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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | The microwave processability of semicrystalline polymers显示文摘 | M Chen J W Hellgeth E J Siochi T C Ward J E Mcgrath | 1993 | Polymer Engineering and Science1993，33，17： | 2 |
| 3 | The oxidative dehydrogenation of ethane by nitrous oxide over molybdenum oxide supported on silica gel显示文摘 | M B Ward M J Lin J H Lousford | 1977 | J Catal1977，50，： | 2 |
| 4 | Interstitial cells of Cajal and electrical activity in ganglionic and aganglionic colons of mice显示文摘 | Ward S M G ershon M D Keef K | 2002 | Am J Physiol2002，283，2： | 2 |
| 5 | Severin classification system for evaluation of the results of operative treatment of congenital dislocation of the hip显示文摘 | Ward WT Vogt M Grudziak JS | 1997 | J Bone Joint Surg1997，79，5： | 2 |
| 6 | Plants pass the salt显示文摘 | Ward J M Hirschi K D Sze H | 2003 | Trends Plant Sci2003，8，5： | 2 |
| 7 | Comparison of six RNA extraction methods for the detection of classical swine fever virus by real-time and conventional reverse transcription-PCR 显示文摘 | DENG M Y WANG H WARD GB | 2005 | J Vet Diagn Invest2005，17，6： | 1 |
| 8 | Paternal smoking, genetic polyrnorphisms in CYP1A1 and childhood leukemia risk 显示文摘 | Lee K M Ward M H Han S | 2009 | Leukemia Res2009，33，2： | 1 |
| 9 | Management of stress urinary incontinence显示文摘 | Ward R M Sung V W | 2008 | Minerva Urol Nefrol2008，60，2： | 1 |
| 10 | Destructible surfactants based on a silicon-oxygen bond显示文摘 | Ward M D | 1982 | J Org Chem1982，47，11： | 1 |
| 11 | Mammalian keratin gene families: organization for genes coding for the B2 high-sulphur proteins sheep wool 显示文摘 | Powell B C Sleigh M J Ward K A | 1983 | Nucleic Acids Res1983，11，： | 1 |
| 12 | improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin 显示文摘 | Bolla M Gonzalez D Warde P | 1997 | N EngtJ Med1997，337，5： | 1 |
| 13 | Difereneesin inflammatory eytokine and Toll - like receptor genes and bacterial vaginosis in pregnancy 显示文摘 | Goepfert AR Vamer M Ward K | 2005 | Am J Obstet Gynecol2005，193，： | 1 |
| 14 | Solving quadratic assignment problems by simulated annealing 显示文摘 | Wilhelm M R Ward T L | 1987 | IEEE Transactions1987，19，1： | 1 |
| 15 | Prospects for expanded utilization of biogas in Germany显示文摘 | POESCHL M WARD S OWENDE P | 2010 | Renewable and Sustainable Energy Reviews2010，14，7： | 1 |
| 16 | Intravenous bisphosphonate therapy for traumatic os- teoneerosis of the femoral head in adolescents显示文摘 | Ramachandran M Ward K Brown RR Munns CF Cowell CT Little DG | 2007 | J Bone Joint Surg Am2007，89，： | 1 |
| 17 | Micro T-mixer as a rapid mixing micromixer 显示文摘 | WONG S H WARD M C L WHARTON C W | 2004 | Sensors and Actuators B-Chemical2004，100，3： | 1 |
| 18 | Perceived Risk and Chinese Consumers' Internet Banking Services Adoption 显示文摘 | Anita Lifen Zhao Stuart Hanmer - Lloyd Philippa Ward Mark M H Goode | 2008 | International Jour- nal of Bank Marketing2008，26，7： | 1 |
| 19 | Meas-uring Banks’Automated Service Quality:A Con-firmatory Factor Analysis Approach显示文摘 | Al-HAWARIi M HARTLEY N WARD T | 2005 | MarketingBulletin2005，16，1： | 1 |
| 20 | KGF facilitates repair of radiation-induced DNA damage in alveolar epithelial cells显示文摘 | Takeoka M Ward WF Pollack H | 1997 | Am J Physiol1997，272，： | 1 |
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