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| 1 | Vascular endothelial dysfunction, cardiomyopathy a major mediator in diabetic cardiomyopathy显示文摘Diabetes mellitus is currently a major public health problem.A common complication of diabetes is cardiac dysfunction,which is recognized as a microvascular disease that leads to morbidity and mortality in diabetic patients.While ischemic events are commonly observed in diabetic patients,the risk for developing heart failure is also increased,independent of the severity of coronary artery disease and hypertension.This diabetes-associated clinical entity is considered a distinct disease process referred to as 'diabetic cardiomyopathy'.However,it is not clear how diabetes promotes cardiac dysfunction.Vascular endothelial dysfunction is thought to be one of the key risk factors.The impact of diabetes on the endothelium involves several alterations,including hyperglycemia,fatty acid oxidation,reduced nitric oxide (NO),oxidative stress,inflammatory activation,and altered barrier function. The current review provides an update on mechanisms that specifically target endothelial dysfunction,which may lead to diabetic cardiomyopathy. | Maura Knapp Xin Tu Rongxue Wu | 2019 | Acta Pharmacologica Sinica2019，40，1： | 34 |
| 2 | Role of Hox genes in stem cell differentiation显示文摘Hox genes are an evolutionary highly conserved gene family. They determine the anterior-posterior body axis in bilateral organisms and influence the developmental fate of cells. Embryonic stem cells are usually devoidof any Hox gene expression, but these transcription factors are activated in varying spatial and temporal patterns defining the development of various body regions. In the adult body, Hox genes are among others responsible for driving the differentiation of tissue stem cells towards their respective lineages in order to repair and maintain the correct function of tissues and organs. Due to their involvement in the embryonic and adult body, they have been suggested to be useable for improving stem cell differentiations in vitro and in vivo. In many studies Hox genes have been found as driving factors in stem cell differentiation towards adipogenesis, in lineages involved in bone and joint formation, mainly chondrogenesis and osteogenesis, in cardiovascular lineages including endothelial and smooth muscle cell differentiations, and in neurogenesis. As life expectancy is rising, the demand for tissue reconstruction continues to increase. Stem cells have become an increasingly popular choice for creating therapies in regenerative medicine due to their self-renewal and differentiation potential. Especially mesenchymal stem cells are used more and more frequently due to their easy handling and accessibility, combined with a low tumorgenicity and little ethical concerns. This review therefore intends to summarize to date known correlations between natural Hox gene expression patterns in body tissues and during the differentiation of various stem cells towards their respective lineages with a major focus on mesenchymal stem cell differentiations. This overview shall help to understand the complex interactions of Hox genes and differentiation processes all over the body as well as in vitro for further improvement of stem cell treatments in future regenerative medicine approaches. | Anne Seifert David F Werheid Silvana M Knapp Edda Tobiasch | 2015 | World Journal of Stem Cells2015，7，3： | 10 |
