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| 1 | Relationship of MTHFR gene polymorphisms with renal and cardiac disease显示文摘AIM: To investigate the effects of different methylenetetrahydrofolate reductase(MTHFR) 677C>T gene polymorphism and hyperhomocysteinemia for the development of renal failure and cardiovascular events, which are controversial.METHODS: We challenged the relationship, if any, of MTHFR 677C>T and MTHFR 1298A>C polymorphisms with renal and heart function. The present article is a reappraisal of these concepts, investigating within a larger population, and including a subgroup of dialysis patients, if the two most common MTHFR polymorphisms, C677 T and A1298 C, as homozygous, heterozygous or with a compound heterozygous state, show different association with chronic renal failure requiring hemodialysis. MTHFR polymorphism could be a favorable evolutionary factor, i.e., a protective factor for many ominous conditions, like cancer and renal failure. A similar finding was reported in fatty liver disease in which it is suggested that MTHFR polymorphisms could have maintained and maintain their persistence by an heterozygosis advantage mechanism. We studied a total of 630 Italian Caucasian subject aged 54.60 ± 16.35 years, addressing to the increased hazard of hemodialysis, if any, according to the studied MTHFR genetic polymorphisms. RESULTS: A favorable association with normal renal function of MTHFR polymorphisms, and notably of MTHFR C677 T is present independently of the negative effects of left ventricular hypertrophy, increased IntraRenal arterial Resistance and hyperparathyroidism. CONCLUSION: MTHFR gene polymorphisms could have a protective role on renal function as suggested by their lower frequency among our dialysis patients in end-stage renal failure; differently, the association with left ventricular hypertrophy and reduced left ventricular relaxation suggest some type of indirect, or concurrent mechanism. | Francesca M Trovato Daniela Catalano Angela Ragusa G Fabio Martines Clara Pirri Maria Antonietta Buccheri Concetta Di Nora Guglielmo M Trovato | 2015 | World Journal of Nephrology2015，4，1： | 10 |
| 2 | 小P值并不能保证可靠结果:以帕金森病的静息态脑功能成像元分析为例显示文摘Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain disorders.For precise localization of abnormal brain activity,a voxel-level comparison is needed.Because of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1]. | 贾熙泽 赵娜 董昊铭 孙家伟 Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa 陈博宇 陈俊 Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito 范国光 Federica Di Nardo 冯怡萱 Brett W.Fling Saurabh Garg Moran Gilat Martin Gorges Shu-Leong Ho Fay B.Horak 胡晓 胡晓飞 黄飚 黄沛钰 贾泽娟 Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani 李静 李晴 刘爱萍 刘波 刘虎 刘卫国 Renaud Lopes 娄毓婷 罗巍 Tara Madhyastha 毛妮妮 Grainne McAlonan Martin J.McKeown Shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica 商慧芳 James M.Shine Priyank Shukla Tomas Slavicek 宋潇鹏 Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt 王健 王珏 Z.Jane Wang 魏鲁庆 邬霞 徐晓俊 闫磊 杨靓 杨万群 姚乃琳 张得龙 张久权 张敏鸣 张艳玲 周彩红 严超赣 左西年 Mark Hallett 吴涛 臧玉峰 | 2021 | Science Bulletin2021，66，21： | 3 |
| 3 | Intestinal permeability test as a predictor of clinical course in Crohn’s disease显示文摘 | Renata D’Incà Vincenza Di Leo Giovanni Corrao Diego Martines Anna D’Odorico Cinzia Mestriner Carla Venturi Giuseppe Longo Giacomo Carlo Sturniolo | 1999 | The American Journal of Gastroenterology1999，，： | 2 |
| 4 | Enhancement of the primary flavor compound methional in potato by increasing the level of soluble methionine显示文摘 | DI R KIM J MARTIN M N | 2003 | Journal of Agricultural and Food Chemistry2003，51，19： | 1 |
| 5 | Arch replacement and downstream stent grafting in complex aortic dissection: first results of an international registry ☆显示文摘 | Konstantinos Tsagakis Davide Pacini Roberto Di Bartolomeo Jaroslav Benedik Stepan Cerny Michael Gorlitzer Martin Grabenwoger Carlos A. Mestres Heinz Jakob | 2011 | European Journal of Cardio-Thoracic Surgery2011，，1： | 1 |
