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| 1 | WJSC 6^(th) Anniversary Special Issues(2):Mesenchymal stem cells Mesenchymal stem cells in the treatment of spinal cord injuries:A review显示文摘With technological advances in basic research,the intricate mechanism of secondary delayed spinal cord injury(SCI)continues to unravel at a rapid pace.However,despite our deeper understanding of the molecular changes occurring after initial insult to the spinal cord,the cure for paralysis remains elusive.Current treatment of SCI is limited to early administration of high dose steroids to mitigate the harmful effect of cord edema that occurs after SCI and to reduce the cascade of secondary delayed SCI.R ecent evident-based clinical studies have cast doubt on the clinical benefit of steroids in SCI and intense focus on stem cell-based therapy has yielded some encouraging results.An array of mesenchymal stem cells(MSCs)from various sources with novel and promising strategies are being developed to improve function after SCI.In this review,we briefly discuss the pathophysiology of spinal cord injuries and characteristics and the potential sources of MSCs that can be used in the treatment of SCI.We will discuss the progress of MSCs application in research,focusing on the neuroprotective properties of MSCs.Finally,we will discuss the results from preclinical and clinical trials involving stem cell-based therapy in SCI. | Venkata Ramesh Dasari Krishna Kumar Veeravalli Dzung H Dinh | 2014 | World Journal of Stem Cells2014，6，2： | 32 |
| 2 | Magnesium matrix composites for biomedical applications:A review显示文摘In recent years,a new wave of bioactive,biocompatibility and biodegradable metallic materials were developed for orthopedic applications.Pure Magnesium,Magnesium alloys,Magnesium alloy-based composites are extensive material to the biomedical applications,by virtue of its high biocompatibility and reasonable strength.Pure magnesium,Magnesium alloys can corrode too fast during the physiological conditions and loses their properties before bone heal.The new era for the development of magnesium-based composites can satisfy the orthopedic applications.Magnesium-based composites,as bio-materials,can produce adjustable mechanical properties like Ultimate tensile strength,ductility,elastic modulus,and corrosion resistance in the physiological conditions.In the Mg based composites,the matrix materials are biomedical magnesium alloys base like Mg-Ca,Mg-Al,Mg-Zn,and Mg-REE alloy and The reinforcements are based on hydroxyapatite(HAP),calcium polyphosphate(CPP),andβ-tricalcium phosphate(β-TCP)particles.This comprehensive review is focused on different grades of biodegradable magnesium matrix composites including their mechanical properties and corrosion resistance. | Vijay Kumar Bommala Mallarapu Gopi Krishna ChTirumala Rao | 2019 | Journal of Magnesium and Alloys2019，7，1： | 12 |
| 3 | 电子束增材制造医用钛合金三维多孔支架力学及生物功能研究进展(英文)显示文摘本文综述了电子束增材制造法(EBM)制备医用钛合金多孔支架植入物的工艺-结构-性能之间关系.传统加工多孔材料方法(如冷冻铸造及烧结法)制备的多孔植入器械由于很难匹配患病部位以及与人体组织在宏微观结构、力学和物理性能存在差异等因素受到很多限制.针对这一问题,EBM方法具有独特的优势.它可以利用患病部位的CT扫描成像或者CAD程序设计制备出复杂个性化多孔植入器械.本文概述了用于组织再生3D打印多孔支架的发展历程,主要包含两部分:第一部分介绍了EBM法制备的具有不同特征(设计、结构单元、加工参数、扫描速率、孔隙率及热处理)钛合金多孔支架的力学性能;第二部分介绍了多孔支架生物响应的改进优化以及表面改性对细胞-材料交互作用的研究进展.最后,本文还讨论了三维多孔钛合金支架的临床试验结果,并展望了其在生物医疗领域的应用前景. | Krishna Chaitanya Nune 李述军 R.Devesh Kumar Misra | 2018 | Science China Materials2018，61，4： | 11 |
| 4 | 脊髓电刺激疗法新进展显示文摘脊髓电刺激疗法(spinal cord stimulation,SCS),俗称镇痛起搏器。是指将刺激电极置入椎管的硬膜外腔,通过电流刺激脊髓后角感觉神经元及后柱传导束,从而阻断疼痛信号传导,以达到治疗疼痛的一种神经调控方法。SCS早已被美国FDA批准成为治疗躯干和四肢慢性疼痛的一种方法。SCS发展了近40年,针对慢性疼痛的治疗,其可行性及高选择性有目共睹。然而,脊髓电刺激疗法仍然面临着其特有的一系列挑战,本文将就椎管内治疗策略、电刺激参数的选择、患者的选择、治疗的成本效益以及提高疗效的策略等问题进行详细描述。 | Krishna Kumar 谢晓燕 | 2016 | 中国疼痛医学杂志2016，22，3： | 11 |
