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| 1 | Alectinib: a novel second generation anaplastic lymphoma kinase(ALK) inhibitor for overcoming clinically-acquired resistance显示文摘The development of inhibitors for the tyrosine anaplastic lymphoma kinase(ALK) has advanced rapidly, driven by biology and medicinal chemistry. The first generation ALK inhibitor crizotinib was granted US FDA approval with only four years of preclinical and clinical testing. Although this drug offers significant clinical benefit to the ALK-positive patients, resistance has been developed through a variety of mechanisms. In addition to ceritinib, alectinib is another second-generation ALK inhibitor launched in 2014 in Japan. This drug has a unique chemical structure bearing a 5H-benzo[b]carbazol-11(6H)-one structural scaffold with an IC_(50) value of 1.9 nmol/L, and is highly potent against ALK bearing the gatekeeper mutation L1196 M with an IC_(50) of 1.56 nmol/L. In the clinic, alectinib is highly efficacious in treatment of ALK-positive non-small cell lung cancer(NSCLC), and retains potency to combat crizotinib-resistant ALK mutations L1196 M, F1174 L, R1275 Q and C1156 Y. | Zilan Song Meining Wang Ao Zhang | 2015 | Acta Pharmaceutica Sinica B2015，5，1： | 10 |
| 2 | Beta-blocker use and risk of symptomatic bradyarrhythmias: a hospital-based case-control study显示文摘在与 -blockers use.MethodsA 的关系调查征兆的 bradyarrhythmias 的风险因素基于医院的盒子控制学习[228 个病人:108 与征兆的 bradyarrhythmias (案例) 和 120 控制] 在 Sultanah Aminah 医院,在 2011 年 1 月之间的马来西亚和 2014 年 1 月 .ResultsThe 平均数年龄里被进行是 61.1 ?? 業牴敩歮?? 呑 ? | Hou Tee Lu Jiyen Kam Rusli Bin Nordin Surinder Kaur Khelae Jing Mein Wang Chun Ngok Choy Chuey Yan Lee | 2016 | Journal of Geriatric Cardiology2016，13，9： | 2 |
| 3 | Biological activity of lycopene metabolites: implications for cancer prevention 显示文摘 | Mein JR Lian F Wang XD | 2008 | Nutr Rev2008，66，12： | 1 |
| 4 | Bone marrow stem cells‐derived microvesicles protect against renal injury in the mouse remnant kidney model显示文摘 | JUAN HE YAN WANG SHU SUN MEINING YU CUIYU WANG XIAOHUA PEI BEI ZHU JIANQING WU WEIHONG ZHAO | 2012 | Nephrology2012，，5： | 1 |
| 5 | Single-atom electrocatalysis: a new approach to in vivo electrochemical biosensing显示文摘Modulation of interfacial electron transfer has been proven to pave a new approach to in vivo electrochemical monitoring of brain chemistry;however,designing and establishing highly efficient electrocatalytic scheme towards neurochemicals remain a longstanding challenge.Here,we find that recently established single-atom catalyst(SAC)can be used for catalyzing the electrochemical process of physiologically relevant chemicals and thus offers a new avenue to in vivo electrochemical biosensing.To prove this new concept,we used Co single-atom catalyst(Co-SAC),in which the atomic active sites are dispersed in ordered porous N-doping carbon matrix at atomic level,as an example of SACs for analyzing glucose as the physiologically relevant model chemicals.We found that Co-SAC catalyzes the electrochemical oxidation of hydrogen peroxide(H2O2)at a low potential of ca.+0.05 V(vs.Ag/AgCl).This property was further used for developing an oxidase-based glucose biosensor that was used subsequently as a selective detector of an online electrochemical system(OECS)for continuous monitoring of microdialysate glucose in rat brain.The OECS with Co-SAC-based glucose biosensor as the online detector was well responsive to glucose without interference from other electroactive species in brain microdialysate.This study essentially offers a new approach to in vivo electrochemical analysis with SACs as electrocatalysts to modulate interfacial electron transfer. | Hanfeng Hou Junjie Mao Yunhu Han Fei Wu Meining Zhang Dingsheng Wang Lanqun Mao Yadong Li | 2019 | Science China Chemistry2019，62，12： | 1 |
| 6 | Bone marrow stem cells‐derived microvesicles protect against renal injury in the mouse remnant kidney model显示文摘 | JUAN HE YAN WANG SHU SUN MEINING YU CUIYU WANG XIAOHUA PEI BEI ZHU JIANQING WU WEIHONG ZHAO | 2012 | Nephrology2012，，5： | 1 |
| 7 | Biological activity of lycopene metabolites: implications for cancer prevention显示文摘 | Mein J R Lian F Wang X D | 2008 | Nutrition Reviews2008，66，12： | 1 |
