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| 1 | Modern approach to cholecysto-choledocholithiasis显示文摘Gallstones and common bile duct calculi are found to be associated in 8%-20% of patients, leading to possible life-threatening complications, such as acute biliary pancreatitis, jaundice and cholangitis. The gold standard of care for gallbladder calculi and isolated common bile duct stones is represented by laparoscopic cholecystectomy and endoscopic retrograde cholangiopancreatography, respectively, while a debate still exists regarding how to treat the two diseases at the same time. Many therapeutic options are also available when the two conditions are associated, including many different types of treatment, which local professionals often administer. The need to limit maximum discomfort and risks for the patients, combined with the economic pressure of reducing costs and utilizing resources, favors single-step procedures. However, a multitude of data fail to strongly demonstrate the superiority of any technique(including a two or multi-step approach), while rigorous clinical trials that include so many different types of treatment are still lacking, and it is most likely unrealistic to conduct them in the future. Therefore, the choice of the best management is often led by the local presence of professional expertise and resources, rather than by a real superiority of one strategy over another. | Lapo Bencini Cinzia Tommasi Roberto Manetti Marco Farsi | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，2： | 28 |
| 2 | Peroxisome proliferator activated receptors at the crossroad of obesity, diabetes, and pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma(PDAC) is the fourth cause of cancer death with an overall survival of 5% at five years. The development of PDAC is characteristically associated to the accumulation of distinctive genetic mutations and is preceded by the exposure to several risk factors. Epidemiology has demonstrated that PDAC risk factors may be non-modifiable risks(sex, age, presence of genetic mutations, ethnicity) and modifiable and co-morbidity factors related to the specific habits and lifestyle. Recently it has become evident that obesity and diabetes are two important modifiable risk factors for PDAC. Obesity and diabetes are complex systemic and intertwined diseases and, over the years, experimental evidence indicate that insulin-resistance, alteration of adipokines, especially leptin and adiponectin, oxidative stress and inflammation may play a role in PDAC. Peroxisome proliferator activated receptor-γ(PPARγ) is a nuclear receptor transcription factor that is implicated in the regulation of metabolism, differentiation and inflammation. PPARγ is a key regulator of adipocytes differentiation, regulates insulin and adipokines production and secretion, may modulate inflammation, and it is implicated in PDAC. PPARγ agonists are used in the treatment of diabetes and oxidative stressassociated diseases and have been evaluated for the treatment of PDAC. PPARγ is at the cross-road of diabetes, obesity, and PDAC and it is an interesting target to pharmacologically prevent PDAC in obese and diabetic patients. | Simone Polvani Mirko Tarocchi Sara Tempesti Lapo Bencini Andrea Galli | 2016 | World Journal of Gastroenterology2016，22，8： | 17 |
| 3 | Laparoscopic approach to gastrointestinal malignancies: Toward the future with caution显示文摘After the rapid acceptance of laparoscopy to manage multiple benign diseases arising from gastrointestinal districts,some surgeons started to treat malignancies by the same way.However,if the limits of laparoscopy for benign diseases are mainly represented by technical issues,oncologic outcomes remain the foundation of any procedures to cure malignancies.Cancerous patients represent an important group with peculiar aspects including reduced survival expectancy,worsened quality of life due to surgery itself and adjuvant therapies,and challenging psychological impact.All these issues could,potentially,receive a better management with a laparoscopic surgical approach.In order to confirm such aspects,similarly to testing the newest weapons(surgical or pharmacologic)against cancer,long-term follow-up is always recommendable to