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| 1 | Predictors of suboptimal bowel preparation in asymptomatic patients undergoing average-risk screening colonoscopy显示文摘AIM To identify risk factors for a suboptimal preparation among a population undergoing screening or surveillance colonoscopy.METHODS Retrospective review of the University of Michigan and Veteran's Administration(VA) Hospital records from 2009 to identify patients age 50 and older who underwent screening or surveillance procedure and had resection of polyps less than 1 cm in size and no more than 2 polyps. Patients with inflammatory bowel disease or a family history of colorectal cancer were excluded. Suboptimal procedures were defined as procedure preparations categorized as fair, poor or inadequate by the endoscopist. Multivariable logistic regression was used to identify predictors of suboptimal preparation.RESULTS Of 4427 colonoscopies reviewed, 2401 met our inclusion criteria and were analyzed. Of our population, 16% had a suboptimal preparation. African Americans were 70% more likely to have a suboptimal preparation(95%CI: 1.2-2.4). Univariable analysis revealed that narcotic and tricyclic antidepressants(TCA) use, diabetes, prep type, site(VA vs non-VA), and presence of a gastroenterology(GI) fellow were associated with suboptimal prep quality. In a multivariable model controlling for gender, age, ethnicity, procedure site and presence of a GI fellow, diabetes [odds ratio(OR) = 2.3; 95%CI: 1.6-3.2], TCA use(OR = 2.5; 95%CI: 1.3-4.9), narcotic use(OR = 1.7; 95%CI: 1.2-2.5) and Miralax-Gatorade prep vs 4L polyethylene glycol 3350(OR = 0.6; 95%CI: 0.4-0.9) were associated with a suboptimal prep quality. CONCLUSION Diabetes, narcotics use and TCA use were identified as predictors of poor preparation in screening colonoscopies while Miralax-Gatorade preps were associated with better bowel preparation. | Shail M Govani Eric E Elliott Stacy B Menees Stephanie L Judd Sameer D Saini Constantinos P Anastassiades Annette L Urganus Suzanna J Boyce Philip S Schoenfeld | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，17： | 7 |
| 2 | Pharmacological effects of lipid-lowering drugs on circulating adipokines显示文摘The cardioprotective effects of lipid-lowering drugs have been primarily attributed to their effects on blood lipid metabolism.However,emerging evidence indicates that lipid-lowering drugs also modulate the synthesis and secretion of adipose tissue-secreted proteins referred to as adipokines.Adipokines influence energy homeostasis and metabolism and have also been shown to modulate the vascular inflammatory cascade.The purpose of this review will be to examine the reported effects of commonly used lipid-lowering drugs(statins,fibrates,niacin and omega-3-fatty acids) on the circulating concentrations of leptin,adiponectin,tumor necrosisfactor-α(TNF-α),Retinol binding protein 4(RBP4) and resistin.Overall,the lipid-lowering drugs reviewed have minimal effects on leptin and resistin concentrations.Conversely,circulating adiponectin concentrations are consistently increased by each lipid-lowering drug reviewed with