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| 1 | Mechanism and its regulation of tumor-induced angiogenesis显示文摘Tumor angiogenesis is the proliferation of a network of blood vessels that penetrates into cancerous growths, supplying nutrients and oxygen and removing waste products. The process of angiogenesis plays an important role in many physiological and pathological conditions. Solid tumors depend on angiogenesis for growth and metastasis in a hostile environment. In the prevascular phase, the tumor is rarely larger than 2 to 3 mm3 and may contain a million or more cells. Up to this size, tumor cells can obtain the necessary oxygen and nutrient supplies required for growth and survival by simple passive diffusion. The properties of tumors to release and induce several angiogenic and antiangiogenic factors which play crucial roles in regulating endothelial cell (EC) proliferation, migration, apoptosis or survival, cell-cell and cell-matrix adhesion through different intracellular signaling are thought to be the essential mechanisms during tumor-induced angiogenesis. Tumor angiogenesis actually starts with tumor cells releasing molecules that send signals to surrounding normal host tissue. This signaling activates certain genes in the host tissue that, in turn, make proteins to encourage growth of new blood vessels. In this review, we focus the mechanisms of tumor-induced angiogenesis, with an emphasis on the regulatory role of several angiogenic and anti-angiogenic agents during the angiogenic process in tumors. Advances in understanding the mechanisms of tumor angiogenesis have led to the development of several most effective antiangiogenic and anti-metastatic therapeutic agents and also have provided several techniques for the regulation of cancer's angiogenic switch. The suggestion is made that standard cytotoxic chemotherapy and angiogenesis inhibitors used in combination may produce complementary therapeutic benefits in the treatment of cancer. | Manoj Kumar Gupta | 2003 | World Journal of Gastroenterology2003，9，6： | 51 |
| 2 | Alteration of somatostatin receptor subtype 2 gene expression in pancreatic tumor angiogenesis显示文摘AIM: To explore the difference of somatostatin receptor subtype 2 (SST2R) gene expression in pancreatic cancerous tissue and its adjacent tissue, and the relationship between the change of SST2R gene expression and pancreatic tumor angiogenesis related genes. METHODS: The expressions of SST2R, DPC4, p53 and ras genes in cancer tissues of 40 patients with primary pancreatic cancer, and the expression of SST2R gene in its adjacent tissue were determined by immunohistochemiscal LSAB method and EnVisionTM method. Chi-square test was used to analyze the difference in expression of SST2R in pancreatic cancer tissue and its adjacent tissue, and the correlation of SST2R gene expression with the expression of p53, ras and DPC4 genes.RESULTS: Of the tissue specimens from 40 patients with primary pancreatic cancer, 35 (87.5%) cancer tissues showeda negative expression of SST2R gene, whereas 34 (85%) a positive expression of SST2R gene in its adjacent tissues. Five (12.5%) cancer tissues and its adjacent tissues simultaneously expressed SST2R. The expression of SST2R gene was markedly higher in pancreatic tissues adjacent to cancer than in pancreatic cancer tissues (P<0.05). The expression rates of p53, ras and DPC4 genes were 50%,60% and 72.5%, respectively. There was a significant negative correlation of SST2R with p53 and ras genes x1^2=9.33,x2^2=15.43, P<0.01), but no significant correlation with DPC4 gene x2=2.08, P >0.05). CONCLUSION: There was a significant difference of SST2R gene expression in pancreatic cancer tissues and its adjacent tissues, which might be one cause for the different therapeutic effects of somatostatin and its analogs on pancreatic cancer patients. There were abnormal expressions of SST2R, DPC4, p53 and ras genes in pancreatic carcinogenesis, and moreover, the loss or decrease of SST2R gene expression was significantly negatively correlated with the overexpression of tumor angiogenesis correlated p53 and ras genes, suggesting that SST2R gene together with p53 and ras genes may participate in pancreatic cancerous angiogenesis. | Manoj Kumar Gupta | 2004 | World Journal of Gastroenterology2004，10，1： | 26 |
