|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Taking central nervous system regenerative therapies to the clinic: curing rodents versus nonhuman primates versus humans显示文摘The central nervous system is known to have limited regenerative capacity.Not only does this halt the human body’s reparative processes after central nervous system lesions,but it also impedes the establishment of effective and safe therapeutic options for such patients.Despite the high prevalence of stroke and spinal cord injury in the general population,these conditions remain incurable and place a heavy burden on patients’families and on society more broadly.Neuroregeneration and neural engineering are diverse biomedical fields that attempt reparative treatments,utilizing stem cells-based strategies,biologically active molecules,nanotechnology,exosomes and highly tunable biodegradable systems(e.g.,certain hydrogels).Although there are studies demonstrating promising preclinical results,safe clinical translation has not yet been accomplished.A key gap in clinical translation is the absence of an ideal animal or ex vivo model that can perfectly simulate the human microenvironment,and also correspond to all the complex pathophysiological and neuroanatomical factors that affect functional outcomes in humans after central nervous system injury.Such an ideal model does not currently exist,but it seems that the nonhuman primate model is uniquely qualified for this role,given its close resemblance to humans.This review considers some regenerative therapies for central nervous system repair that hold promise for future clinical translation.In addition,it attempts to uncover some of the main reasons why clinical translation might fail without the implementation of nonhuman primate models in the research pipeline. | Magdalini Tsintou Kyriakos Dalamagkas Nikos Makris | 2020 | Neural Regeneration Research2020，15，3： | 7 |
| 2 | Investigation of proper modeling of very dense granular flows in the recirculation system of CFBs显示文摘The aim of this paper is the development of new models and/or the improvement of existing numerical models,used for simulating granular flow in CFB(circulating fluidized bed) recirculation systems.Most recent models follow the TFM(two-fluid model) methodology,but they cannot effectively simulate the inter-particle friction forces in the recirculation system,because the respective stress tensor does not incorporate compressibility of flow due to change of effective particle density.As a consequence,the induced normal and shear stresses are not modeled appropriately during the flow of the granular phase in the CFB recirculation system.The failure of conventional models,such as that of von Mises/Coulomb,is mainly caused by false approximation of the yield criterion which is not applicable to the CFB recirculation system.The present work adopts an alternative yield function,used for the first time in TFM Eulerian modeling.The proposed model is based on the Pitman-Schaeffer-Gray-Stiles yield criterion.Both the temporal deformation of the solid granular phase and the repose angle that the granular phase forms are more accurately simulated by this model.The numerical results of the proposed model agree well with experimental data,implying that frictional forces are efficiently simulated by the new model. | Aristeidis Nikolopoulos Nikos Nikolopoulos Nikos Varveris Sotirios Karellas Panagiotis Grammelis Emmanuel Kakaras | 2012 | Particuology2012，10，6： | 7 |
