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| 1 | Wnt/b-catenin signaling plays an ever-expanding role in stem cell self-renewal,tumorigenesis and cancer chemoresistance显示文摘Wnt signaling transduces evolutionarily conserved pathways which play important roles in initiating and regulating a diverse range of cellular activities,including cell proliferation,calcium homeostasis,and cell polarity.The role of Wnt signaling in controlling cell proliferation and stem cell self-renewal is primarily carried out through the canonical pathway,which is the best-characterized the multiple Wnt signaling branches.The past 10 years has seen a rapid expansion in our understanding of the complexity of this pathway,as many new components of Wnt signaling have been identified and linked to signaling regulation,stem cell functions,and adult tissue homeostasis.Additionally,a substantial body of evidence links Wnt signaling to tumorigenesis of cancer types and implicates it in the development of cancer drug resistance.Thus,a better understanding of the mechanisms by which dysregulation of Wnt signaling precedes the development and progression of human cancer may hasten the development of pathway inhibitors to augment current therapy.This review summarizes and synthesizes our current knowledge of the canonical Wnt pathway in development and disease.We begin with an overview of the components of the canonical Wnt signaling pathway and delve into the role this pathway has been shown to play in stemness,tumorigenesis,and cancer drug resistance.Ultimately,we hope to present an organized collection of evidence implicating Wnt signaling in tumorigenesis and chemoresistance to facilitate the pursuit of Wnt pathway modulators that may improve outcomes of cancers in which Wnt signaling contributes to aggressive disease and/or treatment resistance. | Maryam K.Mohammed Connie Shao Jing Wang Qiang Wei Xin Wang Zachary Collier Shengli Tang Hao Liu Fugui Zhang Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Lewis L.Shi Aravind Athiviraham Tong-Chuan He Michael J.Lee | 2016 | Genes & Diseases2016，3，1： | 70 |
| 2 | Multifaceted signaling regulators of chondrogenesis:Implications in cartilage regeneration and tissue engineering显示文摘Defects of articular cartilage present a unique clinical challenge due to its poor self-healing capacity and avascular nature.Current surgical treatment options do not ensure consistent regeneration of hyaline cartilage in favor of fibrous tissue.Here,we review the current understanding of the most important biological regulators of chondrogenesis and their interactions,to provide insight into potential applications for cartilage tissue engineering.These include various signaling pathways,including fibroblast growth factors(FGFs),transforming growth factor b(TGF-b)/bone morphogenic proteins(BMPs),Wnt/b-catenin,Hedgehog,Notch,hypoxia,and angiogenic signaling pathways.Transcriptional and epigenetic regulation of chondrogenesis will also be discussed.Advances in our understanding of these signaling pathways have led to promising advances in cartilage regeneration and tissue engineering. | Jordan D.Green Viktor Tollemar Mark Dougherty Zhengjian Yan Liangjun Yin Jixing Ye Zachary Collier Maryam K.Mohammed Rex C.Haydon Hue H.Luu Richard Kang Michael J.Lee Sherwin H.Ho Tong-Chuan He Lewis L.Shi Aravind Athiviraham | 2015 | Genes & Diseases2015，2，4： | 9 |
| 3 | 单片机双语教学课程建设的实践探索显示文摘针对我国高校双语教学的现状,结合我校'单片机原理及应用'双语教学示范课程建设实际,我院从单片机双语教学课程的教材建设、教学模式选择、教学中英语使用程度的把握、网络信息技术手段在双语教学中的应用以及成绩考核等方面对该类双语课程建设进行了研究与实践。这种探索对此类课程的双语教学建设与发展起到了积极作用,为探索符合我国实际情况的双语教学之路提供了实践例证。 | 孙秀娟 刘法胜 Michael Collier 郭银景 黄鹤松 | 2010 | 电气电子教学学报2010，32，4： | 7 |
| 4 | Repeat endoscopic retrograde cholangiopancreaticography after failed initial precut sphincterotomy for biliary cannulation显示文摘AIM: To investigate the outcome of repeating endoscopic retrograde cholangiopancreaticography(ERCP) after initially failed precut sphincterotomy to achieve biliary cannulation.METHODS: In this retrospective study, consecutive ERCPs performed between January 2009 and September 2012 were included. Data from our endoscopy and radiology reporting databases were analysed for use of precut sphincterotomy, biliary access rate, repeat ERCP rate and complications. Patients with initially failed precut sphincterotomy were identified.RESULTS: From 1839 consecutive ERCPs, 187(10%) patients underwent a precut sphincterotomy during the initial ERCP in attempts to cannulate a native papilla. The initial precut was successful in 79/187(42%). ERCP was repeated in 89/108(82%) of patients with failed initial precut sphincterotomy after a median interval of 4 d, leading to successful biliary cannulation in 69/89(78%). In 5 patients a third ERCP was attempted(successful in 4 cases). Overall, repeat ERCP after failed precut at the index ERCP was successful in 73/89 patients(82%). Complications after precut-sphincterotomy were observed in 32/187(17%) patients including pancreatitis(13%), retroperitoneal perforations(1%), biliary sepsis(0.5%) and haemorrhage(3%).CONCLUSION: The high success rate of biliary cannulation in a second attempt ERCP justifies repeating ERCP within 2-7 d after unsuccessful precut sphincterotomy before more invasive approaches should be considered. | Michael Pavlides Ashley Barnabas Nilesh Fernandopulle Adam A Bailey Jane Collier Jane Phillips-Hughes Anthony Ellis Roger Chapman Barbara Braden | 2014 | World Journal of Gastroenterology2014，20，36： | 3 |
