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| 1 | Contrast-enhanced ultrasound Liver Imaging Reporting and Data System:Lights and shadows in hepatocellular carcinoma and cholangiocellular carcinoma diagnosis显示文摘BACKGROUND Contrast-enhanced ultrasound(CEUS)is considered a secondary examination compared to computed tomography(CT)and magnetic resonance imaging(MRI)in the diagnosis of hepatocellular carcinoma(HCC),due to the risk of misdiagnosing intrahepatic cholangiocarcinoma(ICC).The introduction of CEUS Liver Imaging Reporting and Data System(CEUS LI-RADS)might overcome this limitation.Even though data from the literature seems promising,its reliability in real-life context has not been well-established yet.AIM To test the accuracy of CEUS LI-RADS for correctly diagnosing HCC and ICC in cirrhosis.METHODS CEUS LI-RADS class was retrospectively assigned to 511 nodules identified in 269 patients suffering from liver cirrhosis.The diagnostic standard for all nodules was either biopsy(102 nodules)or CT/MRI(409 nodules).Common diagnostic accuracy indexes such as sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)were assessed for the following associations:CEUS LR-5 and HCC;CEUS LR-4 and 5 merged class and HCC;CEUS LR-M and ICC;and CEUS LR-3 and malignancy.The frequency of malignant lesions in CEUS LR-3 subgroups with different CEUS patterns was also determined.Inter-rater agreement for CEUS LI-RADS class assignment and for major CEUS pattern identification was evaluated.RESULTS CEUS LR-5 predicted HCC with a 67.6%sensitivity,97.7%specificity,and 99.3%PPV(P<0.001).The merging of LR-4 and 5 offered an improved 93.9%sensitivity in HCC diagnosis with a 94.3%specificity and 98.8%PPV(P<0.001).CEUS LR-M predicted ICC with a 91.3%sensitivity,96.7%specificity,and 99.6%NPV(P<0.001).CEUS LR-3 predominantly included benign lesions(only 28.8%of malignancies).In this class,the hypo-hypo pattern showed a much higher rate of malignant lesions(73.3%)than the iso-iso pattern(2.6%).Inter-rater agreement between internal raters for CEUS-LR class assignment was almost perfect(n=511,k=0.94,P<0.001),while the agreement among raters from separate centres was substantial(n=50,k=0.67,P<0.001).Agreement was stronger for arterial phase hyperenhancement(internal k=0.86,P<2.7×10-214;external k=0.8,P<0.001)than washout(internal k=0.79,P<1.6×10-202;external k=0.71,P<0.001).CONCLUSION CEUS LI-RADS is effective but can be improved by merging LR-4 and 5 to diagnose HCC and by splitting LR-3 into two subgroups to differentiate iso-iso nodules from other patterns. | Gianpaolo Vidili Marco Arru Giuliana Solinas Diego Francesco Calvisi Pierluigi Meloni Assunta Sauchella Davide Turilli Claudio Fabio Antonio Cossu Giordano Madeddu Sergio Babudieri Maria Assunta Zocco Giovanni Iannetti Enza Di Lembo Alessandro Palmerio Delitala Roberto Manetti | 2022 | World Journal of Gastroenterology2022，28，27： | 3 |
| 2 | Fuel cell performance assessment for closed-loop renewable energy systems显示文摘Fuel cells and electrolysis are promising candidates for future energy production from renewable energy sources. Usually, polymer electrolyte fuel cell systems run on hydrogen and air, while the most of electrolysis systems vent out oxygen as unused by-product. Replacing air with pure oxygen, fuel cell electrochemical performance, durability and system efficiency can be significantly increased with a further overall system simplification and increased reliability. This work, which represents the initial step for pure H_2/O_2 polymer electrolyte fuel cell operation in closed-loop systems, focuses on performance validation of a single cell operating with pure H_2/O_2 under different relative humidity(RH) levels, reactants stoichiometry conditions and temperature. As a result of this study, the most convenient and appropriate operative conditions for a polymer electrolyte fuel cell stack integrated in a closed loop system were selected. | Fabio V.Matera Irene Gatto Assunta Patti Enza Passalacqua | 2016 | Journal of Energy Chemistry2016，25，3： | 2 |
| 3 | Optimize radiochemotherapy in pancreatic cancer: PARP inhibitors a new therapeutic opportunity显示文摘 | Letizia Porcelli Anna E. Quatrale Paola Mantuano Maria G. Leo Nicola Silvestris Jean F. Rolland Enza Carioggia Marco Lioce Angelo Paradiso Amalia Azzariti | 2013 | Molecular Oncology2013，，3： | 2 |