| 5 | Efficacy of Bacillus subtilis MBI 600 Against Sheath Blight Caused by Rhizoctonia solani and on Growth and Yield of Rice显示文摘Rice sheath blight disease(ShB),caused by Rhizoctonia solani,gives rise to significant grain yield losses.The present study evaluated the efficacy of Integral?,the commercial liquid formulation of Bacillus subtilis strain MBI 600,against rice ShB and for plant growth promotion.In greenhouse studies,four log concentrations of Integral(from 2.2×106 to 2.2×109 cfu/mL) were used as seed treatment(ST).After 25 d,seedlings were dipped(SD) into Integral prior to transplanting.At 30 d after transplanting(DAT),leaf sheaths were inoculated with immature sclerotia of the pathogen.At 45 DAT,a foliar spray(FS) with Integral was applied to some treatments.The fungicide control was 50% carbendazim at 1.0 g/L,and a nontreated control was also included.Overall,there were 10 treatments,each with five replications.ShB severity was rated at 52 DAT,and seedling height and number of tillers per plant were rated at 60 DAT.In 2009,two field trials evaluated Integral at 2.2×108 and 2.2×109 cfu/mL.Integral was applied as ST,and seedlings were produced in a nursery bed.After 32 d,seedlings were treated with Integral as SD and transplanted into 10 m2 blocks.Foliar sprays were given at 45 and 60 DAT.There were seven treatments,each with eight replications arranged as a factorial randomized complete block design.At 20 DAT,the plots were broadcast inoculated with R.solani produced on rice grains.Seedling height before transplanting,ShB severity at 90 DAT,and grain yield at harvest were recorded.Integral at 2.2×109 cfu/mL provided significant increase of seedling heights over other treatments under greenhouse conditions.The Integral treatments of ST + SD + FS at 2.2×109 cfu/mL significantly suppressed ShB over other treatments.In field studies,Integral provided significant increase of seedling height in nursery,and number of tillers per plant,compared with the control.ShB severity was significantly suppressed with higher concentrations of Integral compared to lower concentrations.Grain yield were the highest at an Integral concentration of 2.2×109 cfu/mL.Overall,Integral significantly reduced ShB severity,enhanced seedling growth,number of tillers per plant and grain yield as ST + SD + FS at the concentration of 2.2×109 cfu/mL under the conditions evaluated. | K. VIJAY KRISHNA KUMAR S. KR. YELLAREDDYGARI M. S. REDDY J. W. KLOEPPER K. S. LAWRENCE X. G. ZHOU H. SUDINI D. E. GROTH S. KRISHNAM RAJU M. E. MILLER | 2012 | Rice science2012，19，1： | 11 |
| 6 | Use of a Bioaugmented Organic Soil Amendment in Combination with Gypsum for Withania somnifera Growth on Sodic Soil显示文摘Limited availability of organic matter is a problem to sustain crop growth on sodic soil. Organic soil amendments are a costeffective source of nutrients to enhance crop growth. A field study was conducted to evaluate the effect of an organic soil amendment bioaugmented with plant growth-promoting fungi(SF_(OA) ) in combination with gypsum on soil properties and growth and yield attributes of Withania somnifera, one of the most valuable crops of the traditional medicinal system in the world, on a sodic soil at the Aurawan Research Farm of CSIR-National Botanical Research Institute, Lucknow, India. The SF_(OA) used was prepared by pre-enriching farm waste vermicompost with plant growth-promoting fungi before mixing with pressmud and Azadirachta indica seed cake. The application of SF_(OA) at 10 Mg ha^(-1)after gypsum(25.0 Mg ha^(-1)) treatment significantly(P < 0.05) increased root length(by 96%) and biomass(by 125%) of Withania plants compared to the control without SF_(OA) and gypsum. Similarly, the highest withanolide contents were observed in leaves and roots of Withania plants under 10 Mg ha^(-1)SF_(OA) and gypsum. Combined application of SF_(OA) and gypsum also improved physical, chemical and enzymatic properties of the soil, with the soil bulk density decreasing by 25%, water-holding capacity increasing by 121%, total organic C increasing by 90%, p H decreasing by 17% and alkaline phosphatase, β-glucosidase, dehydrogenase and cellulase activities increasing by 54%, 128%, 81% and 96%, respectively, compared to those of the control. These showed that application of the SF_(OA) tested in this study might reclaim sodic soil and further support Withania cultivation and results were better when the SF_(OA) was applied after gypsum treatment. | Manjul GUPTA Pankaj Kumar SRIVASTAVA SHIKHA Abhishek NIRANJAN Shri Krishna TEWARI | 2016 | Pedosphere2016，26，3： | 7 |
