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| 1 | Second line systemic therapies for hepatocellular carcinoma: Reasons for the failure显示文摘Hepatocellular carcinoma(HCC) is the main cause of death in patients with cirrhosis, with an increasing incidence worldwide. Sorafenib is the choice therapy for advanced HCC. Over time several randomized phase Ⅲ trials have been performed testing sunitinib, brivanib, linifanib and other molecules in head-tohead comparison with Sorafenib as first-line treatment for advanced-stage HCC, but none of these has so far been registered in this setting. Moreover, another feared vacuum arises from the absence of molecules registered as second-line therapy for patients who have failed Sorafenib, representing an urgent unmet medical need. To date all molecules tested as second-line therapies for advanced hepatocellular carcinoma, failed to demonstrate an increased survival compared to placebo. What are the possible reasons for the failure? What we should expect in the near future? | Marcello Maida Massimo Iavarone Maurizio Raineri Calogero Cammà Giuseppe Cabibbo | 2015 | World Journal of Hepatology2015，7，17： | 7 |
| 2 | The Yin-Yang of osteopontin in nervous system diseases: damage versus repair显示文摘Osteopontin is a broadly expressed pleiotropic protein,and is attracting increased attention because of its role in the pathophysiology of several inflammatory,degenerative,autoimmune,and oncologic diseases.In fact,in the last decade,several studies have shown that osteopontin contributes to tissue damage not only by recruiting harmful inflammatory cells to the site of lesion,but also increasing their survival.The detrimental role of osteopontin has been indeed well documented in the context of different neurological conditions(i.e.,multiple sclerosis,Parkinson’s,and Alzheimer’s diseases).Intriguingly,recent findings show that osteopontin is involved not only in promoting tissue damage(the Yin),but also in repair/regenerative mechanisms(the Yang),mostly triggered by the inflammatory response.These two apparently discordant roles are partly related to the presence of different functional domains in the osteopontin molecule,which are exposed after thrombin or metalloproteases cleavages.Such functional domains may in turn activate intracellular signaling pathways and mediate cell-cell and cell-matrix interactions.This review describes the current knowledge on the Yin and Yang features of osteopontin in nervous system diseases.Understanding the mechanisms behind the Yin/Yang would be relevant to develop highly specific tools targeting this multifunctional protein. | Giuseppe Cappellano Domizia Vecchio Luca Magistrelli Nausicaa Clemente Davide Raineri Camilla Barbero Mazzucca Eleonora Virgilio Umberto Dianzani Annalisa Chiocchetti Cristoforo Comi | 2021 | Neural Regeneration Research2021，16，6： | 2 |
| 3 | Roles of AUF1 isoforms, HuR and BRF1 in ARE - dependent mRNA turnover studied by RNA interference 显示文摘 | Raineri I Wegmueller D Gross B | 2004 | Nucleic Acids Research2004，32，4： | 1 |
| 4 | Aedes albopictus in Italy and possible diffusion of the species into the Mediterranean area显示文摘 | Sabatini A Raineri V Trovato G | 1990 | Parassitologia1990，32，3： | 1 |
| 5 | A comparison of methods for the estimation of retroviral burden显示文摘 | Bierley ST Raineri R Poiley JA | 1996 | Dev Biol Stand1996，88，： | 1 |
| 6 | Assesment of human exposure and respons to N-nitroso compounds ,a new riew on the etiology of digestve tract caner显示文摘 | WEISBURGER J H RAINERI R | 1975 | Toxieo App Pharm1975，31，： | 1 |
| 7 | O-Glycosylation of human sex hormone-binding globulin is essential for inhibition of estradiol-induced MCF-7 breast cancer cell proliferation显示文摘 | Raineri M Catalano M G Hammond G L | 2002 | Mol Cell Endocrinol2002，189，12： | 1 |
| 8 | No evidence for infection of human cells with porcine endogenous retrovirus (PERV)after exposure to porcine fetal neuronal cells显示文摘 | Dinsmore J H Manhart C Raineri R | 2000 | Transplantation2000，70，9： | 1 |
| 9 | Remote ischemic post-condi- tioning of the lower limb during primary percutaneous coronary in- tervention safely reduces enzymatic infarct size in anterior myocar- dial infarction: a randomized controlled trial 显示文摘 | Crimi G Pica S Raineri C | 2013 | JACC Cardio- vasc Interv2013，6，10： | 1 |
| 10 | Ion irradiation and defect formation in single layer graphene显示文摘 | Giuseppe Compagnini Filippo Giannazzo Sushant Sonde Vito Raineri Emanuele Rimini | 2009 | Carbon2009，，： | 1 |
| 11 | Multicenter evaluation of a new 4th generation HIV screening assay Elecsys HIV combi显示文摘 | Weber B Orazi B Raineri A etal | 2006 | Clin Lab2006，52，910： | 1 |
| 12 | Genetic analysis of the virD operon of Agrobacterium tumefaciens: a search for function involved jn transport of T-DNA into the plant cell nucleus and in T-DNA intrgration显示文摘 | Koukolikova-Nicola Z Raineri D Stephens K | 1993 | Bacteriol1993，175，： | 1 |
| 13 | Remote ischemic postconditioning as a strategy to reduce acute kidney injury during primary PCI: A post-hoc analysis of a randomized trial显示文摘 | Gabriele Crimi Marco Ferlini Fabio Gallo Maria Pia Sormani Claudia Raineri Ezio Bramucci Gaetano M. De Ferrari Silvia Pica Barbara Marinoni Alessandra Repetto Arturo Raisaro Sergio Leonardi Paolo Rubartelli Luigi Oltrona Visconti Maurizio Ferrario | 2014 | International Journal of Cardiology2014，，： | 1 |
| 14 | Multicenter evaluation of a new 4th Generation HIV Screening Assay Elecsys HIV combi显示文摘 | Weber B Orazi B Raineri A | 2006 | Clin Lab2006，52，910： | 1 |
| 15 | The use of transgenic and mutant mice to study oxygen free radical metabolism显示文摘 | HUANG Ting-ting CARLSON E J RAINERI I | 1999 | Ann N Y Acad Sci1999，893，： | 1 |
| 16 | Agrobacterium-mediated transformation of rice,(Oryza sativa L)显示文摘 | Raineri D M Bottino P Gordon M P | | 0，，08： | 1 |
| 17 | Performance of a multianalyte test as an aid for the diagnosis of ovar- ian cancer in symptomatic women显示文摘 | Autelitano DJ Raineri L Knight K | 2012 | J Transl Med2012，10，1： | 1 |
| 18 | Remote ischemic post - condi- tioning of the lower limb during primary percutaneous coronary in- tervention safely reduces enzymatic infarct size in anterior myocar- dial infarction: a randomized controlled trial 显示文摘 | Crimi G Pica S Raineri C | 2013 | JACC Cardio- vasc Interv2013，6，10： | 1 |
| 19 | Virtual laboratories enhance traditional undergraduate biology laboratories显示文摘 | Deanna Raineri | 2001 | Biochemistry and Molecular Biology Education2001，，29： | 1 |
| 20 | Muhicenter evaluation of a new 4th generation HIV screening assay Elecsys HIV combi 显示文摘 | Weber B Orazi B Raineri A | 2006 | Clin Lab2006，52，46： | 1 |
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