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| 1 | Insights on augmenter of liver regeneration cloning and function显示文摘肝的激发器物质(HSS ) 是被指了一肝特定但是种类非特定的生长因素。HSS 蛋白质的坡度纯化和顺序分析显示它包含了肝新生(ALR ) 的 augmenter,也作为 hepatopoietin (HPO ) 知道。ALR,充当一个 hepatotrophic 生长因素,象肝细胞瘤细胞在试管内一样的有教养的 hepatocytes 的明确地刺激的增长,支持的肝新生和损坏 hepatocytes 和救的尖锐肝的失败在活体内的恢复。ALR 属于新 Erv1/Alr 蛋白质家庭,哪个从酵母在更低、更高的优核质被发现到人并且甚至在一些双 stranded DNA 病毒的成员。现在的评论文章集中于 ALR 的分子的生物学,检验从酵母的 ALR 基因和它到人和 ALR 蛋白质的生物功能的表示。ALR 蛋白质似乎是 non-liver-specific 作为,增加必要性扩大关于在处于正常、反常的细胞的生长的条件的不同纸巾,机关和发展阶段的哺乳动物的 ALR 蛋白质的研究是以前相信了。 | Elisavet Gatzidou Gregory Kouraklis Stamatios Theocharis | 2006 | World Journal of Gastroenterology2006，12，31： | 13 |
| 2 | Current evidence for histone deacetylase inhibitors in pancreatic cancer显示文摘Pancreatic cancer is one of the most aggressive human cancers,with more than 200 000 deaths worldwide every year.Despite recent efforts,conventional treatment approaches,such as surgery and classic chemotherapy,have only slightly improved patient outcomes.More effective and well-tolerated therapies are required to reverse the current poor prognosis of this type of neoplasm.Among new agents,histone deacetylase inhibitors (HDACIs) are now being tested.HDACIs have multiple biological effects related to acetylation of histones and many non-histone proteins that are involved in regulation of gene expression,apoptosis,cell cycle progression and angiogenesis.HDACIs induce cell cycle arrest and can activate the extrinsic and intrinsic pathways of apoptosis in different cancer cell lines.In the present review,the main mechanisms by which HDACIs act in pancreatic cancer cells in vitro,as well as their antiproliferative effects in animal models are presented.HDACIs constitute a promising treatment for pancreatic cancer with encouraging anti-tumor ef-fects,at well-tolerated doses. | Ioannis Koutsounas Constantinos Giaginis Efstratios Patsouris Stamatios Theocharis | 2013 | World Journal of Gastroenterology2013，19，6： | 9 |
| 3 | Platelet-activating factor in liver injury: A relational scope显示文摘hepatocyte,肝的主要细胞的部件,到损害的不同类型的展览变量危险性由内长或外长的因素导致了。肝细胞机能障碍或死亡和新生依赖于在众多的生物学上活跃的分子之间的复杂相互作用。激活血小板的因素(PAF ) 似乎在临床、试验性的背景作为肝损伤的关键调停人起一个枢轴的作用,由它的受体对手的有益的效果暗示了。处于与肝损伤联系的条件的 PAF 的特定的功能、规章的性质的全面新概述在这评论被尝试。 | Nikolaos P Karidis Gregory Kouraklis Stamatios E Theocharis | 2006 | World Journal of Gastroenterology2006，12，23： | 5 |
| 4 | Melatonin attenuates high fat diet-induced fatty liver disease in rats显示文摘AIM:To investigate melatonin's preventive action in oxidative stress in a rat model with high fat diet-induced non-alcoholic fatty liver disease(NAFLD).METHODS:NAFLD was induced by high fat diet(HFD)in adult,male,Wistar rats,weighing 180-230 g.After acclimatization for one week,they were randomly assigned to 6 experimental groups that comprised animals on regular diet plus 5 or 10 mg/kg melatonin,for 4 or 8 wk;animals on HFD,with or without 5 or 10 mg/kg melatonin,for 4 or 8 wk;and animals on HFD for 8 or 12 wk,with melatonin 10 mg/kg for the last 4 wk.Liver damage was assessed biochemically by the serum levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),and histologically.Lipid peroxidation and oxidative stress were assessed by malondialdehyde and glutathione levels in liver tissue.Lipidemic indices and portal vein pressure were also measured.RESULTS:Compared to rats not receiving melatonin,rats on 5 or 10 mg/kg of melatonin had lower mean liver weight(-5.0 g and-4.9 g)(P < 0.001)and lower liver weight