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| 1 | R-spondin-2 is a Wnt agonist that regulates osteoblast activity and bone mass显示文摘The R-spondin family of proteins are Wnt agonists, and the complete embryonic disruption of Rspo2 results in skeletal developmental defects that recapitulate the phenotype observed with Lrp5/6 deficiency. Previous work has shown that R-spondin-2(Rspo2, RSPO2) is both highly expressed in Wnt-stimulated pre-osteoblasts and its overexpression induces osteoblast differentiation in the same cells, supporting its putative role as a positive autocrine regulator of osteoblastogenesis. However, the role of Rspo2 in regulating osteoblastogenesis and bone formation in postnatal bone has not been explored. Here we show that limb-bud progenitor cells from Rspo2 knockout mice undergo reduced mineralization during osteoblastogenesis in vitro and have a corresponding alteration in their osteogenic gene expression profile. We also generated the first Rspo2 conditional knockout(Rspo2 floxed) mouse and disrupted Rspo2 expression in osteoblast-lineage cells by crossing to the Osteocalcin-Cre mouse line(OcnCre + Rspo2 ^(f/f)). Ocn-Cre + Rspo2 f/fmale and female mice at 1, 3, and 6 months were examined. Ocn-Cre + Rspo2 f/fmice are decreased in overall body size compared to their control littermates and have decreased bone mass. Histomorphometric analysis of1-month-old mice revealed a similar number of osteoblasts and mineralizing surface per bone surface with a simultaneous decrease in mineral apposition and bone formation rates. Consistent with this observation, serum osteocalcin in 3-month-old Ocn-Cre +Rspo2 f/fwas reduced, and bone marrow-mesenchymal stem cells from Ocn-Cre + Rspo2 f/fmice undergo less mineralization in vitro.Finally, gene expression analysis and immunohistochemistry of mature bone shows reduced beta-catenin signaling in Ocn-Cre +Rspo2 f/f. Overall, RSPO2 reduces osteoblastogenesis and mineralization, leading to reduced bone mass. | M.Noelle Knight Kannan Karuppaiah Michele Lowe Sarthak Mohanty Robert L.Zondervan Sheila Bell Jaimo Ahn Kurt D.Hankenson | 2018 | Bone Research2018，6，3： | 5 |
| 2 | Alefacept reduces infiltrating T cells, activated dendritic cells, and inflammatory genes in psoriasis vulgaris显示文摘 | Francesca Chamian Michelle A Lowes et al | 2005 | PNAS Feb2005，102，： | 1 |
| 3 | Stereotactic Mammotome breast biopsy: routine clinical experience and correlation with BI- RADS classification and histopathology 显示文摘 | Michel S C Low R Singer G | 2007 | Schweiz Rundsch Med Prax2007，96，39： | 1 |
| 4 | Stereotactic Mam motome breast biopsy:routine clinical experience and correlation with BI-RADS--classification and histopathology显示文摘 | Michel SC Low R Singer G | 2007 | Praxis(Bern 1994)2007，96，39： | 1 |
| 5 | StereotacticMammotome breastbiopsy: routine clinical experience and correlation with B l-RADS-classificafion and histopathology 显示文摘 | Michel SC Low R Singer G | 2007 | Praxis (Bern 1994)2007，96，39： | 1 |
| 6 | Current concepts in the immunopathogenesis of psoriasis显示文摘 | Michelle A. Lowes Wook Lew James G. Krueger | 2004 | Dermatologic Clinics2004，，4： | 1 |
| 7 | Stereotaelic Mammotome breast biopsy: routine clinical experience and correlation with BI- RADS classification and histopathalogy显示文摘 | Michel SC Low R Singer G | 2007 | Sehweiz Rundsch Med Prax2007，96，39： | 1 |
| 8 | L-N-Acetylcysteine protects against radiation-induced apoptosis in a cochlear cell line显示文摘 | Wong-Kein Low Li Sun Michelle G.K. Tan Alvin W.C. Chua De-Yun Wang | 2008 | Acta Oto-Laryngologica2008，，4： | 1 |
