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| 1 | Evaluation of inflammatory activity in Crohn's disease and ulcerative colitis显示文摘Crohn's disease and ulcerative colitis evolve with a relapsing and remitting course.Determination of inflammatory state is crucial for the assessment of disease activity and for tailoring therapy.However,no simple diagnostic test for monitoring intestinal inflammation is available.Noninvasive markers give only indirect assessments of disease activity.Histopathological or endoscopical examinations accurately assess inflammatory activity,but they are invasive,time consuming and expensive and therefore are unsuitable for routine use.Imaging procedures are not applicable for ulcerative colitis.The usefulness of ultrasound and Doppler imag-ing in assessing disease activity is still a matter of discussion for Crohn's disease,and an increased interest in computed tomography enterograph (CTE) has been seen,mainly because it can delineate the extent and severity of bowel wall inflammation,besides detecting extraluminal findings.Until now,the available data concerning the accuracy of magnetic resonance enterography in detecting disease activity is less than CTE.Due to this,clinical activity indices are still commonly used for both diseases. | Eduardo Garcia Vilela Henrique Osvaldo da Gama Torres Fabiana Paiva Martins Maria de Lourdes de Abreu Ferrari Marcella Menezes Andrade Aloísio Sales da Cunha | 2012 | World Journal of Gastroenterology2012，18，9： | 23 |
| 2 | Design and criteria of electrospun fibrous scaffolds for the treatment of spinal cord injury显示文摘The complex pathophysiology of spinal cord injury may explain the current lack of an effective therapeutic approach for the regeneration of damaged neuronal cells and the recovery of motor functions. Many efforts have been performed to design and develop suitable scaffolds for spinal cord regeneration, keeping in mind that the reconstruction of a pro-regenerative environment is the key challenge for an effective neurogenesis. The aim of this review is to outline the main features of an ideal scaffold, based on biomaterials, produced by the electrospinning technique and intended for the spinal cord regeneration. An overview of the polymers more investigated in the production of neural fibrous scaffolds is also provided. | Barbara Vigani Silvia Rossi Giuseppina Sandri Maria Cristina Bonferoni Franca Ferrari | 2017 | Neural Regeneration Research2017，12，11： | 4 |
| 3 | Neutrophil gelatinase-associated lipocalin does not predict acute kidney injury in heart failure显示文摘BACKGROUND Acute cardiorenal syndrome type 1(CRS-1)is defined by a rapid cardiac dysfunction leading to acute kidney injury(AKI).Neutrophil gelatinaseassociated lipocalin(NGAL)is expressed on the surface of human neutrophils and epithelial cells,such as renal tubule cells,and its serum(sNGAL)and urinary have been used to predict AKI in different clinical settings.AIM To characterize CRS-1 in a cohort of patients with acute heart diseases,evaluating the potentiality of sNGAL as an early marker of CRS-1.METHODS We performed a retrospective cohort,multi-centre study.From January 2010 to December 2011,we recruited 202 adult patients admitted to the coronary intensive care unit(CICU)with a diagnosis of acute heart failure or acute coronary syndrome.We monitored the renal function to evaluate CRS-1 development and measured sNGAL levels within 24 h and after 72 h of CICU admission.RESULTS Overall,enrolled patients were hemodynamically stable with a mean arterial pressure of 92(82-107)mmHg,55/202(27.2%)of the patients developed CRS-1,but none of them required dialysis.Neither the NGAL delta value(AUC 0.40,95%CI:0.25-0.55)nor the NGAL peak(AUC 0.45,95%CI:0.36-0.54)or NGAL cutoff(≥140 ng/mL)values were statistically