| 3 | High-flow nasal oxygen availability for sedation decreases the use of general anesthesia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasound显示文摘AIM To examine whether high-flow nasal oxygen(HFNO) availability influences the use of general anesthesia(GA) in patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) and endoscopic ultrasound(EUS) and associated outcomes.METHODS In this retrospective study, patients were stratified into 3 eras between October 1, 2013 and June 30, 2014 based on HFNO availability for deep sedation at the time of their endoscopy. During the first and last 3-mo eras(era 1 and 3), no HFNO was available, whereas it was an option during the second 3-mo era(era 2). The primary outcome was the percent utilization of GA vs deep sedation in each period. Secondary outcomes included oxygen saturation nadir during sedation between periods, as well as procedure duration, and anesthesia-only time between periods and for GA vs sedation cases respectively.RESULTS During the study period 238 ERCP or EUS cases were identified for analysis. Statistical testing was employed and a P < 0.050 was significant unless the Bonferroni correction for multiple comparisons was used. General anesthesia use was significantly lower in era 2 compared to era 1 with the same trend between era 2 and 3(P = 0.012 and 0.045 respectively). The oxygen saturation nadir during sedation was significantly higher in era 2 compared to era 3(P < 0.001) but not between eras 1 and 2(P = 0.028) or 1 and 3(P = 0.069). The procedure time within each era was significantly longer under GA compared to deep sedation(P ≤ 0.007) as was the anesthesia-only time(P ≤ 0.001).CONCLUSION High-flow nasal oxygen availability was associated with decreased GA utilization and improved oxygenation for ERCP and EUS during sedation. | Roman Schumann Nikola S Natov Klifford A Rocuts-Martinez Matthew D Finkelman Tom V Phan Sanjay R Hegde Robert M Knapp | 2016 | World Journal of Gastroenterology2016，22，47： | 9 |
| 4 | Proposed approach to the challenging management of progressive gastroesophageal reflux disease显示文摘The progression of gastroesophageal reflux disease(GERD) in patients who are taking proton pump inhibitors(PPIs) has been reported by several investigators,leading to concerns that PPI therapy does not address all aspects of the disease.Patients who are at risk of progression need to be identified early in the course of their disease in order to receive preventive treatment.A review of the literature on GERD progression to Barrett's esophagus and the associated physiological and pathological changes was performed and risk factors for progression were identified.In addition,a potential approach to the prevention of progression is discussed.Current evidence shows that GERD can progress;however,patients at risk of progression may not be identified early enough for it to be prevented.Biopsies of the squamocolumnar junction that show microscopic intestinalization of metaplastic cardiac mucosa in endoscopically normal patients are predictive of future visible Barrett's esophagus,and an indicator of GERD progression.Such changes can be identified only through biopsy,which is not currently recommended for endoscopically normal patients.GERD treatment should aim to prevent progression.We propose that endoscopically normal patients who partially respond or do not respond to PPI therapy undergo routine biopsies at the squamocolumnar junction to identify histological changes that may predict future progression.This will allow earlier intervention,aimed at preventing Barrett's esophagus. | Joachim Labenz Parakrama T Chandrasoma Laura J Knapp Tom R DeMeester | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 7 |
| 5 | 大距离运动的直线度测量(英文)显示文摘机床轴沿轴向运动的直线度是最重要的性能指标.描述了不同的直线度测量方法(直尺法、钢丝绳法、激光干涉仪法、局部垂直度测量及球板和球杆法等),并讨论了这些方法对测量移动长度超过2 000 mm的机床的适用性.详细叙述了无重叠的球板拼接,估计了测量的不确定度,测量结果不确定度U为3.4μm(因子k=2).给出了减小主要影响测量不确定度,也就是影响机床轴重复性的主要因素的一些可能性。示出了500 mm×500 mm球板拼接测量,并且和轴向移动量900 mm的比较仪进行了比对,两种测量结果的偏差小于0.6μm.因此不会超出原有的测量不确定度范围.球板拼接法也可应用于大距离移动中的垂直度测量.无论是利用垂直平面进行测量或者用近来引进的精密三维机床检测,无重叠的球板拼接均可用于水平和垂直的直线度测量,还可用于定位、倾斜、俯视及偏转等方面的测量. | KNAPP W BRINGMANN B | 2005 | 纳米技术与精密工程2005，3，4： | 5 |