to body weight ratio(-1.0%)(P < 0.001),for the two doses,respectively.All rats fed HFD without melatonin developed severe,grade Ⅲ,steatosis.Rats on HFD with concurrent use of melatonin showed significantly less steatosis,with grade Ⅲ steatosis observed in 1 of 29(3.4%)rats on 10 mg/kg melatonin and in 3 of 27(11.1%)rats on 5 mg/kg melatonin.Melatonin was ineffective in reversing established steatosis.Melatonin also had no effect on any of the common lipidemic serum markers,the levels of which did not differ significantly among the rats on HFD,irrespective of the use or not of melatonin.Liver cell necrosis was significantly less in rats on HFD receiving melatonin than in those not on melatonin,with the AST levels declining by a mean of 170 U/L(P = 0.01)and 224 U/L(P = 0.001),and the ALT levels declining by a mean of 62.9 U/L(P = 0.01)and 93.4 U/L(P < 0.001),for the 5 and 10 mg/kg melatonin dose,respectively.Melatonin mitigated liver damage due to peroxidation and oxidative stress in liver tissue as indicated by a significant decline in MDA production by 12.7(P < 0.001)and 12.2(P < 0.001)μmol/L/mg protein/mg tissue,and a significant increase in glutathione by 20.1(P = 0.004)and 29.2(P < 0.001)μmol/L/mg protein/mg tissue,for the 5 and 10 mg/kg melatonin dose,respectively.CONCLUSION:Melatonin can attenuate oxidative stress,lessen liver damage,and improve liver histology in rats with high fat diet-induced NAFLD,when given concurrently with the diet. | Gregorios Hatzis Panayiotis Ziakas Nikolaos Kavantzas Aggeliki Triantafyllou Panagiotis Sigalas Ioanna Andreadou Konstantinos Ioannidis Stamatios Chatzis Konstantinos Filis Alexandros Papalampros Fragiska Sigala | 2013 | World Journal of Hepatology2013，5，4： | 4 |
| 5 | Cardiovascular Function and Treatment in β-Thalassemia Major: A Consensus Statement From the American Heart Association显示文摘 | Dudley J. Pennell James E. Udelson Andrew E. Arai Biykem Bozkurt Alan R. Cohen Renzo Galanello Timothy M. Hoffman Michael S. Kiernan Stamatios Lerakis Antonio Piga John B. Porter John Malcolm Walker John Wood | 2013 | Circulation2013，，3： | 3 |
| 6 | Histone deacetylase inhibitors and pancreatic cancer:Are there any promising clinical trials?显示文摘Pancreatic cancer,although not very frequent,has an exceptionally high mortality rate,making it one of the most common causes of cancer mortality in developed countries.Pancreatic cancer is difficult to diagnose,allowing few patients to have the necessary treatment at a relatively early stage.Despite a marginal benefit in survival,the overall response of pancreatic cancer to current systemic therapy continues to be poor,and new therapies are desperately needed.Histone deacetylase(HDAC) enzymes play an important role in the development and progression of cancer and HDAC inhibitors(HDACIs) have been shown to induce differentiation and cell cycle arrest,activate the extrinsic or intrinsic pathways of apoptosis,and inhibit invasion,migration and angiogenesis in different cancer cell lines.As a result of promising preclinical data,various HDACIs are being tested as either monotherapeutic agents or in combination regimens for both solid and hematological malignancies.Vorinostat was the first HDACI approved by the Food and Drug Administration for patients with cutaneous T-cell lymphoma.The use of HDACIs in clinical trials,in pretreated and relapsed patients suffering from advanced pancreatic cancer is discussed.Unfortunately,clinical data for HDACIs in patients with pancreatic cancer are inadequate,because only a few studies have included patients suffering from this type of neoplasm and the number of pancreatic cancer patients that entered HDACIs phase Ⅱ/Ⅲ trials,among others with advanced solid tumors,is very limited.More studies recruiting patients with pancreatic cancer remain to determine the efficiency of these therapies. | Ioannis Koutsounas Constantinos Giaginis Stamatios Theocharis | 2013 | World Journal of Gastroenterology2013，19，8： | 3 |