| 7 | Modified chitosan hydrogels as drug delivery and tissue engineering systems:present status and applications显示文摘Chitosan,a natural cationic polysaccharide,is prepared industrially by the hydrolysis of the aminoacetyl groups of chitin,a naturally available marine polymer.Chitosan is a non-toxic,biocompatible and biodegradable polymer and has attracted considerable interest in a wide range of biomedical and pharmaceutical applications including drug delivery,cosmetics,and tissue engineering.The primary hydroxyl and amine groups located on the backbone of chitosan are responsible for the reactivity of the polymer and also act as sites for chemical modification.However,chitosan has certain limitations for use in controlled drug delivery and tissue engineering.These limitations can be overcome by chemical modification.Thus,modified chitosan hydrogels have gained importance in current research on drug delivery and tissue engineering systems.This paper reviews the general properties of chitosan,various methods of modification,and applications of modified chitosan hydrogels. | Tapan Kumar Giri Amrita Thakur Amit Alexander Ajazuddin Hemant Badwaik Dulal Krishna Tripathi | 2012 | Acta Pharmaceutica Sinica B2012，2，5： | 7 |
| 8 | Predicting the impact of climate change on the distribution of two threatened Himalayan medicinal plants of Liliaceae in Nepal显示文摘Predicting the potential distribution of medicinal plants in response to climate change is essential for their conservation and management. Contributing to the management program, this study aimed to predict the distribution of two threatened medicinal plants, Fritillaria cirrhosa and Lilium nepalense. The location of focal species gathered from herbarium specimen housed in different herbaria and online databases were geo-referenced and checked for spatial autocorrelation. The predictive environmental variables were selected, and MaxE nt software was used to model the current and future distributions of focal species. Four Representative Concentration Pathway(RCP) trajectories of the BCC-CSM1.1 model were used as the future(2050) projection layer. The MaxEnt modelling delineated the potential distribution of F. cirrhosa and L. nepalense. The current suitability is projected towards Central and Eastern Hilly/Mountainous regions. Both species gainmaximum suitability in RCP 4.5 which decline towards other trajectories for L. nepalense. Overall, both the focal species shift towards the north-west, losing their potential habitat in hilly and lower mountainous regions by 2050 across all trajectories. Our results highlight the impact of future climate change on two threatened and valuable species. The results can be further useful to initiate farming of these medicinally and economically important species based on climatically suitable zone and for designing a germplasm conservation strategy. | RANA Santosh Kumar RANA Hum Kala GHIMIRE Suresh Kulllar SHRESTHA Krishna Kumar RANJITKAR Sailesh | 2017 | Journal of Mountain Science2017，14，3： | 5 |
| 9 | Hepatoprotective activity of Hepax-A polyherbal formulation显示文摘Objective:To evaluate the hepatoprotective potential of Hepax,a polyherbal formulation,against three experimentally induced hepatotoxicity models in rats.Methods:Hepatoprotective activity of Hepax was studied against three experimentally induced hepatotoxicity models,namely, carbon tetrachloride(CCl_4),paracetamol and thiocetamide induced hepatotoxicity in rats. Results:Administration of hepatotoxins(CCl_4,paracetamol and thiocetamide) showed significant morphological,biochemical and histological deteriorations in the liver of experimental animals. Pretreatment with Hepax had significant protection against hepatic damage by maintaining the morphological parameters(liver weight and liver weight to organ weight ratio) within normal range and normalizing the elevated levels of biochemical parameters(SGPT,SCOT,ALP and total bilirubin),which were evidently showed in histopathological study.Conclusions:The Hepax has highly significant hepatoprotective effect at 100 and 200 mg/kg,p.o.on the liver of all the three experimental animal models. | VC Devaraj B Gopala Krishna GL Viswanatha Jagadish V Kamath Sanjay Kumar | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，2： | 4 |
