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| 1 | Engineered polyketides:Synergy between protein and host level engineering显示文摘Metabolic engineering efforts toward rewiring metabolism of cells to produce new compounds often require the utilization of non-native enzymatic machinery that is capable of producing a broad range of chemical functionalities.Polyketides encompass one of the largest classes of chemically diverse natural products.With thousands of known polyketides,modular polyketide synthases(PKSs)share a particularly attractive biosynthetic logic for generating chemical diversity.The engineering of modular PKSs could open access to the deliberate production of both existing and novel compounds.In this review,we discuss PKS engineering efforts applied at both the protein and cellular level for the generation of a diverse range of chemical structures,and we examine future applications of PKSs in the production of medicines,fuels and other industrially relevant chemicals. | Jesus F.Barajas Jacquelyn M.Blake-Hedges Constance B.Bailey Samuel Curran Jay.D.Keasling | 2017 | Synthetic and Systems Biotechnology2017，2，3： | 3 |
| 2 | Targeted treatment of cancer with radiofrequency electromagnetic fields amplitude-modulated at tumor-specific frequencies显示文摘In the past century, there have been many attempts to treat cancer with low levels of electric and magnetic fields. We have developed noninvasive biofeedback examination devices and techniques and discovered that patients with the same tumor type exhibit biofeedback responses to the same, precise frequencies. Intrabuccal administration of 27.12 MHz radiofrequency(RF) electromagnetic fields(EMF), which are amplitude-modulated at tumor-specific frequencies, results in long-term objective responses in patients with cancer and is not associated with any significant adverse effects. Intrabuccal administration allows for therapeutic delivery of very low and safe levels of EMF throughout the body as exemplified by responses observed in the femur, liver, adrenal glands, and lungs. In vitro studies have demonstrated that tumor-specific frequencies identified in patients with various forms of cancer are capable of blocking the growth of tumor cells in a tissue- and tumor-specific fashion. Current experimental evidence suggests that tumor-specific modulation frequencies regulate the expression of genes involved in migration and invasion and disrupt the mitotic spindle. This novel targeted treatment approach is emerging as an appealing therapeutic option for patients with advanced cancer given its excellent tolerability. Dissection of the molecular mechanisms accounting for the anti-cancer effects of tumor-specific modulation frequencies is likely to lead to the discovery of novel pathways in cancer. | Jacquelyn W.Zimmerman Hugo Jimenez Michael J.Pennison Ivan Brezovich Desiree Morgan Albert Mudry Frederico P.Costa Alexandre Barbault Boris Pasche | 2013 | Chinese Journal of Cancer2013，32，11： | 3 |
| 3 | Divergence in the transcriptional landscape between low temperature and freeze shock in cultivated grapevine (Vitis vinifera)显示文摘Low-temperature stresses limit the sustainability and productivity of grapevines when early spring frosts damage young grapevine leaves.Spring conditions often expose grapevines to low,but not damaging,chilling temperatures and these temperatures have been shown to increase freeze resistance in other model systems.In this study,we examined whole-transcriptome gene expression patterns of young leaf tissue from cuttings of five different grapevine cultivars,exposed to chill and freeze shock,in order to understand the underlying transcriptional landscape associated with cold stress response.No visible damage was observed when grapevine leaves were exposed to chilling temperatures while freeze temperatures resulted in variable damage in all cultivars.Significant differences in gene expression were observed between warm control conditions and all types of cold stress.Exposure to chill stress(4°C)versus freezing stress(−3°C)resulted in very different patterns of gene expression and enriched pathway responses.Genes from the ethylene signaling,ABA signaling,the AP2/ERF,WRKY,and NAC transcription factor families,and starch/sucrose/galactose pathways were among the most commonly observed to be differentially regulated.Preconditioning leaves to chill temperatures prior to freezing temperatures resulted in slight buffering of gene expression responses,suggesting that differences between chill and freeze shock perception complicates identification of candidate genes for cold resistance in grapevine.Overall,the transcriptional landscape contrasts observed between low temperature and freezing stresses demonstrate very different activation of candidate pathways impacting grapevine cold response. | Jason P.Londo Alisson P.Kovaleski Jacquelyn A.Lillis | 2018 | Horticulture Research2018，5，1： | 2 |