significant between the two groups(CRS-1 vs no-CRS1 patients).The area under the ROC curve for the prediction of CRS-1 was 0.40(95%CI:0.25-0.55)for the delta NGAL value and 0.45(95%CI:0.36-0.54)for the NGAL peak value.Finally,in multivariate analysis,the risk of developing CRS-1 was correlated with age>60 years,urea nitrogen at admission and 24 h-urine output(AUC 0.83,SE=60.5%SP=93%),while sNGAL was not significantly correlated.CONCLUSION In our population,sNGAL does not predict CRS-1,probably as a consequence of the mild renal injury and the low severity of heart disease.So,these data might suggest that patient selection should be taken into account when considering the utility of NGAL measurement as a biomarker of kidney damage. | Fiorenza Ferrari Elisa Scalzotto Pasquale Esposito Sara Samoni Flavio Mistrorigo Lilia Maria Rizo Topete Massimo De Cal Grazia Maria Virzì Valentina Corradi Rossella Torregrossa Roberto Valle Stefania Bianzina Nadia Aspromonte Matteo Floris Alessandro Fontanelli Alessandra Brendolan Claudio Ronco | 2020 | World Journal of Clinical Cases2020，8，9： | 3 |
| 4 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 5 | Dietary approach in the treatment of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) has been identified as one of the most prevalent chronic liver disease in adults and children populations. NAFLD is usually associated with the metabolic syndrome(MS), which is chiefly related to insulin resistance and its consequences. Insulin resistance has a crucial role in the pathogenesis of hepatic steatosis and potentially nonalcoholic steatohepatitis(NASH). Because of the contemporary epidemics of MS and obesity, the burden of NAFLD is also expected to rise. Unhealthy diets, such as the so-called western diet, are enriched in fructose, trans-fatty acids and saturated fat and seem to be associated with the development of NAFLD. In human studies, certain dietary sugars, particularly fructose, are used as a substrate for lipogenesis leading to hepatic fatty infiltration, inflammation, and possibly fibrosis. Other investigations have shown that fat consumption especially cholesterol and trans/saturated fatty acids are also steatogenic and seem to increase visceral adiposity. The identification of specific dietary components that favor the development of NASH could be important for the management of this disorder. This review focuses on the effects of different dietary approaches to prevent and treat NAFLD emphasizing the macronutrients and energy composition. | Silvia Marinho Ferolla Luciana Costa Silva Maria de Lourdes Abreu Ferrari Aloísio Sales da Cunha Flaviano dos Santos Martins Cláudia Alves Couto Teresa Cristina Abreu Ferrari | 2015 | World Journal of Hepatology2015，7，24： | 2 |
| 6 | Stepwise combination algorithms of non-invasive markers to diagnose significant fibrosis in chronic hepatitis C显示文摘 | Giada Sebastiani Alessandro Vario Maria Guido Franco Noventa Mario Plebani Roberta Pistis Alessia Ferrari Alfredo Alberti | 2006 | Journal of Hepatology2006，，4： | 2 |
| 7 | Differential Scanning Calorimetry as a Tool to Investigate the Transfer of Anticancer Drugs to Biomembrane Model显示文摘 | Maria Grazia Sarpietro Maria Lorena Accolla Christian Celia Alessandro Grattoni Francesco Castelli Massimo Fresta Mauro Ferrari Donatella Paolino | 2013 | Current Drug Targets2013，，9： | 1 |
| 8 | Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: Effect of viremia levels and antiviral treatment显示文摘 | Simona Urbani Barbara Amadei Daniela Tola Giuseppe Pedrazzi Luca Sacchelli Maria Cristina Cavallo Alessandra Orlandini Gabriele Missale Carlo Ferrari | 2008 | Journal of Hepatology2008，，4： | 1 |