| 3 | COVID-19 pandemic:Pathophysiology and manifestations from the gastrointestinal tract显示文摘The pandemic of coronavirus disease 2019(COVID-19),caused by a newly identifiedβ-coronavirus(SARS-CoV-2)has emerged as a dire health problem,causing a massive crisis for global health.Primary method of transmission was firstly thought to be animal to human transmission.However,it has been observed that the virus is transmitted from human to human via respiratory droplets.Interestingly,SARS-CoV-2 ribonucleic acid(RNA)has been isolated from patient stools,suggesting a possible gastrointestinal(GI)involvement.Most commonly reported clinical manifestations are fever,fatigue and dry cough.Interestingly,a small percentage of patients experience GI symptoms with the most common being anorexia,diarrhea,nausea and vomiting.The presence of viral RNA in stools is also common and fecal tests can be positive even after negative respiratory samples.The exact incidence of digestive symptoms is a matter of debate.The distribution of Angiotensin converting enzyme type 2 receptors in multiple organs in the body provides a possible explanation for the digestive symptoms’mechanism.Cases with solely GI symptoms have been reported in both adults and children.Viral RNA has also been detected in stool and blood samples,indicating the possibility of liver damage,which has been reported in COVID-19 patients.The presence of chronic liver disease appears to be a risk factor for severe complications and a poorer prognosis,however data from these cases is lacking.The aim of this review is firstly,to briefly update what is known about the origin and the transmission of SARS-CoV-2,but mainly to focus on the manifestations of the GI tract and their pathophysiological background,so that physicians on the one hand,not to underestimate or disregard digestive symptoms due to the small number of patients exhibiting exclusively this symptomatology and on the other,to have SARS-CoV-2 on their mind when the“gastroenteritis”type symptoms predominate. | Michail Galanopoulos Filippos Gkeros Aris Doukatas Grigorios Karianakis Christos Pontas Nikolaos Tsoukalas Nikos Viazis Christos Liatsos Gerassimos J Mantzaris | 2020 | World Journal of Gastroenterology2020，26，31： | 7 |
| 4 | 阴茎延长中使用V-Y成形术是否必要?介绍一种新的手术方式:单纯冠状沟下环形切口阴茎延长增粗术显示文摘本研究介绍了一种新的通过冠状沟下环形切口的悬韧带松解术,并确定其安全性和有效性。过去的7年中,我们连续做了82例阴茎增粗术。前35例男性患者接受下腹部V-Y成形切口韧带松解术(A组),后续47例男性患者接受冠状沟下环形切口韧带松解术(B组)。我们比较了两组手术时间、手术并发症和手术前后的阴茎长度和周径值以及手术前后的自信心、满意度评分。患者平均年龄为32岁(18—56岁)。79例患阴茎短小综合征,3例为小阴茎(牵拉长度〈7.5厘米)。A组和B组的平均手术时间分别为150.7分钟和125.2分钟(P=0.005)。4例(11%)A组患者和3例(6%)B组患者术后分别出现了阴茎回缩(P=0.453)。18例(51%)A组患者出现了手术瘢痕增生,而在环形切口手术组则未观察到明显切口并发症。两者阴茎长度和周径改善效果相当。但环形切口手术组满意度和自尊心和性关系问卷(SEAR)改善程度更高(P值分别为0.007和〈0.001)。在严格的病例筛选标准下,与V-Y成形术相比较,环形切口悬韧带松解术在安全性、手术时间、阴茎回缩率和外观方面均有改善,而在阴茎大小改善效果上无差异。 | Nikos Mertziotis Diomidis Kozyrakis Elias Bogris | 2013 | Asian Journal of Andrology2013，15，6： | 5 |
| 5 | Octreotide induces caspase activation and apoptosis in human hepatoma HepG2 cells显示文摘AIM: To investigate the role of octreotide on cellular proliferation and apoptosis of human hepatoma (HepG2) cells. METHODS: We studied cellular proliferation, apoptosis and the possible internal caspase-mediated apoptosis pathway involved, after treatment of HepG2 carcinoma cells with octreotide in comparison with the apoptosis caused by tumor necrosis factor-α (TNF-α). Activities of caspase-3, caspase-9, caspase-8 and caspase-2 were studied, while apoptosis was investigated through detection of DNA fragmentation and through identification of apoptotic cells with the annexin-V/propidium iodide flow cytometric method. RESULTS: After an initial increase in HepG2 cellular proliferation, a significant inhibition was observed with 10-8 mol/L octreotide, while TNF-α dose-dependently decreased proliferation. Early and late apoptosis was significantly increased with both substances. Octreotide significantly increased caspase-3, caspase-8 and caspase-2 activity. TNF-α signifi cantly increased only caspase-2. Cellular proliferation was decreased after treatment with octreotide or TNF-α alone but, in contrast to TNF-α, octreotide decreased proliferation only at concentrations of 10-8 mol/L, while lower concentrations increased proliferation. CONCLUSION: Our findings are suggestive of caspasemediated signaling pathways of octreotide antitumor activity in HepG2 cells, and indicate that measurements of serum octreotide levels may be important, at least in clinical trials, to verify optimal therapeutic drug concentrations. | Nikos J Tsagarakis Ioannis Drygiannakis Antonis G Batistakis George Kolios Elias A Kouroumalis | 2011 | World Journal of Gastroenterology2011，17，3： | 5 |