| 4 | Characterization of Interleukin-17–Producing Regulatory T Cells in Inflamed Intestinal Mucosa From Patients With Inflammatory Bowel Diseases显示文摘 | Zaruhi Hovhannisyan Jacquelyn Treatman Dan R. Littman Lloyd Mayer | 2011 | Gastroenterology2011，，3： | 2 |
| 5 | Estimation of land surface temperature–vegetation abundance relationship for urban heat island studies显示文摘 | Qihao Weng Dengsheng Lu Jacquelyn Schubring | 2003 | Remote Sensing of Environment2003，，4： | 2 |
| 6 | Investigating the Relationship Between the Content of Online Word of Mouth, Advertising, and Brand Performance显示文摘 | Shyam Gopinath Jacquelyn S. Thomas Lakshman Krishnamurthi | 2014 | Marketing Science2014，，2： | 2 |
| 7 | Estimation of land surface temperature-vegetation abundance relationship for urban heat island studies显示文摘 | Qihao Weng Dengsheng Lu Jacquelyn Schubring | 2004 | Remote Sens Environ2004，89，： | 1 |
| 8 | General methods for the synthesis of glycol-pyranosyluronic acid azides 显示文摘 | Jacquelyn Gervay-Hague | 2003 | Carbohydr Res2003，338，： | 1 |
| 9 | What primary microcephaly can tell us about brain growth显示文摘 | James C Andrew P J Jacquelyn B | 2006 | Trends Mol Med2006，12，8： | 1 |
| 10 | Neuroanatomical Abnormalities and Cognitive Impairments Are Shared by Adults with Attention-Deficit/Hyperactivity Disorder and Their Unaffected First-Degree Relatives显示文摘 | Valentino Antonio Pironti Meng-Chuan Lai Ulrich Müller Chris Martin Dodds John Suckling Edward Thomas Bullmore Barbara Jacquelyn Sahakian | 2013 | Biological Psychiatry2013，，： | 1 |
| 11 | The Independent Effects of Environmental,Social and Governance Initiatives on The Performance of UK Firms显示文摘 | Jacquelyn E Humphrey | 2011 | Australian Journal of Management2011，，37： | 1 |
| 12 | What Are Employability Skills The Workplace显示文摘 | Jacquelyn P Robinson | 2009 | :1-32009，，： | 1 |
| 13 | Micro- satellite analysis reveals genetically distinct populations of red pine (Pinus resinosa, Pinaceae) 显示文摘 | Jacquelyn Boys Marilyn Cherry Selvadurai Dayanandan | 2005 | American Journal of Bota- ny2005，92，5： | 1 |
| 14 | Expression of the aryl hydrocarbon receptor is not required for the proliferation, migration, invasion, or estrogen‐dependent tumorigenesis of MCF‐7 breast cancer cells显示文摘 | Barbara C. Spink James A. Bennett Nicole Lostritto Jacquelyn R. Cole David C. Spink | 2013 | Mol. Carcinog2013，，7： | 1 |
| 15 | Investigations of step-growth thiol-ene polymerizations for novel dental restoratives 显示文摘 | Hui Lua Jacquelyn A Carioscia Jeffery W Stansbury | 2005 | Dental Materials2005，21，： | 1 |
| 16 | Believe it or not:Factors influencing credibility on the web显示文摘 | C Nadine Wathen Jacquelyn Burkell | 2002 | Journal of the American Society for Information Science and Technology2002，，： | 1 |
| 17 | Validity and relia- bility of Intraoperative monitoring in pediatric spinal defor- mity surgery显示文摘 | Earl DT Jacquelyn CW Anne MP | 2010 | Spine2010，35，20： | 1 |
| 18 | Urban Farming and Land-Use Planning in the Dominican Republic显示文摘 | Jacquelyne Acevedo Abinader | 2001 | Urban Agriculture Magazine2001，，4： | 1 |
| 19 | Hepatitis C–related hepatocellular carcinoma in the United States: influence of ethnic status显示文摘 | Adrian M Di Bisceglie Andre C Lyra Myron Schwartz Rajender K Reddy Paul Martin Gregory Gores Anna S.F Lok Khozema B Hussain Robert Gish David H Van Thiel Zobair Younossi Myron Tong Tarek Hassanein Luis Balart Jacquelyn Fleckenstein Stephen Flamm Andres Bl | 2003 | The American Journal of Gastroenterology2003，，9： | 1 |
| 20 | Do artificial income smoothing and real income smoothing contribute to firm value equivalently?显示文摘 | Pinghsun Huang Yan Zhang Donald R. Deis Jacquelyn S. Moffitt | 2008 | Journal of Banking and Finance2008，，2： | 1 |
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