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| 1 | Update in management of mesenteric ischemia显示文摘肠系膜局部缺血混乱被剥夺一或几个腹的机关遇见新陈代谢的要求足够的呼吸的一个发行量不足事件猛抛。尽管 mes 伤寒局部缺血不经常发生,死亡率从 60% ~ 100% ,依靠阻塞的消息提供者。成功的结果依赖于怀疑和迅速的管理的一个高索引。我们简短考察病理生理学和演讲各种各样是化学家实体并且在诊断和治疗考察当前的现状。尽管有在诊断和治疗的进展,迅速的诊断和支持的照顾为成功的结果仍然保持批评。新成像技术,血管内治疗和新兴的研究可以改进我们的途径到这个致命的条件。 | Robert W Chang John B Chang Walter E Longo | 2006 | World Journal of Gastroenterology2006，12，20： | 38 |
| 2 | Combined chemo-radiotherapy in locally advanced nasopharyngeal carcinomas显示文摘AIM:To provide efficacy and safety data about the combined use of radiotherapy and chemo-radiotherapy in nasopharyngeal carcinoma(NPC).METHODS:We reviewed data of 40 patients with locally advanced NPC treated with induction chemotherapy followed by concomitant chemo-radiotherapy(CCRT)(22/40 patients)or CCRT alone(18/40)from March 2006 to March 2012.Patients underwent fiberoscopy with biopsy of the primitive tumor,and computed tomography scan of head,neck,chest and abdomen with and without contrast.Cisplatin was used both as induction and as concomitant chemotherapy,while 3D conformal radiation therapy was delivered to the nasopharynx and relevant anatomic regions(total dose,70 Gy).The treatment was performed using 6 MV photons of the linear accelerator administered in 2 Gy daily fraction for five days weekly.This retrospective analysis was approved by the review boards of the participating institutions.Patients gave their consent to treatment and to anonymous analysis of clinical data.RESULTS:Thirty-three patients were males and 7 were females.Median follow-up time was 58 mo(range,1-92 mo).In the sub-group of twenty patients with a follow-up time longer than 36 mo,the 3-year survival and disease free survival rates were 85%and 75%,respectively.Overall response rate both in patients treated with induction chemotherapy followed by CCRT and in those treated with CCRT alone was 100%.Grade 3 neutropenia was the most frequent acute side-effect and it occurred in 20 patients.Grade 2 mucositis was seen in 29 patients,while grade 2 xerostomia was seen in 30 patients.Overall toxicity was manageable and it did not cause any significant treatment delay.In the whole sample population,long term toxicity included grade 2 xerostomia in 22 patients,grade 1 dysgeusia in 17 patients and grade 1 subcutaneous fibrosis in 30 patients.CONCLUSION:Both CCRT and induction chemotherapy followed by CCRT showed excellent activity in locally advanced NPC.The role of adjuvant chemotherapy remains to be defined. | Francesco Perri Giuseppina Della Vittoria Scarpati Carlo Buonerba Giuseppe Di Lorenzo Francesco Longo Paolo Muto Concetta Schiavone Fabio Sandomenico Francesco Caponigro | 2013 | World Journal of Clinical Oncology2013，4，2： | 22 |
| 3 | Pancreatic metastases from renal cell carcinoma:The state of the art显示文摘Pancreatic metastases are rare,with a reported incidence varying from 1.6%to 11%in autopsy studies of patients with advanced malignancy.In clinical series,the frequency of pancreatic metastases ranges from 2%to 5%of all pancreatic malignant tumors.However,the pancreas is an elective site for metastases from carcinoma of the kidney and this peculiarity has been reported by several studies.The epidemiology,clinical presentation,and treatment of pancreatic metastases from renal cell carcinoma are known from singleinstitution case reports and literature reviews.Thereis currently very limited experience with the surgical resection of isolated pancreatic metastasis,and the role of surgery in the management of these patients has not been clearly defined.In fact,for many years pancreatic resections were associated with high rates of morbidity and mortality,and metastatic disease to the pancreas was considered to be a terminal-stage condition.More recently,a significant reduction in the operative risk following major pancreatic surgery has been demonstrated,thus extending the indication for these operations to patients with metastatic disease. | Roberto Ballarin Mario Spaggiari Nicola Cautero Nicola De Ruvo Roberto Montalti Cristina Longo Anna Pecchi Patrizia Giacobazzi Giuseppina De Marco Giuseppe D’Amico Giorgio Enrico Gerunda Fabrizio Di Benedetto | 2011 | World Journal of Gastroenterology2011，17，43： | 21 |