| 7 | GnRH antagonist versus long GnRH agonist protocol in poor IVF responders: a randomized clinical trial显示文摘 | Yannis Prapas Stamatios Petousis Themistoklis Dagklis Yannis Panagiotidis Achilleas Papatheodorou Iuliano Assunta Nikos Prapas | 2012 | European Journal of Obstetrics and Gynecology2012，，： | 2 |
| 8 | Complications of modern pancreaticoduodenectomy:A systematic review and meta-analysis显示文摘Background:In the past decades,the perioperative management of patients undergoing pancreaticoduo-denectomy(PD)has undergone major changes worldwide.This review aimed to systematically determine the burden of complications of PD performed in the last 10 years.Data sources:A systematic review was conducted in PubMed for randomized controlled trials and ob-servational studies reporting postoperative complications in at least 100 PDs from January 2010 to April 2020.Risk of bias was assessed using the Cochrane RoB2 tool for randomized studies and the method-ological index for non-randomized studies(MINORS).Pooled complication rates were estimated using random-effects meta-analysis.Heterogeneity was investigated by subgroup analysis and meta-regression.Results:A total of 20 randomized and 49 observational studies reporting 63229 PDs were reviewed.Mean MINORS score showed a high risk of bias in non-randomized studies,while one quarter of the ran-domized studies were assessed to have high risk of bias.Pooled incidences of 30-day mortality,overall complications and serious complications were 1.7%(95%CI:0.9%-2.9%;I 2=95.4%),54.7%(95%CI:46.4%-62.8%;I 2=99.4%)and 25.5%(95%CI:21.8%-29.4%;I 2=92.9%),respectively.Clinically-relevant postopera-tive pancreatic fistula risk was 14.3%(95%CI:12.4%-16.3%;I 2=92.0%)and mean length of stay was 14.8 days(95%CI:13.6-16.1;I 2=99.3%).Meta-regression partially attributed the observed heterogeneity to the country of origin of the study,the study design and the American Society of Anesthesiologists class.Conclusions:Pooled complication rates estimated in this study may be used to counsel patients scheduled to undergo a PD and to set benchmarks against which centers can audit their practice.However,cautious interpretation is necessary due to substantial heterogeneity. | Stamatios Kokkinakis Evangelos I Kritsotakis Neofytos Maliotis Ioannis Karageorgiou Emmanuel Chrysos Konstantinos Lasithiotakis | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，6： | 2 |
| 9 | A Practical Guide to Multimodality Imaging of Transcatheter Aortic Valve Replacement显示文摘 | Gerald S. Bloomfield Linda D. Gillam Rebecca T. Hahn Samir Kapadia Jonathon Leipsic Stamatios Lerakis Murat Tuzcu Pamela S. Douglas | 2012 | JACC: Cardiovascular Imaging2012，，4： | 2 |
| 10 | Brain tractograpiay using Q-ball imaging and graph theory: improved connectivities through fiber crossings via a model-based approach 显示文摘 | Stamatios NS Li B Paul SM | 2010 | Neu- roImage2010，49，3： | 1 |
| 11 | Modal analysis of graphene microtubes utilizing a two-dimensional vectorial finite element method显示文摘 | VASILEIOS S STAMATIOS A NIKOLAOS K | 2016 | Appl Phys A2016，122，4： | 1 |