| 9 | Localization of a Novel Locus for Autosomal Recessive Early-Onset Parkinsonism, PARK6, on Human Chromosome 1p35-p36显示文摘 | Enza Maria Valente Anna Rita Bentivoglio Peter H. Dixon Alessandro Ferraris Tamara Ialongo Marina Frontali Alberto Albanese Nicholas W. Wood | 2001 | The American Journal of Human Genetics2001，，4： | 1 |
| 10 | Open-Label, Randomized, Placebo-Controlled Evaluation of Intracoronary Adenosine or Nitroprusside After Thrombus Aspiration During Primary Percutaneous Coronary Intervention for the Prevention of Microvascular Obstruction in Acute Myocardial Infarction显示文摘 | Giampaolo Niccoli Stefano Rigattieri Maria Rosaria De Vita Marco Valgimigli Pierfrancesco Corvo Franco Fabbiocchi Enrico Romagnoli Alberto Ranieri De Caterina Giuseppe La Torre Paolo Lo Schiavo Fabio Tarantino Roberto Ferrari Fabrizio Tomai Paolo Olivares | 2013 | JACC: Cardiovascular Interventions2013，，： | 1 |
| 11 | B-cells and mixed cryoglobulinemia显示文摘 | Clodoveo Ferri Alessandro Antonelli Maria Teresa Mascia Marco Sebastiani Poupak Fallahi Daniela Ferrari Marco Giunti Stefano A. Pileri Anna Linda Zignego | 2007 | Autoimmunity Reviews2007，，2： | 1 |
| 12 | When to Perform Bone Scan in Patients with Newly Diagnosed Prostate Cancer: External Validation of the Currently Available Guidelines and Proposal of a Novel Risk Stratification Tool 显示文摘 | Alberto Briganti Niccolò Passoni Matteo Ferrari Umberto Capitanio Nazareno Suardi Andrea Gallina Luigi Filippo Da Pozzo Maria Picchio Valerio Di Girolamo Andrea Salonia Liugi Gianolli Cristina Messa Patrizio Rigatti Francesco Montorsi | 2009 | European Urology2009，，4： | 1 |
| 13 | Remote ischemic postconditioning as a strategy to reduce acute kidney injury during primary PCI: A post-hoc analysis of a randomized trial显示文摘 | Gabriele Crimi Marco Ferlini Fabio Gallo Maria Pia Sormani Claudia Raineri Ezio Bramucci Gaetano M. De Ferrari Silvia Pica Barbara Marinoni Alessandra Repetto Arturo Raisaro Sergio Leonardi Paolo Rubartelli Luigi Oltrona Visconti Maurizio Ferrario | 2014 | International Journal of Cardiology2014，，： | 1 |
| 14 | Influence of the impregnation order of molybdenum and cobalt in carbon-supported catalysts for hydrodeoxygenation reactions 显示文摘 | Maria Ferrari Bernard Delmon Paul Grange | 2002 | Carbon2002，40，4： | 1 |
| 15 | B-cells and mixed cryoglobulinemia显示文摘 | Clodoveo Ferri Alessandro Antonelli Maria Teresa Mascia Marco Sebastiani Poupak Fallahi Daniela Ferrari Marco Giunti Stefano A. Pileri Anna Linda Zignego | 2007 | Autoimmunity Reviews2007，，2： | 1 |
| 16 | Effects of elevated egg corticosterone levels on behavior, growth, and immunity of yellow-legged gull ( Larus michahellis ) chicks显示文摘 | Diego Rubolini Maria Romano Giuseppe Boncoraglio Raffaella Paola Ferrari Roberta Martinelli Paolo Galeotti Mauro Fasola Nicola Saino | 2005 | Hormones and Behavior2005，，5： | 1 |
| 17 | Chemotherapy (Basel, Switzerland) 显示文摘 | Ferrari Lucio Altamura Maria | 2002 | 48(1): 15-202002，48，1： | 1 |
| 18 | Thermal stability improvement of blue colorant C-Phycocyanin from Spirulina platensis for food industry applications显示文摘 | Giulia Martelli Claudia Folli Livia Visai Maria Daglia Davide Ferrari | 2014 | Process Biochemist ry2014，49，1： | 1 |
| 19 | Treatment of mild non-chemotherapy-induced iron deficiency anemia in cancer patients: Comparison between oral ferrous bisglycinate chelate and ferrous sulfate显示文摘 | Paola Ferrari Andrea Nicolini Maria Laura Manca Giuseppe Rossi Loretta Anselmi Massimo Conte Angelo Carpi Ferruccio Bonino | 2012 | Biomedicine & Pharmacotherapy2012，，6： | 1 |
| 20 | Chromia/zirconia catalysts with Cr content exceeding the monolayer:A comparison with chromia/alumina and chromia/silica for isobutane dehydrogenation 显示文摘 | Sergio De Rossi Maria Pia Casaletto Giovanni Ferraris Alessandro Cimino Giuliano Minelli | 1998 | Applied Catalysis A: General1998，167，： | 1 |
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