| 4 | Probiotics to counteract biofilm-associated infections: promising and conflicting data显示文摘Altered bowel flora is currently thought to play a role in a variety of disease conditions, and the use of Bifidobacterium spp. and Lactobacillus spp. as probiotics has been demonstrated to be health-promoting, even if the success of their administration depends on the applied bacterial strain(s) and the targeted disease. In the last few decades, specific probiotics have been shown to be effective in the treatment or the prevention of acute viral gastroenteritis, pediatric post-antibiotic-associated diarrhea, some pediatric allergic disorders, necrotizing enterocolitis in preterm infants, inflammatory bowel diseases and postsurgical pouchitis. The potential application of probiotics is continuously widening, with new evidence accumulating to support their effect on the prevention and treatment of other disease conditions, including several oral diseases, such as dental caries, periodontal diseases and oral malodor, as well as genitourinary and wound infections. Considering the increasingly widespread ability of pathogens to generate persistent biofilm-related infections, an even more attractive proposal is to administer probiotics to prevent or counteract biofilm development.The response of biofilm-based oral, intestinal, vaginal and wound infections to probiotics treatment will be reviewed here in light of the most recent results obtained in this field. | Claudia Vuotto Francesca Longo Gianfranco Donelli | 2014 | International Journal of Oral Science2014，6，4： | 15 |
| 5 | An updated overview on the development of new photosensitizers for anticancer photodynamic therapy显示文摘Photodynamic therapy(PDT), based on the photoactivation of photosensitizers(PSs), has become a well-studied therapy for cancer. Photofrin~?, belonging to the first generation of PS, is still widely used for the treatment of different kinds of cancers; however, it has several drawbacks that significantly limit its general clinical use. Consequently, there has been extensive research on the design of PS molecules with optimized pharmaceutical properties, with aiming of overcoming the disadvantages of traditional PS, such as poor chemical purity, long half-life, excessive accumulation into the skin, and low attenuation coefficients. The rational design of novel PS with desirable properties has attracted considerable research in the pharmaceutical field. This review presents an overview on the classical photosensitizers and the most significant recent advances in the development of PS with regard to their potential application in oncology. | Juan Zhang Chengshi Jiang Joao Paulo Figueiró Longo Ricardo Bentes Azevedo Hua Zhang Luis Alexandre Muehlmann | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 13 |
| 6 | Innovative surgical approaches for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer worldwide,with an increasing diffusion in Europe and the United States.The management of such a cancer is continuously progressing and the objective of this paper is to evaluate innovation in the surgical treatment of HCC.In this review,we will analyze the modern concept of preoperative management,the role of laparoscopic and robotic surgery,the intraoperative use of three dimensional models and augmented reality,as well as the potential application of fluorescence. | Riccardo Memeo Nicola de’Angelis Vito de Blasi Zineb Cherkaoui Oronzo Brunetti Vito Longo Tullio Piardi Daniele Sommacale Jacques Marescaux Didier Mutter Patrick Pessaux | 2016 | World Journal of Hepatology2016，8，13： | 13 |
