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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Impact of on-range choice feeding with black soldier fly larvae(Hermetia illucens)on flock performance,egg quality,and range use of free-range laying hens显示文摘Semi-intensive free-range farm systems are common in Australia, and these systems frequently practise on-range feeding. The objective of this study was to investigate the benefit of on-range choice feeding on flock performance, egg quality, and range use of free-range laying hens using black soldier fly larvae(Hermetia illucens, BSF). A total of 160 mature ISA brown laying hens, previously determined to range daily, were allocated to a control group(control) or a treatment group(BSF) with various replicates depending on the parameter investigated. All hens were fed ad libitum indoors with a wheat-soy based diet formulated according to breed requirements. Black soldier fly hens were offered dried BSF larvae ad libitum on the range. Body weight, feed intake, BSF intake, egg production, feed conversion ratio, internal and external egg quality parameters, and individual range use using radio-frequency identification(RFID)technology was evaluated. Black soldier fly hens consumed on average 15 ± 1.7 g BSF larvae/hen per day.There were no differences between BSF and control hens for any of the performance parameters obtained(P > 0.05). Egg weight, shell weight, and shell thickness of eggs from BSF hens were significantly lower(P = 0.003, P = 0.001, and P = 0.004, respectively) than those of eggs from control hens. Egg yolk colour was significantly paler in eggs from BSF hens(P < 0.001). No significant ranging differences between the BSF and control hens were observed(P > 0.05) except for BSF hens showing longer total maximum time for a single visit to the range(P = 0.011). In conclusion, the average intake of BSF larvae indicated a good level of acceptance. Feed formulation should be adjusted for the intake of the choice fed source. The impact of choice-feeding on range use was minor. | Isabelle Ruhnke Camille Normant Dana L.M.Campbell Zafar Iqbal Caroline Lee Geoff N.Hinch Julie Roberts | 2018 | Animal Nutrition2018，，4： | 12 |
| 3 | Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development显示文摘Chronic obstructive pulmonary disease(COPD) significantly increases the risk of developing cancer. Biomarker studies frequently follow a case-control set-up in which patients diagnosed with a disease are compared to controls. Longitudinal cohort studies such as the COPD-centered German COPD and SYstemic consequences-COmorbidities NETwork(COSYCONET) study provide the patient and biomaterial base for discovering predictive molecular markers. We asked whether microRNA(miRNA) profiles in blood collected from COPD patients prior to a tumor diagnosis could support an early diagnosis of tumor development independent of the tumor type. From 2741 participants of COSYCONET diagnosed with COPD, we selected 534 individuals including 33 patients who developed cancer during the follow-up period of 54 months and 501 patients who did not develop cancer, but had similar age, gender and smoking history. Genome-wide miRNA profiles were generated and evaluated using machine learning techniques. For patients developing cancer we identified nine miRNAs with significantly decreased abundance(two-tailed unpaired t-test adjusted for multiple testing P < 0.05), including members of the miR-320 family. The identified mi RNAs regulate different cancer-related pathways including the MAPK pathway(P = 2.3 x 10^(-5)). We also observed the impact of confounding factors on the generated miRNA profiles, underlining the value of our matched analysis. For selected miRNAs, qRT-PCR analysis was applied to validate the results. In conclusion, we identified several miRNAs in blood of COPD patients, which could serve as candidates for biomarkers to help identify COPD patients at risk of developing cancer. | Andreas Keller Tobias Fehlmann Nicole Ludwig Mustafa Kahraman Thomas Laufer Christina Backes Claus Vogelmeier Caroline Diener Frank Biertz Christian Herr Rudolf A. Jorres Hans-Peter Lenhof Eckart Meese Robert Bals | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 9 |
