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| 1 | Endoscopic transpapillary brush cytology and forceps biopsy in patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the sensitivity of brush cytology and forceps biopsy in a homogeneous patient group with hilar cholangiocarcinoma.METHODS: Brush cytology and forceps biopsy were routinely performed in patients with suspected malignant biliary strictures. Fifty-eight consecutive patients undergoing endoscopic retrograde cholangio-pancreatography (ERCP) including forceps biopsy and brush cytology in patients with hilar cholangiocarcinoma between 1995-2005.RESULTS: Positive results for malignancy were obtained in 24/58 patients (41.4%) by brush cytology and in 31/58 patients (53.4%) by forceps biopsy. The combination of both techniques brush cytology and forceps biopsy resulted only in a minor increase in diagnostic sensitivity to 60.3% (35/58 patients). In 20/58 patients (34.5%), diagnosis were obtained by both positive cytology and positive histology, in 11/58 (19%) by positive histology (negative cytology) and only 4/58 patients (6.9%) were confirmed by positive cytology (negative histology).CONCLUSION: Brush cytology and forceps biopsy have only limited sensitivity for the diagnosis of malignant hilar tumors. In our eyes, additional diagnostic techniques should be evaluated and should become routine in patients with negative cytological and histological findings. | Andreas Weber Claus von Weyhern Falko Fend Jochen Schneider Bruno Neu Alexander Meining Hans Weidenbach Roland M Schmid Christian Prinz | 2008 | World Journal of Gastroenterology2008，14，7： | 17 |
| 2 | Alectinib: a novel second generation anaplastic lymphoma kinase(ALK) inhibitor for overcoming clinically-acquired resistance显示文摘The development of inhibitors for the tyrosine anaplastic lymphoma kinase(ALK) has advanced rapidly, driven by biology and medicinal chemistry. The first generation ALK inhibitor crizotinib was granted US FDA approval with only four years of preclinical and clinical testing. Although this drug offers significant clinical benefit to the ALK-positive patients, resistance has been developed through a variety of mechanisms. In addition to ceritinib, alectinib is another second-generation ALK inhibitor launched in 2014 in Japan. This drug has a unique chemical structure bearing a 5H-benzo[b]carbazol-11(6H)-one structural scaffold with an IC_(50) value of 1.9 nmol/L, and is highly potent against ALK bearing the gatekeeper mutation L1196 M with an IC_(50) of 1.56 nmol/L. In the clinic, alectinib is highly efficacious in treatment of ALK-positive non-small cell lung cancer(NSCLC), and retains potency to combat crizotinib-resistant ALK mutations L1196 M, F1174 L, R1275 Q and C1156 Y. | Zilan Song Meining Wang Ao Zhang | 2015 | Acta Pharmaceutica Sinica B2015，5，1： | 10 |
| 3 | Liver transplantation and alcoholic liver disease:History,controversies,and considerations显示文摘Alcohol consumption accounts for 3.8% of annual global mortality worldwide, and the majority of these deaths are due to alcoholic liver disease(ALD), mainly alcoholic cirrhosis. ALD is one of the most common indications for liver transplantation(LT). However, it remains a complicated topic on both medical and ethical grounds, as it is seen by many as a 'self-inflicted disease'. One of the strongest ethical arguments against LT for ALD is the probability of relapse. However, ALD remains a common indication for LT worldwide. For a patient to be placed on an LT waiting list, 6 mo of abstinence must have been achieved for most LT centers. However, this '6-mo rule' is an arbitrary threshold and has never been shown to affect survival, sobriety, or other outcomes. Recent studies have shown similar survival rates among individuals who undergo LT for ALD and those who undergo LT for other chronic causes of end-stage liver disease. There are specific factors that should be addressed when evaluating LT patients with ALD because these patients commonly have a high prevalence of multisystem alcohol-related changes. Risk factors for relapse include the presence of anxiety or depressive disorders, short pre-LT duration of sobriety, and lack of social support. Identification of risk factors and strengthening of the social support system may decrease relapse among these patients. Family counseling for LT candidates is highly encouraged to prevent alcohol consumption relapse. Relapse has been associated with unique histopathological changes, graft damage, graft loss, and even decreased survival in some studies. Research has demonstrated the importance of a multidisciplinary evaluation of LT candidates. Complete abstinence should be attempted to overcome addiction issues and to allow spontaneous liver recovery. Abstinence is the cornerstone of ALD therapy. Psychotherapies, including 12-step facilitation therapy, cognitive-behavioral therapy, and motivational enhancement therapy, help support abstinence. Nutritional