the greatest effects produced by niacin.Studies that have examined the effects of statins,niacin and omega-3-fatty acids on TNF-α demonstrate that these agents have little effect on circulating TNF-α concentrations.Niacin and fibrates appear to lower RBP4 but not resistin concentrations.The results of the available studies suggest that a strong relationship exists between pharmacological reductions in blood lipids and adiponectin that is not obvious for other adipokines reviewed. | Desiree Wanders Eric P Plaisance Robert L Judd | 2010 | World Journal of Diabetes2010，1，4： | 5 |
| 3 | Artemisinin Biosynthesis in Non-glandular Trichome Cells of Artemisia annua显示文摘Artemisinin-based combination therapy(ACT)forms the first line of malaria treatment.However,the yield fluctuation of artemisinin has remained an unsolved problem in meeting the global demand for ACT.This problem is mainly caused by the glandular trichome(GT)-specific biosynthesis of artemisinin in all currently used Artemisia annua cultivars.Here,we report that non-GT cells of self-pollinated inbred A.annua plants can express the artemisinin biosynthetic pathway.Gene expression analysis demonstrated the transcription of six known pathway genes in GT-free leaves and calli of inbred A.annua plants.LC-qTOF-MS/MS analysis showed that these two types of GT-free materials produce artemisinin,artemisinic acid,and arteannuin B.Detailed IR-MALDESI image profiling revealed that these three metabolites and dihydroartemisinin are localized in non-GT cells of leaves of inbred A.annua plants.Moreover,we employed all the above approaches to examine artemisinin biosynthesis in the reported XL annua glandless(gl)mutant.The resulting data demonstrated that leaves of regenerated gl plantlets biosynthesize artemisinin.Codectively,these findings not only add new knowledge leading to a revision of the current dogma of artemisinin biosynthesis inannua but also may expedite innovation of novel metabolic engineering approaches for high and stable production of artemisinin in the future. | Rika Judd M.Caleb Bagley Mingzhuo Li Yue Zhu Caiyan Lei Seyit Yuzuak Mans Ekelof Gaobin Pu Xiting Zhao David C.Muddiman De-Yu Xie | 2019 | Molecular Plant2019，12，5： | 5 |
| 4 | Adiponectin downregulation is associated with volume overload-induced myocyte dysfunction in rats显示文摘目的: Adiponectin 被报导了在在体积的病理学的室的改变,而是 adiponectin 的角色期间施加保护的效果导致超载的心失败遗体不清楚。在这研究,我们在心脏的 myocyte 上调查了 adiponectin 的效果在 rats.Methods 的可收缩的机能障碍追随者体积超载: 体积超载被 infrarenal 主动脉静脉 cava 通过手术在老鼠导致管。老鼠是在 2- 的静脉内地管理的 adenoviral adiponectin, 6 星期、 9 星期的后面的管。adiponectin, adiponectin 受体(AdipoR1/R2 和 T-cadherin ) 和 AMPK 活动的蛋白质表示用西方的污点分析被测量。孤立的室的 myocytes 在管以后的 12 个星期被准备检验 myocytes 和细胞内部的 Ca 2+ transient.Results 的可收缩的表演: A-V 管在浆液和心肌的 adiponectin 层次导致了重要减小,心肌的 adiponectin 受体(AdipoR1/R2 和 T-cadherin ) 层次,以及心肌的 AMPK 活动。与这些变化一致,孤立的 myocytes 在房间弄短和细胞内部的 Ca 2+ 展出了重要消沉短暂。adenoviral adiponectin 的管理显著地增加了浆液 adiponectin 层次并且阻止了 myocyte 在管老鼠的可收缩的机能障碍。而且,有 recombinant adiponectin 的孤立的 myocytes 的预告的处理(2.5 μ g/mL ) 显著地在管老鼠改进了他们的可收缩的性能,但是没在控制或 adenoviral 有效果管理 adiponectin 的 rats.Conclusion : 这些结果表明在 adiponectin downregulation 和体积之间的积极关联导致超载的室的改变。Adiponectin 在体积起一个保护的作用导致超载的心失败。 | Li-li WANG Dori MILLER Desiree WANDERS Gayani NANAYAKKARA Rajesh AMIN Robert JUDD Edward E MORRI-SON Ju-ming ZHONG | 2016 | Acta Pharmacologica Sinica2016，37，2： | 4 |