| 4 | 冲刷作用下砂土地层中桩的侧向力学性质分析显示文摘[目的]冲刷是在水流以及波浪作用下土体流失的一个过程,它通常发生在桥梁、港口码头、以及海岸平台等结构的基础周围,造成基础的承载力下降,危及上部结构的安全。目前在分析桩的侧向力学行为时,只考虑了冲刷深度对桩的侧向承载力的影响,而忽略了冲刷形成的冲刷孔的影响。事实上,冲刷孔的几何形状不仅包括冲刷深度、还包括了冲刷孔的宽度以及冲刷孔的坡度。目前,工程设计中广泛采用的侧向桩分析方法,即p-y曲线方法无法考虑冲刷孔三维几何形状对桩的侧向力学性质的影响。[方法]针对这个问题,文章提出了一种修正的p-y曲线方法以用于分析砂土地层中桩在冲刷作用下的侧向力学响应。[结果]该方法改进了基于锲形体破坏模型的Reese p-y曲线法,从而能考虑冲刷孔三维几何形状的影响。将计算得到的结果与三维有限差分数值分析的结果进行了比较,验证该修正方法的可靠性。[结论]计算结果表明:在冲刷孔的几何形状参数里,冲刷深度对桩的侧向力学性质的影响最大,其次是冲刷孔的宽度与坡度。忽略冲刷孔几何形状的影响,桩在地面位置的侧向位移会增加49%~68%。 | 林城 韩杰 Caroline BENNETT Robert PARSONS | 2018 | 南方能源建设2018，5，2： | 5 |
| 5 | Heart Disease and Stroke Statistics—2011 Update: A Report From the American Heart Association显示文摘 | Véronique L. Roger Alan S. Go Donald M. Lloyd-Jones Robert J. Adams Jarett D. Berry Todd M. Brown Mercedes R. Carnethon Shifan Dai Giovanni de Simone Earl S. Ford Caroline S. Fox Heather J. Fullerton Cathleen Gillespie Kurt J. Greenlund Susan M. Hailpern | 2011 | Circulation2011，，4： | 4 |
| 6 | Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit显示文摘 | Robert W. Busby Alexander P. Bryant Wilmin P. Bartolini Etchell A. Cordero Gerhard Hannig Marco M. Kessler Shalina Mahajan-Miklos Christine M. Pierce Robert M. Solinga Li Jing Sun Jenny V. Tobin Caroline B. Kurtz Mark G. Currie | 2010 | European Journal of Pharmacology2010，，1： | 2 |
| 7 | Baossi–Warack monogenetic volcanoes, Adamawa Plateau,Cameroon: petrography, mineralogy and geochemistry显示文摘Three monogenetic cones in the Baossi–Warack area, Ngaoundéré, Adamawa Plateau forming part of the Cameroon Volcanic Line(CVL) are documented in this study. Basaltic lavas(<1 km^3) scattered around these vents and restricted volcaniclastic deposits were emplaced by Hawaiian and mild strombolian style eruptions. The lavas are porphyritic, mainly composed of olivine(chrysolite) and clinopyroxene(diopside and augite) phenocrysts and plagioclase(andesine) microphenocrysts. Accessory minerals include titano-magnetite and titano-hematite, nepheline,apatite and amphibole xenocrysts. Sanidine occurs in some samples and sodi-potassic albite in others. Some olivines and clinopyroxenes exhibit resorbed margins and thin reaction rims while plagioclase displays oscillatory zoning, and sieved textures as a result of magma mixing. Whole-rock geochemistry data indicates that the lavas are silica-undersaturated, composed of basanites and basalts, showing little compositional variations(SiO_2: 39.20 wt.%–48.01 wt.%,MgO: 5.29 wt.%–9.70 wt.%). Trace elements patterns of these lavas suggest they are enriched in LILE including Pb,probably due to crustal contamination. REE patterns suggest cogenetic magmas below Baossi 1 and Baossi 2 volcanoes,and distinct sources below Warack volcano and nearby lavas.The lavas studied show affinity to high-μ(HIMU), enriched type Ⅰ(EM1) and Oceanic Island Basalt(OIB)-like mantle signatures and thus indicate a heterogeneous mantle source underneath the vents as noted at other monogenetic and polygenetic volcanoes along the CVL. Primary melts derived from low degrees of partial melting(0.5%–2%) and encountered low rates of fractionation, and crustal contamination coupled with magma mixing. These melts evolved independently through structural weaknesses in the basement. | Anicet Feudjio Tiabou Robert Temdjim Pierre Wandji Jacques-Marie Bardintzeff Vivian Bih Che Edith Ekatah Bate Tibang Caroline Neh Ngwa Fran?ois Xavier Onana Mebara | 2019 | Acta Geochimica2019，38，1： | 2 |
| 8 | 3D numerical simulation of seagrass movement under waves and currents with GPUSPH显示文摘The current study tries a new approach to simulating interactions between waves and seagrass through Smoothed Particle Hydrodynamics(SPH).In this model,the plants are defined as a solid that respects Hooke's law,and are assumed to have direct interaction with the fluid.Given the characteristics of the SPH method,especially in terms of computational time,the dimensions of the simulations were limited.The first goal of the current study was to optimize the approach to avoid reaching certain limits such as the rupture of the simulated plant.Plant movements under waves and/or currents have been studied by several authors in various in-situ,physical,and