| 5 | Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease显示文摘 | Rajarshi Banerjee Michael Pavlides Elizabeth M. Tunnicliffe Stefan K. Piechnik Nikita Sarania Rachel Philips Jane D. Collier Jonathan C. Booth Jurgen E. Schneider Lai Mun Wang David W. Delaney Ken A. Fleming Matthew D. Robson Eleanor Barnes Stefan Neubaue | 2014 | Journal of Hepatology2014，，1： | 2 |
| 6 | An Empirical Study of Collaborative Acoustic Source Localization显示文摘 | Andreas Mantik Ali Shadnaz Asgari Travis C. Collier Michael Allen Lewis Girod Ralph E. Hudson Kung Yao Charles E. Taylor Daniel T. Blumstein | 2009 | Journal of Signal Processing Systems2009，，3： | 1 |
| 7 | Experiences creating three implementations of the repast agent modeling toolkit显示文摘 | Michael J North Nicholson T Collier Jerry R Vos | 2006 | ACM Transactions on Modeling and Computer Simulation2006，16，1： | 1 |
| 8 | Growth and aggregation rates for calcite and calcium oxalate monohydrate显示文摘 | Alan P Collier Michael J Hounslow | 1999 | AIChE J1999，45，11： | 1 |
| 9 | Signal processing for PSoC based PIR motion detection显示文摘A signal processing scheme for a programmable system-on-chip(PSoC)based human body infrared tracking system is described.The purpose of this project is to convert the analog signal from a passive infrared(PIR)sensor to a digital signal which will be used to calculate the correct position of a human body.This paper covers the analog design with PSoC,the analog to digital conversion and the software to eliminate noise. | 王乾 Michael Collier | 2012 | Journal of Measurement Science and Instrumentation2012，3，3： | 1 |
| 10 | Agonistic Autoantibodies as Vasodilators in Orthostatic Hypotension: A New Mechanism显示文摘 | Hongliang Li David C. Kem Sean Reim Muneer Khan Megan Vanderlinde-Wood Caitlin Zillner Daniel Collier Campbell Liles Michael A. Hill Madeleine W. Cunningham Christopher E. Aston Xichun Yu | 2012 | 2012 (2 Su)2012，，2： | 1 |
| 11 | The role of dust in supplying nitrogen and phosphorus to the Southeast Mediterra- nean显示文摘 | Herut Barak Collier Robert Krom Michael D | 2002 | Limnology and Oceanography2002，47，3： | 1 |
| 12 | Complex adaptive systems modeling with Repast Simphony显示文摘 | Michael J North Nicholson T Collier Jonathan Ozik Eric R Tatara Charles M Macal Mark Bragen Pam Sydelko | 2013 | Complex Adaptive Systems Modeling2013，，1： | 1 |
| 13 | Chemerin Is Associated with Metabolic Syndrome Phenotypes in a Mexican-American Population显示文摘 | Kiymet Bozaoglu David Segal Katherine A. Shields Nik Cummings Joanne E. Curran Anthony G. Comuzzie Michael C. Mahaney David L. Rainwater John L. VandeBerg Jean W. MacCluer Greg Collier John Blangero Ken Walder Jeremy B.M. Jowett | 2009 | The Journal of Clinical Endocrinology & Metabolism2009，，8： | 1 |
| 14 | Agonistic Autoantibodies as Vasodilators in Orthostatic Hypotension: A New Mechanism显示文摘 | Hongliang Li David C. Kem Sean Reim Muneer Khan Megan Vanderlinde-Wood Caitlin Zillner Daniel Collier Campbell Liles Michael A. Hill Madeleine W. Cunningham Christopher E. Aston Xichun Yu | 2012 | Hypertension . 2012 (2 Su)2012，，2： | 1 |
| 15 | Experiences Creating Three Implementations of the Repast Agent Modeling Tool-kit 显示文摘 | Michael J North Nicholson T Collier and Jerry R Vos | 2006 | ACM Transactions on Modeling and Computer Simulation2006，16，1： | 1 |
| 16 | A Programmable Timing System for Debating Training and Competitions显示文摘A piece of equipment designed under a multi-disciplinary project in Shandong University of Science and Technology is described.The purpose is to indicate speech-time status to speakers in debates by presenting a three-light output The speech length may be programmed by the user with a combination of buttons and LCD display.The system is portable and microcontroller-based,using on-chip timers for accurate measurement of durations. | Michael Collier Pamela Collier | 2010 | Journal of Measurement Science and Instrumentation2010，1，S1： | 1 |
