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| 1 | Xanthogranulomatous cholecystitis: What every radiologist should know显示文摘Xanthogranulomatous cholecystitis(XGC) is an uncommon variant of chronic cholecystitis characterized by xanthogranulomatous inflammation of the gallbladder. Intramural accumulation of lipid-laden macrophages and acute and chronic inflammatory cells is the hallmark of the disease. The xanthogranulomatous inflammation of the gallbladder can be very severe and can spill over to the neighbouring structures like liver, bowel and stomach resulting in dense adhesions, perforation, abscess formation, fistulous communication with adjacent bowel. Striking gallbladder wall thickening and dense local adhesions can be easily mistaken for carcinoma of the gallbladder, both intraoperatively as well as on preoperative imaging. Besides, cases of concomitant gallbladder carcinoma complicating XGC have also been reported in literature. So, we have done a review of the imaging features of XGC in order to better understand the entity as well as to increase the diagnostic yield of the disease summarizing the characteristic imaging findings and associations of XGC. Among other findings, presence of intramural hypodense nodules is considered diagnostic of this entity. However, in some cases, an imaging diagnosis of XGC is virtually impossible. Fine needle aspiration cytology might be handy in such patients. A preoperative counselling should include possibility of differential diagnosis of gallbladder cancer in not so characteristic cases. | Vaibhav P Singh S Rajesh Chhagan Bihari Saloni N Desai Sudheer S Pargewar Ankur Arora | 2016 | World Journal of Radiology2016，8，2： | 21 |
| 2 | CEACAM-1 Induced CSF3-receptor Downregulation in Bone Marrow Associated With Refractory Neutropenia in Advanced Cirrhosis显示文摘Background and Aims:Cirrhosis patients exhibit cyto-penia,and,at times refractory neutropenia to granulocyte colony-stimulating factor(G-CSF),which acts through the CSF3-receptor(CSF3R),and changes in CSF3R can affect the response.We conducted this study to assess the CSF3R status and its relevance in cirrhotic patients.Methods:Cirrhotic patients(n=127)and controls(n=26)with clini-cally indicated bone marrow(BM)examination were stud-ied.BM assessment was done by qRT-PCR and immunohis-tochemistry(IHC)for CSF3R.Circulating G-CSF,CSF3R,and carcinoembryonic antigen cell adhesion molecule-1(CEACAM1)were measured.BM hematopoietic precursor cells and their alterations were examined by flow cytom-etry.The findings were validated in liver cirrhosis patients who received G-CSF for severe neutropenia.Results:The mean age was 48.6±13.4 years,and 80.3%were men.Circulatory CSF3R reduction was noted with the advance-ment of cirrhosis,and confirmed by qRT-PCR and IHC in BM.CSF3R decline was related to decreased hematopoietic stem cells(HSCs)and downregulation of CSF3R in the re-maining HSCs.Cocultures confirmed that CEACAM1 led to CSF3R downregulation in BM cells by possible lysosomal degradation.Baseline low peripheral blood-(PB)-CSF3R also predisposed development of infections on follow-up.Decreased CSF3R was also associated with nonresponse to exogenous G-CSF treatment of neutropenia.Conclu-sions:Advanced liver cirrhosis was associated with low CSF3R and high CEACAM1 levels in the BM and circula-tion,making patients prone to infection and inadequate response to exogenous G-CSF. | Chhagan Bihari Sukriti Baweja Seggere Murlaikrishna Shasthry Deepika Lal Preeti Negi Swati Thangariyal Dinesh Mani Tripathi Shiv Kumar Sarin | 2022 | Journal of Clinical and Translational Hepatology2022，10，1： | 2 |
