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| 1 | Sonographic markers for early diagnosis of fetal malformations显示文摘Fetal malformations are very frequent in industrialized countries.Although advanced maternal age may affect pregnancy outcome adversely,80%-90%of fetal malformations occur in the absence of a specific risk factor for parents.The only effective approach for prenatal screening is currently represented by an ultrasound scan.However,ultrasound methods present two important limitations:the substantial absence of quantitative parameters and the dependence on the sonographer experience.In recent years,together with the improvement in transducer technology,quantitative and objective sonographic markers highly predictive of fetal malformations have been developed.These markers can be detected at early gestation(11-14 wk)and generally are not pathological in themselves but have an increased incidence in abnormal fetuses.Thus,prenatal ultrasonography during the second trimester of gestation provides a'genetic sonogram',including,for instance,nuchal translucency,short humeral length,echogenic bowel,echogenic intracardiac focus and choroid plexus cyst,that is used to identify morphological features of fetal Down’s syndrome with a potential sensitivity of more than 90%.Other specific and sensitive markers can be seen in the case of cardiac defects and skeletal anomalies.In the future,sonographic markers could limit even more the use of invasive and dangerous techniques of prenatal diagnosis(amniocentesis,etc.). | Maria Daniela Renna Paola Pisani Francesco Conversano Emanuele Perrone Ernesto Casciaro Gian Carlo Di Renzo Marco Di Paola Antonio Perrone Sergio Casciaro | 2013 | World Journal of Radiology2013，5，10： | 12 |
| 2 | Radiofrequency Ablation of Small Hepatocellular Carcinoma in Cirrhotic Patients Awaiting Liver Transplantation: A Prospective Study显示文摘 | Vincenzo Mazzaferro Carlo Battiston Stefano Perrone Andrea Pulvirenti Enrico Regalia Raffaele Romito Dario Sarli Marcello Schiavo Francesco Garbagnati Alfonso Marchianò Carlo Spreafico Tiziana Camerini Luigi Mariani Rosalba Miceli Salvatore Andreola | 2004 | Annals of Surgery2004，，5： | 3 |
| 3 | Is human hepatocellular carcinoma a hormone-responsive tumor?显示文摘Before the positive results recently obtained with multitarget tyrosine kinase inhibitor sorafenib,there was no standard systemic treatment for patients with advanced hepatocellular carcinoma(HCC).Sex hormones receptors are expressed in a significant proportion of HCC samples.Following preclinical and epidemiological studies supporting a relationship between sex hormones and HCC tumorigenesis,several randomized controlled trials (RCTs)tested the efficacy of the anti-estrogen tamoxifen as systemic treatment.Largest among these trials showed no survival advantage from the administration of tamoxifen,and the recent Cochrane systematic review produced a completely negative result.This questions the relevance of estrogen receptor-mediated pathways in HCC.However,a possible explanation for these disappointing results is the lack of proper patients selection according to sex hormones receptors expression,but unfortunately the interaction between this expression and efficacy of tamoxifen has not been studied adequately.It has been also proposed that negative results might be explained if tamoxifen acts in HCC via an estrogen receptor-independent pathway,that requires higher doses than those usually administered, but an Asian RCT conducted to assess dose-response effect was completely negative.Interesting,preliminaryresults have been obtained when hormonal treatment (tamoxifen or megestrol)has been selected according to the presence of wild-type or variant estrogen receptors respectively,but no large RCTs are available to support this strategy.Negative results have been obtained also with anti-androgen therapy.In conclusion,there is no robust evidence to consider HCC a hormone-responsive tumor.Hormonal treatments should not be part of the current management of HCC. | Massimo Di Maio Bruno Daniele Sandro Pignata Ciro Gallo Ermelinda De Maio Alessandro Morabito Maria Carmela Piccirillo Francesco Perrone | 2008 | World Journal of Gastroenterology2008，14，11： | 2 |
| 4 | Epigenetics and chemoresistance in colorectal cancer: An opportunity for treatment tailoring and novel therapeutic strategies显示文摘 | Francesco Crea Stefania Nobili Elisa Paolicchi Gabriele Perrone Cristina Napoli Ida Landini Romano Danesi Enrico Mini | 2011 | Drug Resistance Updates2011，，6： | 1 |
| 5 | Molecular aspects of the cardioprotective effect of exercise in the elderly显示文摘 | Giuseppe Rengo Valentina Parisi Grazia Daniela Femminella Gennaro Pagano Claudio de Lucia Alessandro Cannavo Daniela Liccardo Francesco Giallauria Oriana Scala Carmela Zincarelli Pasquale Perrone Filardi Nicola Ferrara Dario Leosco | 2013 | Aging Clinical and Experimental Research2013，，5： | 1 |
| 6 | Radiofrequency Ablation of Small Hepatocellular Carcinoma in Cirrhotic Patients Awaiting Liver Transplantation: A Prospective Study显示文摘 | Vincenzo Mazzaferro Carlo Battiston Stefano Perrone Andrea Pulvirenti Enrico Regalia Raffaele Romito Dario Sarli Marcello Schiavo Francesco Garbagnati Alfonso Marchianò Carlo Spreafico Tiziana Camerini Luigi Mariani Rosalba Miceli Salvatore Andreola | 2004 | Annals of Surgery2004，，5： | 1 |
| 7 | Takotsubo Cardiomyopathy: Overview显示文摘 | Eduardo Bossone Gianluigi Savarese Francesco Ferrara Rodolfo Citro Susanna Mosca Francesca Musella Giuseppe Limongelli Roberto Manfredini Antonio Cittadini Pasquale Perrone Filardi | 2012 | Heart Failure Clinics2012，，： | 1 |
| 8 | Prognostic value of CD40 in adult soft tissue sarcomas显示文摘 | Alessandro Ottatano Anna De Chiara Francesco Perrone | 2004 | Clinical Cancer Research2004，10，： | 1 |
| 9 | Dicer and Drosha expression and response to Bevacizumab-based therapy in advanced colorectal cancer patients显示文摘 | Bruno Vincenzi Alice Zoccoli Gaia Schiavon Michele Iuliani Francesco Pantano Emanuela Dell’Aquila Raffaele Ratta Andrea Onetti Muda Giuseppe Perrone Chiara Brunelli Pierpaolo Correale Elisabetta Riva Antonio Russo Fotios Loupakis Alfredo Falcone Daniele S | 2012 | European Journal of Cancer2012，，： | 1 |
| 10 | A prospective study of pelvic floor dysfunctions related to delivery显示文摘 | Gabriella Torrisi Gianfranco Minini Francesco Bernasconi Antonio Perrone Gennaro Trezza Vincenzo Guardabasso Giuseppe Ettore | 2011 | European Journal of Obstetrics and Gynecology2011，，1： | 1 |
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