numerical experiments concerning various vegetation species,thus proving that plant movements can be successfully reproduced by SPH 2D/3D.Manning's roughness coefficient,n,was calculated to confirm that the results were in accordance with what had been measured in flume studies.Even though there is still room for improvement,it is shown that this method can be used to estimate Manning's coefficient for coastal vegetation(seagrass and saltmarsh vegetation)and to greatly improve the modeling and forecasting of coastal erosion and storm surge risks by including the effects of vegetation in integrated models. | Anne-Eleonore Paquier Thibault Oudart Caroline Le Bouteiller Samuel Meule Philippe Larroude Robert A.Dalrymple | 2021 | International Journal of Sediment Research2021，36，6： | 2 |
| 9 | Development of chlorine dioxide related by-product models for drinking water treatment显示文摘 | Caroline K Robert C Anderews B | 2002 | Water Res2002，36，1： | 1 |
| 10 | A Retrospective Review of Enteroclysis in Patients with Obscure Gastrointestinal Bleeding and Chronic Abdominal Pain of Undetermined Etiology显示文摘 | Aslam Malik MD Kathleen Lukaszewski MD Dina Caroline MD Henry Parkman MD Joshua DeSipio MD Felice Banson MD Khalid Bazir MD Lakshmi Reddy MD Radhika Srinivasan MD Robert Fisher MD Larry Miller MD | 2005 | Digestive Diseases and Sciences2005，，4： | 1 |
| 11 | Biomechanical and morphological corneal response to placement of intrastromal corneal ring segments for keratoconus显示文摘 | Caroline Dauwe David Touboul Cynthia J. Roberts Ashraf M. Mahmoud Julien Kérautret Pierre Fournier Fran?ois Malecaze Joseph Colin | 2009 | Journal of Cataract & Refractive Surgery2009，，10： | 1 |
| 12 | SSJD14073000005013显示文摘 | Karen L. Morris Jonathan D. Tugwood Leila Khoja Matthew Lancashire Robert Sloane Debbie Burt Patrick Shenjere Cong Zhou Clare Hodgson Toshihiko Ohtomo Atsuhiko Katoh Takahiro Ishiguro Juan W. Valle Caroline Dive | 2014 | Cancer Chemotherapy and Pharmacology2014，，2： | 1 |
| 13 | Development of chlorine dioxide-related by-product models for drinking water treatment显示文摘 | Caroline Korn Robert C Andrews | 2002 | Water Res2002，，36： | 1 |
| 14 | Metabolic and Hormonal Changes After Laparoscopic Roux-en-Y Gastric Bypass and Sleeve Gastrectomy: a Randomized, Prospective Trial显示文摘 | Ralph Peterli Robert Steinert Bettina Woelnerhanssen Thomas Peters Caroline Christoffel-Courtin Markus Gass Beatrice Kern Markus Fluee Christoph Beglinger | 2012 | Obesity Surgery2012，，5： | 1 |
| 15 | Levels of Neonatal Thyroid Hormone in Preterm Infants and Neurodevelopmental Outcome at 5? Years: Millennium Cohort Study显示文摘 | Caroline Delahunty Shona Falconer Robert Hume Lesley Jackson Paula Midgley Marie Mirfield Simon Ogston Oliver Perra Judith Simpson Jennifer Watson Peter Willatts Fiona Williams | 2010 | The Journal of Clinical Endocrinology & Metabolism2010，，11： | 1 |
| 16 | Development of chlorine dioxide related by-product models for drinking water treatment显示文摘 | ROBERT C ANDREWS B | 2002 | Water Research2002，36，： | 1 |
| 17 | Dose–response relationships within the parotid gland after radiotherapy for head and neck cancer显示文摘 | Barbara Bussels Annelies Maes Patrick Flamen Philippe Lambin Katrien Erven Robert Hermans Sandra Nuyts Caroline Weltens Silvia Cecere Emmanuel Lesaffre Walter Van den Bogaert | 2004 | Radiotherapy and Oncology2004，，： | 1 |
| 18 | A comparison of trajectory and air mass approaches to examine ozone variability显示文摘 | Robert E. Davis Caroline P. Normile Luke Sitka David M. Hondula David B. Knight Stephen P. Gawtry Philip J. Stenger | 2009 | Atmospheric Environment2009，，1： | 1 |
| 19 | Flowering time control: another window to the connection between antisense RNA and chromatin显示文摘 | Robert Ietswaart Zhe Wu Caroline Dean | 2012 | Trends in Genetics2012，，9： | 1 |
| 20 | Predictors of follow-up exercise behavior 6?months after a randomized trial of exercise training during breast cancer chemotherapy显示文摘 | Kerry S. Courneya Christine M. Friedenreich Robert D. Reid Karen Gelmon John R. Mackey Aliya B. Ladha Caroline Proulx Jeffrey K. Vallance Roanne J. Segal | 2009 | Breast Cancer Research and Treatment2009，，1： | 1 |
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