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| 1 | Calcium-sensing receptor in colorectal inflammation and cancer:Current insights and future perspectives显示文摘The extracellular calcium-sensing receptor(CaSR) is best known for its action in the parathyroid gland and kidneys where it controls body calcium homeostasis. However, the CaSR has different roles in the gastrointestinal tract, where it is ubiquitously expressed. In the colon, the CaSR is involved in controlling multiple mechanisms, including fluid transport, inflammation, cell proliferation and differentiation. Although the expression pattern and functions of the CaSR in the colonic microenvironment are far from being completely understood, evidence has been accumulating that the Ca SR might play a protective role against both colonic inflammation and colorectal cancer. For example, CaSR agonists such as dipeptides have been suggested to reduce colonic inflammation, while dietary calcium was shown to reduce the risk of colorectal cancer. CaSR expression is lost in colonic malignancies, indicating that the CaSR is a biomarker for colonic cancer progression. This dual anti-inflammatory and anti-tumourigenic role of the CaSR makes it especially interesting in colitisassociated colorectal cancer. In this review, we describe the clinical and experimental evidence for the role of the CaSR in colonic inflammation and colorectal cancer, the intracellular signalling pathways which are putatively involved in these actions, and the possibilities to exploit these actions of the CaSR for future therapies of colonic inflammation and cancer. | Luca Iamartino Taha Elajnaf Eniko Kallay Martin Schepelmann | 2018 | World Journal of Gastroenterology2018，24，36： | 9 |
| 2 | Viral vectors for gene-directed enzyme prodrug therapy显示文摘 | Schepelmann S Springer CJ | 2006 | Curr Gene Ther2006，6，6： | 1 |
| 3 | The calcium-sensing receptor: one of a kind显示文摘 | Lopez-Femandez I Schepelmann M Brerman S C | 2015 | Exp Physiol2015，，： | 1 |
| 4 | Heahh-related quality of life in ALS, myasthenia gravis and facioscapulohumeral muscular dystrophy 显示文摘 | Winter Y Schepelmann K Spottke AE | 2010 | J Neruol2010，257，9： | 1 |
| 5 | Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2 显示文摘 | Schepelmann S Ogilvie LM He dley D | 2007 | Cancer Res2007，67，10： | 1 |
| 6 | Pulmonary ischemia reperfusion injury:a quantitative study of structure and function in isolated heart-lungs of the rat显示文摘 | Fehrenbach H Schepelmann D Albes JM | 1999 | Anat Rec1999，255，： | 1 |
| 7 | Menstrual Variation in Experimental Pain: Correlation with Gonadal Hormones显示文摘 | Teepker M Peters M Vedder H Schepelmann K Lautenbacher S | 2010 | Neuropsychobiology2010，，3： | 1 |
| 8 | Options for broadening and deepening the LCA approaches显示文摘 | JESWANI H K AZAPAGIC A SCHEPELMANN P | 2010 | Journal of Cleaner Production2010，18，2： | 1 |
| 9 | Viral vectors for gene-directed en- zyme prodmg therapy 显示文摘 | Schepelmann S Springer CJ | 2006 | Curr Gene Thor2006，6，6： | 1 |
| 10 | Emerging roles of the extracellular calcium-sensing receptor in nutrient sensing: control of taste modulation and intestinal hormone secretion显示文摘 | Sarah C. Brennan Thomas S. Davies Martin Schepelmann Daniela Riccardi | 2014 | British Journal of Nutrition2014，，1： | 1 |
| 11 | Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma显示文摘 | Polina L. Yarova Alecia L. Stewart Venkatachalem Sathish Rodney D. Britt Michael A. Thompson Alexander P. P. Lowe Michelle Freeman Bharathi Aravamudan Hirohito Kita Sarah C. Brennan Martin Schepelmann Thomas Davies Sun Yung Zakky Cholisoh Emma J. Kidd Wil | 2015 | Science Translational Medicine . 2015 (284)2015，，284： | 1 |
| 12 | The calcium‐sensing receptor: one of a kind显示文摘 | Irene Lopez‐Fernandez Martin Schepelmann Sarah C. Brennan Polina L. Yarova Daniela Riccardi | 2015 | Exp Physiol2015，，12： | 1 |
| 13 | Viral vectors for gene-directed enzyme prodrug therapy显示文摘 | Schepelmann S Springer CJ | 2006 | Curr Gene Ther2006，6，6： | 1 |
| 14 | Pulmona- ry ischemia/reperfusion injury: a quantitative study of structure and function in isolated heart-lungs of the rat 显示文摘 | Fehrenbach H Schepelmann D Albes J M | 1999 | Anat Rec1999，258，1： | 1 |
| 15 | Etiology and diagnostics of headaches and facial pain from the neurological point of view 显示文摘 | Teepker M Schepelmann K | 2007 | HNO2007，55，52： | 1 |
| 16 | Options for broadening and deepening the ICA approaches显示文摘 | Jeswani H K Azapagic A Schepelmann P | | 0，，18： | 1 |
| 17 | Pulmonary ischemia/reperfusion injury: a quantitative study of structure and function in isolated heart-lungs of the rat 显示文摘 | FEHRENBACH H SCHEPELMANN D ALBES JM | 1999 | Anat Rec1999，255，1： | 1 |
| 18 | Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2显示文摘 | Schepelmann S Ogilvie LM Hedley D | 2007 | Cancer Res2007，67，10： | 1 |
| 19 | Viral vectors for gene-directed enzymeprodrug therapy显示文摘 | Schepelmann S Springer CJ | 2006 | Curr Gene Ther2006，6，6： | 1 |
| 20 | Investigation of porcine circovirus contamination in human vaccines显示文摘 | Sarah M. Gilliland Lindsay Forrest Heather Carre Adrian Jenkins Neil Berry Javier Martin Philip Minor Silke Schepelmann | 2012 | Biologicals2012，，4： | 1 |
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