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| 1 | Evaluation of brain tumor metabolism with [^(11)C] choline PET and ~1H-MRS.显示文摘BACKGROUND:The signal of choline containing compounds(Cho)in proton magnetic resonance spectroscopy(1H-MRS)is elevated in brain tumors.[11C]choline uptake as assessed using positron emission tomography(PET)has also been suggested to be higher in brain tumors than in the normal brain.We examined whetherquantitative analysis of choline accumulation and content using these 1wo novel techniques would be helpful innon-invasive,preoperative evaluation of suspected brain tumors and tumor malignancy grade.METHODS:12patients with suspected brain tumor were studied using[11C]choline PET,gadolinium enhanced 3-D magneticresonance imaging and1H-MRS prior to diagnostic biopsy or resection.Eleven normal subjects served as | Utriainen M Komu M Vuorinen V Lehikoinen P Sonninen P Kurki T Utriainen T Roivainen A Kalimo H Minn H | 2003 | 中国神经肿瘤杂志2003，1，2： | 8 |
| 2 | Effects of the viability of Lactobacillus rhamnosus GG on rotavirus infection in neonatal rats显示文摘AIM:To study the effects of live and dead Lactobacillus rhamnosus GG(GG) on rotavirus infection in a neonatal rat model.METHODS:At the age of 2 d,suckling Lewis rat pups were supplemented with either live or dead GG and the treatment was continued daily throughout the experi-ment.At the age of 5 and 6 d the pups received oral rotavirus(RV) SA-11 strain.The pups were sacrificed at the age of 7 or 8 d by decapitation.The gastrointestinal tract was removed and macroscopic observations were done.The consistency of feces in the colon was classified using a four-tier system.RV was detected from the plasma,small intestine,colon and feces by real-time quantitative polymerase chain reaction(PCR).RESULTS:In this neonatal rat model,RV induced a mild-to-moderate diarrhea in all except one pup of the RV-inoculated rats.RV moderately reduced body weight development from day 6 onwards.On day 7,after 2 d of RV infection,live and dead GG groups gained significantly more weight than the RV group without probiotics [36%(P = 0.001) and 28%(P = 0.031),respectively].In addition,when compared with the RV control group,both live and dead GG reduced the weight ratio of colon/animal body weight to the same level as in the healthy control group,with reductions of 22%(P = 0.002) and 28%(P < 0.001),respectively.Diarrhea increased moderately in both GG groups.However,the diarrhea incidence and severity in the GG groups were not statistically significantly different as compared with the RV control group.Moreover,observed diarrhea did not provoke weight loss or death.The RV control group had the largest amount of RV PCR-positive samples among the RV-infected groups,and the live GG group had the smallest amount.Rats receiving live GG had significantly less RV in the colon(P = 0.027) when compared with the RV control group.Live GG was also more effective over dead GG in reducing the quantity of RV from plasma(P = 0.047).CONCLUSION:Both live and dead GG have beneficial effects in RV infection.GG may increase RV clearance from the body and reduce colon swelling. | Hanna Ventola Liisa Lehtoranta Mari Madetoja Marja-Leena Simonen-Tikka Leena Maunula Merja Roivainen Riitta Korpela Reetta Holma | 2012 | World Journal of Gastroenterology2012，18，41： | 2 |
| 3 | Infections,Inflamma- tion, and the risk of coronary heart disease 显示文摘 | Roivainen M Kiik M Kajander MV | 2000 | Circula - tion2000，101，3： | 1 |