| 5 | Hormone naive prostate cancer: predicting and maximizing response intervals显示文摘 | Judd W Moul | 2015 | Asian Journal of Andrology2015，17，6： | 4 |
| 6 | An NF90/NF110-mediated feedback amplification loop regulates dicer expression and controls ovarian carcinoma progression显示文摘 | Jerome Barbier Xin Chen Gabriel Sanchez Muyan Cai Marion Helsmoortel Takuma Higuchi Pierre Giraud Xavier Contreras Gangjun Yuan Zihao Feng Rima Nait-Saidi Olivier Deas Lisa Bluy Jean-Gabriel Judde Sylvie Rouquier William Ritchie Shuji Sakamoto Dan Xie Rosemary Kiernan | 2018 | Cell Research2018，28，5： | 3 |
| 7 | Gut microbiome profiling and colorectal cancer in African Americans and Caucasian Americans显示文摘AIM To determine whether and to what extent the gut microbiome is involved in regulating racial disparity in colorectal cancer(CRC). METHODS All patients were recruited and experiments were performed in accordance with the relevant guidelines and regulations by the Institutional Review Boards (IRB), committees of the John D. Dingell VAMC and Wayne State University guidelines. African American (AA) and Caucasian American (CA) patients were scheduled for an outpatient screening for colonoscopy, and no active malignancy volunteer patients were doubly consented, initially by the gastroenterologist and later by the study coordinator, for participation in the study. The gut microbial communities in colonic effluents from AAs and CAs were examined using 16 sRNA profiling, and bacterial identifications were validated by performing SYBR-based Real Time PCR. For metagenomic analysis to characterize the microbial communities, multiple software/tools were used, including Metastats and R statistical software.RESULTS It is generally accepted that the incidence and mortality of CRC is higher in AAs than in CAs. However, the reason for this disparity is not well understood. We hypothesize that the gut microbiome plays a role in regulating this disparity. Indeed, we found significant differences in species richness and diversity between AAs and CAs. Bacteroidetes was more abundant in AAs than in CAs. In particular, the pro-inflammatory bacteria Fusobacterium nucleatum and Enterobacter species were significantly higher in AAs, whereas probiotic Akkermansia muciniphila and Bifidobacterium were higher in CAs. The polyphyletic Clostridia class showed a divergent pattern, with Clostridium XI elevated in AAs, and Clostridium IV, known for its beneficial function, higher in CAs. Lastly, the AA group had decreased microbial diversity overall in comparison to the CA group. In summary, there were significant differences in pro-inflammatory bacteria and microbial diversity between AA and CA, which may help explain the CRC disparity between groups.CONCLUSION Our current investigation, for the first time, demonstrates microbial dysbiosis between AAs and CAs, which could contribute to the racial disparity of CRC. | Lulu Farhana Fadi Antaki Farhan Murshed Hamidah Mahmud Stephanie L Judd Pratima Nangia-Makker Edi Levi Yingjie Yu Adhip PN Majumdar | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，2： | 3 |