| 7 | 健康成年人血浆肉毒碱水平和日尿肉毒碱排出量测定显示文摘目的测定健康成年人血浆肉毒碱水平及日尿肉毒碱排出量,为研究疾病状态下肉毒碱代谢改变提供参考依据。方法给予40名健康成年人(男、女各20名)标准饮食,用高效液相色谱法测定其空腹血浆总肉毒碱(TC)、游离肉毒碱(FC)和乙酰肉毒碱(AC)水平及日尿TC、FC和AC排出量。结果血浆和尿液肉毒碱测定的变异系数在9.1%以下,偏差不超过5.6%,标准曲线的相关强度r2≥0.999。给予健康成年人标准饮食后,男性血浆TC、FC和AC水平眼(53.1±8.5)、(41.2±6.1)、(6.2±0.6)μmol/L演高于女性眼(45.4±5.6)、(35.2±4.9)、(5.7±0.7)μmol/L演(P=0.002、0.002、0.035);男性日尿TC、FC和AC排出量眼穴386.1±22.9雪、穴180.5±31.8雪、穴33.8±3.3雪μmol演高于女性眼穴240.1±35.6雪、穴112.7±22.6雪、穴29.3±4.3雪μmol演穴P<0.0005、<0.0005、<0.0005雪。空腹血浆TC、FC和AC水平及日尿TC、FC和AC排出量均与机体瘦体重有关穴r=0.501~0.856雪。男性血浆穴TC-FC雪/FC比值为0.29±0.05,女性为0.29±0.04。结论以高效液相色谱法测定血浆肉毒碱水平和日尿肉毒碱排出量,其重复性好,回收率高。给予健康成年人标准饮食后,空腹血浆肉毒碱水平和日尿肉毒碱排出量均与机体瘦体重呈正相关。 | 牛玉坚 蒋朱明 舒红 李春风 刘卫 姚国相 江骥 李井泉 Longo A | 2002 | 中国医学科学院学报2002，24，2： | 12 |
| 8 | Utility of magnetic resonance imaging in anorectal disease显示文摘Imaging of both benign and malignant anorectal diseases has traditionally posed a challenge to clinicians, and as a result history and physical exam have been relied on heavily. CT scanning and endorectal ultrasound have become popular in assessment of anatomy and staging of tumors, but have limitations. Magnetic resonance imaging (MRI) has the capability to fill in the gaps left open by more conventional imaging modalities and continues to be promising as the definitive imaging technique in the pelvis, especially with advancement of emerging technologies in this field. A comprehensive review of this topic has been undertaken. Anorectal disease is divided into three broad categories: cancer, fistula/abscess, and pelvic floor disorders. A review of the literature is performed to evaluate the use of MRI and other imaging modalities in these three areas. Preoperative imaging is useful in the evaluation of all three areas of anorectal disease. MRI is an effective tool in delineating anatomy and, when correlating with the specific clinical scenario, is an effective adjunct in clinical decision-making in order to optimize outcome. MRI continues to be a promising and novel approach to imaging various afflictions of the anorectum and the pelvic floor. Its role is more well-established in some areas than in others, and there are still signif icant limitations. As technology advances, MRI will shed more light on a complex anatomical area. | Loren Berman Gary M Israel Shirley M McCarthy Jeffrey C Weinreb Walter E Longo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 9 | Growth mechanism of octahedron-like BaMoO_4 microcrystals processed in microwave-hydrothermal:Experimental observations and computational modeling显示文摘Octahedron-like BaMoO4 microcrystals were synthesized by the co-precipitation method at room temperature and processed in microwave-hydrothermal at 413 K for different times (from 30 min to 5 h). These microcrystals were analyzed by X-ray diffraction (XRD),field-emission gun scanning electron microscopy (FEG-SEM) and transmission electron microscopy (TEM). XRD patterns showed that this material presents a tetragonal structure without the presence of deleterious phases. FEG-SEM and TEM micrographs revealed that the BaMoO4 microcrystals present an octahedron-like morphology with agglomerate nature and poly-disperse particle size distribution. These micrographs also indicated that the microcrystals grow along the [0 0 1] direction. The observed crystallographic planes in these structures were modeled computationally and a crystal growth model was proposed in order to explain the morphological changes as a function of processing time. | Laécio Santos Cavalcante Júlio César Sczancoski Rircado Luis Tranquilin José Arana Varela Elson Longo Marcelo Ornaghi Orlandi | 2009 | Particuology2009，7，5： | 9 |
