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| 1 | The influence of microwave irradiation on rocks for microwaveassisted underground excavation显示文摘Demand is growing for explosive-free rock breakage systems for civil and mining engineering, and spaceindustry applications. This paper highlights the work being undertaken in the Geomechanics Laboratoryof McGill University to make a real application of microwave-assisted mechanical rock breakage to fullfacetunneling machines and drilling. Comprehensive laboratory tests investigated the effect of microwaveradiation on temperature profiles and strength reduction in hard rocks (norite, granite, and basalt)for a range of exposure times and microwave power levels. The heating rate on the surface of the rockspecimens linearly decreased with distance between the sample and the microwave antenna, regardlessof microwave power level and exposure time. Tensile and uniaxial compressive strengths were reducedwith increasing exposure time and power level. Scanning electron micrographs (SEMs) highlightedfracture development in treated basalt. It was concluded that the microwave power level has a strongpositive influence on the amount of heat damage induced to the rock surface. Numerical simulations ofelectric field intensity and wave propagation conducted with COMSOL Multiphysics software generatedtemperature profiles that were in close agreement with experimental results. | Ferri Hassani Pejman M.Nekoovaght Nima Gharib | 2016 | Journal of Rock Mechanics and Geotechnical Engineering2016，8，1： | 69 |
| 2 | 微波辅助机械破岩试验和理论研究进展显示文摘微波辅助机械破岩是微波加热技术和机械破岩技术相结合的一种混合型破岩方法。岩石内不同矿物成分对微波能具有不同的吸收特性,各矿物不同的热膨胀产生的内应力使岩石内发生沿晶断裂和穿晶断裂,使试样产生损伤和微裂纹,这会引起岩石强度的降低。辐射功率和辐射时间是影响岩石力学特性的重要参数,一定功率的微波辐射处理后,试样的点荷载强度、单轴抗压强度和抗拉强度发生显著降低,微波功率越高,辐射时间越长,对试样强度的折减效果越明显。数值研究结果与试验研究结果基本一致,增加功率的同时降低辐射时间对试样强度折减具有更好的效果。岩石点荷载强度、单轴抗压强度和抗拉强度的降低能够显著提高机械破岩设备刀具的侵入率和刀具寿命,解决机械刀具的磨损问题。微波辅助机械破岩对钻孔、TBM掘进和实现金属矿矿岩连续开采都具有重要影响作用。 | 卢高明 李元辉 HASSANI Ferri 张希巍 | 2016 | 岩土工程学报2016，38，8： | 63 |
| 3 | Current guidelines for the management of non-alcoholic fatty liver disease:A systematic review with comparative analysis显示文摘The current epidemic of non-alcoholic fatty liver disease(NAFLD) is reshaping the field of hepatology all around the world.The widespread diffusion of metabolic risk factors such as obesity,type2-diabetes mellitus,and dyslipidemia has led to a worldwide diffusion of NAFLD.In parallel to the increased availability of effective anti-viral agents,NAFLD is rapidly becoming the most common cause of chronic liver disease in Western Countries,and a similar trend is expected in Eastern Countries in the next years.This epidemic and its consequences have prompted experts from all over the word in identifying effective strategies for the diagnosis,management,and treatment of NAFLD.Different scientific societies from Europe,America,and Asia-Pacific regions have proposed guidelines based on the most recent evidence about NAFLD.These guidelines are consistent with the key elements in the management of NAFLD,but still,show significant difference about some critical points.We reviewed the current literature in English language to identify the most recent scientific guidelines about NAFLD with the aim to find and critically analyse the main differences.We distinguished guidelines from 5 different scientific societies whose reputation is worldwide recognised and who are representative of the clinical practice in different geographical regions.Differences were noted in: the definition of NAFLD,the opportunity of NAFLD screening in high-risk patients,the noninvasive test proposed for the diagnosis of NAFLD and the identification of NAFLD patients with advanced fibrosis,in the follow-up protocols and,finally,in the treatment strategy(especially in the proposed pharmacological management).These difference have been discussed in the light of the possible evolution of the scenario ofNAFLD in the next years. | Simona Leoni Francesco Tovoli Lucia Napoli Ilaria Serio Silvia Ferri Luigi Bolondi | 2018 | World Journal of Gastroenterology2018，24，30： | 42 |