| 8 | Targeting STAT3 in gastric cancer显示文摘 | Andrew S Giraud Trevelyan R Menheniott Louise M Judd | 2012 | Expert Opinion on Therapeutic Targets2012，，9： | 3 |
| 9 | Secondary angiodysplasia-associated gastrointestinal bleeding in end-stage renal disease: Results from the nationwide inpatient sample显示文摘BACKGROUND Chronic kidney disease is associated with angiodysplasia of gastrointestinal tract leading to increased risk of gastrointestinal bleeding.AIM To determine the nationwide prevalence,trends,predictors and resource utilization of angiodysplasia-associated gastrointestinal bleeding in end-stage renal disease hospitalizations.METHODS The Nationwide Inpatient Sample database from 2009 to 2014,was utilized to conduct a retrospective study on patients with angiodysplasia associatedgastrointestinal bleeding and end-stage renal disease.Hospitalizations with endstage renal disease were included in the Nationwide Inpatient Sample database and a subset of hospitalizations with end-stage renal disease and angiodysplasiaassociated gastrointestinal bleeding were identified with International Classification of Diseases,9th revision,Clinical Modification codes for both endstage renal disease(585.6)and angiodysplasia(569.85,537.83).RESULTS The prevalence of angiodysplasia-associated gastrointestinal bleeding was 0.45%(n=24709)among all end-stage renal disease patients(n=5505252)that were hospitalized.Multivariate analysis indicated that the following were significant factors associated with higher odds of angiodysplasia associated-gastrointestinal bleeding in end-stage renal disease patients:an increasing trend from 2009-2014(P<0.01),increasing age(P<0.0001);African American race(P=0.0206);increasing Charlson-Deyo Comorbidity Index(P<0.01);hypertension(P<0.0001);and tobacco use(P<0.0001).Diabetes mellitus(P<0.0001)was associated with lower odds of angiodysplasia associated-gastrointestinal bleeding in end-stage renal disease patients.In comparison with urban teaching hospitals,rural and urban nonteaching hospitals were associated with decreased odds of angiodysplasia associated-gastrointestinal hemorrhage.CONCLUSION Angiodysplasia-associated gastrointestinal bleeding in end-stage renal disease patients showed an increasing trend from 2009-2014.Advanced age,African American race,overall high comorbidities,hypertension and smoking were significant factors for angiodysplasia-associated gastrointestinal bleeding in bleeding in these patients. | Tooba Tariq Patrick Karabon Furqan B Irfan Sachin Goyal Matthew Masaru Mayeda Austin Parsons Stephanie Judd Murray Ehrinpreis | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，10： | 3 |
| 10 | 小儿急性腹泻病的临床管理显示文摘 | Joy Phumaphi Joe Judd 林燕芬 龚四堂 | 2004 | 广东医学2004，25，8： | 3 |