| 3 | Using lanthanum to enhance the overall ignition, hardness, tensile and compressive strengths of Mg-0.5Zr alloy显示文摘Near dense Mg 0.5 wt.% Zr(0,1,2.5 and 4) wt.% La alloys were successfully synthesized by disintegrated melt deposition technique followed by hot extrusion and were characterized for their microstructural, ignition, hardness, tensile and compression properties. Combined effects of Zr and La assisted in significant grain refinement of Mg and Mg 0.5 wt.% Zr 4 wt.% La exhibited an average grain size as low as ~2.75 μm. High ignition temperature of ~645 oC was realized with Mg 0.5 wt.% Zr(1,2.5 and 4) wt.% La alloys. Microhardness value as high as ~103 Hv was observed with Mg 0.5 wt.% Zr 4 wt.% La alloy. Under room temperature tensile and compression loading, significant improvements in the strength properties of pure Mg with the addition of 0.5 wt.% Zr(0, 1, 2.5 and 4) wt.% La was observed. Mg 0.5 wt.% Zr 4 wt.% La exhibited the maximum 0.2% tensile and compression yield strengths of ~283 MPa and ~264 MPa, respectively. The tensile and compression fracture strain values of synthesized pure Mg were found to be unaffected with the addition of 0.5 wt.% Zr. But the tensile fracture strain reduced with the addition of La while the compressive fracture strain was unaffected. Minimal tensile-compression asymmetry(~1) was exhibited by Mg 0.5 wt.% Zr(1 and 2.5) wt.% La alloys. | Ganesh Kumar Meenashisundaram Tiong Hou Damien Ong Gururaj Parande Vyasaraj Manakari 向抒林 Manoj Gupta | 2017 | Journal of Rare Earths2017，35，7： | 5 |
| 4 | 基于RAPD-PCR标记的印度亚麻品种遗传多样性和指纹图谱分析(英文)显示文摘栽培的亚麻(L.usitatissimum)通常为亚麻籽,以其油分和纤维而被认为是具有较高经济价值的作物之一。开发亚麻遗传资源并进一步进行遗传改良,须了解其遗传变异的范围和结构。位于坎普尔的C.S.农业科技大学种质管理单位保存有广泛收集而来的2772份栽培和野生亚麻资源。从中选出23份不同基因型栽培亚麻品种包括5份两用品种、4份种用品种、14份具有不同形态和经济特性的引进种用品种以及1份野生品系(L.grandiflorum),采用RAPD标记进行遗传多样性分析。20条随机引物共产生242条带,每条引物扩增带数为1~20条,平均为10.95条。所有基因型和位点的RAPD多态性比例为90.49%。DICE系数相似矩阵分析揭示其遗传相似性为0.63~0.97,平均相似系数为82%,说明这些亚麻品种(系)的遗传背景较窄。采用UPGMA法以及NTSYS-pc软件的SAHN聚类分析模型对遗传相似矩阵进行聚类分析,发现属于L.uitatisimums的所有栽培品种在X轴上可聚为一类,而L.grandiflorum野生种单独在Y轴上聚为一类。主成分分析结果表明,除了Shekha(r优良种用品种)和野生种L.grandiflorum广泛分布外,其他所有种用品种、两用品种和外来品种聚类很近。由于亚麻栽培品种的遗传关系相近,须对亚麻种质的各种基因型进行鉴定,以拓宽今后育种计划中的遗传基础。 | Prashant Shekhar Gupta Sangeeta Srivastava Manoj Kumar Srivastava Abhilash Gupta | 2010 | 广西农业科学2010，41，3： | 2 |
| 5 | A Review and Analysis of Localization Techniques in Underwater Wireless Sensor Networks显示文摘In recent years,there has been a rapid growth in Underwater Wireless Sensor Networks(UWSNs).The focus of research in this area is now on solving the problems associated with large-scale UWSN.One of the major issues in such a network is the localization of underwater nodes.Localization is required for tracking objects and detecting the target.It is also considered tagging of data where sensed contents are not found of any use without localization.This is useless for application until the position of sensed content is confirmed.This article’s major goal is to review and analyze underwater node localization to solve the localization issues in UWSN.The present paper describes various existing localization schemes and broadly categorizes these schemes as Centralized and Distributed localization schemes underwater.Also,a detailed subdivision of these localization schemes is given.Further,these localization schemes are compared from different perspectives.The detailed analysis of these schemes in terms of certain performance metrics has been discussed in this paper.At the end,the paper addresses several future directions for potential research in improving localization problems of UWSN. | Seema Rani Anju Anupma Sangwan Krishna Kumar Kashif Nisar Tariq Rahim Soomro Ag.Asri Ag.Ibrahim Manoj Gupta Laxmi Chandand Sadiq Ali Khan | 2023 | Computers, Materials & Continua2023，，6： | 1 |
| 6 | Catalytic functionalities of FSM-16 ordered mesoporus silica supported molybdenum hydroprocessing catalysts显示文摘 | Shelu Garg Kapil Soni Manoj Kumar Thallada Bhaskar J.K. Gupta K.S. Rama Rao G. Murali Dhar | 2012 | Catalysis Today2012，，1： | 1 |
| 7 | Prognostic significance of Her2/neu overexpression in patients with muscle invasive urinary bladder cancer treated with radical cystectomy显示文摘 | Surendra B. Kolla Amlesh Seth Manoj K. Singh Narmada P. Gupta Ashok K. Hemal Prem N. Dogra Rajeev Kumar | 2008 | International Urology and Nephrology2008，，2： | 1 |
