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| 1 | 外伤性脾破裂317例诊治分析显示文摘目的探讨在条件有限的基层医院中脾破裂患者的诊疗方法。方法回顾性分析瓦努阿图共和国维拉中心医院8年间住院的317例脾破裂患者的临床资料,分析B超诊断的出血情况和非手术治疗、手术治疗的结果。结果B超诊断被膜下出血者30例,真性脾破裂者287例。参考B超结果对29例患者采用非手术治疗,288例采用手术治疗。结论B超诊断脾破裂阳性率高,诊断出血量与手术结果较符合;参考B超结果选择符合脾切除术指征的病例进行手术是治疗脾破裂确切有效的手段。 | 李亿程 王巍 唐健雄 袁祖荣 Santus Wari | 2005 | 中国普通外科杂志2005，14，7： | 10 |
| 2 | The role of chemosensory protein 10 in the detection of behaviorally active compounds in brown planthopper, Nilaparvata lugens显示文摘Chemosensory proteins(CSPs)play important roles in insects’chemoreception,although their specific functional roles have not been fully elucidated.In this study,we conducted the developmental expression patterns and competitive binding assay as well as knock‐down assay by RNA interference both in vitro and in vivo to reveal the function of NlugCSP10 from the brown planthopper(BPH),Nilaparvata lugens(Stål),a major pest in rice plants.The results showed that NlugCSP10 messenger RNA was significantly higher in males than in females and correlated to gender,development and wing forms.The fluorescence binding assays revealed that NlugCSP10 exhibited the highest binding affinity with cis‐3‐hexenyl acetate,eicosane,and(+)‐β‐pinene.Behavioral assay revealed that eicosane displayed attractant activity,while cis‐3‐hexenyl acetate,similar to(+)‐β‐pinene significantly repelled N.lugens adults.Silencing of NlugCSP10,which is responsible for cis‐3‐hexenyl acetate binding,significantly disrupted cis‐3‐hexenyl acetate communication.Overall,findings of the present study showed that NlugCSP10 could selectively interrelate with numerous volatiles emitted from host plants and these ligands could be designated to develop slow‐release mediators that attract/repel N.lugens and subsequently improve the exploration of plans to control this insect pest. | Muhammad Irfan Waris Aneela Younas Muhammad Muzammal Adeel Shuang-Gang Duan Sundas Rana Quershi Rana Muhammad Kaleem Ullah Man-Qun Wang | 2020 | Insect Science2020，27，3： | 9 |
| 3 | Hepatitis C virus NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis显示文摘AIM: To investigate the mechanisms of insulin resistance in human hepatoma cells expressing hepatitis C virus(HCV) nonstructural protein 5A(NS5A).METHODS: The human hepatoma cell lines,Huh7 and Huh7.5,were infected with HCV or transientlytransfected with a vector expressing HCV NS5 A. The effect of HCV NS5 A on the status of the critical players involved in insulin signaling was analyzed using realtime quantitative polymerase chain reaction and Western blot assays. Data were analyzed using Graph Pad Prism version 5.0.RESULTS: To investigate the effect of insulin treatment on the players involved in insulin signaling pathway,we analyzed the status of insulin receptor substrate-1(IRS-1) phosphorylation in HCV infected cells or Huh7.5 cells transfected with an HCV NS5 A expression vector. Our results indicated that there was an increased phosphorylation of IRS-1(Ser307) in HCV infected or NS5 A transfected Huh7.5 cells compared to their respective controls. Furthermore,an increased phosphorylation of Akt(Ser473) was observed in HCV infected and NS5 A transfected cells compared to their mock infected cells. In contrast,we observed decreased phosphorylation of Akt Thr308 phosphorylation in HCV NS5 A transfected cells. These results suggest that Huh7.5 cells either infected with HCV or ectopically expressing HCV NS5 A alone have the potential to induce insulin resistance by the phosphorylation of IRS-1 at serine residue(Ser307) followed by decreased phosphorylation of Akt Thr308,Fox01 Ser256 and GSK3β Ser9,the downstream players of the insulin signalingpathway. Furthermore,increased expression of PECK and glucose-6-phosphatase,the molecules involved in gluconeogenesis,in HCV NS5 A transfected cells was observed.CONCLUSION: Taken together,our results suggest the role of HCV NS5 A in the induction of insulin resistance by modulating various cellular targets involved in the insulin signaling pathway. | Fahed Parvaiz Sobia Manzoor Jawed Iqbal Mehuli Sarkar-Dutta Muhammad Imran Gulam Waris | 2015 | World Journal of Gastroenterology2015，21，43： | 7 |
