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| 1 | Is there an association of microscopic colitis and irritable bowel syndrome-A subgroup analysis of placebo-controlled trials显示文摘TO THE EDITOR
With great interest we read the recent retrospectice study by Barta et al (1) dealing with the clinical presentation of patients with microscopic colitis. They investigated in a cohort of 53 patients with microscopic colitis (46 with collagenous colitis, 7 with lymphocytic colitis)the relationship between microscopic colitis and both constipation and diarrhea. One of their mean finding was that abdominal pain, diarrhea and constipation was a common symptom complex of patients with microscopic colitis, thus the face of microcopic colitis resembles the subgroups of irritable bowel syndrome (IBS). | Ahmed Madisch Birgit Bethke Manfred Stolte Stephan Miehlke | 2005 | World Journal of Gastroenterology2005，11，41： | 4 |
| 2 | Strictures, diaphragms, erosions or ulcerations of ischemic type in the colon should always prompt consideration of nonsteroidal anti-inflammatory drug-induced lesions显示文摘AIM: To investigate whether NSAIDs/ASA lesions in the colon can histologically be diagnosed on the basis of ischemic necrosis similar to biopsy-based diagnosis of NSAIDs/ASA-induced erosions and ulcers of the stomach.METHODS: In the period between 1997 and 2002, we investigated biopsy materials obtained from 611 patients (415 women, 196 men, average age 60.5 years) with endoscopic focal erosions, ulcerations, strictures or diaphragms in the colon. In the biopsies obtained from these lesions, we always established the suspected diagnosis of NSAID-induced lesions whenever necroses of the ischemic type were found. Together with the histological report, we endosed a questionnaire to investigate the use of medication.The data provided by the questionnaire were then correlated with the endoscopic findings, the location, number and nature of the lesions, and the histological findings.RESULTS: At the time of their colonoscopy, 86.1% of the patients had indeed been taking NSAID/ASA medication for years (43.9%) or months (29.5%). The most common indication for the use of these drugs was pain (64.3%),and the most common indication for colonoscopy was bleeding (55.5%). Endoscopic inspection revealed multiple erosions and/or ulcers in 60.6%, strictures in 15.8%, and diaphragms in 3.0% of the patients. The lesions were located mainly in the right colon including the transverse colon (79.9%). A separate analysis of age and sex distribution,endoscopic and histological findings for NSAIDs alone,ASA alone, combined NSAID/ASA, and for patients denying the use of such drugs, revealed no significant differences among the groups.CONCLUSION: This uncontrolled retrospective study based on the histological finding of an ischemic necrosis shows that the histologically suspected diagnosis of NSAID-induced lesions in the colon is often correct. The true diagnostic validity of this finding and the differentiation from ischemic colitis should, however, be investigated in a prospective controlled study. | Manfred Stolte Diana Karimi Michael Vieth Hildegard Volkholz Klaus Dirschmid Sigrid Rappel Birgit Bethke | 2005 | World Journal of Gastroenterology2005，11，37： | 3 |
| 3 | A Comparison of Helicobacter pylori and H. heilmannii Gastritis: A Matched Control Study Involving 404 Patients显示文摘 | M. Stolte G. Kroher A. Meining A. Morgner E. Bayerd?rffer B. Bethke | 1997 | Scandinavian Journal of Gastroenterology1997，，1： | 2 |
| 4 | Selective CO oxidation in a hydrogen-rich stream over Au/γ-Al2O3 catalysts显示文摘 | Bethke G K Kung H H | 2000 | Applied Catalysis A:General2000，19，： | 2 |
| 5 | Stomatal and normtonmatal components to inhibition of photosynthesis in leaves of Captcum annuum during progressive exposure to NaCl salinity显示文摘 | Bethke PC Drew M C | 1992 | Plant Physiol1992，99，： | 1 |
| 6 | Supported Ag catalysts for the lean reduction of NO with C3H6显示文摘 | Bethke K A Kung H H | 1997 | Journal of Catalysis1997，172，1： | 1 |
| 7 | Supported Ag catalysts for the lean reduction of NO with C3H6 显示文摘 | BETHKE K A KUNG H H | 1997 | J Catal1997，172，1： | 1 |
| 8 | Dormancy of Arabidopsisseeds and barley grains can be broken by nitric oxide显示文摘 | Bethke P C Gubler F Jacobsen J V | 2004 | Plan-ta2004，219，： | 1 |
| 9 | Biological studies of Liriomyza huidobrensis (Diptera:Agromyzidae) on chrysanthemum,aster,and pea显示文摘 | PARRELLA M P BETHKE J A | 1984 | J Econ Entomol1984，77，： | 1 |
| 10 | Comparative biology, morphometrics and development of two populations of Bemisia tabaci (Homoptera: Aleyrodidae) on cotton and poinsettia显示文摘 | BETHKE J A PAINE T D NUESSLY G S | 1991 | Ann Entomol Soc Am1991，84，4： | 1 |
| 11 | Apoplastic synthesis of nitric oxide by plant tissues显示文摘 | Bethke PC Badger MR Jonew RL | 2004 | Plant Cell2004，，16： | 1 |
| 12 | Long-range pe-troleum migration in the Illinois basin显示文摘 | BETHKE C M REED J D OLTZ D F | 1991 | AAPG Bulle-tin1991，75，5： | 1 |
| 13 | Long-range petroleum migration in the Illinois Basin显示文摘 | BETHKE C M REED J D OLTZ D F | 1991 | AAPG1991，75，5： | 1 |
| 14 | Relationship between degree of Helocobacter pylori colonization and degree and activity of gastritis,surface epithelial degeneration and mucuc secretion显示文摘 | Stolte M Stadelman O Bethke B | | 0，，02： | 1 |
| 15 | Nextel陶瓷纤维及其纺织品的新用途显示文摘引言连续长丝陶瓷纤维的诞生标志着耐火纤维技术的一大进步,这些纤维实际上是金属氧化物制成的连续长丝,它能容易地加工成陶瓷纺织品以满足高温工作环境中的韧性要求。因为这种长丝是连续的,强度较高,所以在加工陶瓷纺织品时可以不加入其它纤维或金属丝。织物、条带、管状织物、绳索、运输带及热电偶金属丝隔热套都是其典型产品。 | Bethke Ulrich 吴文英 | 1992 | 产业用纺织品1992，10，5： | 1 |
| 16 | Improved integral joint casing connections can reduce well costs显示文摘 | Bethke M Morey S Schwind B | 1994 | Oil and Gas Journal1994，45，5： | 1 |
| 17 | Calcium Homeostasis in plants显示文摘 | Gilroy S Bethke P C Jones R L | 1993 | Journal of Cell Sci1993，106，： | 1 |
| 18 | Stomatal and nonstonmatal components to inhibition of photosynthesis in leaves of Captcum annuum during progressive exposure to NaCl salinity 显示文摘 | BETHKE P CfDREW M C | 1992 | Plant Physio1992，99，： | 1 |
| 19 | A call to Civil Society显示文摘 | Jean Bethke Elshtain | 1999 | Society1999，，5： | 1 |
| 20 | Stomatal and Nonstomatal Compo- nents to Inhibition of Photosynthesis in Leaves of Capsicum annuum during Progressive Exposure to NaC1 Salinity 显示文摘 | Bethke P C Drew M C | 1992 | Plant Physiol1992，99，1： | 1 |
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