| 10 | Chronic exposure to ethanol causes steatosis and inflammation in zebrafish liver显示文摘AIM To evaluate the effects of chronic exposure to ethanol in the liver and the expression of inflammatory genesin zebrafish.METHODS Zebrafish(n = 104),wild type,adult,male and female,were divided into two groups:Control and ethanol(0.05 v/v).The ethanol was directly added into water;tanks water were changed every two days and the ethanol replaced.The animals were fed twice a day with fish food until satiety.After two and four weeks of trial,livers were dissected,histological analysis(hematoxilineosin and Oil Red staining) and gene expression assessment of adiponectin,adiponectin receptor 2(adipor2),sirtuin-1(sirt-1),tumor necrosis factor-alpha(tnf-a),interleukin-1b(il-1b) and interleukin-10(il-10) were performed.Ultrastructural evaluations were conducted at fourth week.RESULTS Exposing zebrafish to 0.5% ethanol developed intense liver steatosis after four weeks,as demonstrated by oil red staining.In ethanol-treated animals,the main ultrastructural changes were related to cytoplasmic lipid particles and droplets,increased number of rough endoplasmic reticulum cisterns and glycogen particles.Between two and four weeks,hepatic mR NA expression of il-1b,sirt-1 and adipor2 were upregulated,indicating that ethanol triggered signaling molecules which are key elements in both hepatic inflammatory and protective responses.Adiponectin was not detected in the liver of animals exposed and not exposed to ethanol,and il-10 did not show significant difference.CONCLUSION Data suggest that inflammatory signaling and ultrastructural alterations play a significant role during hepatic steatosis in zebrafish chronically exposed to ethanol. | Ana Claudia Reis Schneider Cleandra Gregório Carolina Uribe-Cruz Ranieli Guizzo Tais Malysz Maria Cristina Faccioni-Heuser Larisse Longo Themis Reverbel da Silveira | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 11 | 中等收入国家年轻人脑卒中发病率增加:基于10年人口的研究显示文摘高收入国家年轻人脑卒中的发病率正在上升。然而,低收入和中等收入国家年轻人的脑卒中发病趋势仍未知。该研究旨在分析2005—2015年在巴西Joinville的年轻人的缺血性脑卒中(isehemic stroke,IS)和脑出血的发病趋势。 | 刘莉 叶鹏 Cabral NL Freire AT Conforto AB Dos Santos N Reis FI Nagel V Guesser VV Safanelli J Longo AL | 2017 | 中华高血压杂志2017，25，11： | 6 |
| 12 | Mayombian ethnic,vegetables low intake,insulin treatment,diabetic nephropathy and severe diabetic retinopathy are determinants of blindness in diabetic Africans显示文摘AIM:to determine the frequency and causes of blindness in diabetic Africans.METHODS:The study was a cross-sectional survey carried out among known black diabetics consecutively admitted at the Teaching Hospital,University of Kinshasa,between 2005 and 2007.Examination methods included interviewer-administered structured question naire,eye examinations(visual acuity,tonometry,funduscopy),and fasting plasma glycaemia test.RESULTS:Of the 227 patients examined,15.9% had blindness.Univariate analyses showed significant association between female,severity of diabetic retinopathy,Mayombian ethnic group,use of insulin treatment,low intake of vegetables,diabetic nephropathy,open angle glaucoma and blindness in all diabetics.After logistic regression,only diabetic nephropathy,use of insulin treatment,macular oedema,Mayombian ethnic group and vegetables low intake were the independent risk factors of blindness in all diabetics.However,after logistic regression in the sub-group with diabetic retinopathy,only open angle glaucoma and proliferative diabetic retinopathy were the independent determinants of blindness.CONCLUSION:The majority of the causes of blindness in these diabetic Africans are avoidable.It is recommended that appropriate diabetes care,nutrition education,periodic eye examination and laser photocoagulation facilities should be provided for treating diabetics in sub-Saharan Africa. | Mvitu Muaka Moise Longo-Mbenza Benjamin Cibanda Yokobo Enoch Longo Phemba Igor | 2013 | International Journal of Ophthalmology(English edition)2013，6，5： | 6 |
| 13 | 36例小细胞骨肉瘤的临床病理学、免疫组化及分子分析显示文摘Righi A,Gambarotti M,Longo S,et al. Sma11 ce11 osteosarco-ma:c1inicopatho1ogic,immunohistochemica1,and mo1ecu1ar a-na1ysis of 36 cases. Am J Surg Patho1,2015,39(5):691-9.小细胞骨肉瘤是骨肉瘤的一种非常罕见亚型,组织学类似骨的其它小细胞恶性肿瘤,特别是尤因肉瘤。为鉴别小细胞骨肉瘤及骨的其他原发性小细胞恶性肿瘤,作者对36例原发性骨的小细胞骨肉瘤进行CD99和SATB2(一种成骨细胞分化标志物)的免疫组化(IHC)表达情况评估。并通过荧光原位杂交和(或)逆转录聚合酶链反应( RT-PCR)分析了EWSR1和FUS 基因突变情况,进一步评估小细胞骨肉瘤和尤因肉瘤是否有相同的遗传性学改变。 | Righi A Gambarotti M Longo S 魏建国 许春伟 邰艳红 | 2015 | 临床与实验病理学杂志2015，31，6： | 5 |