| 6 | Diagnosis and staging of head and neck cancer:a comparison of modern imaging modalities (positron emission tomography,computed tomography,color-coded duplex sonography) with panendospic and histopathologic findings显示文摘 | Di Martin E Nowak B Hassan HA | | 0，，12： | 1 |
| 7 | Genome sequence and analysis of the tuber crop potato显示文摘 | Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Tones M Lnzano R Ponce O Martinez D De la Cruz G Chakrabarti S K Patil V U Skryabin K G Kuznetsov B B Ravin N V Kolganova T V Beletsky A V Mardanov A V Di Genova A Bolser D M Martin D M Li G Yang Y Kuang H Hu Q Xiong X Bishop G J Sagredo B Mejia N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M Herrera Mdel R Giuliano G Pietrella M Perrotta G Faeella P O 'Brien K Feingold S E Barreiro L E Massa G A Diambra L Whitty B R Vaillancourt B Lin H Massa A N Geoffroy M Lundback S DellaPenna D Buell C R Sharma S K Marshall D F Waugh R Bryan G J Destefanis M Nagy I Milbourne D Thomson S J Fiefs M Jacobs J M Nielsen K L Sonderkaer M Iovene M Tortes G A Jiang J Veilleux R E Bachem C W de Boer J Bonn T Kloosterman B van Eck H Datema E Hekkert B Goverse A van Ham R C Visser R G | 2011 | Nature2011，475，7355： | 1 |
| 8 | Application of accel- erated electron beam and microwave irradiation to biological waste treatment显示文摘 | Martin DI Margaritescu I Cirstea E | 2005 | Vacuum2005，77，4： | 1 |
| 9 | Hepatitis C–related hepatocellular carcinoma in the United States: influence of ethnic status显示文摘 | Adrian M Di Bisceglie Andre C Lyra Myron Schwartz Rajender K Reddy Paul Martin Gregory Gores Anna S.F Lok Khozema B Hussain Robert Gish David H Van Thiel Zobair Younossi Myron Tong Tarek Hassanein Luis Balart Jacquelyn Fleckenstein Stephen Flamm Andres Bl | 2003 | The American Journal of Gastroenterology2003，，9： | 1 |
| 10 | Glycosyltransferase domain of penicillin -binding protein 2a from Streptococcus pneumoniae is mem~ brane associated显示文摘 | DI GUILMI A M MOUZ N MARTIN L | 1999 | J Bacteriol1999，181，9： | 1 |
| 11 | Valproic acid-mediated neuroprotection and regeneration in injured retinal ganglion cells 显示文摘 | Biermann J Grieshaber P Goebel U Martin G Thanos S Di Giovanni S | 2010 | Invest Oph- thalmol Vis Sc/2010，51，1： | 1 |
| 12 | Germline epimutation in humans 显示文摘 | Cropley JE Martin DI Suter CM | 2008 | Pharmacogenomics2008，9，12： | 1 |
| 13 | The point prevalence of otitis media with effusion among primary school children in Western Sicily 显示文摘 | Martines F Bentivegna D Di Piazza F | 2010 | Eur Arch Torhinolaryngol2010，267，5： | 1 |
| 14 | Biolistic transfer and expression of a uidA reporter gene in different tissues of Allium sativum L显示文摘 | Barandiaran X Di Pietro A Martin J | 1998 | Plant Cell Reports1998，17，： | 1 |
| 15 | A human homologue of the Drosophila developmental gene,Notch,is expressed in CD34+ hematopoietic precursors显示文摘 | Milner LA Kopan R Martin DI | 1994 | Blood1994，83，8： | 1 |
| 16 | Application of accelerated electron beam and microwave irradiation to biological waste treatment显示文摘 | Martin DI Margaritescu I Cirstea E | 2005 | Vacuum2005，，： | 1 |
| 17 | Epigenetic inheritance at the agouti locus in the mouse 显示文摘 | Morgan HD Suther/and HG Martin DI | 1999 | Nat Genet1999，23，3： | 1 |
| 18 | MicroR?NAs control translation initiation by inhibiting eukaryotic initia?tion factor 4E/cap and poly (A) tail function显示文摘 | HUMPHREYS DT WESTMAN BJ MARTIN DI | 2005 | Proc Natl Acad Sci USA2005，102，16： | 1 |
| 19 | Multiple-drug–resistant bacteria in patients with severe acute exacerbation of chronic obstructive pulmonary disease: Prevalence, risk factors, and outcome显示文摘 | Saad Nseir Christophe Di Pompeo Béatrice Cavestri Elsa Jozefowicz Martine Nyunga Stéphane Soubrier Micheline Roussel-Delvallez Fabienne Saulnier Daniel Mathieu Alain Durocher | 2006 | Critical Care Medicine2006，，12： | 1 |
| 20 | Transcriptional interference by independently regulated genes occurs in any relative arrangement of the genes and is influenced by chromosomal integration position 显示文摘 | Eszterhas SK Bouhassira EE Martin DI | 2002 | Mol Cell Biol2002，22，2： | 1 |
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