| 6 | A historical view of alveolar echinococcosis, 160 years after the discovery of the first case in humans: part 1. What have we learnt on the distribution of the disease and on its parasitic agent?显示文摘自从著名科学家鲁道夫·弗乔在 1855 在疾病的起源在南部的德国和一个寄生虫的正确鉴定观察的开始的 2 个盒子,牙槽的包虫病(AE ) 的地方性的区域的边阶从来没停下来过膨胀。寄生虫连续地在瑞士被认出,然后为疾病在长的俄国,奥地利和法国考虑了同样唯一的地方性的区域。盒子在 1939 在土耳其被揭示;然后,许多注意对阿拉斯加并且到北海道被给予,在日本。状况完全由科学家的国际社区在中国地方性的区域的识别以后在 1991 变化了。世界地图被 AE 的鉴定,并且由盒子的识别在中亚在大多数中央 / 东方的欧洲和波罗的语州的国家在第 21 世纪的开始完成。直到现在,疾病从来然而没在南方半球并且在英国被报导过。在 mid-1950s ,由在阿拉斯加的 Rausch 和德国诗人,并且由在德国的 Vogel 的示范,在 2 寄生虫种类之间的区别负责分别地为膀胱的包虫病(“胞虫疾病”)和 AE 结束在“二元论者”之间的长持续的争论,谁相信了那最后证明了真的理论,和“ unicists ”,相信了为两疾病负责的单个种。在第 20 世纪的结束,分子的生物学充分证实了“二元论者”理论当把几新种加到开始描述的 E 时。granulosus;在过去的十年以内,它也证实很少变化在西藏的高原上在一些中间的动物宿主在包虫(E.) multilocularis 种类,和那 AE-Iooking 感染以内存在确实由于新种,从 E 不同。multilocularis,命名 E。shiquicus。自从 1970 年代,在风景之间的唯一的生态的相互作用,主人,和 E。multilocu/aris 日益增多地被描出。为寄生虫周期的维护的啮齿类动物 / 兔类动物水库尺寸的重要角色在第 20 世纪的最后 2 十年以内被认出了。并且在在由农业 / 林地的陆地使用的小哺乳动物和个性的高密度之间的一种靠近的关系的发现在污染压力上强调了政治 / 经济的决定的责任。在欧洲和日本和在中国的狗的主要角色的狐狸的都市化关于权威的主人和预防措施在 21 st 世纪的开始代表新买卖。 | Dominique Angele Vuitton WANG Qian ZHOU Hong-xia Francis Raoul Jenny Knapp Solange Bresson-Hadni WEN Hao Patrick Giraudoux | 2011 | Chinese Medical Journal2011，，18： | 5 |
| 7 | The Shenzhen Declaration on Plant Sciences Uniting plant sciences and society to build a green, sustainable Earth显示文摘 | Peter R. Crane Song Ge De-Yuan Hong Hong-Wen Huang Gen-Lin Jiao Sandra Knapp W. John Kress Harold Mooney Peter H. Raven Jun Wen Wei-Hua Wu Huan-Ming Yang Wei-Hua Zhu Yu-Xian Zhu | 2017 | Journal of Systematics and Evolution2017，55，5： | 3 |
| 8 | Geometric error measurement and compensation of machines—An update显示文摘 | H. Schwenke W. Knapp H. Haitjema A. Weckenmann R. Schmitt F. Delbressine | 2008 | CIRP Annals - Manufacturing Technology2008，，2： | 3 |
| 9 | Evaluation of a gravel transport sensor for bed load measurements in natural flows显示文摘A recent acoustic instrument(Gravel Transport Sensor,GTS) was tested for predicting sediment transport rate(bed load rate) in gravel bed streams. The GTS operation is based on the particle collision theory of submerged obstacles in fluids. When particles collide with the GTS cylinder their momentum is recorded in the form of ping rates. The GTS is attractive for further consideration here because of its potential to provide continuous unattended local bed load measurements,especially in areas found in streams that access may be difficult under extreme conditions. Laboratory experiments coupled with numerical simulations for the same flow conditions were performed in order to determine the conditions under which particles of different size will hit the GTS cylinder and be able to register a ping rate. The GTS was able to detect the number of particles with diameter in the range of 15.9 to 25.4 mm,with reasonable accuracy,if the applied Shields effective stress τe=ττcr was in the range of 0.006 to 0.015. A drawback of the tested prototype GTS,however,was that it exerted increased resistance on the incoming particles. The added drag effects increased the overall resistance that was exerted by the flow on particles and thus increased the likelihood that particles will rest in the ambient region of the cylinder instead of hitting it. Numerical simulation of the flow around the GTS cylinder revealed that changing the prototype geometry from cylindrical to ellipsoid or rhomboid will increase the likelihood of the particles hitting the instrument under the same flow conditions failed by the original tested GTS cylinder. | Athanasios N.(Thanos) PAPANICOLAOU Mohamed ELHAKEEM Doug KNAPP | 2009 | International Journal of Sediment Research2009，24，1： | 3 |
| 10 | Mortality at 12 and 24 Months After Stroke May Be Associated With Depressive Symptoms at 1 Month显示文摘 | Allan House Peter Knapp John Bamford Andy Vail | 2001 | Stroke: Journal of the American Heart Association2001，，3： | 3 |
