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| 1 | 世界家庭医生组织(WONCA)研究论文摘要汇编——以家庭为中心的抗抑郁疗法治疗老年男性抑郁患者遇到的挑战和解决方案:一项对利益相关者的研究显示文摘背景家庭成员在老年男性抑郁患者的生活中起到了非常重要的作用,其经常陪同患者去社区医院就诊。然而,对如何最有效地让患者家庭成员参与患者的治疗过程相关研究较少。由于一些原因,如抑郁的'病耻心'与家庭成员间的冲突,导致家庭成员很难参与患者的抗抑郁治疗。本研究旨在探究家庭成员参与老年男性抑郁患者的治疗所遇到的困难及其措施。方法本项横断面定性描述性访谈研究在位于加利福尼亚中央谷地的'安全网'联邦合格健康服务中心进行。37例研究对象中包含15例老年(≥60岁)男性抑郁患者(由邮件招募、候诊室招募和转诊患者组成)、12例患者家庭成员(在参与研究的患者家庭成员中招募),以及10例全科医务人员(通过目的抽样抽取)。对研究对象关于把家庭干预列为治疗老年男性抑郁的全科疗法之一的看法,进行了半结构式的访谈。访谈内容被录音、记录。结果访谈结果表明,家庭成员参与老年男性抑郁患者的治疗所遇到的主要困难有:让患者在适当的时机接受治疗;保持患者的自主性;处理患者个人隐私问题;处理家庭成员之间的冲突。对于如何解决这些困难,研究对象也提出了可行性的建议。结论尽管以家庭为中心的抗抑郁疗法是一项治疗老年男性抑郁患者有效的全科疗法,但是实施起来尚有一定困难。此疗法的继续开展以及临床应用需要研制出解决这些困难的方案和指南。 | HINTON L SCIOLLA A F UNüTZER J 本刊编辑部 | 2017 | 中国全科医学2017,20,32: | 4 |
| 2 | 通过使用转基因小鼠来了解沃尔夫/附睾管发育的正常与异常显示文摘沃尔夫/附睾管的发育对雄性生殖系统的正常功能以及相应的男性生育力至关重要。附睾的发育过程复杂,它起始于一个短暂的胚肾,而后中肾形成,中肾进一步在雄激素与生长激素的影响下经历形态发生最终形成附睾。因此,要了解它完整的发育过程需要一个广泛的、多学科的视角。这篇综述着力探讨表现出沃尔夫管与中肾发育异常的小鼠模型、这些小鼠模型对了解生殖道发育的重要性、以及这些模型如何帮助我们了解诸如先天性肾脏和尿路畸形(CAKUT)这样的人类临床异常表现。 | Aki Murashima Bingfang Xu Barry T Hinton | 2015 | Asian Journal of Andrology2015,17,5: | 4 |
| 3 | β-defensins and the epididymis: contrasting influences of prenatal, postnatal, and adult scenarios显示文摘β -defensins 是主人防卫的部件,与抗菌剂和多种的免疫调节的性质。在最后 15 年的研究表明了许多 β 的丰富的表示;在不同种类的出生后的 epididymis 的 -defensins。这些蛋白质的区域特定、房间特定的表示的一个坡度在出生后的 epididymis 的上皮被观察。他们进到他们沿着 epididymis 旅行的精子的钠液体和绑定的分泌物在繁殖特定的任务建议了他们的参与。因此,连续注意被给了各种各样的 β为他们在精子功能和富饶的角色的 -defensins。尽管 β -defensins 大部分依赖于雄激素,在 epididymis 调整他们的表达式和函数的内在的机制很好没被理解。最近的调查指出了到在哪儿的一种新、有趣的情形 β ; -defensins 在 Wolffian 管与一个不同表示模式出现, epididymis 的胚胎的先锋与成年 epididymis 对比,从而有关 β 的多功能的角色重新定义这个概念;在发展中的 epididymis 的 -defensins 。在这评论,我们总结 β 的一些当前的看法;在在 prenatal-to-postnatal 转变期间在发展中的 epididymis 在他们的角色上加亮我们的最近的数据和推测的 epididymis 的 -defensins ,在可以贡献 epididymal 生物学和男富饶的更好的理解的这个研究区域把注意带到许多未答复的问题。 | Camilla M Ribeiro Erick JR Silva Barry T Hinton Maria Christina W Avellar | 2016 | Asian Journal of Andrology2016,18,2: | 4 |
| 4 | A review of homogenization and topology optimization Ⅰ 显示文摘 | Hassani B Hinton E | 1998 | Computers and Structures1998,69,: | 2 |
| 5 | Mutational Processes Molding the Genomes of 21 Breast Cancers显示文摘 | Serena Nik-Zainal Ludmil B. Alexandrov David C. Wedge Peter Van Loo Christopher D. Greenman Keiran Raine David Jones Jonathan Hinton John Marshall Lucy A. Stebbings Andrew Menzies Sancha Martin Kenric Leung Lina Chen Catherine Leroy Manasa Ramakrishna Ric | 2012 | Cell2012,,5: | 2 |
| 6 | 燃用乙醇、汽油混合物和含水乙醇的GDI发动机运行(英文)显示文摘作为可再生燃料和改善能源安全的手段,乙醇被逐步推广使用。为研究含水的混合乙醇的燃烧性能以及水与乙醇一汽油的溶混性,试验了含乙醇0-100%的汽油、乙醇混合物,评价了混合物的喷雾特性、燃烧性能和颗粒物排放性能,进行了汽油、乙醇、水的三相图分析和试验。结果表明:在含水量不大于40%时,汽油乙醇混合物中水的存在,不妨碍混合物用作汽油直喷发动机燃料。向喷射汽油中加注乙醇,增大了喷射燃料的体积;以这种燃料注入并持续喷雾,尤其是在冷发动机情况下,降低了混合物均匀性,减少了燃烧稳定性,对于当量比混合物,还增加了颗粒物的排放。向喷射燃料的乙醇中加注水,在含水量不大于30%时,燃烧持续时间不明显增加,燃烧稳定性不明显减小。 | Richard STONE 陈龙飞 Nathan HINTON Felix LEACH 徐帆 | 2012 | 汽车安全与节能学报2012,3,3: | 2 |
| 7 | Migration of retinal pigment epithelium cells in vitro is regulated by protein kinase C显示文摘 | Murphy TL Sakamoto T Hinton DR | 1995 | Exp Eye Res1995,60,6: | 2 |
| 8 | A review of homogenization and topology optimization I-Homogenization theory for media with periodic structure显示文摘 | Hassani B Hinton E | 1998 | Computer & Structures1998,69,: | 2 |
| 9 | A review of homogenization and topology optimization I—homogenization theory for media with periodic structure显示文摘 | B. Hassani E. Hinton | 1998 | Computers and Structures1998,,6: | 2 |