| 3 | Comorbidities and mortality among chil- dren hospitalized with diarrheal disease in an area of high prevalenceof human immunodeficiency virus infection 显示文摘 | Chhagan MK Kauchali S | 2006 | Pediatr Infect Dis J2006，25，4： | 1 |
| 4 | Hydrogen storage in Mg: A most promising material 显示文摘 | JA1N I P CHHAGAN L ANKUR J | 2010 | International Journal of Hydrogen Energy2010，35，10： | 1 |
| 5 | Design and development of a self correcting monolithic gastroretentive tablet of baclofen 显示文摘 | RISHAD R J CHHAGAN N P NURUDDIN P J | 2009 | Sci Pharm2009，77，： | 1 |
| 6 | Controlled attenuation parameter for non‐invasive assessment of hepatic steatosis: Does etiology affect performance?显示文摘 | Manoj Kumar Archana Rastogi Tarandeep Singh Chhagan Behari Ekta Gupta Hitendra Garg Ramesh Kumar Vikram Bhatia Shiv K Sarin | 2013 | J Gastroenterol Hepatol2013，，7： | 1 |
| 7 | Liver Stiffness Measurements in Patients with Different Stages of Nonalcoholic Fatty Liver Disease: Diagnostic Performance and Clinicopathological Correlation显示文摘 | Ramesh Kumar Archana Rastogi Manoj Kumar Sharma Vikram Bhatia Pankaj Tyagi Praveen Sharma Hitendra Garg K. N. Chandan Kumar Chhagan Bihari Shiv Kumar Sarin | 2013 | Digestive Diseases and Sciences2013，，1： | 1 |
| 8 | Liver Stiffness Measurements in Patients with Different Stages of Nonalcoholic Fatty Liver Disease: Diagnostic Performance and Clinicopathological Correlation显示文摘 | Ramesh Kumar Archana Rastogi Manoj Kumar Sharma Vikram Bhatia Pankaj Tyagi Praveen Sharma Hitendra Garg K. N. Chandan Kumar Chhagan Bihari Shiv Kumar Sarin | 2013 | Digestive Diseases and Sciences2013，，1： | 1 |
| 9 | Efficacy of insecticides against the tomato/potato psyllid (Bactericera cockerelli)显示文摘 | Page-Weir N E M Jamieson L E Chhagan A | 2011 | N Z Plant Protect2011，64，： | 1 |
| 10 | Hydrogen storage in Mg: A most promising material显示文摘 | I.P. Jain Chhagan Lal Ankur Jain | 2009 | International Journal of Hydrogen Energy2009，，10： | 1 |
| 11 | Effect of micronutrient supplementation on diarrhoeal disease among stunted children in rural South Africa显示文摘 | Chhagan MK Van den Broeck J Luabeya KK | | 0，，07： | 1 |
| 12 | Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014显示文摘 | Shiv Kumar Sarin Chandan Kumar Kedarisetty Zaigham Abbas Deepak Amarapurkar Chhagan Bihari Albert C. Chan Yogesh Kumar Chawla A. Kadir Dokmeci Hitendra Garg Hasmik Ghazinyan Saeed Hamid Dong Joon Kim Piyawat Komolmit Suman Lata Guan Huei Lee Laurentius A. | 2014 | Hepatology International2014，，4： | 1 |
| 13 | Liver Stiffness Measurements in Patients with Different Stages of Nonalcoholic Fatty Liver Disease: Diagnostic Performance and Clinicopathological Correlation显示文摘 | Ramesh Kumar Archana Rastogi Manoj Kumar Sharma Vikram Bhatia Pankaj Tyagi Praveen Sharma Hitendra Garg K. N. Chandan Kumar Chhagan Bihari Shiv Kumar Sarin | 2013 | Digestive Diseases and Sciences2013，，1： | 1 |
| 14 | Hydrogen storage in Mg:A most promising material显示文摘 | JAIN I P CHHAGAN L ANKUR J | 2010 | International Journal of Hydrogen Energy2010，35，： | 1 |
| 15 | Diabetes mellitus as a consequence of acute severe pancreatitis:Unraveling the mystery显示文摘The occurrence of diabetes mellitus(DM)in pancreatitis is being increasingly recognized lately.Diabetes can develop not only with chronic pancreatitis but even after the first episode of acute pancreatitis(AP).The incidence of diabetes after AP varies from 18%to 23%in 3 years and reaches up to 40%over 5 years.The exact pathogenesis of diabetes after AP is poorly understood and various mechanisms proposed include loss of islet cell mass,AP-induced autoimmunity,and alterations in the insulin incretin axis.Risk factors associated with increased risk of diabetes includes male sex,recurrent attacks of pancreatitis,presence of pancreatic exocrine insufficiency