| 4 | Localization of a Novel Locus for Autosomal Recessive Early-Onset Parkinsonism, PARK6, on Human Chromosome 1p35-p36显示文摘 | Enza Maria Valente Anna Rita Bentivoglio Peter H. Dixon Alessandro Ferraris Tamara Ialongo Marina Frontali Alberto Albanese Nicholas W. Wood | 2001 | The American Journal of Human Genetics2001，，4： | 1 |
| 5 | Optimize radiochemotherapy in pancreatic cancer: PARP inhibitors a new therapeutic opportunity显示文摘 | Letizia Porcelli Anna E. Quatrale Paola Mantuano Maria G. Leo Nicola Silvestris Jean F. Rolland Enza Carioggia Marco Lioce Angelo Paradiso Amalia Azzariti | 2012 | Molecular Oncology2012，，： | 1 |
| 6 | PEG-PLGA electrospun nanofibrous membranes loaded with Au@Fe2O3 nanoparticles for drug delivery applications显示文摘与黄金和氧化铁 nanoparticles 并且与 silibinin 装载的 PEGylated-PLGA 随机的 nanofibrous 膜被 electrospinning 免职准备。nanofibrous 膜能遥远地被控制并且由一盏激光灯或磁场激活在需求上释放生物代理人。nanosystems 用扫描电子显微镜学被描绘,红外线的光谱学,原子磁性的回声光谱学,和 thermogravimetric 分析的 Fourier 变换。装载效率和药内容百分比的药被紫外力的光吸收光谱学决定。nanofibrous 膜由相对低紧张的激光照耀或由一个磁场刺激了为至少 60 h 显示出持续 silibinin 版本,没有爆炸效果。建议便宜 electrospinning 过程能够集合,经由一个一步舞过程,有外部地为控制的药交货要激活的金属性的 nanoparticles 的刺激应答的装载药的 nanosystem。 | Salvatore Spadaro Marco Santoro Francesco Barreca Angela Scala Simona Grimato Fortunato Neri Enza Fazio | 2018 | Frontiers of physics2018，13，1： | 1 |
| 7 | Molecular pathways in sporadic PD显示文摘 | Enza MV Giuseppe A Liliana T | 2012 | Parkinsonism Relat Disord2012，18，： | 1 |
| 8 | Infectious diseases and risk of leukemia and non-Hodgkin's lymphoma: A case- control study 显示文摘 | Stefano P Irene S Enza M | 2012 | Leuk Res2012，36，11： | 1 |
| 9 | Antibody-selected mimics of hepatitis C virus hypervariable region 1 activate both primary and memory Th lymphocytes显示文摘 | Loredana Frasca Cristiano Scottà Paola Del Porto Alfredo Nicosia Caterina Pasquazzi Ilaria Versace Anna Maria Masci Luigi Racioppi Enza Piccolella | 2003 | Hepatology2003，，3： | 1 |
| 10 | Incidence of neural tube defects in Ontario, 1986- 1999 显示文摘 | Enza Gucciardi Mary Anne Pietrusiak Donna L Reynolds | 2002 | CMAJ2002，167，3： | 1 |
| 11 | 90K (Mac-2 BP) and galectins in tumor progression and metastasis显示文摘 | Antonino Grassadonia Nicola Tinari Ida Iurisci Enza Piccolo Alba Cumashi Pasquale Innominato Maurizia D’Egidio Clara Natoli Mauro Piantelli Stefano Iacobelli | 2002 | Glycoconjugate Journal (-)2002，，7： | 1 |
| 12 | Pancreatic cancer stem cells-update and future perspectives显示文摘 | Enza L Patrick C.Hermann Christopher Heeschen | | 0，，05： | 1 |
| 13 | High Prevalence of Hypervariable Region 1-Specific and -Cross-Reactive CD4 + T Cells in HCV-Infected Individuals Responsive to IFN-α Treatment显示文摘 | Paola Del Porto Giulia Puntoriero Cristiano Scottà Alfredo Nicosia Enza Piccolella | 2000 | Virology2000，，2： | 1 |
| 14 | The role of cannabinoid re-ceptors in the descending modulation of pain显示文摘 | Enza P Livio L Vito de N | 2010 | Pharma-ceuticals2010，3，8： | 1 |
| 15 | Progmm design features that can improve participation in health education interventions显示文摘 | Enza Gucciardi Jill 1 Cameron Chen Di Liao etc | 2007 | BMC Med Res Methodol2007，，7： | 1 |
| 16 | Serotonin 5-HT7 re-ceptor agents:Structure-activity relationships and potentialtherapeutic applications in central nervous system disor-ders显示文摘 | Marcello L Enza L Francesco B | 2011 | Pharmacol Ther2011，129，2： | 1 |
| 17 | Molecular profile of human immunodeficiency virus type 1 infection in symptomless patients and in patients with AIDS显示文摘 | MENZO S VAL ENZA A etal | 1992 | J Virol1992，66，12： | 1 |
| 18 | Primary Non-Hodgkin's lymphoma of the bone:treatment and analysis of prognostic factors for stage I and stage II显示文摘 | Silvia Cammelli Flornna Mauro | 2004 | Int J Radiation Oncology Biol Phy2004，59，3： | 1 |
| 19 | Postoperative dysphagia versus neurogenic dysphagia:scintigraphic assessment显示文摘 | Gall I J Val enza V D'alalri L | 2003 | Ann Otol Rhinol laryngol(S0003-4894)2003，112，1： | 1 |
| 20 | Serotonin 5-HT7 receptor agents:Structure-activity relationships and potential thera- peutic applications in central nervous system disorders显示文摘 | MARCELLO L ENZA L FRANCESCO B | 2011 | PHAR- MACACOL THERAPEUT2011，129，2： | 1 |
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