| 4 | Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review显示文摘 | Natalie A. Molodecky Ing Shian Soon Doreen M. Rabi William A. Ghali Mollie Ferris Greg Chernoff Eric I. Benchimol Remo Panaccione Subrata Ghosh Herman W. Barkema Gilaad G. Kaplan | 2012 | Gastroenterology2012，，1： | 33 |
| 5 | 美国医师的职责显示文摘在此讨论的主要问题是 :什么样的社会力量能使医师对诊治病人和技术操作的质量担负起责任 ?这种社会力量的来源之一是职业理念 ;另一种约束力来自于正规社会机构的直接管理 ,相关权限的依据是国家和地区规范医院和医师行为的法律 ;第三种规范的形式和政府司法部门紧密相关 ,它在很大程度上是一种间接性的约束力 ,涉及病人因医疗事故对医生及其投保的责任保险公司所进行的索赔和诉讼。强调了第三种力量 ,并突出了在医师和医疗行业圈之外的社会力量对医疗活动的指导作用。 | Ferris J.Ritchey 张琳 | 2002 | 医学与哲学2002，23，11： | 21 |
| 6 | Platelet-to-lymphocyte ratio in the setting of liver transplantation for hepatocellular cancer: A systematic review and meta-analysis显示文摘AIM To perform a systematic review and meta-analysis on platelet-to-lymphocyte ratio(PLR) as a risk factor for post-transplant hepatocellular cancer(HCC) recurrence. METHODS A systematic literature search was performed using PubM ed. Participants of any age and sex, who underwent liver transplantation for HCC were considered following these criteria:(1) studies comparing pre-transplant low vs high PLR values;(2) studies reporting post-transplant recurrence rates; and(3) if more than one study was reported by the same institute, only the most recent was included. The primary outcome measure was set for HCC recurrence after transplantation. RESULTS A total of 5 articles, published between 2014 and 2017, fulfilled the selection criteria. As for the quality of the reported studies, all the investigated articles presented an overall high quality. A total of 899 cases were investigated: 718 cases(80.0%) were males. Three studies coming from European countries and one from Japan presented HCV as the main cause of cirrhosis. On the opposite, one Chinese study presented a greater incidence of HBV-related cirrhotic cases. In all the studies apart one, the PLR cut-off value of 150 was reported. At meta-analysis, high PLR value was associated with a significant increase in recurrence after transplantation(OR = 3.33; 95%CI: 1.78-6.25; P < 0.001). A moderate heterogeneity was observed among the identified studies according to the Higgins I^2 statistic value.CONCLUSION Pre-transplant high PLR values are connected with an increased risk of post-operative recurrence of hepatocellular cancer. More studies are needed for better clarify the biological mechanisms of this results. | Quirino Lai Fabio Melandro Zoe Larghi Laureiro Francesco Giovanardi Stefano Ginanni Corradini Flaminia Ferri Redan Hassan Massimo Rossi Gianluca Mennini | 2018 | World Journal of Gastroenterology2018，24，15： | 19 |