| 8 | Growth performance of different Epichloësinensis strains on media with different additives显示文摘Background:Epichloësinensis is a newly found endophyte species that is frequently involved in symbiosis with Festuca sinensis.There are a little reports on the characteristics of E.sinensis in vitro.Methods:In the present study,five E.sinensis endophyte strains(strain ID 1,2,41D,57D,111D)isolated from different F.sinensis ecotypes were used to evaluate their antioxidant capacities and enzyme activities.Also,the growth of E.sinensis on potato dextrose agar(PDA)with different additives was investigated.Results:The five strains had significantly different(p<0.05)total antioxidant capacities and radical-scavenging abilities.In most cases,the growth rate of strain 1 was the fastest(p<0.05),and that of strain 57D was the slowest(p<0.05).The growth rates of these five strains on PDA with vitamins significantly(p<0.05)increased with increasing vitamin concentration.The growth rates of these five strains on PDA with plant growth regulators also significantly(p<0.05)increased;however,the increase was inconsistent at different concentrations of indole-3-acetic acid and gibberellin.Low concentrations(5 and 10 mg L−1)of forchlorfenuron(KT-30)significantly promoted the growth of all five strains,whereas high concentrations(20 and 40 mg L−1)of KT-30 significantly inhibited their growth(p<0.05).The Na+,Cd2+,Zn2+,and Cr6+ions all inhibited the growth of these five strains,and their growth rates were significantly decreased with an increase in ion concentrations(p<0.05).Under Na+stress,strain 41D grew the fastest and had the strongest tolerance(p<0.05);under Cd2+,Zn2+,and Cr6+stresses,strain 111D grew the fastest and had the strongest tolerance(p<0.05).Conclusions:The results indicated that the E.sinensis had antioxidant activities and hydrolase activities.Additives could promote or inhibit the growth of the strains in different degrees.All these evaluations in the present study improve our understanding of the E.sinensis endophyte and provide referenced information for further studies. | Pei Tian Meining Wang Yang Luo Xingdi Wang Wenbo Xu | 2022 | Grassland Research2022，1，3： | 0 |
| 9 | Nkx2.1 downregulation is involved in brain abnormality induced by excess retinoic acid显示文摘Abnormal development of central nervous system(CNS)caused by neural tube defects is not only a major con tributor in the prevale nee of stillbirths and n eonatal deaths but also causes lifelong physical disability in surviving infants.Due to insufficient known investigated causes,CNS developmental abnormality has brought sever burden on health around the world.From previous results of high throughput transcriptome sequencing,we selected transcription factor Nkx2.1 as a candidate to investigate its role on brain abnormalities induced by excessive retinoic acid.The result of in situ hybridization showed that Nkx2.1 was mainly expressed in mouse brain.After the Nkx2.1 gene was sileneed,retarded proliteration and accelerated apoptosis were found in mouse Neuro-2a(N2a)cells.Furthermore,our results indicated that the main components of sonic hedgehog(Shh)signaling pathway were affected in Nkx2.7-silenced cells,implying that Nkx2.1 plays an important role in the development of mouse brain by regulating Shh signaling pathway. | Sansan Jia Li Zhang Kaili Zhang Lei Wang Ajab Khan Juan Zhang Yuqing Sun Yufei Wang Meiyan Song Yi Lyu Meining Li Xin Lu Bo Niu Zhizhen Liu Jun Xie | 2020 | Acta Biochimica et Biophysica Sinica2020，52，6： | 0 |
| 10 | Synthesis Study toward Mayamycin显示文摘自然产品 mayamycin 是在在 benz 的 C5 位置展示一个 C-glycoside 连接的 angucycline 班上的第一个例子[一] 有显著生物活动的 anthracenone 核心。我们成功地综合了二 retrosynthetic 碎片,但是发现最后的 C-glycosylation 没发生。或者, A-ring 浸透了 aglycon 被准备,但是建议 C-glycosylation 仍然没继续。最后,简化底层被使用,随后的 C-glycosylation 顺利通过了,给 mayamycin 的二戒指的更少类似物。 | Kui Wu Meining Wang Qizheng Yao Ao Zhang | 2013 | Chinese Journal of Chemistry2013，31，1： | 0 |
| 11 | Calculation of seismic transmission speed of HTI medium显示文摘During the seismic wave propagation process,as for the anisotropic lower medium,the speed is a function of the propagating direction.This article focuses on solving the problem how to get the transmittance angle and speed,knowing the upper seismic wave propagation velocity and the angle of incidence conditions.The main theories used Snell law,Christoffel equation and speed characteristics.Taking the HTI medium as an example,the authors give the detailed solving process and draw the space velocity characteristic curve. | WANG Hongwei FAN Meining | 2013 | Global Geology2013，16，4： | 0 |
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