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| 1 | Multifaceted signaling regulators of chondrogenesis:Implications in cartilage regeneration and tissue engineering显示文摘Defects of articular cartilage present a unique clinical challenge due to its poor self-healing capacity and avascular nature.Current surgical treatment options do not ensure consistent regeneration of hyaline cartilage in favor of fibrous tissue.Here,we review the current understanding of the most important biological regulators of chondrogenesis and their interactions,to provide insight into potential applications for cartilage tissue engineering.These include various signaling pathways,including fibroblast growth factors(FGFs),transforming growth factor b(TGF-b)/bone morphogenic proteins(BMPs),Wnt/b-catenin,Hedgehog,Notch,hypoxia,and angiogenic signaling pathways.Transcriptional and epigenetic regulation of chondrogenesis will also be discussed.Advances in our understanding of these signaling pathways have led to promising advances in cartilage regeneration and tissue engineering. | Jordan D.Green Viktor Tollemar Mark Dougherty Zhengjian Yan Liangjun Yin Jixing Ye Zachary Collier Maryam K.Mohammed Rex C.Haydon Hue H.Luu Richard Kang Michael J.Lee Sherwin H.Ho Tong-Chuan He Lewis L.Shi Aravind Athiviraham | 2015 | Genes & Diseases2015，2，4： | 9 |
| 2 | Analysis of gateroad stability at two longwall mines based on field monitoring results and numerical model analysis显示文摘Coal mine longwall gateroads are subject to changing loading conditions induced by the advancing longwall face. The ground response and support requirements are closely related to the magnitude and orientation of the stress changes, as well as the local geology. This paper presents the monitoring results of gateroad response and support performance at two longwall mines at a 180-m and 600-m depth of cover.At the first mine, a three-entry gateroad layout was used. The second mine used a four-entry, yieldabutment-yield gateroad pillar system. Local ground deformation and support response were monitored at both sites. The monitoring period started during the development stage and continued during first panel retreat and up to second panel retreat. The two data sets were used to compare the response of the entries in two very different geotechnical settings and different gateroad layouts. The monitoring results were used to validate numerical models that simulate the loading conditions and entry response for these widely differing conditions. The validated models were used to compare the load path and ground response at the two mines. This paper demonstrates the potential for numerical models to assist mine engineers in optimizing longwall layouts and gateroad support systems. | Gabriel S.Esterhuizen David F.Gearhart Ted Klemetti Heather Dougherty Mark van Dyke | 2019 | International Journal of Mining Science and Technology2019，29，1： | 5 |
| 3 | Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis显示文摘 | Liu Weicheng Chen Yunzi Golan Maya Aharoni Annunziata Maria L Du Jie Dougherty Urszula Kong Juan Musch Mark Huang Yong Pekow Joel Zheng Changqing Bissonnette Marc Hanauer Stephen B Li Yan Chun | 2013 | Journal of Clinical Investigation2013，，9： | 2 |
| 4 | Condition Monitoring of Wooden Railway Sleepers显示文摘 | SIRIL Yella MARK Dougherty NARENDRAK Gupta | | 0，，： | 1 |
| 5 | Combining Kohonen maps with ARIMA time series models to forecast traffic flow 显示文摘 | Mascha Dougherty Mark Watson Susan | 1996 | Transportation Research Part C:Emerging Technologies v 4 n 5 Oct1996，1996，： | 1 |
| 6 | Assessing the Status of Onsite Wastewater Treatment Systems in the Alabama Black Belt Soil Area显示文摘 | Jiajie He Mark Dougherty Richard Zellmer | 2011 | Environmental Engineering Science2011，28，10： | 1 |
| 7 | The influence of hospital and surgeon volume on in-hospital mortality for colectomy, gastrectomy, and lung lobectomy in patients with cancer显示文摘 | Edward L Hannan Mark Radzyner David Rubin James Dougherty Murray F Brennan | 2002 | Surgery2002，，1： | 1 |
| 8 | Should we use neural networks or statistical models for short-term motorway traffic forecasting?显示文摘 | Howard R. Kirby Susan M. Watson Mark S. Dougherty | 1997 | International Journal of Forecasting1997，，1： | 1 |
| 9 | Combining kohonen maps with ARIMA time series models to forecast traffic flow显示文摘 | Maschavan Der Voort Mark Dougherty Susan Watson | 1996 | Transportation Research Part C1996，4，5： | 1 |
| 10 | Assessing support alternatives for longwall gateroads subject to changing stress显示文摘Longwall gateroad entries are subject to changing horizontal and vertical stress induced by redistribution of loads around the extracted panel.The stress changes can result in significant deformation of the entries that may include roof sag,rib dilation,and floor heave.Mine operators install different types of supports to control the ground response and maintain safe access and ventilation of the longwall face.This paper describes recent research aimed at quantifying the effect of longwall-induced stress changes on ground stability and using the information to assess support alternatives.The research included monitoring of ground and support interaction at several operating longwall mines in the U.S.,analysis and calibration of numerical models that adequately represent the bedded rock mass,and observation of the support systems and their response to changes in stress.The models were then used to investigate the impact of geology and stress conditions on ground deformation and support response for various depths of cover and geologic scenarios.The research results were summarized in two regression equations that can be used to estimate the likely roof deformation and height of roof yield due to longwall-induced stress changes.This information is then used to assess the ability of support systems to maintain the stability of the roof.The application of the method is demonstrated with a retrospective analysis of the support performance at an operating longwall mine that experienced a headgate roof fall.The method is shown to produce realistic estimates of gateroad entry stability and support performance,allowing alternative support systems to be assessed during the design and planning stage of longwall operations. | Gabriel S.Esterhuizen I.Berk Tulu Dave F.Gearhart Heather Dougherty Mark Van Dyke | 2021 | International Journal of Mining Science and Technology2021，31，1： | 0 |
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