| 8 | Controlled attenuation parameter for non‐invasive assessment of hepatic steatosis: Does etiology affect performance?显示文摘 | Manoj Kumar Archana Rastogi Tarandeep Singh Chhagan Behari Ekta Gupta Hitendra Garg Ramesh Kumar Vikram Bhatia Shiv K Sarin | 2013 | J Gastroenterol Hepatol2013，，7： | 1 |
| 9 | Expression of TREM-1 mRNA in acute pancreatitis显示文摘AIM: To explore the expression of triggering receptor expressed on myeloid cells (TREM-I) mRNA in acute pancreatitis (AP).METHODS: Using the reverse transcription polymerase chain reaction (RT-PCR), we examined the expression of TREM-1 mRNA in 10 cases of mild acute pancreatitis (MAP), 8 cases of severe acute pancreatitis (SAP), and 10 cases of healthy control subjects. And we also examined the expression of TREM-1 mRNA in 14 cases of AP (including 10 MAP and 4 SAP) before treatment, after successful therapy and clinically cured.RESULTS: The expression of TREM-1 mRNA in the groups of MAP, SAP patients and healthy control subjects was 0.771±0.274, 1.092±0.331 and 0.459±0.175, respectively;there was a significant difference among the three groups (P<0.05). And there was also a significant difference between the AP patients (0.914±0.341) and healthy control subjects (0.459+0.175) (P<0.05). Moreover, in the 14 cases of AP, before treatment, after successful therapy and clinically cured, the expression of TREM-1 mRNA was 0.905±0.226,0.739±0.169 and 0.633±0.140, respectively, and there was a significant difference among the three stages (P<0.05).CONCLUSION: The expression of TREM-1 mRNA in the patients with AP increases obviously, and correlates with the degree of AP. Furthermore, the expression of TREM-1 mRNA is distinctly different at the different stages of AP. It indicates TREM-1 may play an important role in the occurrence and development of AP. | Manoj Kumar Gupta | 2004 | World Journal of Gastroenterology2004，10，18： | 1 |
| 10 | Ocular chemical injuries and their management显示文摘 | Parul Singh Manoj Tyagi Yogesh Kumar K Gupta P Sharma | 2013 | Oman Journal of Ophthalmology2013，，2： | 1 |
| 11 | Light weight HTPB-clay nanocomposites (HCN) with enhanced ablation performance as inhibition materials for composite propellant显示文摘In the present study,organically modified Montmorillonite clay with polar moiety,the Cloisite 30B,is used for preparation of Hydroxyl terminated polybutadiene(HTPB)-clay nanocomposites(HCN)by dispersion of nanoclay in polymer matrix under high shear mixing.The nanocomposites thus prepared are evaluated in composite propellants as inhibitor material for their functional utility.Several inhibition formulations containing 5 wt%-15 wt%of nanoclay,with or without the conventional filler Sb2O3,were prepared.All these formulations were evaluated for their physical,mechanical,thermal,and ablative properties.Ablation rate and density of the compositions containing Cloisite 30B is around 23%and 5%lower respectively in comparison of the base composition.Strain capability of these compositions is twofold higher than that of base composition.These compositions have also been evaluated for their smoke generation tendency by measuring infra red(IR)attenuation in the wavelength range 1.3 mm e5.6 mm and 8 mme13 mm and thereby compared with the base composition.The corresponding results confirmed that the compositions containing Cloisite 30B as filler have much lower IR attenuation than compositions with conventional filler,Sb2O3.Replacement of 5%Sb2O3 by nanoclay showed 8%reduction in IR attenuation rate which further reduced to 16%on replacement of 15%of Sb2O3.Interfacial bonding of HCN based inhibitors is also comparable or even better than conventional inhibitors.Precisely,the nanoclay composites with Cloisite 30B as filler exhibit all desirable properties of an inhibitor. | Kavita Ghosh L.V.Gaikwad R.K.Kalal P.A.Kulkarni Arvind Kumar Shaibal Banerjee Manoj Gupta | 2021 | Defence Technology(防务技术)2021，17，2： | 1 |
| 12 | Characterization of ZrO2-Al2O3 mixed oxides support prepared by urea hydrolysis 显示文摘 | Folorunsho Aberuagba Manoj Kumar Jai Krishna Gupta | 2003 | React Kinet Catal Lett2003，80，2： | 1 |
| 13 | Microwave synthesis and characterization of metastable (AVFi) and hybrid (Al/l'i+ SiC) composites显示文摘 | Sanjay Kumar Thakur Tung Siew Kong Manoj Gupta | 2007 | Mater Sci Eng2007，452，： | 1 |