| 14 | Total and not bevacizumab-bound vascular endothelial growth factor as potential predictive factors to bevacizumab-based chemotherapy in colorectal cancer显示文摘AIM: To identify suitable biomarkers of response to bevacizumab(BV)- it remains an open question. The measurement of serum vascular endothelial growth factor(VEGF) has been proposed as a predictive factor for this drug, even if literature data are contradictory. METHODS: We prospectively evaluated the role of BV, total and not BV-bound VEGF and angiopoietin-2(Ang-2) serum levels as potential predictive factors of response for BV in combination with an oxaliplatinbased chemotherapy. BV, Ang-2, total and not BVbound VEGF levels were measured at baseline, before 2^(nd) and 5^(th) cycle of oxaliplatin-based chemotherapy in 20 consecutive metastatic colorectal cancer patients. RESULTS: Results were correlated to response to treatment. Variability in BV levels have been found, with decreased level in less responding patients. In particular, the concentration of BV increased of 3.96 ± 0.69 folds in serum of responsive patients after 3 more cycles of therapy compared to those with stable or progressive disease with a 0.72 ± 0.25 and 2.10 ± 0.13 fold increase, respectively. The determination of free and total VEGF demonstrated that the ratio between the two values, evaluated immediately before the 2^(nd) and the 5^(th) cycle of therapy, decreased from 26.65% ± 1.33% to 15.50% ± 3.47% in responsive patients and from 53.41% ± 4.75 to 34.95% ± 2.88% in those with stable disease. Conversely, in those with progression of disease, the ratio showed the opposite behavior coming up from 25.99% ± 5.23% to 51.71% ± 5.28%. The Ang-2 levels did not show any relationship. CONCLUSION: Our data show that the ratio of not BV-bound VEGF to total VEGF serum and BV plasma concentrations for predicting the response to BV plus oxaliplatin-based chemotherapy could be a promising biomarker of response to BV. | Amalia Azzariti Letizia Porcelli Oronzo Brunetti Marzia Del Re Vito Longo Patrizia Nardulli Michele Signorile Jian-Ming Xu Angela Calabrese Anna Elisa Quatrale Evaristo Maiello Vito Lorusso Nicola Silvestris | 2016 | World Journal of Gastroenterology2016，22，27： | 4 |
| 15 | Retinopathy in non diabetics, diabetic retinopathy and oxidative stress: a new phenotype in Central Africa?显示文摘AIM:To evaluate the rates of retinopathy without diabetes and diabetic retinopathy(DR),associated with some markers of oxidative stress,antioxidants and cardiometabolic risk factors.METHODS:We determined the prevalence of DR in 150type 2 diabetes mellitus(T2DM)patients,that of retinopathy in 50 non diabetics,the levels of body mass index(BMI),waist circumference(WC),blood pressure,lipids,8-isoprostane,8-hydroxydeoxyguanosine(8-oHdG),gamma-glutamyl transferase(GGT),oxidized low density lipoprotein(LDL)(OxLDL),thiobarbituric acid reacting substances(TBARS),reduced glutathione(GSH),superoxide dismutase(SOD),uric acid,creatinine,albumin,total antioxidant status(TAOS),zinc,selenium,magnesium,vitamin C,vitamin D,vitamin E,glucose,apolipoprotein B(ApoB).RESULTS:The prevalences of DR at 53y and Rtp at62y were 44%(n=66)and 10%(n=5),respectively.Thehighest levels of 8-isoprostane,8-OHdG,TBARS,SOD,and OxLDL were in DR.The lowest levels of vitamin D,vitamin C,TAOS,and vitamin E were in DR.In the casecontrol study discriminant analysis,the levels of vitamin C,vitamin D,ApoB,8-OHdG,creatinine,Zn,vitamin E,and WC distinguished significantly non-diabetics without DR(controls),T2DM patients without DR and T2DM patients with DR.CONCLUSION:Anticipation of DR onset is significantly associated with the exageration of oxidative stress biomarkers or decrease of antioxidants in African type 2diabetics.Prevention of oxidative stress and abdominal obesity is needed.Supplementation in vitamin C,D,and E should be recommended as complement therapies of T2DM. | Benjamin Longo-Mbenza Moise Mvitu Muaka Wayiza Masamba Lucien Muizila Kini Igor Longo Phemba Dalida Kibokela Ndembe Doris Tulomba Mona | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 4 |