| 10 | Trends and outcomes of transarterial chemoembolization in hepatocellular carcinoma:a national survey显示文摘BACKGROUND:Transarterial chemoembolization(TACE) is a palliative procedure frequently used in patients with advanced hepatocellular carcinoma(HCC). We examined the national inpatient trends of TACE and related outcomes in the United States over the last decade.METHODS:We utilized the National Inpatient Sample(2002 to 2012) and performed trend analyses of TACE for HCC in all adult patients(age >18 years). Multivariate analyses for the outcomes of in-hospital 'procedure-related complications'(PRCs) and 'post-procedure complications'(PPCs) were performed. We also compared early(2002 to 2006) and late(2007 to 2012) eras by multivariate analyses to identify predictors of complications, healthcare resource utilization and mortality.RESULTS:Overall, 19058 patients underwent TACE for HCC where PRCs and PPCs were seen in 24.2% and 17.6% of patients, respectively. The overall trends in the use of TACE(P<0.001) and associated PRCs(P=0.006) were observed to be increasing. There was less mortality [adjusted Odds ratio(a OR):0.58; 95% CI:0.41, 0.82], reduced length of hospital stay(-1.87 days; 95% CI:-2.77,-0.97) and increased hospital charges($19232; 95% CI:11013, 27451) in the late era. Additionally, there was increased mortality(a OR:4.07; 95% CI:2.96, 5.59), PRCs(a OR:3.21; 95% CI:2.56, 4.02), and PPCs(a OR:2.70; 95% CI:2.11, 3.46) among patients with coagulopathy.CONCLUSIONS:There is an increasing trend of TACE utilization in HCC. However, the outcomes are worse in patients with coagulopathy. Although PRCs have increased, mortality has decreased in recent years. These findings should be considered during TACE evaluation in patients with HCC. | Khalid Mumtaz Nishi Patel Rohan M Modi Vihang Patel Alice Hinton James Hanje Sylvester M Black Somashaker Krishna | 2017 | Hepatobiliary & Pancreatic Diseases International2017,16,6: | 2 |
| 11 | A Fast Learning Algorithm for Deep Belief Nets显示文摘 | Geoffrey E. Hinton Simon Osindero Yee-Whye Teh | 2006 | Neural Computation2006,,: | 2 |
| 12 | Up-regulation of the cAMP/PKA pathway inhibits proliferation,induces differentiation,and leads to apoptosis in malignant gliomas显示文摘 | Chen T C Hinton D R Zidovetzki R | | 0,,: | 2 |
| 13 | Learning representation by BP errors显示文摘 | David E Rumelhart Geoffrey E Hinton Ronald J Williams | 1986 | Nature1986,,7: | 2 |
| 14 | The inhibition of aluminum alloy corrosion by rare earth metal cations显示文摘 | Hinton B R W | 1985 | Corrosion Australas1985,210,3: | 1 |
| 15 | Connectionist learning procedures 显示文摘 | HINTON G E | 1998 | Artificial Intelligence1998,40,13: | 1 |
| 16 | Performance of an adaptive multichannel combiner for long range underwater communications显示文摘 | Sharif B S Neasham J A Hinton O R Adams A E | 1996 | IEE Electronics letters1996,32,3: | 1 |
| 17 | MMP-2 and MMP-9 secretion by rpe is stimulated by angiogenic molecules found in choroidal neovascular membranes 显示文摘 | Hoffmann S He S Ehren M Ryan S J Wiedemann P Hinton DR | 2006 | Retina2006,26,4: | 1 |
| 18 | Leaming representations by back-propagating errors显示文摘 | Rumelhart DE Hinton GE Williams RJ | 1986 | Nature1986,323,: | 1 |
| 19 | The inhabition of aluminum corrision by cerium cations显示文摘 | Hinton B R | 1984 | Metals Forum1984,,4: | 1 |
| 20 | The Corrosion Inhibition of Zn With Cerous Chloride显示文摘 | Hinton BR W | 1992 | Corros Science1992,,7: | 1 |