| 17 | The Conversion of a Zimbabwean Processing Plant from Manual to Smart Operation显示文摘The automation of several key processes in a factory in Zimbabwe is described.The plant is a producer of bolts and nails for the southern Africa region.Being built in the 1950s,the equipment was intended for manual operation.To improve efficiency and reduce overhead costs, this project was commissioned to add electronic intelligence to some of the processing equipment.In particular the conversion of forging furnaces to computer control and the intelligent implementation of heat-treatment processes are described.Results of the project in economic and quality terms are presented. | Michael Collier Ernest Bhero | 2010 | Journal of Measurement Science and Instrumentation2010，1，S1： | 1 |
| 18 | Estimating the subsolar magnetopause position from soft X-ray images using a low-pass image filter显示文摘The Lunar Environment heliospheric X-ray Imager(LEXI)and Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)missions will image the Earth’s dayside magneto pause and cusps in soft X-rays after their respective launches in the near future,to specify glo bal magnetic reconnection modes for varying solar wind conditions.To suppo rt the success of these scientific missions,it is critical to develop techniques that extract the magnetopause locations from the observed soft X-ray images.In this research,we introduce a new geometric equation that calculates the subsolar magnetopause position(RS)from a satellite position,the look direction of the instrument,and the angle at which the X-ray emission is maximized.Two assumptions are used in this method:(1)The look direction where soft X-ray emissions are maximized lies tangent to the magnetopause,and(2)the magnetopause surface near the subsolar point is almost spherical and thus RSis nea rly equal to the radius of the magneto pause curvature.We create synthetic soft X-ray images by using the Open Geospace General Circulation Model(OpenGGCM)global magnetohydrodynamic model,the galactic background,the instrument point spread function,and Poisson noise.We then apply the fast Fourier transform and Gaussian low-pass filte rs to the synthetic images to re move noise and obtain accurate look angles for the soft X-ray pea ks.From the filte red images,we calculate RS and its accuracy for different LEXI locations,look directions,and solar wind densities by using the OpenGGCM subsolar magnetopause location as ground truth.Our method estimates RS with an accuracy of<0.3 RE when the solar wind density exceeds>10 cm-3.The accuracy improves for greater solar wind densities and during southward interplanetary magnetic fields.The method ca ptures the magnetopause motion during southwa rd interplaneta ry magnetic field turnings.Consequently,the technique will enable quantitative analysis of the magnetopause motion and help reveal the dayside reconnection modes for dynamic solar wind conditions.This technique will suppo rt the LEXI and SMILE missions in achieving their scientific o bjectives. | Hyangpyo Kim Hyunju K.Connor Jaewoong Jung Brian M.Walsh David Sibeck Kip D.Kuntz Frederick S.Porter Catriana K.Paw U Rousseau A.Nutter Ramiz Qudsi Rumi Nakamura Michael Collier | 2024 | Earth and Planetary Physics2024，8，1： | 1 |
| 19 | Recurrent lymphoma presenting as painless, chronic intussusception: A case report显示文摘BACKGROUND The clinical presentation of acute lymphoblastic lymphoma is highly varied.While prognosis is good, recurrence of disease can occur. Gastrointestinal relapse, including intussusception, is well-described but the absence of abdominal pain in this setting is rare.CASE SUMMARY We report a 13-year-old male with B-cell precursor acute lymphoblastic leukemia in remission presenting with anemia and weight loss. Examination was significant for absence of abdominal pain, but a stool sample was positive for occult blood. Pan-endoscopy was performed with colonoscopy revealing a mass filling the colonic lumen. Biopsy of the mass confirmed recurrence of recurrent Bcell lymphoma. Computed tomography scan revealed ileocolic intussusception resulting from the tumor. This case is unusual in that the patient had no abdominal pain despite the presence of intussusception.CONCLUSION While intestinal involvement with lymphoma has been well described in the literature, presentation as painless intussusception has not been reported. This case report highlights the wide spectrum of clinical manifestations of recurrent Bcell lymphoma involving the gastrointestinal tract, in particular the near absence of symptoms despite the finding of intussusception. | Parker Giroux Anderson Collier Michael Nowicki | 2020 | World Journal of Clinical Cases2020，8，2： | 1 |
| 20 | 数字电视NAND Flash驱动程序的设计与实现显示文摘随着全球电视数字广播的发展,数字电视已然成为市场的主流,集成模拟和数字电视信源解码和高端后处理能力的SOC核心处理器芯片具有广阔的市场前景。NAND Flash作为一种大容量的存储设备,满足了数字电视嵌入式系统对功耗、体积、成本及抗震性的苛刻要求,因而得到了广泛的应用。该论文主要探讨NAND Flash设备在数字电视中的工作原理以及基于Linux系统框架下的NAND Flash驱动程序的设计与实现。 | 李洋 Michael Collier | 2012 | 电脑知识与技术2012，8，1： | 1 |
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