| 11 | 全科医学中的心理健康病案研究(二十六)--抑郁与恶性肿瘤显示文摘中国全科医学杂志与澳大利亚Monash大学和Melbourne大学的全科医学专家和心理学专家在2012年伊始共同推出“全科医学中的心理健康病案研究”学术专栏,该专栏由澳大利亚的几位专家轮流撰写,以介绍社区常见的心理问题及其解决方法为主要内容,获得了读者的广泛好评。今年我刊将继续该学术专栏的登载,以推动我国社区心理学服务的能力建设,并带动社区心理学研究的深入。与此同时,由几位澳大利亚教授合作撰写的著作《全科医学之心理健康》已经由中国全科医学杂志社与国内外专家合作进行翻译,并在中国出版发行。希望通过本学术专栏和翻译名著等工作,让中国的全科医学在心理健康服务方面迈上新的台阶。在此衷心感谢担任本栏目翻译点评工作的我刊编委、澳大利亚Monash大学杨辉教授对中国全科医学发展给予的帮助和支持! | Sasha Fehily Grant Blashki Fiona Judd Leon Piterman Hui Yang Shane Thomas | 2014 | 中国全科医学2014，17，7： | 3 |
| 12 | Embeding as a modeing problem显示文摘 | Judd Kevin Alstair Mess | 1998 | Phys D1998，120，4： | 3 |
| 13 | 顽固性高血压与由心内容积决定的血管内液体潴留无关显示文摘顽固性高血压(refractory hypertension,RfHTN)是一种极端的抗高血压治疗失败的表现形式,定义为使用了包括长效噻嗪类和盐皮质激素受体拮抗剂在内的≥5种药时血压仍控制欠佳。RfHTN是难治性高血压(resistant hypertension,RHTN)的一个亚组,RHTN定义为使用≥3种降压药(包括利尿剂)后血压仍〉135/85mm Hg(1mm Hg=0.133kPa)。 | 刘青 叶鹏 Velasco A Siddiqui M Kreps E Kolakalapudi P Dudenbostel T Arora G Judd EK Prabhu SD Lloyd SG Oparil S Calhoun DA | 2018 | 中华高血压杂志2018，26，7： | 2 |
| 14 | 全科医学中的心理健康病案研究(二十二)--帕金森病和抑郁显示文摘中国全科医学杂志与澳大利亚Monash大学和Melbourne大学的全科医学专家和心理学专家在2012年伊始共同推出'全科医学中的心理健康病案研究'学术专栏,该专栏由澳大利亚的几位专家轮流撰写,以介绍社区常见的心理问题及其解决方法为主要内容,获得了读者的广泛好评。今年我刊将继续该学术专栏的登载,以推动我国社区心理学服务的能力建设,并带动社区心理学研究的深入。与此同时,由几位澳大利亚教授合作撰写的著作《全科医学中的精神病学》正在由中国全科医学杂志社与国内外专家合作进行翻译,期望不久在中国出版。希望通过本学术专栏和翻译名著等工作,让中国的全科医学在心理健康服务方面迈上新的台阶。在此衷心感谢担任本栏目翻译点评工作的我刊编委、澳大利亚Monash大学杨辉教授对中国全科医学发展给予的帮助和支持! | Sasha Fehily Grant Blashki Fiona Judd Malcolm Home Leon Piterman Hui Yang | 2013 | 中国全科医学2013，16，28： | 2 |
| 15 | 全科医学中的心理健康病案研究(八)--神经性厌食显示文摘中国唐盛时期的丰肥浓丽是那个时代的标记,如今清秀苗条成为时尚。有不少年轻女生甚至追求'去性别化',不仅要瘦,甚至要'骨感美'。然而故意和过度地降低体质量,可以导致严重营养不良和极度衰竭,影响身心健康和发育,甚至危及生命。神经性厌食(anorexia nervosa,AN)是一种病因尚未完全清楚的疾病,目前认为是生物、心理和社会因素的综合影响。几年前,中国的精神科医生还只是听说过这个疾病名称,不过现在已经不时地接待来就诊的神经性厌食患者。中国还没有神经性厌食的流行病学报告。作为全科医生,可能会遇到这类患者。怎么诊断和管理这类患者呢?澳大利亚的全科医学专家与大家共同分享一个案例并讨论合理的管理策略。 | Fiona Judd Grant Blashki Leon Piterman 杨辉 | 2012 | 中国全科医学2012，15，22： | 2 |
| 16 | 全科医学中的心理健康病案研究(二十五)--更年期与心理健康显示文摘中国全科医学杂志与澳大利亚Monash大学和Melbourne大学的全科医学专家和心理学专家在2012年伊始共同推出“全科医学中的心理健康病案研究”学术专栏,该专栏由澳大利亚的几位专家轮流撰写,以介绍社区常见的心理问题及其解决方法为主要内容,获得了读者的广泛好评。今年我刊将继续该学术专栏的登载,以推动我国社区心理学服务的能力建设,并带动社区心理学研究的深入。与此同时,由几位澳大利亚教授合作撰写的著作《全科医学之心理健康》已经由中国全科医学杂志社与国内外专家合作进行翻译,并在中国出版发行。希望通过本学术专栏和翻译名著等工作,让中国的全科医学在心理健康服务方面迈上新的台阶。在此衷心感谢担任本栏目翻译点评工作的我刊编委、澳大利亚Monash大学杨辉教授对中国全科医学发展给予的帮助和支持! | Fiona Judd Grant Blashki Leon Piterman Hui Yang | 2014 | 中国全科医学2014，17，4： | 2 |
| 17 | Polyoxometalates in medicine显示文摘 | Rhule J T Hill C L Judd D A | | 0，，： | 2 |
| 18 | Detection of Myocardial Damage in Patients With Sarcoidosis显示文摘 | Manesh R. Patel Peter J. Cawley John F. Heitner Igor Klem Michele A. Parker Wael A. Jaroudi Trip J. Meine James B. White Michael D. Elliott Han W. Kim Robert M. Judd Raymond J. Kim | 2009 | Circulation2009，，： | 2 |
| 19 | 全科医学中的心理健康病案研究(三)——精神病显示文摘中国全科医学杂志与澳大利亚Monash大学和Melbourne大学的全科医学专家和心理学专家共同推出'全科医学中的心理健康病案研究'学术专栏,该专栏由澳大利亚的几位专家轮流撰写,以介绍社区常见的心理问题及其解决方法为主要内容。这个新专栏的诞生将推动我国社区心理学服务的能力建设,并带动社区心理学研究的深入。与此同时,由几位澳大利亚教授合作撰写的著作《全科医学中的精神病学》正在由中国全科医学杂志与国内外专家合作进行翻译,期望不久在中国出版。我们共同希望通过本学术专栏和翻译名著等努力,让中国的全科医学在心理健康服务方面迈上新的台阶。在此衷心感谢担任本栏目翻译点评工作的我刊编委、澳大利亚Monash大学杨辉教授对中国全科医学发展给予的帮助和支持! | Fiona Judd Grant Blashki Leon Piterman 杨辉 | 2012 | 中国全科医学2012，15，7： | 2 |
| 20 | Antiscale magnetic pretreatment of reverse osmosis feedwater显示文摘 | Judd S J Parsons S A | 1997 | Desalination1997，110，12： | 1 |
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