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| 1 | Efficacy and safety of granulocyte, monocyte/macrophage adsorptive in pediatric ulcerative colitis显示文摘AIM: To investigate efficacy and safety for granulocyte, monocyte apheresis in a population of pediatric patients with ulcerative colitis.METHODS: The ADAPT study was a prospective, openlabel, multicenter study in pediatric patients with moderate, active ulcerative colitis with pediatric ulcerative colitis activity index(PUCAI) of 35-64. Patients received one weekly apheresis with Adacolumn granulocyte, monocyte/macrophage adsorptive(GMA) apheresis over 5 consecutive weeks, optionally followed by up to 3 additional apheresis treatments over 3 consecutive weeks. The primary endpoint was the change in mean PUCAI between baseline and week 12; the secondary endpoint was improvement in PUCAI categorized as(Significant Improvement, PUCAI decrease of ≥ 35), Moderate Improvement(PUCAI decrease of 20 < 35), Small Improvement(PUCAI decrease of 10 < 20) or No change(PUCAI decrease of < 10). RESULTS: Twenty-five patients(mean age 13.5 years; mean weight 47.7 kg) were enrolled. In the intention-to-treat set(ITT), the mean value for PUCAI improvement was 22.3 [95%CI: 12.9-31.6; n = 21]. In the per-protocol(PP) set, the mean improvement was 36.3 [95%CI: 31.4-41.1; n = 8]. Significant Improvement was recorded for 9 out of 20 patients(45%); 5 out of 20 patients(25%) had Moderate Improvement and one patient(5%) had No Change in PUCAI score at week 12. In the PP set, six out of eight patients(75%) showed Significant Improvement; and in two out of eight patients(25%) Moderate Improvement was recorded. The endoscopic activity index(EAI) decreased by 3 points on average. Seven(7) out of 21(33%) patients in ITT and 4 out of 8(50%) patients in PP have used steroids during the clinical investigation. The mean steroid dosage for these patients in the ITT set decreased from a mean 12.4 mg to 10 mg daily on average from Baseline to week 12.CONCLUSION: Adacolumn; GMA apheresis treatment was effective in pediatric patients with moderate active Ulcerative Colitis. No new safety signals were reported. The present data contribute to considering GMA apheresis as a therapeutic option in pediatric patients having failed first line therapy. | Tarja Ruuska Peter Küster Lena Grahnquist Fredrik Lindgren Anne Vibeke Wewer | 2016 | World Journal of Gastroenterology2016，22，17： | 3 |
| 2 | A new governance approach for multi-firm projects: Lessons from Olkiluoto 3 and Flamanville 3 nuclear power plant projects显示文摘 | Inkeri Ruuska Tuomas Ahola Karlos Artto Giorgio Locatelli Mauro Mancini | 2010 | International Journal of Project Management2010，，6： | 2 |
| 3 | Upper gastrointestinal endoscopy in recurrent abdominal pain of childhood显示文摘 | Maki M Ruuska T etal | 1993 | J Pediatr gastroenterol Nutr1993，16，： | 1 |
| 4 | Leucocyte apheresis in the treatment of paediatric ulcerative colitis显示文摘 | Tarja Ruuska Marja-Leena L? hdeaho Yelda Sutas Merja Ashorn Juhani Gr? nlund | 2007 | Scandinavian Journal of Gastroenterology2007，，11： | 1 |
| 5 | Early development of human gastric H,K-adenosine triphosphatase显示文摘 | Grahnquist L Ruuska T Finkel Y | 2000 | J Pediatr Gast roenterol Nutr2000，30，5： | 1 |
| 6 | Normal C3b receptor ( CR1 ) genomic polymor-phism in patients with insulin-dependent diabetesmellitus( IDDM ) : is the low erythrocyte CR1 expression an acquired phenomenon 显示文摘 | Ruuska PE Ikaheimo I Silvennoinen-Kassinen S etal | 1992 | Clin Exp Immu-nol1992，89，1： | 1 |
| 7 | Distinct roles for cellular retinoic acid-binding proteins Ⅰ and Ⅱ in regulating signaling by retinoic acid显示文摘 | Dong D Ruuska SE Levinthal DJ | 1999 | Biol Chem1999，274，23： | 1 |
| 8 | Characteristics of knowledge sharing communities in project organizations 显示文摘 | Ruuska I Vartiainen M | 2005 | International Journal of Project Management2005，23，5： | 1 |
| 9 | Electron flow to oxygen in higher plants and algae: rates and conrol of direct photoreduction (Mehler reaction) and rubisco oxygenase显示文摘 | Bader M R Ruuska S Nakano H | 2000 | Biological Sciences2000，1402，： | 1 |
| 10 | Implementing the replication strategy in uncertain and complex investment projects显示文摘 | RUUSKA I BRADY T | 2011 | International Journal of Project Management2011，29，4： | 1 |
| 11 | Electron flow to oxygen in higher plants and algae:Rates and con- trol of direct photoreduetion(Mehler reaction) and rubisco oxygenase显示文摘 | Badger M R Von Caemmerer S Ruuska S Nakano H | 2000 | Biological Sciences2000，355，： | 1 |
| 12 | Rectal bleeding in infancy:clinical,allergological,and microbiological examination显示文摘 | Arvola T Ruuska T Keranen J | 2006 | Pediatrics2006，117，4： | 1 |
| 13 | Electron flow to oxygen in higher plants and algae: rates and conrol of direct photoreduction (Mehler reaction) and rubisco oxygenase显示文摘 | Bader M R Ruuska S Nakano H | 2000 | Biological Sciences2000，1402，： | 1 |
| 14 | Rotavirus disease in Finnish children: use of numerical scores for clinical severity of diarrhoeal epi- sodes 显示文摘 | Ruuska T Vesikari T | 1990 | Scand J Infect Dis1990，22，3： | 1 |
| 15 | A new governance ap- proach for multi-firm projects : lessons from Olkiluoto 3 and Flamanville 3 nuclear power plant projects 显示文摘 | Ruuska I Ahola T Artto K | 2011 | International Journal of Project Management2011，29，6： | 1 |
| 16 | Large scale transcriptome analysis of the effects of nitrogen nutrition on accumulation of stem carbohydrate reserves in repro- ductive stage wheat显示文摘 | Ruuska S A Lewis D C Kennedy G | 2008 | Plant Molecular Biology2008，66，： | 1 |
| 17 | Electron flow to oxygen in higher plants and algae:rates and control of direct photoreduction(Mehler reaction)and rubisco oxygenase显示文摘 | Bader M R Caemmerer S Ruuska S | 2000 | Biol Sci2000，355，1402： | 1 |
| 18 | Rectal bleeding in infancy:clinical,allergological,and microbiological examination显示文摘 | Arvola T Ruuska T Keranen J | 2006 | Pediatrics2006，117，： | 1 |
| 19 | Early development of human gastric H, K-adenosine triphosphatase 显示文摘 | Grahnquist L Ruuska T Finkel Y | 2000 | J Pediatr Gastroenterol Nutr2000，30，5： | 1 |
| 20 | Acquired myopathic intestinal pseudo-obstruction may be due to autoimmune enteric leiomyositis 显示文摘 | Ruuska TH Karikoski R Smith VV | 2002 | Gastroenterology2002，122，4： | 1 |
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