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| 1 | Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide显示文摘Long-acting glucagon-like peptide-1(GLP-1) analogues marketed for type 2 diabetes(T2D) treatment have been showing positive and protective effects in several different tissues, including pancreas, heart or even brain. This gut secreted hormone plays a potent insulinotropic activity and an important role in maintaining glucose homeostasis. Furthermore, growing evidences suggest the occurrence of several commonalities between T2 D and neurodegenerative diseases, insulin resistance being pointed as a main cause for cognitive decline and increased risk to develop dementia. In this regard, it has also been suggested that stimulation of brain insulin signaling may have a protective role against cognitive deficits. As GLP-1 receptors(GLP-1R) are expressed throughout the central nervous system and GLP-1 may cross the blood-brain-barrier, an emerging hypothesis suggests that they may be promising therapeutic targets against brain dysfunctional insulin signaling-related pathologies. Importantly, GLP-1 actions depend not only on the direct effect mediated by its receptor activation, but also on the gut-brain axis involving an exchange of signals between both tissues via the vagal nerve, thereby regulating numerous physiological functions(e.g., energy homeostasis, glucose-dependent insulin secretion, as well as appetite and weight control). Amongst the incretin/GLP-1 mimetics class of anti-T2 D drugs with an increasingly described neuroprotective potential, the already marketed liraglutide emerged as a GLP-1R agonist highly resistant to dipeptidyl peptidase-4 degradation(thereby having an increased half-life) and whose systemic GLP-1R activity is comparable to that of native GLP-1. Importantly, several preclinical studies showed anti-apoptotic, anti-inflammatory, anti-oxidant and neuroprotective effects of liraglutide against T2 D, stroke and Alzheimer disease(AD), whereas several clinical trials, demonstrated some surprising benefits of liraglutide on weight loss, microglia inhibition, behavior and cognition, and in AD biomarkers. Herein, we discuss the GLP-1 action through the gut-brain axis, the hormone's regulation of some autonomic functions and liraglutide's neuroprotective potential. | Emanuel Monteiro Candeias Inês Carolina Sebastio Susana Maria Cardoso Sónia Catarina Correia Cristina Isabel Carvalho Ana Isabel Plácido Maria Sancha Santos Catarina Resende Oliveira Paula Isabel Moreira Ana Isabel Duarte | 2015 | World Journal of Diabetes2015，6，6： | 9 |
| 2 | Mutational Processes Molding the Genomes of 21 Breast Cancers显示文摘 | Serena Nik-Zainal Ludmil B. Alexandrov David C. Wedge Peter Van Loo Christopher D. Greenman Keiran Raine David Jones Jonathan Hinton John Marshall Lucy A. Stebbings Andrew Menzies Sancha Martin Kenric Leung Lina Chen Catherine Leroy Manasa Ramakrishna Ric | 2012 | Cell2012，，5： | 2 |
| 3 | Secondary voltage control: analysis, solutions and simulation results for the spanish transmission system显示文摘 | SANCHA J L FERNANDEZ J L CORTES A | 1996 | IEEE Trans on Power Systems1996，11，2： | 1 |
| 4 | Techniques and Training with GreenLight HPS 120-W Laser Therapy of the Prostate: Position Paper显示文摘 | Gordon Muir Fernando Gómez Sancha Alexander Bachmann Benjamin Choi Edward Collins Jean de la Rosette Oliver Reich Shahin Tabatabaei Henry Woo | 2007 | European Urology Supplements2007，，： | 1 |
| 5 | Secondary voltage con- troh analysis, solutions and simulation results for the spanish transmission system显示文摘 | Sancha J L Fernandez J L Cortes A | 1996 | IEEE Transactions on Power Systems1996，11，2： | 1 |
| 6 | Secondary voltage control:analysis,solutions and simulation results for the Spanish transmission system显示文摘 | SANCHA J L FERNANDEZ J L CORTES A | 1996 | IEEE Transactions on Power Systems1996，11，2： | 1 |
| 7 | Homocysteine, folio acid and B-group vitamins in obstetrics and gynaecology 显示文摘 | Usandizaga R Sancha M | 2003 | Eur J Obstet Gynecol Reprod Biol2003，107，2： | 1 |
| 8 | Managing hazardous pollutants in Chile:Arsenic显示文摘 | Sancha A M O' Ryan R | 2008 | Reviews of Environmental Contamination and Toxicology2008，196，： | 1 |
| 9 | Review of coagulation technology for removal of arsenic: ease of Chile显示文摘 | Sancha A M | 2006 | Journal of Health Population and Nutrition2006，24，3： | 1 |
| 10 | Homocysteine, folic aeid and B-group vitam in sinobstetrics and gynaecology显示文摘 | DE LA CALLE M USANDIZAGA R SANCHA M | 2003 | Eur J Obstet Gyn R B2003，107，2： | 1 |
| 11 | Secondary voltage control: Analysis , solutions and simulation results for the Spanish transmission system显示文摘 | Sancha J L Fernandez J L Cortes A | 1996 | IEEE Trans on Power Systems1996，11，63： | 1 |
| 12 | Intron-mediated gusA expression in tritordeum and wheat resulting from particle bombardment显示文摘 | Sancha Salgueiro Cristina Pignocchi Martin A.J. Parry | 2000 | Plant Molecular Biology2000，，4： | 1 |
| 13 | Secondary voltage control:analysis,solutions and simulation results for the Spanish transmission system显示文摘 | SANCHA J L FERNANDEZ J L CORTES A | 1996 | IEEE Trans on Power Systems1996，11，2： | 1 |
| 14 | Effect of mois- ture and temperature on the degradability of fibre and on nitrogen fractions in barley straw treated with urea显示文摘 | Caneque V Velasco S Sancha J L | 1998 | Anim Feed Sci Tech1998，74，： | 1 |
| 15 | Allergen-specific immunotherapy:updale on Immunological mechanisms显示文摘 | Alvaro M Sancha J Larrammona H | 2013 | Allergul Immunopath ol (Madr)2013，41，4： | 1 |
| 16 | Boron exposure assessment using drinking water and urine in the north of Chile显示文摘 | Cortes S Reynaga - Delgado E Sancha AM | 2011 | Sci Total Environ2011，410，： | 1 |
| 17 | Secondary Voltage Control:Analysis, Solutions and Simulation Results for the Spanish Transmission System 显示文摘 | Sancha J L Fernandez J L | 1996 | IEEE Trans on Power Systems1996，11，2： | 1 |
| 18 | Secondary Voltage Control:Analysis,Solutions and Simulation Results for the Spanish Transmission System显示文摘 | Sancha J L Fernandez J L Cortes A | 1996 | IEEE Trans on Power Systems1996，11，2： | 1 |
| 19 | Secondary voltage control:analysis,solution and simulation results for the spanish transmission system显示文摘 | Sancha J L Fernandez J L Cortes A | | 0，，2： | 1 |
| 20 | Allergen-specificimmunotherapy:Update on immunological mechanisms 显示文摘 | Alvaro M Sancha J Larramona H | 2013 | Allergol Immunopathol (Madr)2013，41，4： | 1 |
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