| 7 | Portal hypertension: Imaging of portosystemic collateral pathways and associated image-guided therapy显示文摘Portal hypertension is a common clinical syndrome, defined by a pathologic increase in the portal venous pressure. Increased resistance to portal blood flow, the primary factor in the pathophysiology of portal hypertension, is in part due to morphological changes occurring in chronic liver diseases. This results in rerouting of blood flow away from the liver through collateral pathways to low-pressure systemic veins. Through a variety of computed tomographic, sonographic, magnetic resonance imaging and angiographic examples, this article discusses the appearances and prevalence of both common and less common portosystemic collateral channels in the thorax and abdomen. A brief overview of established interventional radiologic techniques for treatment of portal hypertension will also be provided. Awareness of the various imaging manifestations of portal hypertension can be helpful for assessing overall prognosis and planning proper management. | Murad Feroz Bandali Anirudh Mirakhur Edward Wolfgang Lee Mollie Clarke Ferris David James Sadler Robin Ritchie Gray Jason Kam Wong | 2017 | World Journal of Gastroenterology2017，23，10： | 14 |
| 8 | 国外膏体充填基础理论研究综述显示文摘膏体充填是将尾砂、胶结剂和水进行优化组合,配制成的牙膏状胶结体,通过管道以柱塞流的形态输送到充填采场。膏体充填与以往浆体充填相比有很多技术优势,如早期强度大有利于缩短充填时间,充填所需水泥用量少降低采矿成本等等,受到了世界各地现代矿山企业的青睐。本文基于对膏体充填技术发展史的回顾,总结了过去30年内世界各地对膏体充填技术研究的新进展,得出以下结论:膏体的充填材料成分及粒度分布对膏体的流动性能及力学性能有显著影响,膏体的配料中-20μm颗粒的含量必须大于15%;膏体属于结构流体,具有较高的屈服应力和黏度,管道输送速度小于1m/s,明确膏体的流动特性和如何降低屈服应力是其输送系统的关键;采场中充填后内部应力变化复杂,产生拱效应,由于拱效应的影响使充填强度大幅升高,在充填设计中需考虑拱效应以降低充填成本。 | 李亮 张希巍 Hassani Ferri | 2016 | 中国矿业2016，25，11： | 13 |
| 9 | 膏体尾矿屈服应力的塌落度试验研究显示文摘屈服应力是高浓度非牛顿膏体的关键流变参数,是膏体充填输送系统设计的基础。工程应用中采用塌落度这一经验参数评判其流动性,却无法获取准确的屈服应力参数值。通过构建圆柱和圆锥2种理论模型并利用模型与流变仪的测试结果对比,明确塌落度与屈服应力的反比例关系;通过模型计算屈服应力,在较低屈服应力,圆柱比圆锥模型计算结果准确。尾砂膏体塌落度试验表明增大塌落筒的尺寸可以提高模型计算结果的准确性。添加胶结剂的塌落度试验,因胶结剂的物理化学作用,颗粒间产生絮网结构形成悬浊液,料浆更加均质,却增加了料浆的内摩擦力,屈服应力升高。不同粗砂比的塌落度试验显示:因添加的粗颗粒降低了物料整体的比表面积,物料吸附水的能力下降,使大量水分子由吸附态转变为游离态,增强料浆的可流动性使料浆屈服应力显著降低。 | 李亮 张柬 Hassani Ferri 张希巍 | 2017 | 金属矿山2017，46，1： | 12 |
| 10 | Hepatitis C virus syndrome: A constellation of organ-and non-organ specific autoimmune disorders, B-cell nonHodgkin's lymphoma, and cancer显示文摘The clinical course of chronic hepatitis C virus(HCV)infection is characterized by possible development of both liver and extrahepatic disorders. The tropism of HCV for the lymphoid tissue is responsible for several immune-mediated disorders; a poly-oligoclonal B-lymphocyte expansion, commonly observed in a high proportion of patients with HCV infection, are responsible for the production of different autoantibodies and immune-complexes, such as mixed cryoglobulins. These serological alterations may characterize a variety of autoimmune or neoplastic diseases. Cryoglobulinemic vasculitis due to small-vessel deposition of circulating mixed cryoglobulins is the prototype of HCV-driven immune-mediated and lymphoproliferative disorders; interestingly, in some cases the disease may evolve to frank malignant lymphoma. In addition, HCV shows an oncogenic potential as suggested by several clinicoepidemiological and laboratory studies; in addition to hepatocellular carcinoma that represents the most frequent HCV-related malignancy, a causative role of HCV has been largely demonstrated in a significant percentage of patients with isolated B-cells nonHodgkin's lymphomas. The same virus may be also involved in the pathogenesis of papillary thyroid cancer, a rare neoplastic condition that may complicate HCVrelated thyroid involvement. Patients with HCV infection are frequently asymptomatic or may develop only hepatic alteration, while a limited but clinically relevant number can develop one or more autoimmune and/or neoplastic disorders. Given the large variability of their prevalence among patients' populations from different countries, it is possible to hypothesize a potential role of other co-factors, i.e., genetic and/or environmental, in the pathogenesis of HCV-related extra-hepatic diseases. | Clodoveo Ferri Marco Sebastiani Dilia Giuggioli Michele Colaci Poupak Fallahi Alessia Piluso Alessandro Antonelli Anna Linda Zignego | 2015 | World Journal of Hepatology2015，7，3： | 11 |