| 4 | C-reactive protein and seizures in focal epilepsy:A video-electroencephalographic study显示文摘 | Alapirtti T Waris M Fallah M | 2012 | Epilepsia2012，53，5： | 1 |
| 5 | Human hepatitis C virus NS5A protein alters intracellular calcium levels,induces oxidative stress,and activates STAT-3 and NF-κB显示文摘 | Gong G Waris G Tanveer R | 2001 | Proc Natl Acad Sci USA2001，98，17： | 1 |
| 6 | Is there a rationale for prescription of benzodiazepines in the elderly?Review of the literature显示文摘 | Petrovic M Mariman A Warie H | 2003 | Acta Clin Belg2003，58，1： | 1 |
| 7 | Etiology of communityacquired pneumonia in 254 hospitalized children 显示文摘 | Juven T Mertsola J Waris M | 2000 | Pediatr Infect Dis J2000，19，4： | 1 |
| 8 | Interf eron al- pha induct ion of STAT1 and STAT2 and their prog- nostic significance in carcinoid turnors显示文摘 | ZHOU Y WARY S GOBL A | 2001 | Oncolo-gy2001，60，： | 1 |
| 9 | Distinct roles of the adaptor protein She and focal adhesion kinase in integrin signaling to ERK显示文摘 | Barberis L Wary KK Fiucci G | 2000 | J Biol Chem2000，275，36： | 1 |
| 10 | Is there a rationale for prescription of benzodiazepines in the elderly? Review of the literature显示文摘 | Petrovic M Mariman A Warie H | 2003 | Acta Clin Belg2003，58，： | 1 |
| 11 | Prospects and Potential of Acid Methyl Esters of Some Non-Traditional Seed Oils for Use As Biodiesel in India显示文摘 | AZAM M M WARIS A NAHAR N M | | 0，，04： | 1 |
| 12 | Rhinovirus?associated wheezing in infancy: comparison with respiratory syncytial virus bronchiolitis显示文摘 | Korppi M Kotanierni-Syrjanen A Waris M | 2004 | Pediatr Infect DisJ2004，23，1： | 1 |
| 13 | Diagnosis of Mycoplasma pneumoniae pneumonia in children显示文摘 | Waris ME Toikka P Saarinen T | 1998 | J Clin Mierobiol1998，36，11： | 1 |
| 14 | Etiology of community-acquired pneumonia in 254 hospitalized children显示文摘 | TAINA JUVéN JUSSI MERTSOLA MATTI WARIS MAIJA LEINONEN OLLI MEURMAN MERJA ROIVAINEN JUSSI ESKOLA PEKKA SAIKKU OLLI RUUSKANEN | 2000 | The Pediatric Infectious Disease Journal2000，，： | 1 |
| 15 | Iramunogenicity of superoxlde radical modified-DNA: studies on induced antibodies and SLE anti-DNA autoantibodies显示文摘 | I Waris G Alam K | 2004 | Life Sci2004，75，22： | 1 |
| 16 | Priming with live respiratory syncytial virus(RSV) prevents the enhanced pulmonary inflammatory response seen after RSV challenge in Balb/c mice immunized with formalin-inactivated RSV显示文摘 | Waris Me Tsou C Erdman DD | 1997 | J Virol1997，71，： | 1 |
| 17 | Is there a rationale for prescription of benzodiazepines in the elderly? Review of the literature显示文摘 | Petrovic M Mariman A Warie H | 2003 | Acta Clin Belg2003，58，1： | 1 |
| 18 | Natural circulation studies in a lead bismuth eutectic loop显示文摘 | BOROHAIN A JAISWAL B K MAHESH- WARI N K | 2011 | Progress in Nu- clear Energy2011，53，4： | 1 |
| 19 | Macrophage2colony stimulating factor (M-CSF)is increased in the synovial-like membrane of the periprosthetic tissure in the aseptic loosening of total hip replacement (THR)显示文摘 | Konttinen YT Waris V | 1997 | Clin Rheumatol1997，16，： | 1 |
| 20 | Diagnosis of Mycoplasma pneumoniae pneumonia in children 显示文摘 | WARIS M E TOIKKA P SAARINFN T | 1998 | J Clin Microbiol1998，36，： | 1 |
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