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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | FVC2000: fingerprint verification competition 显示文摘 | MAIO D MALTONI D CAPPELLI R | 2002 | IEEE Trans on PAMI2002，24，3： | 2 |
| 3 | Real-time face location on gray-scale static images显示文摘 | MAIO D MALTONI D | 2000 | Pattern recognition2000，33，9： | 2 |
| 4 | A polarimetric adaptive matched filter显示文摘 | Maio A D Ricci G | 2001 | Signal Processing2001，81，3： | 1 |
| 5 | Performance evaluation of fingerprint verification systems显示文摘 | CAPPELLI R MAIO D MALTONI D | 2006 | IEEE Transactions on Pattern Analysis and Machine Intelligence2006，28，1： | 1 |
| 6 | Experimental performance analysis of distributed targets coherent radar detector显示文摘 | Moya J C Maio A D | | 0，，3： | 1 |
| 7 | Identification of glycopror teins that are receptors for peanut agglutinin on immature (cortical) mouse thymocytes显示文摘 | MAIO A D LIS H GERSHONI J M | 1986 | Febs Letters1986，194，1： | 1 |
| 8 | Myocardial cytoprotection by trimetazidine against anthracycline-induced eardiotoxicity in anticaneer chemotherapy显示文摘 | Tallarico D Rizzo V Di Maio F | 2003 | Angiology2003，54，2： | 1 |
| 9 | Sulfate attack on concrete with mineral admix-tures 显示文摘 | E F Irassar A D Maio O R Batie | 1996 | Cement and Concrete Research1996，26，1： | 1 |
| 10 | Needle Artifact Localization in 3T MR Images显示文摘 | Di Maio S P Kacher D F Ellis R E | 2006 | Stud Health Teehnol Inform2006，119，： | 1 |
| 11 | An efficient fingerprint verification system using integrated Gabor filters and Parzen window classifier显示文摘 | MAIO D NANNI L | 2005 | Neurocomputing2005，68，7： | 1 |
| 12 | Gingival endothelial and inducible nitric oxide synthase levels during orthodontic treatment: A cross-sectional study显示文摘 | D'Attillio M Di Maio F D'Arcangela C | 2004 | Angle Orthod2004，74，6： | 1 |
| 13 | Monte Carlo simulation of a typical ^60 Co therapy source显示文摘 | MORA G M MAIO A ROGERS D W O | 1999 | Med Phys1999，26，11： | 1 |
| 14 | Fingerprint classification by directional image partitioning 显示文摘 | Cappelli R Lumini A Maio D | 1999 | IEEE Transactions on Pattern Analysis and Machine Intelligence1999，21，5： | 1 |
| 15 | Poly (lactic acid) / organoclay nanocomposites:Thermal, rheological properties and foam processing显示文摘 | Di Y lannace S Maio E D | 2005 | Polym Sci Part B:Polym Phy2005，43，6： | 1 |
| 16 | A polarimetric adaptive matched filter显示文摘 | Maio A D and Ricci G | 2001 | Signal Processing2001，81，12： | 1 |
| 17 | Heat shock proteins:facts,thoughts and dreams显示文摘 | Maio A D | 1999 | Shock1999，1，1： | 1 |
| 18 | FVC2000: Fingerprint verification competition显示文摘 | Maio D Maltoni D Cappelli R | 2002 | IEEE Transactions on Pattern Analysis Machine Intelligenc2002，24，3： | 1 |
| 19 | Petretto F, Myocardial cytoprotection by tfimetazidine against anthracycline-induced cardiotoxicity in anti- cancer chemotherapy 显示文摘 | Tallarico D Rizzo V Di Maio F | 2003 | Angiology2003，54，2： | 1 |
| 20 | Fingerprint image reconstruction from standard templates显示文摘 | CAPPELLI R LUMINI A MAIO D | 2007 | Pattern Analysis and MachineIntelligence IEEE Transactions on2007，29，9： | 1 |
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