| 16 | 经自然腔道取标本手术(NOSES)治疗结直肠癌的国际共识显示文摘近年来,经自然腔道取标本手术(NOSES)治疗结直肠癌已引起了广泛关注。NOSES应用于结直肠手术的潜在优势包括减轻术后疼痛,减少伤口并发症,减少对术后镇痛的需求,加快肠道功能的恢复,缩短住院时间,更好的美容效果,以及给患者带来了更佳的心理状态。尽管NOSES的手术创伤显著减轻,然而该技术也存在一些潜在问题。尤其随着这项新技术的兴起,人们对其无菌的把控、肿瘤学结果和病例选择等问题表示出关切。因此,迫切需要一部操作指南来规范NOSES手术在结直肠癌中的开展。经过国际NOSES联盟全体成员的三轮讨论,最终形成了该部共识。这一共识有助于NOSES在全球范围内的长远发展。 | Xu Guan Zheng Liu Antonio Longo Jian-Chun Cai William Tzu-Liang Chen Lu-Chuan Chen Ho-Kyung Chun Joaquim Manuel da Costa Pereira Sergey Efetov Ricardo Escalante Qing-Si He Jun-Hong Hu Cuneyt Kayaalp Seon-Hahn Kim Jim S.Khan Li-Jen Kuo Atsushi Nishimura Fernanda Nogueira Junji Okuda Avanish Saklani Ali A.Shafik Ming-Yin Shen Jung-Tack Son Jun-Min Song Dong-Hui Sun Keisuke Uehara Gui-Yu Wang Ye Wei Zhi-Guo Xiong Hong-Liang Yao Gang Yu Shao-Jun Yu Hai-Tao Zhou Suk-Hwan Lee Petr V.Tsarkov Chuan-Gang Fu Xi-Shan Wang The International Alliance of NOSES | 2019 | Gastroenterology Report2019，7，1： | 3 |
| 17 | Reporting rotator cuff tears on magnetic resonance arthrography using the Snyder's arthroscopic classification显示文摘AIM To determine diagnostic performance of magnetic resonance arthrography(MRA) in evaluating rotator cuff tears(RCTs) using Snyder's classification for reporting.METHODS One hundred and twenty-six patients(64 males, 62 females; median age 55 years) underwent shoulder MRA and arthroscopy, which represented our reference standard. Surgical arthroscopic reports were reviewed and the reported Snyder's classification was recorded. MRA examinations were evaluated by two independent radiologists(14 and 5 years' experience) using Snyder's classification system, blinded to arthroscopy. Agreement between arthroscopy and MRA on partial-and fullthickness tears was calculated, first regardless of their extent. Then, analysis took into account also the extent of the tear. Interobserver agreement was also calculated the quadratically-weighted Cohen kappa statistics.RESULTS On arthroscopy, 71/126 patients(56%) had a fullthickness RCT. The remaining 55/126 patients(44%) had a partial-thickness RCT. Regardless of tear extent, out of 71 patients with arthroscopically-confirmed fullthickness RCTs, 66(93%) were correctly scored by both readers. All 55 patients with arthroscopic diagnosis of partial-thickness RCT were correctly assigned as having a partial-thickness RCT at MRA by both readers. Interobserver reproducibility analysis showed total agreement between the two readers in distinguishing partial-thickness from full-thickness RCTs, regardless of tear extent(k = 1.000). With regard to tear extent, in patients in whom a complete tear was correctly diagnosed, correct tear extent was detected in 61/66 cases(92%); in the remaining 5/66 cases(8%), tear extent was underestimated. Agreement was k = 0.955. Interobserver agreement was total(k = 1.000).CONCLUSION MRA shows high diagnostic accuracy and reproducibility in evaluating RCTs using the Snyder's classification for reporting. Snyder's classification may be adopted for routine reporting of MRA. | Alberto Aliprandi Carmelo Messina Paolo Arrigoni Michele Bandirali Giovanni Di Leo Stefano Longo Sandro Magnani Chiara Mattiuz Filippo Randelli Silvana Sdao Francesco Sardanelli Luca Maria Sconfienza Pietro Randelli | 2017 | World Journal of Radiology2017，9，3： | 3 |
| 18 | Liver Resection for Metastatic Colorectal Cancer in the Age of Neoadjuvant Chemotherapy and Bevacizumab显示文摘 | Peter S. Yoo Reynold I. Lopez-Soler Walter E. Longo Charles H. Cha | 2006 | Clinical Colorectal Cancer2006，，3： | 3 |