| 9 | MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia显示文摘 | Chong Chen Yu Liu Amy R. Rappaport Thomas Kitzing Nikolaus Schultz Zhen Zhao Aditya S. Shroff Ross A. Dickins Christopher R. Vakoc James E. Bradner Wendy Stock Michelle M. LeBeau Kevin M. Shannon Scott Kogan Johannes Zuber Scott W. Lowe | 2014 | Cancer Cell2014，，5： | 1 |
| 10 | Head trauma and in vivo measures of amyloid and neurodegeneration in a population-based study显示文摘 | Michelle M. Mielke Rodolfo Savica Heather J. Wiste Stephen D. Weigand Prashanthi Vemuri David S. Knopman Val J. Lowe Rosebud O. Roberts Mary M. Machulda Yonas E. Geda Ronald C. Petersen Clifford R. Jack | 2014 | Neurology2014，，1： | 1 |
| 11 | Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment显示文摘 | Jason R. Clapper Michelle D. Hendricks Guibao Gu Carrie Wittmer Carrie S. Dolman John Herich Jennifer Athanacio Christiane Villescaz Soumitra S. Ghosh Joseph S. Heilig Carolyn Lowe Jonathan D. Roth | 2013 | AJP: Gastrointestinal and Liver Physiology2013，，7： | 1 |
| 12 | Britain's Regional Shopping Centres: New Urban Forms?显示文摘 | Lowe Michelle S | 2000 | Urban Studies2000，37，2： | 1 |
| 13 | Stereotactic Mammotome breast biopsy: routine clinical experience and correlation with BI- RADS classification and histopathology 显示文摘 | Michel Sc Low R Singer (} | 2007 | Praxis (Bern 1994)2007，96，39： | 1 |
| 14 | Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma显示文摘 | Polina L. Yarova Alecia L. Stewart Venkatachalem Sathish Rodney D. Britt Michael A. Thompson Alexander P. P. Lowe Michelle Freeman Bharathi Aravamudan Hirohito Kita Sarah C. Brennan Martin Schepelmann Thomas Davies Sun Yung Zakky Cholisoh Emma J. Kidd Wil | 2015 | Science Translational Medicine . 2015 (284)2015，，284： | 1 |
| 15 | Angina and intermittent claudication in 7403 participants of the 2003 Scottish Health Survey: Impact on general and mental health, quality of life and five-year mortality显示文摘 | Sally C. Inglis James D. Lewsey Gordon D.O. Lowe Pardeep Jhund Michelle Gillies Simon Stewart Simon Capewell Kate MacIntyre John J.V. McMurray | 2012 | International Journal of Cardiology2012，，： | 1 |
| 16 | Self-centering steel plate shear walls for improving seismic resilience显示文摘作为为地震工程模拟研究的一个网络的部分,工程在公牛,和关于地震工程的研究的台湾公民中心在大学与合作者一起在华盛顿大学由研究人员带了,一个自我集中的钢盘子砍墙( SC-SPSW )系统被开发了完成提高的地震性能目的,包括重新集中。SC-SPSW 由薄钢填入面板组成,叫作是服务的网盘子主要侧面抵抗负担并且系统的精力驱散元素。Posttensioned (磅) beam-to-column 连接提供重新集中的系统能力。一个基于表演的设计过程为 SC-SPSW 被开发了,并且一系列非线性的反应历史分析被进行了在多重危险层次验证打算的地震性能。伪静电干扰组件测试,伪静电干扰和放大三故事的标本的饮料桌子测试,和二照原尺寸的二故事的 SC-SPSWs 的伪 dynamic 测试被进行了。作为这多年的一个顶点,多机构的工程,这篇论文将给出 SCSPSW 数字、试验性的研究程序的概述。这篇论文将也讨论被调查改进 constructability,跳回,和地震性能并且能被用于自我集中的其它和钢板的创新的磅连接和网板图案砍墙系统。 | Patricia M. CLAYTON Daniel M. DOWDEN Chao-Hsien LI Jeffrey W. BERMAN Michel BRUNEAU Laura N. LOWES Keh-Chuan TSAI | 2016 | Frontiers of Structural and Civil Engineering2016，10，3： | 1 |
| 17 | Renegotiating the Domestic Division of Labor? A Study of Dual Career Households in Northeast and Southeast England显示文摘 | Gregson Nicky & Lowe Michelle | 1993 | Sociological Review1993，41，： | 1 |
| 18 | 被难倒的“大侦探”显示文摘丹尼尔非常擅长推理,他帮助别人解决了许多难题,因此被誉为“四年级最棒的侦探”。一次,珍妮告诉丹尼尔,他们的同学科比在周一一大早被接走后就再也没有来过学校。珍妮想知道科比去哪儿了。随着目击证人提供各种线索,丹尼尔也一步步接近事实真相。然而在这时,他突然决定停止这次调查任务。 | Chris Low Michelle Simpson | 2022 | 英语沙龙(原版阅读)2022，，5： | 0 |
| 19 | 多相流测量新技术显示文摘一种新的地面流量计从根本上改变了我们测量生产井复杂流动的方式。这种新技术引发的改变使我们能准确测量三相流体中的快速变化,包括以前很难定量测量的段塞流、泡状流和稳定乳状液流等。实时测量多相流提高了作业效率,节省了时间和费用。 | Ian Atkinson Bertrand Theuveny Michel Berard Gilbert Conort Trey Lowe Allan McDiarmid Parviz Mehdizadeh Bruno Pinguet Gerald Smith Kerry J.Willimnson | 2005 | 国外测井技术2005，20，6： | 0 |
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