assess the real benefits in terms of overall survival,cancer-free survival and quality of life.Furthermore,it seems of crucial importance that surgeons will be correctly trained in specific oncologic principles of surgical oncology as well as in modern miniinvasive technologies.Therefore,laparoscopic treatment of gastrointestinal malignancies requires more caution and deep analysis of published evidences,as compared to those achieved for inflammatory bowel diseases,gastroesophageal reflux disease or diverticular disease.This review tries to examine the evidence available to date for the use of laparoscopy and robotics in malignancies arising from the gastrointestinal district. | Lapo Bencini Marco Bernini Marco Farsi | 2014 | World Journal of Gastroenterology2014，20，7： | 6 |
| 4 | Esophageal surgery in minimally invasive era显示文摘The widespread popularity of new surgical technologies such as laparoscopy, thoracoscopy and robotics has led many surgeons to treat esophageal diseases with these methods. The expected benefits of minimally invasivesurgery(MIS) mainly include reductions of postoperative complications, length of hospital stay, and pain and better cosmetic results. All of these benefits could potentially be of great interest when dealing with the esophagus due to the potentially severe complications that can occur after conventional surgery. Moreover, robotic platforms are expected to reduce many of the difficulties encountered during advanced laparoscopic and thoracoscopic procedures such as anastomotic reconstructions, accurate lymphadenectomies, and vascular sutures. Almost all esophageal diseases are approachable in a minimally invasive way, including diverticula, gastro-esophageal reflux disease, achalasia, perforations and cancer. Nevertheless, while the limits of MIS for benign esophageal diseases are mainly technical issues and costs, oncologic outcomes remain the cornerstone of any procedure to cure malignancies, for which the long-term results are critical. Furthermore, many of the minimally invasive esophageal operations should be compared to pharmacologic interventions and advanced pure endoscopic procedures; such a comparison requires a difficult literature analysis and leads to some confounding results of clinical trials. This review aims to examine the evidence for the use of MIS in both malignancies and more common benign disease of the esophagus, with a particular emphasis on future developments and ongoing areas of research. | lapo bencini luca moraldi ilenia bartolini andrea coratti | 2016 | World Journal of Gastrointestinal Surgery2016，8，1： | 5 |
| 5 | Minimally invasive surgical approach to pancreatic malignancies显示文摘Pancreatic surgery for malignancy is recognized as challenging for the surgeons and risky for the patientsdue to consistent perioperative morbidity and mortality. Furthermore, the oncological long-term results are largely disappointing, even for those patients who experience an uneventfully hospital stay. Nevertheless, surgery still remains the cornerstone of a multidisciplinary treatment for pancreatic cancer. In order to maximize the benefits of surgery, the advent of both laparoscopy and robotics has led many surgeons to treat pancreatic cancers with these new methodologies. The reduction of postoperative complications, length of hospital stay and pain, together with a shorter interval between surgery and the beginning of adjuvant chemotherapy, represent the potential advantages over conventional surgery. Lastly, a better cosmetic result, although not crucial in any cancerous patient, could also play a role by improving overall well-being and patient self-perception. The laparoscopic approach to pancreatic surgery is, however, difficult in inexperienced hands and requires a dedicated training in both advanced laparoscopy and pancreatic surgery. The recent large diffusion of the da Vinci® robotic platform seems to facilitate many of the technical maneuvers, such as anastomotic biliary and pancreatic reconstructions, accurate lymphadenectomy, and vascular sutures. The two main pancreatic operations, distal pancreatectomy and pancreaticoduodenectomy, are approachable by a minimally invasive path, but more limited interventions such as enucleation