| 10 | Biliary atresia: Where do we stand now?显示文摘The pathway from clinical suspicion to establishing the diagnosis of biliary atresia in a child with jaundice is a daunting task. However, investigations available help to point towards the correct diagnosis in reasonable time frame. Imaging by Sonography has identified several parameters which can be of utility in the diagnostic work up. Comparison of Sonography with imaging by Nuclear medicine can bring out the significant differences and also help in appropriate imaging. The battery of Biochemical tests, available currently, enable better understanding of the line-up of investigations in a given child with neonatal cholestasis. Management protocols enable standardized care with optimal outcome. The place of surgical management in biliary atresia is undisputed, although Kasai procedure and primary liver transplantation have been pitted against each other. This article functions as a platform to bring forth the various dimensions of biliary atresia. | Krishna Kumar Govindarajan | 2016 | World Journal of Hepatology2016，8，36： | 4 |
| 11 | Undiagnosed Hoffa fracture of medial femoral condyle presenting as chronic pain in a post-polio limb显示文摘有未经触动的侧面的大腿骨的髁的中间的大腿骨的髁的孤立的花冠骨折是极其稀罕的。怀疑的一个高索引在 undisplaced 破裂的情况下特别为早诊断是必要的。这里,我们在作为长期的疼痛介绍的脊髓灰质炎以后的手足报导中间的 Hoffa 骨折的一个案例。鉴于骨质疏松症和骨状的发育不全,在脊髓灰质炎的迟了的 sequelae 影响的手足的如此的破裂的管理是特别地有问题的。破裂通过中间的 parapatellar 关节切开术被接近,固定在 anteroposterior 方向用完了 cannulated cancellous 螺丝钉。联合在 16 被完成;星期。 | Aditya Krishna Mootha Priyanka Majety Vishal Kumar | 2014 | Chinese Journal of Traumatology2014，17，3： | 4 |
| 12 | 在在印度的心血管的风险因素的地区性的变化: 印度心手表显示文摘 Cardiovascular disease(CVD) is an important cause of mortality and morbidity in India.Mortality statistics and morbidity surveys indicate substantial regional variations in CVD prevalence and mortality rates.Data from the Registrar General of India reported greater ageadjusted cardiovascular mortality in southern and eastern states of the country.Coronary heart disease(CHD) mortality is greater in south India while stroke is more common in the eastern Indian states.CHD prevalence is higher in urban Indian populations while stroke mortality is similar in urban and rural regions.Case-control studies in India have identified that the common major risk factors account for more than 90% of incident myocardial infarctions and stroke.The case-control INTERHEART and INTERSTROKE studies reported that hypertension,lipid abnormalities,smoking,obesity,diabetes,sedentary lifestyle,low fruit and vegetable intake,and psychosocial stress are as important in India as in other populations of the world.Individual studies have reported that there are substantial regional variations in risk factors in India.At a macro-level these regional variations in risk factors explain some of the regional differences in CVD mortality.However,there is need to study the prevalence of multiple cardiovascular risk factors in different regions of India and to correlate them with variations in CVD mortality using a uniform protocol.There is also a need to determine the 'causes of the causes' or fundamental determinants of these risk factors.The India Heart Watch study has been designed to study socioeconomic,anthropometric and biochemical risk factors in urban populations in different regions of the country in order to identify regional differences. | Rajeev Gupta Soneil Guptha Krishna Kumar Sharma Arvind Gupta Prakash Deedwania | 2012 | World Journal of Cardiology2012，4，4： | 3 |
