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| 1 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 2 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 3 | The influence of sediment recycling and basement composition on evolution of mudrock chemistry in the southwestern United States显示文摘 | Rónald Cox Donald R. Lowe R.L. Cullers | 1995 | Geochimica et Cosmochimica Acta1995，，14： | 2 |
| 4 | The gene encoding the splicing factor SF2/ASF is a proto-oncogene 显示文摘 | Karni R Stanchina E Lowe W | 2007 | Nat Struct Mol Bioi2007，14，3： | 1 |
| 5 | Formation of nitrate and ammonium-ions in titanium-dioxide mediated photocatalytic degradation of organic-compounds compounds containing nitrogen-atoms 显示文摘 | McEvoy S R Matthews R W 1991 | 1991 | Environ Sci Technol1991，25，： | 1 |
| 6 | The influence of sediment recycling and basement composition on evolution of mudrock chemistry in the southwestern United States显示文摘 | COX R LOW D R | 1995 | Geochimica et Cosmochimica Acta1995，59，： | 1 |
| 7 | The ecology of the European rabbit (Oyctolagus cuniculus) in coastal southwestern Australia显示文摘 | Twigg L E Lowe T J Martin G R | 1998 | Wildl Res1998，25，： | 1 |
| 8 | Invasive infection due to Streptococcus iniae: a new or previously unrecognized disease显示文摘 | WEINSTEIN M R LOW D E McGeer A | 1996 | Ontario CCDR1996，22，： | 1 |
| 9 | Pattern analysis with two dimensional spectral localization: application of two dimensional S-transform 显示文摘 | Mansinha L Stockwell R G Lowe R P | 1997 | Physic A1997，239，3： | 1 |
| 10 | tRNAscanSE: A program for improved detection of Transfer RNA genes in genomic sequence显示文摘 | Lowe T M Eddy S R | 1997 | Nucleic Acids Research1997，25，5： | 1 |
| 11 | Survival characteristics of periodontally- involved teeth : a 40-year study 显示文摘 | Chace R Sr Low SB | 1993 | J Periodontol1993，64，8： | 1 |
| 12 | An Investigation of the Plastic Fracture of AISI 4340 and 18Nickel -200 Grade Maraging Steels 显示文摘 | Cox T B Low J R | 1974 | Metallurgical Transac- tions1974，5，6： | 1 |
| 13 | Carboxyl ester lipase from either mother's milk or the pancreas is required for efficient dietary triglyceride digestion in suckling mice显示文摘 | Miller R Lowe ME | 2008 | The Journal of Nutrition2008，138，5： | 1 |
| 14 | 查看详情显示文摘 | Lowe A B Wang R | | 0，，08： | 1 |
| 15 | Chronology of Early Archean granite-greenstone evolution in the Barberton Mountain Land, South Africa, based on precise dating by single zircon evaporation 显示文摘 | Kr6ner A Byerly G R Lowe D R | 1991 | Earth and Planetary Science Letters1991，103，14： | 1 |
| 16 | Thermal cycling analysis of flip-chip solder joint reliability 显示文摘 | Pang J H L Chong D Y R Low T H | 2001 | Components and Packaging Technologies2001，24，4： | 1 |
| 17 | 钙离子拮抗挤对心血管功能的作用[J]显示文摘 | Low R I 周也卿 | 1983 | 国外医学·心血管疾病分册1983，，1： | 1 |
| 18 | Localization ofthe complex spectrum: The S transform显示文摘 | Stockwell R G Mansinha L Lowe R P | 1996 | IEEE Transactions on Signal Processing1996，44，4： | 1 |
| 19 | Predictive value of electronic fetal monitoring for intrapartum fetal asphyxia with metabolic acidosis显示文摘 | Low J A Victory R Derrick E J | 1999 | Obstet Gynecol1999，93，2： | 1 |
| 20 | Severe tissue damage in Atlantic cod larvae under increasing ocean acidification显示文摘 | Frommel A Y Maneja R Lowe D | 2012 | Nature Climate Change2012，2，1： | 1 |
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