| 12 | A Unified Security Framework for Wi-MAX over EPON access networks 显示文摘 | GU WEN VERMA PRAMODE K KARTALOPOULOS STAMATIOS V | 2011 | Security and Communication Networks2011，4，6： | 1 |
| 13 | Current concepts and controversies in the management of radial head fractures显示文摘 | Nikolaos T Roidis MD PHD DSC Stamatios A | 2006 | Orthopedics2006，29，： | 1 |
| 14 | Ankle-brachial index as a predictor of the extent of coronary atherosclerosis and cardiovascular events in patients with coronary artery disease显示文摘 | Christos M Papamichael John P Lekakis Kimon S Stamatelopoulos Theodoros G Papaioannou Maria K Alevizaki Adriana T Cimponeriu John E Kanakakis Aggeliki Papapanagiotou Anastasios Th Kalofoutis Stamatios F Stamatelopoulos | 2000 | The American Journal of Cardiology2000，，6： | 1 |
| 15 | Evaluation of thin-layer drying models for describing drying kinetics of figs( Ficus carica) 显示文摘 | Stamatios J B Elias P Nikolas K | 2006 | Journal of Food Engineering2006，75，2： | 1 |
| 16 | Atorvastatin Improves Left Ventricular Systolic Function and Serum Markers of Inflammation in Nonischemic Heart Failure显示文摘 | Srikanth Sola Muhammad Q.S. Mir Stamatios Lerakis Neeraj Tandon Bobby V. Khan | 2006 | Journal of the American College of Cardiology2006，，2： | 1 |
| 17 | Pregnane X Receptor (PXR) at the Crossroads of Human Metabolism and Disease显示文摘 | Ioannis Koutsounas Stamatios Theocharis Efstratios Patsouris Constantinos Giaginis | 2013 | Current Drug Metabolism2013，，3： | 1 |
| 18 | Current conceptsan dcontroversies in the management of radial headfractures显示文摘 | Nikolaos T Roidis MD Stamatios A | 2009 | Orthopedics2009，29，： | 1 |
| 19 | Conservative management of cervical pregnancy with intramuscular administration of methotrexate and KCl injection: Case report and review of the literature显示文摘We report the case of a cervical pregnancy successfully treated with intramuscular injection of methotrexate(MTX) and intramniotic administration of potassium chloride. A 41-year-old woman was admitted to our Department with the suspicion of ectopic pregnancy. Transvaginal ultrasound revealed empty endometrialcavity, gestational sac within the cervical canal and embryonic echo measuring crown rump length 1.5 mm. Serum beta human chorionic gonadotropine(β-HCG) was measured 28590 IU/L. No cardiac activity was detected. The diagnosis of a cervical pregnancy was made. Patient was treated with intramuscular administration of methotrexate(50 mg/m2) in combination with ultrasoundguided intramniotic injection of KCl(2 meq/mL). Gradual decrease of β-HCG levels as well as ultrasound observation of collapsed gestational sac was observed. No curettage was necessitated. Patient was discharged on day 10 th and was set in follow-up on a weekly basis. β-HCG values were measured < 10 IU/L on 56 th day after MTX administration. Intramuscular administration of MTX may be effective in treatment of cervical pregnancy without additional interventional measures. | Stamatios Petousis Chrysoula Margioula-Siarkou Ioannis Kalogiannidis George Karavas Vasileios Palapelas Nikolaos Prapas David Rousso | 2015 | World Journal of Clinical Cases2015，3，1： | 1 |
| 20 | Induction of metallothionein in the liver of carbon tetrachloride intoxicated rats:an immunohistochemical study显示文摘 | Stamatios E T Alexandra P M Spyridon D S | 2001 | Toxicology2001，161，12： | 1 |
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