| 13 | Support vector regression modeling in recursive just-in-time learning framework for adaptive soft sensing of naphtha boiling point in crude distillation unit显示文摘Prediction of primary quality variables in real time with adaptation capability for varying process conditions is a critical task in process industries.This article focuses on the development of non-linear adaptive soft sensors for prediction of naphtha initial boiling point(IBP)and end boiling point(EBP)in crude distillation unit.In this work,adaptive inferential sensors with linear and non-linear local models are reported based on recursive just in time learning(JITL)approach.The different types of local models designed are locally weighted regression(LWR),multiple linear regression(MLR),partial least squares regression(PLS)and support vector regression(SVR).In addition to model development,the effect of relevant dataset size on model prediction accuracy and model computation time is also investigated.Results show that the JITL model based on support vector regression with iterative single data algorithm optimization(ISDA)local model(JITL-SVR:ISDA)yielded best prediction accuracy in reasonable computation time. | Venkata Vijayan S Hare Krishna Mohanta Ajaya Kumar Pani | 2021 | Petroleum Science2021，18，4： | 3 |
| 14 | A rare case of bicondylar Hoffa fracture associated with ipsilateral tibial spine avulsion and extensor mechanism disruption显示文摘远侧的腿节的 Intra 关节的花冠破裂(Hoffas 破裂) 是稀罕的。尽管在这些破裂的 bicondylar 参与与高速度 traumata 联合在文学被报导了,这些的出现断裂包含伸肌机制破裂和 ipsilateral 的撕裂胫骨的脊骨极其稀罕。到我们的相识,如此的一个破裂模式到目前为止还没在文学被报导了。在这篇文章,我们报导一个如此的案例并且在如此的 cases.We 的管理讨论早诊断和迅速的内部固定的重要性相信损害的这些稀罕联合应该被早开的减小和解剖僵硬内部固定好攻击地对待以便完成好恢复工作。 | Kamal Bali Aditya Krishna Mootha Vibhu Krishnan Vishal Kumar Saurabh Rawall | 2011 | Chinese Journal of Traumatology2011，14，4： | 3 |
| 15 | CFD modeling to study the effect of particle size on dispersion in 20l explosion chamber: An overview显示文摘Mine disasters occur predominantly due to methane or coal dust explosion or a combination of both.Among the top ten worst coal mine disasters in India, nine are due to coal dust explosion. The current paper describes a general overview of the parameters causing dispersion leading to coal dust explosion,and computational fluid dynamics(CFD) simulation study to observe the effects of particle size on dispersion in Indian coal mines. Turbulent kinetic energy(TKE) and velocity vector path of dust-air mixture and dust-free air were simulated to understand their effects on coal dust dispersion. The TKE contours and velocity vector paths for dust-free air were uniform and symmetrical due to resistance-free path available. The TKE contours and velocity vector paths for dust-air mixture shows the asymmetrical distribution of contours, due to entrainment of air with dust particles. Vortices were observed in velocity vector paths which gradually diminish on increment of time sequence. These vortices are dead centres where velocity and coal dust particles concentration are both zero. | Santosh Kumar Ray Niroj Kumar Mohalik Asfar Mobin Khan Debashish Mishra Nikhil Kumar Varma Jai Krishna Pandey Pradeep Kumar Singh | 2020 | International Journal of Mining Science and Technology2020，30，3： | 3 |
| 16 | A review on current status of municipal solid waste management in India显示文摘Municipal solid waste management is a major environmental issue in India. Due to rapid increase in urbanization, industrialization and population, the generation rate of municipal solid waste in Indian cities and towns is also increased. Mismanagement of municipal solid waste can cause adverse environmental impacts, public health risk and other socio-economic problem. This paper presents an overview of current status of solid waste management in India which can help the competent authorities responsible for municipal solid waste management and researchers to prepare more efficient plans. | Neha Gupta Krishna Kumar Yadav Vinit Kumar | 2015 | Journal of Environmental Sciences2015，27，11： | 3 |