| 6 | Numerical modeling of centrifuge cyclic lateral pile load experiments显示文摘To gain insight into the inelastic behavior of piles, the response of a vertical pile embedded in dry sand and subjected to cyclic lateral loading was studied experimentally in centrifuge tests conducted in Laboratoire Central des Ponts et Chaussées. Three types of cyclic loading were applied, two asymmetric and one symmetric with respect to the unloaded pile. An approximately square-root variation of soil stiffness with depth was obtained from indirect in-flight density measurements, laboratory tests on reconstituted samples, and well-established empirical correlations. The tests were simulated using a cyclic nonlinear Winkler spring model, which describes the full range of inelastic phenomena, including separation and re-attachment of the pile from and to the soil. The model consists of three mathematical expressions capable of reproducing a wide variety of monotonic and cyclic experimental p-y curves. The physical meaning of key model parameters is graphically explained and related to soil behavior. Comparisons with the centrifuge test results demonstrate the general validity of the model and its ability to capture several features of pile-soil interaction, including: soil plastifi cation at an early stage of loading, 'pinching' behavior due to the formation of a relaxation zone around the upper part of the pile, and stiffness and strength changes due to cyclic loading. A comparison of the p–y curves derived from the test results and the proposed model, as well as those from the classical curves of Reese et al. (1974) for sand, is also presented. | Nikos Gerolymos Sandra Escoffier George Gazetas Jacques Garnier | 2009 | Earthquake Engineering and Engineering Vibration2009，8，1： | 5 |
| 7 | Long‐term administration of rifaximin improves the prognosis of patients with decompensated alcoholic cirrhosis显示文摘 | Jiannis Vlachogiannakos Nikos Viazis Panagiota Vasianopoulou Irene Vafiadis Dimitrios G Karamanolis Spiros D Ladas | 2013 | J Gastroenterol Hepatol2013，，3： | 4 |
| 8 | Computational neuroscience:a frontier of the 21^st century显示文摘THEORY IN NEUROSCIENCE The human brain is a biological organ,weighing about three pounds or 1.4 kg,that determines our behaviors,thoughts,emotions and consciousness.Although comprising only 2%of the total body weight,the brain consumes about 20%of the oxygen entering the body.With the expensive energy demand,the brain enables us to perceive and act upon the external world,as well as reflect on our internal thoughts and feelings. | Xiao-Jing Wang Hailan Hu Chengcheng Huang Henry Kennedy Chengyu Tony Li Nikos Logothetis Zhong-Lin Lu Qingming Luo Mu-ming Poo Doris Tsao Si Wu Zhaohui Wu Xu Zhang Douglas Zhou | 2020 | National Science Review2020，7，9： | 4 |
| 9 | A prospective cross-over study using a sphincterotome and a guidewire to increase the success rate of common bile duct cannulation显示文摘AIM: During endoscopic retrograde cholangiopancreatography (ERCP), selective cannulation of the common bile duct (CBD) is required in most of the cases.METHODS: From June 2001 till December 2002, all patients referred to our unit for ERCP were considered for entry into the study. Selective CBD cannulation was first attempted with a standard catheter with or without the use of a guidewire. In cases, where CBD cannulation was considered unsuccessful, patients were crossed over to a double-lumen sphincterotome and a guidewire. All patients were hospitalized for 24 h after the procedure in order to assess the incidence of post-ERCP complications.RESULTS: The study sample consisted of 158 patients.Selective CBD cannulation using a standard ERCP catheter with or without the assistance of a guidewire, was accomplished in 129 patients (success rate: 81.65%).From the 29 patients who were crossed over to a sphincterotome and a guidewire, selective CBD cannulation was achieved in 24; the overall success rate rising to 96.8%. Meanwhile, the use of this technique did not increase the incidence of post-ERCP complications.CONCLUSION: The use of a sphincterotome and a guidewire increases the success rate of selective bile duct cannulation in cases that this has not been accomplished with a standard catheter. | Georgios Karamanolis Aikaterini Katsikani Nikos Viazis Gerasimos Stefanidis Spilios Manolakopoulos Spiros Sgouros Efthimia Papadopoulou Apostolos Mantides | 2005 | World Journal of Gastroenterology2005，11，11： | 3 |
