | Di S Wang C Cappello F | 2013 | IEEE Trans Cloud Comput2013，2，2： | 1 |
| 15 | Prevention of TNBS-induced colitis by probiotic supplement in mice显示文摘 | Gabriele Brecchia Francesca Rappa Francesco Cappello Giovanna Traina | 2014 | Journal of Biotechnology2014，，： | 1 |
| 16 | Protection against ischemia/reperfusion injuries by vasostatin-1 in the isolated rat heart显示文摘 | Cappello S Rastaldo R | 2007 | Comp Biochem Physiol A Mol Integr Physiol2007，147，1： | 1 |
| 17 | The expression of HSP60 andHSP10 in large bowel carcinomas with lymph node metastase显示文摘 | Cappello F David S Rappa F | 2005 | BMC Cancer2005，5，： | 1 |
| 18 | 2001 Identification and characterization of the IgE-binding protein 2S albumin and conglutin in alnond (Prunus dulcis) seed 显示文摘 | POLTRONIERI P CAPPELLO M S DOMHMEA N | 2001 | Int Arch Allergy Immunol2001，128，： | 1 |
| 19 | A tool for checking probabilis-tic properties of COWS services显示文摘 | CAPPELLO I QUAGLIA P | 2010 | Lecture Notes in Com-puter Science2010，6084，： | 1 |
| 20 | Improvement of solubility and stability of valsartan by hydroxypropyl-\boldbeta-cyclodextrin 显示文摘 | CAPPELLO B DI MAIO C IERVOLINO M | 2006 | J lrtcl Phenom Macro2006，54，3： | 1 |
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