| 17 | Improving Performance of a Distributed File System Using a Speculative Semantics-Based Algorithm显示文摘File-sharing semantics is used by the file systems for sharing data among concurrent client processes in a consistent manner. Session semantics is a widely used file-sharing semantics in Distributed File Systems(DFSs). The main disadvantage of session semantics is that writes to an open file are visible to the concurrent client processes only during their next session. Recently, 'linearizability semantics' was introduced in Blob Seer DFS, in which a Read Client Process(RCP) can read only a previous version of a binary large object(blob), while update operations are carried out on that blob in a concurrent manner. In this paper, we propose a new type of file-sharing semantics, namely 'speculative semantics', which permits writes to an open file to be visible to other concurrent processes provided that data consistency is not affected. In addition, we propose a new read algorithm for DFSs based on speculative semantics and a new performance measurement metric called Currency. The experimental results obtained using Blob Seer DFS indicate that the proposed read algorithm performs better than the existing read algorithm of Blob Seer DFS. | Talluri Lakshmi Siva Rama Krishna Thirumalaisamy Ragunathan Sudheer Kumar Battula | 2015 | Tsinghua Science and Technology2015，20，6： | 2 |
| 18 | 材料模型对高温Ti-6Al-4V合金理论成形极限图预测的影响(英文)显示文摘成形极限图是一种用来描述使板材不发生局部颈缩所需最大主应变的重要图形。它是一种预测板材变形过程中变形极限的方便、有效的工具。本研究中,在400°C和不同样品宽度的条件,通过Nakazima实验得到了Ti-6Al-4V合金的成形极限图。此外,为了使用成形极限图对材料参数进行理论预测,提出了不同的各向异性屈服准则(Barlat 1989,Barlat 1996,Hill 1993)和不同的硬化模型(Hollomon幂定律、Johnson-Cook(JC)模型、改进的Zerilli-Armstrong(m-ZA)和Arrhenius(m-Arr)模型)。结合所提出的屈服准则和本构模型,通过Marciniak和Kuczynski(M-K)理论确定了Ti-6Al-4V合金的成形极限图。结果表明:屈服模型对材料成形极限图的影响大于本构模型的影响。然而,材料的厚度缺陷系数(f_0)与其硬化模型密切相关。Hill(1993)屈服准则最适合于成形极限图右边区域的预测,而Barlat(1989)屈服准最适合于成形极限图左边区域的预测。由于所得到的混合理论成形极限图兼具Barlat(1989)和Hill(1993)屈服模型和m-Arr硬化模型的优点,因此,它与实验得到的成形极限图吻合很好。 | Nitin KOTKUNDE Sashank SRINIVASAN Geetha KRISHNA Amit Kumar GUPTA Swadesh Kumar SINGH | 2016 | Transactions of Nonferrous Metals Society of China2016，26，3： | 2 |
| 19 | Follow-up of Primary Angle Closure Suspects After Laser Peripheral Iridotomy Using Ultrasound Biomicroscopy and A-Scan Biometry for a Period of 2 Years显示文摘 | Krishna Kumar Ramani Baskaran Mani Ronnie J. George Vijaya Lingam | 2009 | Journal of Glaucoma2009，，7： | 2 |
| 20 | Modeling and multi-response optimization of machining performance while turning hardened steel with self-propelled rotary tool显示文摘There are many advanced tooling approaches in metal cutting to enhance the cutting tool performance for machining hard-to-cut materials.The self propelled rotary tool(SPRT) is one of the novel approaches to improve the cutting tool performance by providing cutting edge in the form of a disk,which rotates about its principal axis and provides a rest period for the cutting edge to cool and allow engaging a fresh cutting edge with the work piece.This paper aimed to present the cutting performance of SPRT while turning hardened EN24 steel and optimize the machining conditions.Surface roughness(R_a) and metal removal rate(r_(MMR)) are considered as machining performance parameters to evaluate,while the horizontal inclination angle of the SPRT,depth of cut,feed rate and spindle speed are considered as process variables.Initially,design of experiments(DOEs) is employed to minimize the number of experiments.For each set of chosen process variables,the machining experiments are conducted on computer numerical control(CNC) lathe to measure the machining responses.Then,the response surface methodology(RSM) is used to establish quantitative relationships for the output responses in terms of the input variables.Analysis of variance(ANOVA) is used to check the adequacy of the model.The influence of input variables on the output responses is also determined.Consequently,these models are formulated as a multi-response optimization problem to minimize the R_a and maximize the r_(MMR)simultaneously.Non-dominated sorting genetic algorithmII(NSGA-II) is used to derive the set of Pareto-optimal solutions.The optimal results obtained through the proposed methodology are also compared with the results of validation experimental runs and good correlation is found between them. | Thella Babu Rao A.Gopala Krishna Ramesh Kumar Katta Konjeti Rama Krishna | 2015 | Advances in Manufacturing2015，3，1： | 2 |
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