| 11 | 植物科学深圳宣言--植物科学携手社会大众,共建绿色永续发展的地球显示文摘1至关重要的联系当今世界比以往任何时候都更需要制定出一些重大行动计划和优先发展领域,从而在全球植物科学家群体与不断变化的社会之间建立更紧密的联系.环境退化、资源利用的不可持续以及生物多样性流失等问题的解决都需要借助综合的手段,通过合作而加以解决.2正在变化的世界作为植物科学家,面对我们这个星球和社会不断发生的变化,我们越来越感到关切和担忧.在有生之年, | Peter R.Crane 葛颂 洪德元 黄宏文 焦根林 Sandra Knapp W.John Kress Harold Mooney Peter H.Raven Jun Wen 武维华 杨焕明 朱伟华 朱玉贤 | 2017 | 科学通报2017，62，33： | 2 |
| 12 | Progress in reducing the pale, soft and exudative (PSE) problem in pork and poultry meat显示文摘 | S. Barbut A.A. Sosnicki S.M. Lonergan T. Knapp D.C. Ciobanu L.J. Gatcliffe E. Huff-Lonergan E.W. Wilson | 2007 | Meat Science2007，，1： | 2 |
| 13 | 提高阅读理解技能显示文摘本文将不拘形式地同读者探讨阅读理解的教学。本文将分析我们现在正用来帮助学生阅读技能的哪些方法---那些我们大多数人一直在使用的传统的课堂教学方法---并且评价它们的有效性。这将涉及到首先要探讨什么是阅读---什么是阅读理解技能---这反过来将使我们进一步考虑,需要在认识上和实践上做哪些改变以促进我们的阅读教学。 | Donald Knapp 马广惠 | 1994 | 外语教学理论与实践1994，，2： | 2 |
| 14 | 铜线生产中的断线显示文摘铜线生产过程中发生断线,就会导致设备停车,产量下降,并且需耗费重新穿线的时间。使用自动化设备生产时,更易发生断线,由断线造成的后果则更复杂。为了避免断线现象,需要了解铜线生产中断线的各种不同形式,发生断线的原因及各种影响因素。 | Susanne Knapp 谭克新 | 1997 | 电线电缆1997，，2： | 2 |
| 15 | Effects of zinc oxide and Enterococcus faecium SF68 dietary supplementation on the performance, intestinal microbiota and immune status of weaned piglets显示文摘 | L.J. Broom H.M. Miller K.G. Kerr J.S. Knapp | 2005 | Research in Veterinary Science2005，，1： | 2 |
| 16 | Probing thermally-induced structural evolution during the synthesis of layered Li-, Na-, or K-containing 3d transition-metal oxides显示文摘Layered alkali-containing 3d transition-metal oxides are of the utmost importance in the use of electrode materials for advanced energy storage applications such as Li-,Na-,or K-ion batteries.A significant challenge in the field of materials chemistry is understanding the dynamics of the chemical reactions between alkali-free precursors and alkali species during the synthesis of these compounds.In this study,in situ high-resolution synchrotron-based X-ray diffraction was applied to reveal the Li/Na/K-ion insertion-induced structural transformation mechanism during high-temperature solid-state reaction.The in situ diffraction results demonstrate that the chemical reaction pathway strongly depends on the alkali-free precursor type,which is a structural matrix enabling phase transi-tions.Quantitative phase analysis identifies for the first time the decomposition of lithium sources as the most critical factor for the formation of metastable intermediates or impurities during the entire process of Li-rich layered Li[Li_(0.2)Ni_(0.2)Mn_(0.6)]O_(2) formation.Since the alkali ions have different ionic radii,Na/K ions tend to be located on prismatic sites in the defective layered structure(Na_(2/3-x)[Ni_(0.25)Mn_(0.75)]O_(2) or K_(2/3-x)[Ni_(0.25)Mn_(0.75)]O_(2))during calcination,whereas the Li ions prefer to be localized on the tetrahedral and/or octahedral sites,forming O-type structures. | Weibo Hua Xiaoxia Yang Nicola PMCasati Laijun Liu Suning Wang Volodymyr Baran Michael Knapp Helmut Ehrenberg Sylvio Indris | 2022 | eScience2022，2，2： | 2 |
| 17 | 在墨尔本召开的第18届国际植物学大会做出的有关名称发表要求的变化——电子出版物对你意味着什么?显示文摘《国际植物命名法规》的修订由每六年一次的国际植物学大会(IBC)命名分会来决定。第18届国际植物学大会在澳大利亚墨尔本举行;命名分会于2011年7月18日至22日召开,其决议获得7月30日的全体会议通过。'墨尔本法规'有几个重要的变化,将影响新名称的发表。这些变化中的两个将在'墨尔本法规'出版前的几个月,即于2012年1月1日起生效。通过以移动文档格式(Portable Document Format;pdf)在线发表的具有国际标准连续出版物号(ISSN)或国际标准图书编号(ISBN)的电子出版物,将构成有效发表。新分类群名称的合格发表所必须的拉丁文描述或特征集要将更改为拉丁文或英文描述或特征集要。此外,自2013年1月1日起,被处理为真菌的生物的新名称必须在原始资料(某一名称合格发表时与之有关的所有资料)中引证一个由一家公认的存储库(例如MycoBank)签发的标识码,才构成合格发表。本文提供了有关电子出版物的新规则的草案文本,并概述了相应的最佳做法。 | Sandra Knapp John McNeill Nicholas J.Turland 张丽兵 | 2011 | 植物分类与资源学报2011，33，5： | 2 |
| 18 | Variation among biomes in temproal dynamics of abovegroung primary production显示文摘 | Knapp A K Smith M D | 2001 | Nature2001，291，： | 1 |
| 19 | FK506 treatment inhibits caspase-3 activation and promotes oligodendroglial survival following traumatic spinal cord injury显示文摘 | Nottingham S Knapp P Springer J | 2002 | Exp Neurol2002，177，1： | 1 |
| 20 | Hydrodynamic delivery 显示文摘 | AL-DOSARI M S KNAPP J E LIU D | 2005 | Adv Genet2005，54，： | 1 |
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