| 11 | Hepatocellular carcinoma in viral and autoimmune liver diseases:Role of CD4+CD25+Foxp3+regulatory T cells in the immune microenvironment显示文摘More than 90%of cases of hepatocellular carcinoma(HCC)occurs in patients with cirrhosis,of which hepatitis B virus and hepatitis C virus are the leading causes,while the tumor less frequently arises in autoimmune liver diseases.Advances in understanding tumor immunity have led to a major shift in the treatment of HCC,with the emergence of immunotherapy where therapeutic agents are used to target immune cells rather than cancer cells.Regulatory T cells(Tregs)are the most abundant suppressive cells in the tumor microenvironment and their presence has been correlated with tumor progression,invasiveness,as well as metastasis.Tregs are characterized by the expression of the transcription factor Foxp3 and various mechanisms ranging from cell-to-cell contact to secretion of inhibitory molecules have been implicated in their function.Notably,Tregs amply express checkpoint molecules such as cytotoxic T lymphocyte-associated antigen 4 and programmed cell-death 1 receptor and therefore represent a direct target of immune checkpoint inhibitor(ICI)immunotherapy.Taking into consideration the critical role of Tregs in maintenance of immune homeostasis as well as avoidance of autoimmunity,it is plausible that targeting of Tregs by ICI immunotherapy results in the development of immune-related adverse events(irAEs).Since the use of ICI becomes common in oncology,with an increasing number of new ICI currently under clinical trials for cancer treatment,the occurrence of irAEs is expected to dramatically rise.Herein,we review the current literature focusing on the role of Tregs in HCC evolution taking into account their opposite etiological function in viral and autoimmune chronic liver disease,and we discuss their involvement in irAEs due to the new immunotherapies. | Alessandro Granito Luigi Muratori Claudine Lalanne Chiara Quarneti Silvia Ferri Marcello Guidi Marco Lenzi Paolo Muratori | 2021 | World Journal of Gastroenterology2021，27，22： | 11 |
| 12 | Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): a randomised, open-label phase 3 trial显示文摘 | Tom Waddell Ian Chau David Cunningham David Gonzalez Alicia Frances Clare Okines Andrew Wotherspoon Claire Saffery Gary Middleton Jonathan Wadsley David Ferry Wasat Mansoor Tom Crosby Fareeda Coxon David Smith Justin Waters Timothy Iveson Stephen Falk Sar | 2013 | Lancet Oncology2013，，6： | 10 |
| 13 | Diagnosis and treatment of pancreas divisum: A literature review显示文摘Background:Pancreas divisum is a congenital embryological disease caused by a lack of fusion between the ventral and dorsal pancreatic ducts in the early stages of embryogenesis.Recurrent acute pancreatitis,chronic pancreatitis or chronic abdominal pain are the main clinical syndromes at presentation and occur in only 5%of the patients with pancreas divisum.This review aimed to discuss diagnosis and treatment strategies in patients with symptomatic pancreas divisum.Data sources:We report a literature review from 1990 up to January 2018 to explore the various diagnostic modalities and surgical techniques and results reported in the surgical treatment of pancreas divisum.Results:There are limited reports available on this topic in the literature.We analyzed and described the main indications in the treatment of pancreas divisum,focusing on surgical treatment and a discussion of