and level of pancreatitic necrosis.Diagnosis of post-pancreatitis DM(PPDM)is often excluded.Treatment includes a trial of oral antidiabetic drugs in mild diabetes.Often,insulin is required in uncontrolled diabetes.Given the lack of awareness of this metabolic disorder after AP,this review will evaluate current information on epidemiology,risk factors,diagnosis and management of PPDM and identify the knowledge gaps. | Manish Manrai Anupam K Singh Chhagan Lal Birda Jimil Shah Aditya Dutta Sanjay Kumar Bhadada Rakesh Kochhar | 2023 | World Journal of Diabetes2023，14，8： | 0 |
| 16 | Prolonged existence of SARS-CoV-2 RNAs in the extracellular vesicles of respiratory specimens from patients with negative reverse transcription-polymerase chain reaction显示文摘Background and aim:Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is primarily in the respiratory tract,particularly in patients with underlying comorbidities.This study aimed to investigate the presence of the virus inside the extracellular vesicles(EVs)in patients with and without chronic liver disease(CLD).Methods:Eighty patients with positive SARS-CoV-2,including twenty-four patients with CLD and fiftysix patients without CLD,and five healthy controls with negative SARS-CoV-2 were enrolled.Nasal swab specimens were tested for the detection of SARS-CoV-2 using reverse transcription-polymerase chain reaction(RT-PCR).Patients with coronavirus disease 2019(COVID-19)were followed up on days 7 and 14.Nasal swab,collected in viral transport media(VTM),and plasma samples were investigated at each time point.EVs were isolated from the nasal swabs(collected in VTM)and plasma using differential ultracentrifugation and estimated at each time point.The transmission or replication by the EVs was assessed in Vero E6 cells.Results:In patients with baseline RT-PCR positive,SARS-CoV-2 RNAs inside the EVs were found in 68/80(85%)patients with higher viral load in the nasal swabs than in the EVs(cycle threshold(Ct)value,23.4±5.7 vs.30.3±5.0,P<0.001).On follow-up at day 7,of the 32 patients negative for COVID-19,15(46.9%)had virus persistence in the EVs(Ct value,30.7±2.7),and on day 14,of the 56 patients with negative SARS-CoV-2,16 patients(28.6%)had positive SARS-CoV-2 RNAs in the EVs(Ct value,31.4±3.0).The mean viral load decreased on days 7 and 14 compared to baseline in the nasal swabs(P<0.001)but not in the EVs.Additionally,SARS-CoV-2 RNAs were undetectable in the plasma,but 12.5% of patients were positive in the plasma EVs.Significantly prolonged and high viral load was found in the EVs on day 14 in COVID-19 patients combined with CLD compared with COVID-19 patients(P?0.0004).We found significant higher levels of EV-associated with endothelial cells and hepatocytes in the COVID-19 t CLD group than COVID-19 group(P?0.032 and P?0.002,respectively),suggesting more endothelial cells and hepatocytes cellular injury in liver disease patients with COVID-19.Interestingly,we also found EVs could transmit SARS-CoV-2 RNAs into Vero E6 cells at 24 h post-infection.Conclusions:The identification of SARS-CoV-2 RNAs in the EVs in patients with negative RT-PCR indicates the persistence of infection and likely recurrence of the infection.It is suggestive of another route of transmission as EVs harbor SARS-CoV-2 RNAs.EV-associated RNAs may determine the ongoing inflammation and clinical course of subjects with undetectable SARS-CoV-2 virus and this may have relevance to better management of patients with CLD. | P.Debishree Subudhi Sheetalnath Rooge Chhagan Bihari Swati Thangariyal Sivang Goswami Reshu Agarwal Savneet Kaur Ekta Gupta Sukriti Baweja | 2023 | Liver Research2023，7，3： | 0 |
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