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| 1 | Increased hepcidin expression in colorectal carcinogenesis显示文摘AIM:To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anae- mia and whether it might have a role in colorectal car- cinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using im- munohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was posi- tively associated with increasing T-stage of colorectal cancer (P < 0.05). Furthermore, we report that hepcidin mRNA is expressed in 34% of colorectal cancer tissue specimens and was correlated with ferroportin repres- sion. This was supported by hepcidin immunoreactivity in colorectal cancer tissue. CONCLUSION: We demonstrate that systemic hepcidin expression is unlikely to be the cause of the systemic anaemia associated with colorectal cancer. However, we demonstrate for the first time that hepcidin is expressed by colorectal cancer tissue and that this may represent a novel oncogenic signalling mechanism. | Douglas G Ward Keith Roberts Matthew J Brookes Howard Joy Ashley Martin Tariq Ismail Robert Spychal Tariq Iqbal Chris Tselepis | 2008 | World Journal of Gastroenterology2008，14，9： | 12 |
| 2 | 接头连接PCR步行法鉴定转基因烟草显示文摘应用接头连接PCR步行法,建立了分子水平鉴定不同转基因事件的方法和体系;并利用不同转基因事件外源基因与植物基因组DNA整合位点处核酸序列的差异,设计了不同转基因烟草事件的标签引物,成功地对几个转TMV-CP材料进行了鉴定。 | 万秀清 JUTTA TUERCK MARTIN WARD 郭兆奎 李丽杰 颜培强 徐香玲 | 2007 | 烟草科技2007，40，4： | 3 |
| 3 | The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate显示文摘 | Patrick S. Ward Jay Patel David R. Wise Omar Abdel-Wahab Bryson D. Bennett Hilary A. Coller Justin R. Cross Valeria R. Fantin Cyrus V. Hedvat Alexander E. Perl Joshua D. Rabinowitz Martin Carroll Shinsan M. Su Kim A. Sharp Ross L. Levine Craig B. Thompson | 2010 | Cancer Cell2010，，3： | 2 |
| 4 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 5 | Effects of planting stock quality and browse protection-type on height growth of northern red oak and eastern white pine显示文摘 | Jeffrey S Ward Martin P.N Gent George R Stephens | 2000 | Forest Ecology and Management2000，，1： | 1 |
| 6 | Mood as input:People have to interpret the motivational implications of their moods显示文摘 | Martin L L Ward D W Achee J W | 1993 | Journal of Personality and Social Psychology1993，，3： | 1 |
| 7 | Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation显示文摘 | Maria E. Figueroa Omar Abdel-Wahab Chao Lu Patrick S. Ward Jay Patel Alan Shih Yushan Li Neha Bhagwat Aparna Vasanthakumar Hugo F. Fernandez Martin S. Tallman Zhuoxin Sun Kristy Wolniak Justine K. Peeters Wei Liu Sung E. Choe Valeria R. Fantin Elisabeth P | 2010 | Cancer Cell2010，，6： | 1 |
| 8 | Mood as Input:PeopleHave to Interpret the Motivational Implications of Their Moods显示文摘 | Martin L L Ward D W Achee J W | 1993 | Journal of Personality and Social Psychology1993，，3： | 1 |
| 9 | Effects of hypoxia on rat airway smooth muscle cell proliferation显示文摘 | Cogo A Napolitano G Michoud MC Barbon DR Ward M Martin JG | 2003 | J Appl Physiol2003，94，： | 1 |
| 10 | Recognizing entailment inintelligent tutoring systems 显示文摘 | Nielsen R Ward W Martin J | 2009 | Natural Language Enginee-ring2009，15，4： | 1 |
| 11 | Viscosity of rice flour:a rheological and biological study显示文摘 | Fitzgerald M A Martin M Ward R M | 2003 | Journal of Agricultural and Food Chemistry2003，51，8： | 1 |
| 12 | Examining platelet-fibrin interactions during traumatic shock in a swine model using platelet contractile force and clot elastic modulus 显示文摘 | White NJ Martin EJ Brophy DF Ward KR | 2011 | Blood Coagul Fibrinolysis2011，22，5： | 1 |
| 13 | Germline epimutation of MLH1 in individuals with multiple cancers 显示文摘 | Suter CM Martin DI Ward RL | 2004 | Nat Genet2004，36，5： | 1 |
| 14 | Germline epimutation: A basis for epigenetic disease in humans 显示文摘 | Martin DI Ward R Suter CM | 2005 | Ann N Y Acad Sci2005，1054，： | 1 |
| 15 | No Role for Routine Chest Radiography in Stage I Seminoma Surveillance显示文摘 | Shaun Tolan Danny Vesprini Michael A.S. Jewett Padraig R. Warde Martin O'Malley Tony Panzarella Jeremy F.G. Sturgeon Malcolm Moore Betty Tew-George Mary K. Gospodarowicz Peter W.M. Chung | 2009 | European Urology2009，，3： | 1 |
| 16 | Mechanisms of copy number variation and hybrid gene formation in the KIR immune gene complex 显示文摘 | Traherne J A Martin M Ward R | 2010 | Hum Mol Genet2010，19，： | 1 |
| 17 | Comparing Temporary Mobility with Permanent Migration 显示文摘 | MARTIN BELL GARY WARD | 2000 | Tourism Geographies2000，2，1： | 1 |
| 18 | (2002) Students with mental illnesses in university setting: Faculty and student attitudes, beliefs, know ledges and experiences 显示文摘 | Marion Becker Lee Martin Emad Wajeeh John Ward& David Shem | 2002 | Psychiatric Rehabilitation Journal2002，25，4： | 1 |
| 19 | Alcoholic skeletal myopathy,a clinical and pathological study显示文摘 | Martin F Ward K Slavin G | 1985 | Q J Med1985，55，： | 1 |
| 20 | Mood as input:People have to interpret the motivational implications of their moods显示文摘 | Martin L Ward D Achee J Wyer R | | 0，，64： | 1 |
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