the different approaches.Furthermore,we report the results from our experience in two cases of pancreas divisum treated by pancreatic head resection with segmental duodenectomy(the Nakao procedure).Conclusions:Pancreas divisum is a common pancreatic malformation in which only a few patients develop a symptomatic disease.Surgical treatment is needed in case of endoscopic drainage failure and in cases complicated with chronic pancreatitis and local complications.Many techniques,of greater or lesser complexity,have been proposed. | Valentina Ferri Emilio Vicente Yolanda Quijano Benedetto Ielpo Hipolito Duran Eduardo Diaz Isabel Fabra Riccardo Caruso | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，4： | 9 |
| 14 | Evidence based medicine and surgical approaches for colon cancer: Evidences, benefits and limitations of the laparoscopic vs open resection显示文摘AIM:To report a meta-analysis of the studies that compared the laparoscopic with the open approach for colon cancer resection.METHODS:Forty-seven manuscripts were reviewed,33 of which employed for meta-analysis according to the PRISMA guidelines.The results were differentiated according to the study design(prospective randomized trials vs case-control series)and according to the tu-mor’s location.Outcome measures included:(1)shortterm results(operating times,blood losses,bowel function recovery,post-operative pain,return to the oral intake,complications and hospital stay);(2)oncological adequateness(number of nodes harvested in the surgical specimens);and(3)long-term results(including the survivals’rates and incidence of incisional hernias)and(4)costs.RESULTS:Meta-analysis of trials provided evidences in support of the laparoscopic procedures for a several short-term outcomes including:a lower blood loss,an earlier recovery of the bowel function,an earlier return to the oral intake,a shorter hospital stay and a lower morbidity rate.Opposite the operating time has been confirmed shorter in open surgery.The same trend has been reported investigating case-control series and cancer by sites,even though there are some concerns regarding the power of the studies in this latter field due to the small number of trials and the small sample of patients enrolled.The two approaches were comparable regarding the mean number of nodes harvested and long-term results,even though these variables were documented reviewing the literature but were not computable for meta-analysis.The analysis of the costs documented lower costs for the open surgery,however just few studies investigated the incidence of postoperative hernias.CONCLUSION:Laparoscopy is superior for the majority of short-term results.Future studies should better differentiate these approaches on the basis of tumors’location and the post-operative hernias. | Laura Lorenzon Marco La Torre Vincenzo Ziparo Francesco Montebelli Paolo Mercantini Genoveffa Balducci Mario Ferri | 2014 | World Journal of Gastroenterology2014，20，13： | 8 |
| 15 | 响应面分析法优化仙鹤草总黄酮提取工艺显示文摘为优化仙鹤草中总黄酮的提取方法,在单因素试验基础上,选取提取时间、提取温度、乙醇浓度和料液比为自变量,仙鹤草总黄酮提取率为响应值,采用响应曲面试验设计方法,研究各自变量及其交互作用对总黄酮提取率的影响。采用Design-Expert软件,建立总黄酮得率与因素间的二次回归模型。结果表明:该回归模型极显著,预测性强。乙醇浓度和提取温度是影响提取率的主要因素;优化得到的最佳提取工艺条件:提取时间100 min、提取温度100℃、乙醇浓度30%、料液比1∶15(g/m L)。在此提取工艺条件下平行3次进行验证,总黄酮得率为9.92%。 | 叶春林 MUNYONHO Ferris Tatenda 黄盼盼 李嘉骏 经洁 方慧 | 2017 | 食品研究与开发2017，38，18： | 8 |