| 19 | Hepatocellular carcinoma staging systems: Hong Kong liver cancer vs Barcelona clinic liver cancer in a Western population显示文摘BACKGROUND Despite being the world’s most widely used system for staging and therapeutic guidance in hepatocellular carcinoma(HCC)treatment,the Barcelona clinic liver cancer(BCLC)system has limitations,especially regarding intermediate-grade(BCLC-B)tumors.The recently proposed Hong Kong liver cancer(HKLC)staging system appears useful but requires validation in Western populations.AIM To evaluate the agreement between BCLC and HKLC staging on the management of HCC in a Western population,estimating the overall patient survival.METHODS This was a retrospective study of HCC patients treated at a university hospital in southern Brazil between 2011 and 2016.Demographic,clinical,and laboratory data were collected.HCC staging was carried out according to the HKLC and BCLC systems to assess treatment agreement.Overall survival was estimated based on the treatment proposed in each system.RESULTS A total of 519 HCC patients were assessed.Of these,178(34.3%)were HKLC-I;95(18.3%)HKLC-IIA;47(9.1%)HKLC-IIB;29(5.6%)HKLC-IIIA;30(5.8%)HKLCIIIB;75(14.4%)HKLC-IV;and 65(12.5%)HKLC-V.According to the BCLC,25(4.9%)were BCLC-0;246(47.4%)BCLC-A;107(20.6%)BCLC-B;76(14.6%)BCLCC;and 65(12.5%)BCLC-D.The general agreement between the two systems was 80.0%-BCLC-0 and HKLC-I(100%);BCLC-A and HKLC-I/HKLC-II(96.7%);BCLC-B and HKLC-III(46.7%);BCLC-C and HKLC-IV(98.7%);BCLC-D and HKLC-V(41.5%).When sub-classifying BCLC-A,HKLC-IIB,HKLC-IIIA and HKLC-IIIB stages according to the up-to-7 in/out criterion,13.4,66.0,100 and 36.7%,respectively,of the cases were classified as up-to-7 out.CONCLUSION In a Western population,the general agreement between the two systems was 80.0%,although in BCLC-B cases the agreement was low,suggesting that some individuals could be candidates for the curative treatment recommended by the HKLC.The authors suggest that the BCLC system should be routinely employed,although for BCLC-B cases it should be associated with the HKLC system. | Laura Bainy Rodrigues de Freitas Larisse Longo Deivid Santos Ivana Grivicich Mário Reis Alvares-da-Silva | 2019 | World Journal of Hepatology2019，11，9： | 3 |
| 20 | Heavily calcified gastrointestinal stromal tumors:Pathophysiology and implications of a rare clinicopathologic entity显示文摘Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract, and are characterized by a broad spectrum of clinical, histological and molecular features at presentation. Although focal and scattered calcifications are not uncommon within the primary tumor mass, heavy calcification within a GIST is rarely described in the literature and the clinical-biological meaning of this feature remains unclear. Cases with such an atypical presentation are challenging and may be associated with diagnostic pitfalls. Herein, we report a gastric GIST with the unusual presentation of prominent calcifications that was identified incidentally on imaging during a post-trauma diagnostic work-up. The patient underwent laparoscopic surgery with a radical resection of the mass, which was subsequently characterized by histological analysis as spindle-shaped tumor cells, positive for CD117/c-KIT, CD34 and DOG1, and with calcified areas. Given the intermediate risk of recurrence, no adjuvant therapy was recommended andthe patient underwent regular follow-up for 22 mo, with no evidence of relapse. Our case can be considered of interest because of the rarity of clinical presentation and the uniquely large size of the GIST at diagnosis(longest diameter exceeding 9 cm). In closing, we discuss the pathophysiology and clinical implications of calcifications in GISTs by reviewing the most up-to-date relevant literature. | Massimiliano Salati Giulia Orsi Luca Reggiani Bonetti Fabrizio Di Benedetto Giuseppe Longo Stefano Cascinu | 2017 | World Journal of Gastrointestinal Oncology2017，9，3： | 2 |
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