| 10 | Colon capsule endoscopy is feasible to perform after incomplete colonoscopy and guides further workup in clinical practice显示文摘 | Konstantinos Triantafyllou Nikos Viazis Panagiotis Tsibouris Georgios Zacharakis Chryssostomos Kalantzis Demetrios G. Karamanolis Spiros D. Ladas | 2014 | Gastrointestinal Endoscopy2014，，2： | 3 |
| 11 | 室温及非传统条件下AlCl3-尿素低共熔溶剂中铝的电沉积(英文)显示文摘研究在接近室温下AlCl3-尿素低共熔溶剂(DESs)体系中铝在玻璃碳和铝基底上的电沉积,而不需要对用于制备电解质的化学试剂进行额外的净化处理,也没有严格控制工作场所中的水分和氧气。研究改变温度、工作电势、受控沉积电流密度和沉积时间对在不搅拌电解质情况下沉积铝的形貌的影响。采用恒电势和恒电流技术,25~50℃下,在低共熔溶剂(n(AlCl3):n(Urea)=1.6:1)中将铝电沉积到玻璃状碳和铝基底上。利用SEM、EDS和XRD技术对两种基底进行研究,证实在恒电势和恒电流两种情形下均存在铝沉积物。所沉积的A1晶粒的形状和尺寸取决于沉积时间,尺寸从纳米级到微米级,形状从规则晶体到针状和片状结构。 | Vesna SCVETKOVIĆ Nataša MVUKIĆEVIĆ Niko JOVIĆEVIĆ Jasmina SSTEVANOVIĆ Jovan NJOVIĆEVIĆ | 2020 | Transactions of Nonferrous Metals Society of China2020，30，3： | 3 |
| 12 | Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting显示文摘 | ChrisostomiGialeli Achilleas D.Theocharis Nikos K.Karamanos | 2010 | FEBS Journal2010，，1： | 3 |
| 13 | Cost benefit analysis of the use of tranexamic acid in primary lower limb arthroplasty: A retrospective cohort study显示文摘AIM: To examine the cost benefit conferred by the perioperative administration of intravenous tranexamic acid(TXA) in lower limb arthroplasty.METHODS: This study evaluates the use of TXA in 200 consecutive lower limb arthroplasties performed in a single surgeon series. The initial 100 patients(control group) underwent surgery without perioperative administration of TXA while the subsequent 100 patients(TXA group) all received 1 g TXA at the time of induction of anaesthesia. Pre- and post-operative haemoglobin, platelet count, haematocrit, the use of blood product post-operatively, length of stay were examined. A financial analysis of both groups was then undertaken. RESULTS: The mean age of patients in both groups was 63 ± 13 years. There were no significant differences between groups in terms of gender(P = 0.47), proportion of total hip replacement to total knee replacement(P = 0.25) or pre-operative haemoglobin(P = 0.43). In the control group, the transfusion rate was 22%. In the TXA group, the transfusion rate dropped to 2%(P < 0.001). The mean post-operative haemoglobin was 10.82 ± 1.55g/dL in the control group vs 11.33 ± 1.27 g/dL in the TXA group(P = 0.01). The total cost of transfused blood products was €11055 and €603 respectively. The mean length of stay in the control group was 6.53 ± 5.93 d vs 5.47 ± 4.26 d in the TXA group(P = 0.15) leading to an estimated financial saving of €114586. There was one pulmonary embolus in the control group and one deep venous thrombosis in the TXA group.CONCLUSION: Intravenous TXA reduces blood loss in lower limb arthroplasty. This leads to lower transfusion rates, shorter length of stay in hospital and significant financial savings. | Niall P McGoldrick Eabhann M O'Connor Nikos Davarinos Rose Galvin John F Quinlan | 2015 | World Journal of Orthopedics2015，6，11： | 3 |
| 14 | Big-Data Processing Techniques and Their Challenges in Transport Domain显示文摘This paper describes the fundamentals of cloud computing and current big-data key technologies. We categorize big-data processing as batch- based, stream- based, graph- based,DAG-based, interactive-based, or visual-based according to the processing technique. We highlight the strengths and weaknesses of various big-data cloud processing techniques in order to help the big-data community select the appropriate processing technique. We also provide big data research challenges and future directions in aspect to transportation management systems. | Aftab Ahmed Chandio Nikos Tziritas Cheng-Zhong Xu | 2015 | ZTE Communications2015，13，1： | 3 |