| 16 | Hepatitis C virus infection and type 1 and type 2 diabetes mellitus显示文摘Hepatitis C virus(HCV) infection and diabetes mellitus are two major public health problems that cause devastating health and financial burdens worldwide. Diabetes can be classified into two major types: type 1 diabetes mellitus(T1DM) and T2 DM. T2 DM is a common endocrine disorder that encompasses multifactorial mechanisms, and T1 DM is an immunologically mediated disease. Many epidemiological studies have shown an association between T2 DM and chronic hepatitis C(CHC) infection. The processes through which CHC is associated with T2 DM seem to involve direct viral effects, insulin resistance, proinflammatory cytokines, chemokines, and other immunemediated mechanisms. Few data have been reported on the association of CHC and T1 DM and reports on the potential association between T1 DM and acute HCV infection are even rarer. A small number of studies indicate that interferon-α therapy can stimulate pancreatic autoim-munity and in certain cases lead to the development of T1 DM. Diabetes and CHC have important interactions. Diabetic CHC patients have an increased risk of developing cirrhosis and hepatocellular carcinoma compared with nondiabetic CHC subjects. However, clinical trials on HCV-positive patients have reported improvements in glucose metabolism after antiviral treatment. Further studies are needed to improve prevention policies and to foster adequate and cost-effec-tive programmes for the surveillance and treatment of diabetic CHC patients. | Alessandro Antonelli Silvia Martina Ferrari Dilia Giuggioli Andrea Di Domenicantonio Ilaria Ruffilli Alda Corrado Silvia Fabiani Santino Marchi Clodoveo Ferri Ele Ferrannini Poupak Fallahi | 2014 | World Journal of Diabetes2014，5，5： | 7 |
| 17 | Introduction and evaluation of a novel hybrid brattice for improved dust control in underground mining faces: A computational study显示文摘A proper control and management of dust dispersion is essential to ensure safe and productive underground working environment. Brattice installation to direct the flow from main shaft to the mining face was found to be the most effective method to disperse dust particle away from the mining face. However,it limits the movement and disturbs the flexibility of the mining fleets and operators at the tunnel. This study proposes a hybrid brattice system- a combination of a physical brattice together with suitable and flexible directed and located air curtains- to mitigate dust dispersion from the mining face and reduce dust concentration to a safe level for the working operators. A validated three-dimensional computational fluid dynamic model utilizing Eulerian–Lagrangian approach is employed to track the dispersion of dust particle. Several possible hybrid brattice scenarios are evaluated with the objective to improve dust management in underground mine. The results suggest that implementation of hybrid brattice is beneficial for the mining operation: up to three times lower dust concentration is achieved as compared to that of the physical brattice without air curtain. | Kurnia Jundika C. Sasmito Agus P. Hassani Ferri P. Mujumdar Arun S. | 2015 | International Journal of Mining Science and Technology2015，25，4： | 7 |
| 18 | 亚洲玉米螟对Cry1Ab蛋白抗性的遗传规律与分子机理显示文摘 | 何康来 常雪 常雪艳 王振营 Natalie Ferry Angharad M.R.Gatehouse | 2007 | 植物保护2007，33，5： | 6 |