| 4 | Enterovirus, mycoplasma and other infections as predictors for myocardial infarction 显示文摘 | Reunanen A Roivainen M Kleemola M | 2002 | J Intern Med2002，252，5： | 1 |
| 5 | Providing Network Connectivity for Small Appliances: A Functionally Minimized Embedded Web Server 显示文摘 | Saaranen M J Roivainen J Soininen J P | 2001 | IEEE Communications2001，01，63680401： | 1 |
| 6 | ^68Ga-labeled Oligonucleotides for in Vivo Imaging With PET显示文摘 | ROIVAINEN A TOLVANEN T SALOMAKI S | 2004 | J Nucl Med2004，45，： | 1 |
| 7 | Antibodies to the vitronectin receptor ( integrin αvβ3 ) inhibit binding and infection of foot-andmouth disease virus to cultured calls显示文摘 | Berinstein A Roivainen M Hovi T | 1995 | J Virol1995，69，4： | 1 |
| 8 | Inflammation,and the risk of coronary heart disease显示文摘 | Roivainen M Kiik M Kajander MV | | 0，，04： | 1 |
| 9 | Highly divergent neurovirulent vaccine-derived polioviruses of all three serotypes are recurrently detected in Finnish sewage显示文摘 | Roivainen M Blomqvist S Al-Hello H | 2010 | Eure Surveill2010，15，19： | 1 |
| 10 | Blood metabolism of ^11C- choline,implications for in vivo imaging with positron emission tomography显示文摘 | Roivainen A forsback S Gronroos T | 2000 | Eur J Nucl Med2000，27，1： | 1 |
| 11 | Blood metabolism of[methyl-11C]choline;implications for in vivo imaging with positron emission tomography显示文摘 | ROIVAINEN A FORSBACK S GRONROOS T | | 0，，01： | 1 |
| 12 | Etiology of community-acquired pneumonia in 254 hospitalized children显示文摘 | TAINA JUVéN JUSSI MERTSOLA MATTI WARIS MAIJA LEINONEN OLLI MEURMAN MERJA ROIVAINEN JUSSI ESKOLA PEKKA SAIKKU OLLI RUUSKANEN | 2000 | The Pediatric Infectious Disease Journal2000，，： | 1 |
| 13 | Enterovirus,mycoplasma and other infections as predictors for myocardial infarction显示文摘 | Reunanen A Roivainen M Kleemola M | 2002 | J Intern Med2002，252，5： | 1 |
| 14 | Antibodies to the vitronectin receptor (integrin αvβ3 ) inhibit binding and infection of foot-and-mouth disease virus to cultured cells 显示文摘 | Berinstein A Roivainen M Hovi T | 1995 | J Virol1995，69，： | 1 |
| 15 | Specific induc- tion of protein kinase Ct3 subspecies after transient middle cere- bral artery occlusion in the rat brain: inhibition by MK-801 显示文摘 | Miettinen S Roivainen R Keinanen R | 1996 | J Neurosci1996，16，19： | 1 |
| 16 | Providing network connectivity for small appliances:A functionally minimized embedded web server显示文摘 | Mahonen P Saaranen M J Roivainen J Soininen J P | 2001 | IEEE Communications Magazine2001，39，10： | 1 |
| 17 | Antibodies to the vitrone- ctin receptor (integrin ct V β 3 ) inhibit binding and infection of foot-and- mouth diseatse vin*s to cuhured cells显示文摘 | BERINSTEIN A ROIVAINEN M HOVI T | 1995 | Journal of Virology1995，69，4： | 1 |
| 18 | Serum antibody response to periodontal pathogens and herpes simplex virus in relation to classic risk factors of cardiovascular disease显示文摘 | Vilkuna-Rautiainen T Pussinen PJ Roivainen M | 2006 | Int J Epidemiol2006，35，6： | 1 |
| 19 | Bloodmetabolism ofcholine;implicationsfor in vivo imaging with positron emissiontomography显示文摘 | Roivainen A Fomback S Gmnroons T et a1 | 2000 | Eur J Nucl Med2000，27，1： | 1 |
| 20 | Co-circulation of coxsackieviruses A6 and A10 in hand, foot and mouth disease outbreak in Finland显示文摘 | Soile Blomqvist P?ivi Klemola Svetlana Kaijalainen Anja Paananen Marja-Leena Simonen Tytti Vuorinen Merja Roivainen | 2010 | Journal of Clinical Virology2010，，1： | 1 |
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