| 15 | ZnO-SiO_2体系的热力学评价(英文)显示文摘含ZnO炉渣是贱金属和钢的火法冶金过程中常见的炉渣,这导致人们对于ZnO-SiO_2体系热力学的兴趣。本文作者对ZnO-SiO_2体系进行全面的文献评述,对现有实验数据进行批判性评价,对体系相平衡进行热力学优化,给出了ZnO-SiO_2体系在1.013×10~5Pa总压力下的热力学性质。将熔融氧化物视为缔合溶液,重新评估了液相的性质。对固体Zn_2SiO_4吉布斯自由能的焓项重新进行拟合,使之与硅锌矿初晶区的新数据相符。所得热力学数据与新近的实验观测结果吻合良好。这些结果可用于预测热力学性质和相图中的相区,如液相混溶区的临界点,预测准确度优于以往的方法。获得了一组优化的模型参数,在整个组成范围内,温度从298 K到液相线温度,重新生成了可靠的热力学和相平衡数据,其误差在实验误差范围内。建立的数据库可用于Gibbs自由能最小化软件中热力学性质和有关相图截面的计算。 | Iikka ISOMAKI Rui ZHANG 夏隆巩 Niko HELLSTEN Pekka A.TASKINEN | 2018 | Transactions of Nonferrous Metals Society of China2018，28，9： | 2 |
| 16 | GnRH antagonist versus long GnRH agonist protocol in poor IVF responders: a randomized clinical trial显示文摘 | Yannis Prapas Stamatios Petousis Themistoklis Dagklis Yannis Panagiotidis Achilleas Papatheodorou Iuliano Assunta Nikos Prapas | 2012 | European Journal of Obstetrics and Gynecology2012，，： | 2 |
| 17 | Towards adaptable and tunable cloud-based map-matching strategy for GPS trajectories显示文摘智慧城市为智能交通管理和交通网络智能应用的发展提供了巨大推动力。近来,智能交通系统(Intelligent transportation systems,ITSs)和移动位置服务(Location-based services,LBSs)也成为了研究领域的热点。交通领域数据量在快速不断增长,云计算在巨量数据的存储、接入、管理和处理方面有着巨大作用。交通领域相当比例的数据为GPS数据,此类数据具有非频繁、含噪声等特性,这使得维护基于GPS的实时交通软件的服务质量较为困难。在诸多智能交通系统应用中,地图匹配处理起着将GPS观测点准确排列于路网中的关键作用。考虑到准确性时,地图匹配策略的性能由两个连续的GPS观测点间的最短路径决定;另一方面,处理最短路径查询(Processing shortest path queries,SPQs)耗费着较高计算量。现有的地图匹配技术采用固定参数(固定的候选点数量,固定的误差圆半径)的办法,这可能导致确认线路分段时产生不确定性,也可导致低精度结果(或需进行大量SPQ处理以保证精度)。此外,由于采样错误的存在,较高采样时间(大于10 s)内的GPS数据常含有冗余数据,这也导致需要额外的SPQ处理。由于SPQ处理导致的高运算量问题,现有的地图匹配策略并不能实现实时应用。在本文中,我们提出一种实时地图匹配方法(Real-time map-matching,RT-MM)。该方法以云计算为基础,是一种全自适应地图匹配策略,能够应对实时GPS轨迹地图匹配中SPQ处理的关键问题。本研究还通过基于虚拟数据和实际数据的仿真,对所述方法与现有方法的性能进行了比较。 | Aftab Ahmed CHANDIO Nikos TZIRITAS Fan ZHANG Ling YIN Cheng-Zhong XU | 2016 | Frontiers of Information Technology & Electronic Engineering2016，17，12： | 2 |
| 18 | Reasons of PEG failure to eliminate gastroesophageal reflux in mechanically ventilated patients显示文摘AIM:To investigate factors predicting failure of percutaneous endoscopic gastrostomy(PEG)to eliminate gastroesophageal reflux(GER). METHODS:Twenty-nine consecutive mechanically ventilated patients were investigated.Patients were evaluated for GER by pH-metry pre-PEG and on the 7th post-PEG day.Endoscopic and histologic evidence of reflux esophagitis was also carried out.A beneficial response to PEG was considered when pH-metry on the 7th post-PEG day showed that GER was below 4%. RESULTS:Seventeen patients responded(RESP group)and 12 did not respond(N-RESP)to PEG.The mean age,sex,weight and APACHEⅡscore were similar in both groups.GER(%)values were similar in both groups at baseline,but were significantly reduced in the RESP group compared with the N-RESP group on the 7th post-PEG day[2.5(0.6-3.8)vs 8.1(7.4-9.2, P<0.001)].Reflux esophagitis and the gastroesophageal flap valve(GEFV)grading differed significantly between the two groups(P=0.031 and P=0.020, respectively).Histology revealed no significant differences between the two groups.CONCLUSION:Endoscopic grading of GEFV and the presence of severe reflux esophagitis are predisposing factors for failure of PEG to reduce GER in mechanically ventilated patients. | Emmanuel E Douzinas Ilias Andrianakis Olga Livaditi Dimitrios Bakos Katerina Flevari Nikos Goutas Dimitrios Vlachodimitropoulos Marios-Konstantinos Tasoulis Alex P Betrosian | 2009 | World Journal of Gastroenterology2009，15，43： | 2 |
| 19 | Endothelial Microparticle–Mediated Transfer of MicroRNA-126 Promotes Vascular Endothelial Cell Repair via SPRED1 and Is Abrogated in Glucose-Damaged Endothelial Microparticles显示文摘 | Felix Jansen Xiaoyan Yang Marion Hoelscher Arianna Cattelan Theresa Schmitz Sebastian Proebsting Daniela Wenzel Sarah Vosen Bernardo S. Franklin Bernd K. Fleischmann Georg Nickenig Nikos Werner | 2013 | Circulation2013，，18： | 2 |
| 20 | Macromolecular architectures by living and controlled/living polymerizations显示文摘 | Nikos Hadjichristidis Hermis Iatrou Marinos Pitsikalis Jimmy Mays | 2006 | Progress in Polymer Science2006，，12： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员