| 19 | A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes显示文摘AIM:To investigate the effectiveness of antioxidant compounds in modulating mitochondrial oxidative alterations and lipids accumulation in fatty hepatocytes.METHODS:Silybin-phospholipid complex containing vitamin E(Realsil) was daily administered by gavage(one pouch diluted in 3 mL of water and containing 15 mg vitamin E and 47 mg silybin complexed with phospholipids) to rats fed a choline-deprived(CD) or a high fat diet [20% fat,containing 71% total calories as fat,11% as carbohydrate,and 18% as protein,high fat diet(HFD)] for 30 d and 60 d,respectively.The control group was fed a normal semi-purified diet containing adequate levels of choline(35% total calories as fat,47% as carbohydrate,and 18% as protein).Circulating and hepatic redox active and nitrogen regulating molecules(thioredoxin,glutathione,glutathione peroxidase),NO metabolites(nitrosothiols,nitrotyrosine),lipid peroxides [malondialdehyde-thiobarbituric(MDA-TBA)],and pro-inflammatory keratins(K-18) were measured on days 0,7,14,30,and 60.Mitochondrial respiratory chain proteins and the extent of hepatic fatty infiltration were evaluated.RESULTS:Both diet regimens produced liver steatosis(50% and 25% of liver slices with CD and HFD,respectively) with no signs of necro-inflammation:fat infiltration ranged from large droplets at day 14 to disseminated and confluent vacuoles resulting in microvesicular steatosis at day 30(CD) and day 60(HFD).In plasma,thioredoxin and nitrosothiols were not significantly changed,while MDA-TBA,nitrotyrosine(from 6 ± 1 nmol/L to 14 ± 3 nmol/L day 30 CD,P < 0.001,and 12 ± 2 nmol/L day 60 HFD,P < 0.001),and K-18(from 198 ± 20 to 289 ± 21 U/L day 30 CD,P < 0.001,and 242 ± 23 U/L day 60 HFD,P < 0.001) levels increased significantly with ongoing steatosis.In the liver,glutathione was decreased(from 34.0 ± 1.3 to 25.3 ± 1.2 nmol/mg prot day 30 CD,P < 0.001,and 22.4 ± 2.4 nmol/mg prot day 60 HFD,P < 0.001),while thioredoxin and glutathione peroxidase were initially increased and then decreased.Nitrosothiols were constantly increased.MDA-TBA levels were five-fold increased from 9.1 ± 1.2 nmol/g to 75.6 ± 5.4 nmol/g on day 30,P < 0.001(CD) and doubled with HFD on day 60.Realsil administration significantly lowered the extent of fat infiltration,maintained liver glutathione levels during the first half period,and halved its decrease during the second half.Also,Realsil modulated thioredoxin changes and the production of NO derivatives and significantly lowered MDA-TBA levels both in liver(from 73.6 ± 5.4 to 57.2 ± 6.3 nmol/g day 30 CD,P < 0.01 and from 27.3 ± 2.1 nmol/g to 20.5 ± 2.2 nmol/g day 60 HFD,P < 0.01) and in plasma.Changes in mitochondrial respiratory complexes were also attenuated by Realsil in HFD rats with a major protective effect on Complex Ⅱ subunit CII-30.CONCLUSION:Realsil administration effectively contrasts hepatocyte fat deposition,NO derivatives formation,and mitochondrial alterations,allowing the liver to maintain a better glutathione and thioredoxin antioxidant activity. | Ignazio Grattagliano Catia V Diogo Maria Mastrodonato Ornella de Bari Michele Persichella David QH Wang Adriana Liquori Domenico Ferri Maria Rosaria Carratù Paulo J Oliveira Piero Portincasa | 2013 | World Journal of Gastroenterology2013，19，20： | 6 |
| 20 | Latitudinal diversity gradients in bryophytes and woody plants: Roles of temperature and water availability显示文摘微生物和宏有机体的纬度的差异坡度是否被一样的宏环境的变量驾驶,仍然保持不清楚。我们在中国使用了最新完成的种类目录和藓苔类的植物的分发信息探索他们的空间种类丰富模式,并且在塑造这些模式调查精力可获得性,气候的 seasonality,和环境异质的内在的角色。我们然后把这些模式比作作出对有利的裁决的那些木质的植物。我们发现苔藓和地钱不同于木质的植物,在种类丰富显示出仅仅弱否定的纬度的趋势。地钱丰富和苔藓丰富的空间模式被当代的环境变量压倒性地解释,尽管解释变化为木质的植物是比那低的。类似于假设作为解释变量统治,但是在塑造藓苔类的植物的分发显示出高冗余性的木质的植物,精力和气候的 seasonality。水变量,也就是说在降水的年度可获得性, intra 年度的可变性和空间异质,在解释藓苔类的植物的种类丰富的空间变化起了一个占优势的作用特别为地钱,而木质的植物丰富被温度变量最影响。我们建议关于藓苔类的植物的空间模式的进一步的研究应该在他们的生态生理学和进化上合并知识。 | Sheng-Bin Chen J. W. Ferry Slik Jie Gao Ling-Feng Mao Meng-Jie Bi Meng-Wei Shen Ke-Xin Zhou | 2015 | Journal of Systematics and Evolution2015，53，6： | 6 |
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