therapy helps to reverse muscle wasting, weight loss, vitamin deficiencies, and trace element deficiencies associated with ALD. For muscular recovery, supervised physical activity has been shown to lead to a gain in muscle mass and improvement of functional activity. Early LT for acute alcoholic hepatitis has been the subject of recent clinical studies, with encouraging results in highly selected patients. The survival rates after LT for ALD are comparable to those of patients who underwent LT for other indications. Patients that undergo LT for ALD and survive over 5 years have a higher risk of cardiorespiratory disease, cerebrovascular events, and de novo malignancy. | Claudio Augusto Marroni Alfeu de Medeiros Fleck Jr Sabrina Alves Fernandes Lucas Homercher Galant Marcos Mucenic Mario Henrique de Mattos Meine Guilherme Mariante-Neto Ajacio Bandeira de Mello Brandao | 2018 | World Journal of Gastroenterology2018，24，26： | 7 |
| 4 | Argon Plasma Coagulation of Cervical Heterotopic Gastric Mucosa as an Alternative Treatment for Globus Sensations显示文摘 | Monther Bajbouj Valentin Becker Florian Eckel Stephan Miehlke Oliver Pech Christian Prinz Roland M. Schmid Alexander Meining | 2009 | Gastroenterology2009，，2： | 2 |
| 5 | Beta-blocker use and risk of symptomatic bradyarrhythmias: a hospital-based case-control study显示文摘在与 -blockers use.MethodsA 的关系调查征兆的 bradyarrhythmias 的风险因素基于医院的盒子控制学习[228 个病人:108 与征兆的 bradyarrhythmias (案例) 和 120 控制] 在 Sultanah Aminah 医院,在 2011 年 1 月之间的马来西亚和 2014 年 1 月 .ResultsThe 平均数年龄里被进行是 61.1 ?? 業牴敩歮?? 呑 ? | Hou Tee Lu Jiyen Kam Rusli Bin Nordin Surinder Kaur Khelae Jing Mein Wang Chun Ngok Choy Chuey Yan Lee | 2016 | Journal of Geriatric Cardiology2016，13，9： | 2 |
| 6 | A Comparison of Helicobacter pylori and H. heilmannii Gastritis: A Matched Control Study Involving 404 Patients显示文摘 | M. Stolte G. Kroher A. Meining A. Morgner E. Bayerd?rffer B. Bethke | 1997 | Scandinavian Journal of Gastroenterology1997，，1： | 2 |
| 7 | Retinoic Acid–Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt–β-Catenin Signaling to Slow Tumor Progression显示文摘 | Fieke E.M. Froeling Christine Feig Claude Chelala Richard Dobson Charles E. Mein David A. Tuveson Hans Clevers Ian R. Hart Hemant M. Kocher | 2011 | Gastroenterology2011，，4： | 2 |
| 8 | Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors显示文摘 | Sarah Schwitalla Paul K. Ziegler David Horst Valentin Becker Irina Kerle Yvonne Begus-Nahrmann André Lechel K. Lenhard Rudolph Rupert Langer Julia Slotta-Huspenina Franz G. Bader Olivia Prazeres da Costa Markus F. Neurath Alexander Meining Thomas Kirchner | 2013 | Cancer Cell2013，，： | 2 |
| 9 | 电动汽车蓄电池的充电方案显示文摘对于世界上第一辆汽车的发明者Karl Benz先生的妻子Bertha Benz驾驶第一辆汽车进行首次远行时提出的要求和我们今天驾车出行的要求完全一样:油箱即将空了的时候需要加油。但当时对Bertha | Jurgen Meins | 2011 | 汽车制造业2011，，19： | 2 |
| 10 | Detection of Myocardial Damage in Patients With Sarcoidosis显示文摘 | Manesh R. Patel Peter J. Cawley John F. Heitner Igor Klem Michele A. Parker Wael A. Jaroudi Trip J. Meine James B. White Michael D. Elliott Han W. Kim Robert M. Judd Raymond J. Kim | 2009 | Circulation2009，，： | 2 |
| 11 | EndoResect study: endoscopic full-thickness resection of gastric subepithelial tumors显示文摘 | C. Schlag D. Wilhelm S. von Delius H. Feussner A. Meining | 2013 | Endoscopy2013，，01： | 2 |
| 12 | S3 Guideline: Sedation for gastrointestinal endoscopy 2008显示文摘 | A. Riphaus T. Wehrmann B. Weber J. Arnold U. Beilenhoff H. Bitter S. von Delius D. Domagk A. Ehlers S. Faiss D. Hartmann W. Heinrichs M.-L. Hermans C. Hofmann S. In der Smitten M. Jung G. K?hler M. Kraus J. Martin A. Meining J. Radke T. R?sch H. Seifert A | 2009 | Endoscopy2009，，09： | 1 |
| 13 | Flexible Specialization, The New Competition and Industrial Districts 显示文摘 | Meine P | 1995 | Small Business Economics1995，7，1： | 1 |
| 14 | Modeling infiltration during a steady rain显示文摘 | Mein R G Larson C L | 1973 | Water Resources Research1973，9，2： | 1 |
| 15 | A search for type 1 diabetes susceptibility genes in families from the united kingdom显示文摘 | MEIN C A ESPOSITO L DUNN M G | 1998 | Nat Genet1998，19，： | 1 |
| 16 | Which controls the depolymerization of cellulose in ionic liquids : the solid acid cata- lyst or cellulose? 显示文摘 | Rinaldi R Meine N yore Stein J | 2010 | ChemSusChem2010，3，2： | 1 |
| 17 | Biological activity of lycopene metabolites: implications for cancer prevention 显示文摘 | Mein JR Lian F Wang XD | 2008 | Nutr Rev2008，66，12： | 1 |
| 18 | Physiological compensation in antisense transformants: specific induction of an ' ersatz' glucan endo-1,3-beta-glucosidase in plants infected with necrotizing viru- ses 显示文摘 | Beffa R S Neuhaus J M Meins F | 1993 | Proc Natl Acad Sci USA1993，90，19： | 1 |
| 19 | Colonoscopy:propofol well suited for sedation显示文摘 | Meining A | 2012 | Dtsch Med Wochenschr2012，137，38： | 1 |
| 20 | RNA degradation and models for post-transcriptional gene silencing显示文摘 | Meins F | 2000 | Plant molecular Biology2000，43，： | 1 |
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