are also feasible. Nevertheless, a word of caution should be taken into account when considering the increasing costs of these newest technologies because the main concerns regarding these are the maintenance of all oncological standards and the lack of long-term follow-up. The purpose of this review is to examine the evidence for the use of minimally invasive surgery in pancreatic cancer(and less aggressive tumors), with particular attention to the oncological results and widespread reproducibility of each technique. | Lapo Bencini Mario Annecchiarico Marco Farsi Ilenia Bartolini Vita Mirasolo Francesco Guerra Andrea Coratti | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 3 |
| 6 | Effects of Neoadjuvant Intraperitoneal/Systemic Chemotherapy (Bidirectional Chemotherapy) for the Treatment of Patients with Peritoneal Metastasis from Gastric Cancer显示文摘 | Yutaka Yonemura Ayman Elnemr Yoshio Endou Haruaki Ishibashi Akiyoshi Mizumoto Masahiro Miura Yan Li Lapo Bencini | 2012 | International Journal of Surgical Oncology2012，，： | 2 |
| 7 | Helicobacter pylori secreted peptidyl prolyl cis , trans -isomerase drives Th17 inflammation in gastric adenocarcinoma显示文摘 | Amedeo Amedei Fabio Munari Chiara Della Bella Elena Niccolai Marisa Benagiano Lapo Bencini Fabio Cianchi Marco Farsi Giacomo Emmi Giuseppe Zanotti Marina Bernard Manikuntala Kundu Mario Milco D’Elios | 2014 | Internal and Emergency Medicine2014，，3： | 2 |
| 8 | Ex vivo analysis of pancreatic cancer-infiltrating T lymphocytes reveals that ENO-specific Tregs accumulate in tumor tissue and inhibit Th1/Th17 effector cell functions显示文摘 | Amedeo Amedei Elena Niccolai Marisa Benagiano Chiara Della Bella Fabio Cianchi Paolo Bechi Antonio Taddei Lapo Bencini Marco Farsi Paola Cappello Domenico Prisco Francesco Novelli Mario Milco D’Elios | 2013 | Cancer Immunology, Immunotherapy2013，，7： | 2 |
| 9 | Emifentanil-sevoflurane anaesthesia for laparoscopic cholecystectomy:comparison of three dose regimens显示文摘 | Van Delden PG Houweling PL Bencini AF | 2002 | Anesthesia2002，57，3： | 1 |
| 10 | DNA binding by a new metallointercalator that contains a proflavine group bearing a hanging chelating unit显示文摘 | Bazzicalupi C Bencini A Bianchi A Biver T Boggioni A Bonacchi A Danesi A Giorgi C Gratteri P Ingrán A.M Secco F Sissi C Valtancoli B Venturini M | | 0，，1： | 1 |
| 11 | Incisional hernia:repair retrospective comparison of laparoscopic and open techniques显示文摘 | Bencini L Sanchez L Boffi B | 2003 | Surg Endosc2003，17，10： | 1 |
| 12 | Remifentanil-sevoflurane anaesthesia for laparoscopic cholecystectomy:comparison of three dose regimens显示文摘 | Van Delden PG Houweling PL Bencini AF | 2002 | Anaesthesia2002，57，3： | 1 |
| 13 | The contribution of argument structure constructions to sentence meaning显示文摘 | Bencini G & Goldberg A | 2000 | Journal of Memory and Language2000，，43： | 1 |
| 14 | 查看详情显示文摘 | Bazzicalupi C Chioccioli M Sissi C Porcù E Bonaccini C Pivetta C Bencini A Giorgi C Valtancoli B. Melani F | | 0，，： | 1 |
| 15 | Modem approach to cho- lecysto-choledocholithiasis 显示文摘 | Bencini L Tommasi C Manetti R | 2014 | World J Gastrointest Endosc2014，6，2： | 1 |
| 16 | CO2 geological storage by ECBM techniques in the Sulcis Area (SW Sardinia Region, Italy)显示文摘 | Amorino C Bencini R Cara R | 2005 | Second International Conference on Clean Coal Technologies for Our Future Sardinia Italy2005，，： | 1 |
| 17 | Preparation and in vitro evaluation of the antiviral activity of the Acyclovir complex of a β - cyclodextrin/poly (amidoamine) copolymer显示文摘 | BENCINI M RANUCCI E FERRUTI P | 2004 | Journal of Controlled Release2004，126，1： | 1 |
| 18 | Early and late (ten years) experience with circular stapler hemorrhoidectomy 显示文摘 | Pemice LM Bartalucci B Bencini L | 2001 | Dis Colon Rectum2001，44，6： | 1 |
| 19 | A study of polymorphism in milk proteins from local and imported dairy sheep in Australia by capillary electrophoresis显示文摘 | CLEMENT P AGBOOLA S O BENCINI R | 2006 | LWT-Food Sci Technol2006，39，： | 1 |
| 20 | Intrinsic and environmental effects in the structure and magnetic properties of organic molecular magnets:bis(imino)nitroxide 显示文摘 | Barone V Bencini A Matteo A D | 1997 | J Am Chem Soc1997，119，10： | 1 |
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