| 14 | Temperatureprogrammed reduction and acidic properties of molybdenum supported on MgO-Al2O03 and their correlation with catalytic activity显示文摘 | Manoj Kumar Abemagba F Gupta J K | 2004 | Journal of Molecular Catalysis A: Chemical2004，213，2： | 1 |
| 15 | Ocular chemical injuries and their management显示文摘 | Parul Singh Manoj Tyagi Yogesh Kumar K Gupta P Sharma | 2013 | Oman Journal of Ophthalmology2013，，2： | 1 |
| 16 | Emerging risk factors for cardiovascular diseases: Indian context显示文摘 | Sushil Gupta Ramesh Gudapati Kumar Gaurav Manoj Bhise | 2013 | Indian Journal of Endocrinology and Metabolism2013，，5： | 1 |
| 17 | Assessment of nutrient composition and antioxidant potential of Caulerpaceae seaweeds显示文摘 | Manoj Kumar Vishal Gupta Puja Kumari C.R.K. Reddy B. Jha | 2010 | Journal of Food Composition and Analysis2010，，2： | 1 |
| 18 | Cylindrical gate all around Schottky barrier MOSFET with insulated shallow extensions at source/drain for removal of ambipolarity:a novel approach显示文摘In this paper TCAD-based simulation of a novel insulated shallow extension(ISE) cylindrical gate all around(CGAA) Schottky barrier(SB) MOSFET has been reported, to eliminate the suicidal ambipolar behavior(bias-dependent OFF state leakage current) of conventional SB-CGAA MOSFET by blocking the metal-induced gap states as well as unwanted charge sharing between source/channel and drain/channel regions. This novel structure offers low barrier height at the source and offers high ON-state current. The I_(ON)/I_(OFF) of ISE-CGAA-SB-MOSFET increases by 1177 times and offers steeper subthreshold slope(~60 mV/decade). However a little reduction in peak cut off frequency is observed and to further improve the cut-off frequency dual metal gate architecture has been employed and a comparative assessment of single metal gate, dual metal gate, single metal gate with ISE, and dual metal gate with ISE has been presented. The improved performance of Schottky barrier CGAA MOSFET by the incorporation of ISE makes it an attractive candidate for CMOS digital circuit design. The numerical simulation is performed using the ATLAS-3D device simulator. | Manoj Kumar Yogesh Pratap Subhasis Haldar Mridula Gupta R.S.Gupta | 2017 | Journal of Semiconductors2017，38，12： | 0 |
| 19 | Paget-Schroetter Syndrome显示文摘To the Editor:A 40-year-old male working as a manual labor with a history of smoking presented with a swelling in the neck and right upper extremity with the breathlessness since 5 days.The swelling in the neck region was acute in onset,pain associated with the generalized swelling in a right upper extremity.Breathlessness was acute in onset but was not associated with chest pain.There was no history of cough,fever,trauma and family history of other coagulopathies. | Manoj Meena Sabarigirivasan Harish Jai Prakash Kewlani Neeraj Gupta Vinay Kumar Meena | 2015 | Chinese Medical Journal2015，，19： | 0 |
| 20 | Design of a 2-DOF-PID controller using an improved sine-cosine algorithm for load frequency control of a three-area system with nonlinearities显示文摘This paper proposes an improved sine-cosine algorithm(ISCA)based 2-DOF-PID controller for load frequency control.A three-area test system is built for study,while some physical constraints(nonlinearities)are considered for the investigation of a realistic power system.The proposed method is used as the parameter optimizer of the LFC control-ler in different scenarios.The 2-DOF-PID controllers are used because of their capability of fast disturbance rejection without significant increase of overshoot in set-point tracking.The 2-DOF-PID controllers’efficacy is observed by examining the responses with the outcomes obtained with PID and FOPID controllers.The simulation results with the suggested scheme are correlated with some of the existing algorithms,such as SCA,SSA,ALO,and PSO in three dif-ferent scenarios,i.e.,a disturbance in two areas,in three areas,and in the presence of physical constraints.In addition,the study is extended to a four-area power system.Statistical analysis is performed using the Wilcoxon Sign Rank Test(WSRT)on 20 independent runs.This confirms the supremacy of the proposed method. | Neelesh Kumar Gupta Manoj Kumar Kar Arun Kumar Singh | 2022 | Protection and Control of Modern Power Systems2022，7，1： | 0 |
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